Gene Page:GPX3

Summary?
GeneID 2878
Symbol GPX3
Synonyms GPx-P|GSHPx-3|GSHPx-P
Description glutathione peroxidase 3
Reference MIM:138321|HGNC:HGNC:4555|Ensembl:ENSG00000211445|HPRD:11750|Vega:OTTHUMG00000163693
Gene type protein-coding
Map location 5q33.1
Pascal p-value 0.22
Sherlock p-value 0.497
Fetal beta -0.486
eGene Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.0032
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01718
GSMA_IIA 基因组扫描荟萃分析(所有样品) Psr: 0.00459
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10484691 chr6 62444039 GPX3 2878 0.08 trans
rs7011197 chr8 54240481 GPX3 2878 0.14 trans
rs7816572 chr8 54265565 GPX3 2878 0.17 trans
rs1872761 chr15 40003815 GPX3 2878 0.1 trans
snp_a-1955963 0 GPX3 2878 7.33E-4 trans
rs9952767 chr18 7350414 GPX3 2878 0.15 trans
rs9304098 chr18 29083629 GPX3 2878 0.15 trans
rs2704052 chr18 29095433 GPX3 2878 0.12 trans
rs7065377 chrX 65081776 GPX3 2878 0.1 trans
rs6624825 chrX 65094493 GPX3 2878 0.1 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FNDC3A 0.74 0.84
KCTD3 0.73 0.78
AGL 0.73 0.81
WDR44 0.72 0.81
BRWD2 0.71 0.78
SH3GLB1 0.71 0.76
ASCC3 0.71 0.81
SEMA6D 0.71 0.77
ZMYND11 0.71 0.80
HMGCS1 0.70 0.77
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.55 -0.66
FXYD1 -0.54 -0.64
MYL3 -0.54 -0.66
AF347015.31 -0.52 -0.62
COPZ2 -0.51 -0.58
AF347015.33 -0.51 -0.60
AF347015.8 -0.51 -0.62
AF347015.21 -0.50 -0.62
AF347015.27 -0.49 -0.60
HIGD1B -0.49 -0.63

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0004602 glutathione peroxidase activity IDA 1897960|3693360
GO:0008430 selenium binding IDA 2491950|3693360
GO:0008134 transcription factor binding TAS 8056346
GO:0016491 oxidoreductase activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006982 response to lipid hydroperoxide TAS 2491950
GO:0006979 response to oxidative stress IEA -
GO:0051289 protein homotetramerization IDA 3693360
GO:0042744 hydrogen peroxide catabolic process TAS 2491950
GO:0055114 oxidation reduction IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region IEA -
GO:0005615 extracellular space IDA 1897960

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG GLUTATHIONE METABOLISM 50 34 All SZGR 2.0 genes in this pathway
KEGG ARACHIDONIC ACID METABOLISM 58 36 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN 116 79 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367 220 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536 332 All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN 291 176 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 128 95 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 117 84 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 65 DN 37 22 All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST PRENEOPLASTIC DN 55 33 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 DN 149 93 All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS AND ESOPHAGUS CANCER DN 37 22 All SZGR 2.0 genes in this pathway
WANG ESOPHAGUS CANCER VS NORMAL DN 101 66 All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION DN 100 64 All SZGR 2.0 genes in this pathway
XU HGF TARGETS REPRESSED BY AKT1 DN 95 58 All SZGR 2.0 genes in this pathway
WEINMANN ADAPTATION TO HYPOXIA UP 29 24 All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS DN 124 79 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203 134 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 UP 140 85 All SZGR 2.0 genes in this pathway
HOUSTIS ROS 36 29 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398 262 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
ABBUD LIF SIGNALING 1 UP 46 29 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX DN 80 49 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP 225 139 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249 170 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP 105 73 All SZGR 2.0 genes in this pathway
SIMBULAN PARP1 TARGETS UP 31 23 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
KEEN RESPONSE TO ROSIGLITAZONE DN 106 68 All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC UP 202 115 All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS 90 71 All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202 132 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430 288 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP 131 79 All SZGR 2.0 genes in this pathway
VANASSE BCL2 TARGETS DN 74 50 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435 289 All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356 214 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536 296 All SZGR 2.0 genes in this pathway
LIU VAV3 PROSTATE CARCINOGENESIS UP 89 61 All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN 181 97 All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP 83 63 All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR UP 101 65 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266 180 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA2 DN 80 51 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN UP 56 38 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE 317 190 All SZGR 2.0 genes in this pathway
AZARE NEOPLASTIC TRANSFORMATION BY STAT3 UP 121 70 All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS UP 169 105 All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 403 240 All SZGR 2.0 genes in this pathway
PEDERSEN TARGETS OF 611CTF ISOFORM OF ERBB2 76 45 All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308 187 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-24 703 709 m8 hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-378 49 55 1A hsa-miR-378 CUCCUGACUCCAGGUCCUGUGU