Gene Page:GRK5

Summary?
GeneID 2869
Symbol GRK5
Synonyms GPRK5
Description G protein-coupled receptor kinase 5
Reference MIM:600870|HGNC:HGNC:4544|Ensembl:ENSG00000198873|HPRD:02926|Vega:OTTHUMG00000019149
Gene type protein-coding
Map location 10q26.11
Pascal p-value 0.167
Sherlock p-value 0.133
Fetal beta 0.305
DMG 3 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 3
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 3
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg09085932 10 121172083 GRK5 4.422E-4 0.395 0.045 DMG:Wockner_2014
cg23303782 10 120967744 GRK5 -0.023 0.26 DMG:Nishioka_2013
cg27315279 10 120966843 GRK5 5.9E-9 -0.013 3.17E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs3766034 chr1 169087664 GRK5 2869 0.05 trans
rs6686962 chr1 174953568 GRK5 2869 0.04 trans
rs10484468 chr6 106083705 GRK5 2869 0.17 trans
rs11755501 chr6 106084205 GRK5 2869 0.17 trans
rs6975312 chr7 50620029 GRK5 2869 0.13 trans
rs11203077 chr10 91097084 GRK5 2869 0.04 trans
rs17119672 chr10 91100630 GRK5 2869 0.01 trans
rs7911396 chr10 91101614 GRK5 2869 0.01 trans
rs7099668 chr10 91107381 GRK5 2869 0.01 trans
rs7907341 chr10 91108070 GRK5 2869 0.01 trans
rs12266581 chr10 91109911 GRK5 2869 0.01 trans
rs1041540 chr10 91111556 GRK5 2869 0.01 trans
rs4378299 chr10 91111779 GRK5 2869 0.01 trans
rs6586191 chr10 91135428 GRK5 2869 0.01 trans
rs12395234 chrX 52617968 GRK5 2869 0.12 trans
rs6568279 0 GRK5 2869 0.16 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FMNL1 0.56 0.53
DDN 0.56 0.50
ICAM5 0.55 0.52
PKD2L1 0.55 0.49
CX3CL1 0.55 0.52
KCNH3 0.55 0.55
C2orf55 0.55 0.49
ADAMTS8 0.54 0.48
CHRM1 0.54 0.49
FAM131A 0.54 0.54
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SH2D2A -0.31 -0.36
KIAA1949 -0.31 -0.22
LEMD1 -0.31 -0.21
AF186192.1 -0.30 -0.32
TUBB2B -0.30 -0.26
DYNLT1 -0.29 -0.33
TIGD1 -0.29 -0.22
AC005035.1 -0.29 -0.33
TMSB15A -0.29 -0.24
GPR125 -0.29 -0.30

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AGTR1 AG2S | AGTR1A | AGTR1B | AT1 | AT1B | AT1R | AT2R1 | AT2R1A | AT2R1B | HAT1R angiotensin II receptor, type 1 Affinity Capture-Western BioGRID 9211925
AVPR1A AVPR1 arginine vasopressin receptor 1A - HPRD,BioGRID 10858434
AVPR1B AVPR3 arginine vasopressin receptor 1B - HPRD 10858434
AVPR2 ADHR | DI1 | DIR | DIR3 | MGC126533 | MGC138386 | NDI | V2R arginine vasopressin receptor 2 - HPRD,BioGRID 10858434
CALM1 CALML2 | CAMI | DD132 | PHKD calmodulin 1 (phosphorylase kinase, delta) Reconstituted Complex BioGRID 9092566
CAV1 CAV | MSTP085 | VIP21 caveolin 1, caveolae protein, 22kDa Reconstituted Complex BioGRID 10085129
CHRM2 FLJ43243 | HM2 | MGC120006 | MGC120007 cholinergic receptor, muscarinic 2 - HPRD,BioGRID 8288567
GIT1 - G protein-coupled receptor kinase interacting ArfGAP 1 - HPRD 9826657
GRK5 GPRK5 G protein-coupled receptor kinase 5 Biochemical Activity BioGRID 8144599
OXTR OT-R oxytocin receptor Affinity Capture-Western BioGRID 10858434
RCVRN RCV1 recoverin - HPRD,BioGRID 12507501
RHO CSNBAD1 | MGC138309 | MGC138311 | OPN2 | RP4 rhodopsin - HPRD,BioGRID 8144599|8288567
SNCA MGC110988 | NACP | PARK1 | PARK4 | PD1 synuclein, alpha (non A4 component of amyloid precursor) Biochemical Activity BioGRID 10852916
SNCB - synuclein, beta Biochemical Activity BioGRID 10852916
SNCG BCSG1 | SR synuclein, gamma (breast cancer-specific protein 1) - HPRD,BioGRID 10852916
TACR1 NK1R | NKIR | SPR | TAC1R tachykinin receptor 1 - HPRD,BioGRID 12067742
TBXA2R TXA2-R thromboxane A2 receptor - HPRD 11504827


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CHEMOKINE SIGNALING PATHWAY 190 128 All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS 183 132 All SZGR 2.0 genes in this pathway
PID ALPHA SYNUCLEIN PATHWAY 33 25 All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184 116 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP 351 230 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460 312 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER BASAL VS MESENCHYMAL DN 50 36 All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL DN 86 59 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY UP 78 41 All SZGR 2.0 genes in this pathway
PAPASPYRIDONOS UNSTABLE ATEROSCLEROTIC PLAQUE DN 43 29 All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS DN 240 171 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459 276 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN 142 95 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355 243 All SZGR 2.0 genes in this pathway
PEREZ TP53 AND TP63 TARGETS 205 145 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 XPCS DN 88 71 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392 251 All SZGR 2.0 genes in this pathway
XU HGF SIGNALING NOT VIA AKT1 48HR UP 35 20 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
TOMLINS METASTASIS UP 14 9 All SZGR 2.0 genes in this pathway
SPIELMAN淋巴母细胞欧洲和亚洲的DN 584 395 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
CHESLER BRAIN QTL CIS 75 51 All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS DN 87 69 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207 145 All SZGR 2.0 genes in this pathway
YE METASTATIC LIVER CANCER 27 13 All SZGR 2.0 genes in this pathway
ZHANG TARGETS OF EWSR1 FLI1 FUSION 88 68 All SZGR 2.0 genes in this pathway
HADDAD T LYMPHOCYTE AND NK PROGENITOR UP 78 56 All SZGR 2.0 genes in this pathway
STOSSI RESPONSE TO ESTRADIOL 50 35 All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 DN 77 48 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298 200 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
MA PITUITARY FETAL VS ADULT DN 19 17 All SZGR 2.0 genes in this pathway
XU GH1 EXOGENOUS TARGETS UP 85 50 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
OUILLETTE CLL 13Q14 DELETION DN 60 38 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430 288 All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS MODEL UP 45 26 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435 289 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442 275 All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356 214 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 13 30 20 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS UP 91 59 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN UP 90 58 All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456 287 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430 288 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259 159 All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP 271 165 All SZGR 2.0 genes in this pathway
PURBEY CTBP1没有SATB1的目标 344 215 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337 236 All SZGR 2.0 genes in this pathway