Gene Page:GPX2

Summary?
GeneID 2877
Symbol GPX2
Synonyms GI-GPx|GPRP|GPRP-2|GPx-2|GPx-GI|GSHPX-GI|GSHPx-2
Description glutathione peroxidase 2
Reference MIM:138319|HGNC:HGNC:4554|Ensembl:ENSG00000176153|HPRD:11818|Vega:OTTHUMG00000171677
Gene type protein-coding
Map location 14q24.1
Pascal p-value 0.684
Fetal beta -0.307

Gene in Data Sources
Gene set name Method of gene set Description Info
PMID:cooccur High-throughput literature-search 系统搜索PubMed co-occ基因urring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SMAD7 0.83 0.84
ADCY3 0.80 0.82
SYVN1 0.80 0.79
TBC1D9B 0.80 0.81
KIAA0664 0.80 0.80
CLCN7 0.79 0.81
BACE1 0.78 0.79
ARHGEF17 0.78 0.79
FURIN 0.78 0.80
AGPAT3 0.77 0.79
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.59 -0.48
C1orf54 -0.56 -0.50
GNG11 -0.55 -0.51
CLEC2B -0.53 -0.47
SYCP3 -0.53 -0.52
AL050337.1 -0.52 -0.47
AF347015.31 -0.48 -0.40
C1orf61 -0.48 -0.39
RPS27L -0.47 -0.41
AP002478.3 -0.46 -0.42

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG GLUTATHIONE METABOLISM 50 34 All SZGR 2.0 genes in this pathway
KEGG ARACHIDONIC ACID METABOLISM 58 36 All SZGR 2.0 genes in this pathway
PID DELTA NP63 PATHWAY 47 34 All SZGR 2.0 genes in this pathway
PID TAP63 PATHWAY 54 40 All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP 285 181 All SZGR 2.0 genes in this pathway
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE UP 108 67 All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
IGARASHI ATF4 TARGETS DN 90 65 All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258 141 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS UP 194 112 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN 229 142 All SZGR 2.0 genes in this pathway
WANG ESOPHAGUS CANCER VS NORMAL UP 121 72 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS DN 193 112 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
HOUSTIS ROS 36 29 All SZGR 2.0 genes in this pathway
ABBUD LIF SIGNALING 2 UP 14 13 All SZGR 2.0 genes in this pathway
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN UP 30 21 All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND TBH 60 42 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C1 72 45 All SZGR 2.0 genes in this pathway
YANG MUC2 TARGETS DUODENUM 6MO UP 10 5 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
HANN RESISTANCE TO BCL2 INHIBITOR UP 36 24 All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP 174 96 All SZGR 2.0 genes in this pathway
HUPER BREAST BASAL VS LUMINAL UP 54 29 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS POLYSOMY7 DN 24 17 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE UP 62 42 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SURVIVAL UP 73 49 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266 180 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718 401 All SZGR 2.0 genes in this pathway
ZEMBUTSU SENSITIVITY TO CYCLOPHOSPHAMIDE 18 12 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP 271 165 All SZGR 2.0 genes in this pathway
MADAN DPPA4 TARGETS 46 26 All SZGR 2.0 genes in this pathway
KOHOUTEK CCNT1 TARGETS 50 26 All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308 187 All SZGR 2.0 genes in this pathway