Gene Page:GRB10
Summary？
| 基因 | 2887 |
| 象征 | GRB10 |
| Synonyms | GRB-IR|Grb-10|IRBP|MEG1|RSS |
| Description | growth factor receptor bound protein 10 |
| Reference | MIM：601523|HGNC:HGNC:4564|Ensembl:ENSG00000106070|HPRD：03312|Vega：Otthumg00000150622 |
| 基因类型 | 蛋白质编码 |
| Map location | 7p12.2 |
| Pascal p-value | 0.005 |
| 胎儿β | -0.079 |
| Support | G2Cdb.humanPSD G2Cdb.humanPSP Ascano FMRP targets |
Gene in Data Sources
| 基因集名称 | Method of gene set | Description | 信息 |
|---|---|---|---|
| 简历：Gwascat | Genome-wide Association Studies | 该数据集包括与精神分裂症相关的560个SNP。总共将486个基因映射到50kb内的这些SNP。 | |
| CV:GWASdb | Genome-wide Association Studies | 精神分裂症的GWASDB记录 | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID：cooccur | High-throughput literature-search | PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | 点击显示详细信息 |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | PPI网络中最短路径的贡献：0.0161 |
Section I. Genetics and epigenetics annotation
第二节。转录组注释
一般基因表达（GTEX）
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达（brainspan）
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
某fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。
大脑区域的顶级共表达基因
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MLL2 | 0.83 | 0.86 |
| PRICKLE2 | 0.83 | 0.85 |
| RAPH1 | 0.83 | 0.86 |
| C12orf51 | 0.82 | 0.84 |
| RNF150 | 0.82 | 0.84 |
| TANC2 | 0.82 | 0.85 |
| KIAA2018 | 0.81 | 0.83 |
| XKR4 | 0.80 | 0.85 |
| SOCS7 | 0.80 | 0.84 |
| CUGBP2 | 0.80 | 0.81 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| serpinb6 | -0.58 | -0.70 |
| RHOC | -0.54 | -0.69 |
| BDH2 | -0.51 | -0.62 |
| FXYD1 | -0.51 | -0.66 |
| TLCD1 | -0.50 | -0.66 |
| DCXR | -0.50 | -0.62 |
| DBI | -0.50 | -0.69 |
| S100A16 | -0.50 | -0.66 |
| SAT1 | -0.50 | -0.71 |
| AC021016.1 | -0.50 | -0.66 |
第三节。基因本体论注释
| 分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
|---|---|---|---|---|
| 去：0005070 | SH3/SH2 adaptor activity | TAS | 9006901 | |
| 去：0005515 | 蛋白质结合 | IEA | - | |
| 去：0005515 | 蛋白质结合 | IPI | 8798570 | |
| 生物过程 | 去学期 | 证据 | 神经关键字 | PubMed ID |
| GO:0007267 | 细胞细胞信号传导 | TAS | 9006901 | |
| GO:0007165 | 信号转导 | IEA | - | |
| GO:0008286 | 胰岛素受体信号通路 | TAS | 9006901 | |
| GO：0048009 | 胰岛素样生长因子受体信号通路 | IEA | - | |
| Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
| 去：0005737 | cytoplasm | TAS | 9006901 | |
| 去：0005886 | plasma membrane | TAS | 9006901 |
Section IV. Protein-protein interaction annotation
| 互动者 | 别名b | 官方全名b | 实验 | Source | PubMed ID |
|---|---|---|---|---|---|
| ABL1 | ABL |JTK7 |BCR/ABL |c-abl |P150 |V-ABL | C-ABL癌基因1，受体酪氨酸激酶 | 亲和力捕获 - 韦斯特恩 重构的复合物 |
Biogrid | 9006901|9747873 |
| AKT1 | akt |MGC99656 |PKB |pkb-alpha |Prkba |RAC |Rac-Alpha | v-akt小鼠胸腺瘤病毒致癌基因同族体1 | - | HPRD | 11809791 |
| BCR | 全部|BCR-ABL1 |BCR1 |CML |D22S11 |D22S662 |FLJ16453 |phl | breakpoint cluster region | - | HPRD,BioGRID | 9747873 |
| egfr | ERBB |ERBB1 |her1 |PIG61 |梅纳 | 表皮生长因子受体（红细胞性白血病病毒（V-ERB-B）癌基因同源物，鸟类） | Grb10 interacts with EGFR. | 绑定 | 9506989 |
| egfr | ERBB |ERBB1 |her1 |PIG61 |梅纳 | 表皮生长因子受体（红细胞性白血病病毒（V-ERB-B）癌基因同源物，鸟类） | - | HPRD,BioGRID | 9006901|9506989 |
| ELK1 | - | ELK1, member of ETS oncogene family | - | HPRD | 8798570 |
| EPHB1 | ELK | EPHT2 | FLJ37986 | Hek6 | NET | EPH receptor B1 | Two-hybrid | Biogrid | 8798570 |
| Fyn | MGC45350 | SLK | SYN | Fyn Oncogene与SRC，FGR，是的 | - | HPRD,BioGRID | 10871840 |
| GHR | GHBP | 生长激素受体 | - | HPRD,BioGRID | 9632636 |
| Gigyf1 | GYF1 | PERQ1 | GRB10相互作用GYF蛋白1 | - | HPRD,BioGRID | 12771153 |
| gigyf2 | DKFZP686I15154 |DKFZP686J17223 |FLJ23368 |gyf2 |KIAA0642 |park11 |perq2 |perq3 |TNRC15 | GRB10相互作用GYF蛋白2 | - | HPRD,BioGRID | 12771153 |
| IGF1R | CD221 |igfir |JTK13 |MGC142170 |MGC142172 |MGC18216 | insulin-like growth factor 1 receptor | - | HPRD | 8621530|8764099 |
| IGF1R | CD221 |igfir |JTK13 |MGC142170 |MGC142172 |MGC18216 | insulin-like growth factor 1 receptor | Grb10 interacts with IGFIR. | 绑定 | 9506989 |
| IGF1R | CD221 |igfir |JTK13 |MGC142170 |MGC142172 |MGC18216 | insulin-like growth factor 1 receptor | 亲和力捕获 - 韦斯特恩 体外 in vivo 重构的复合物 Two-hybrid |
Biogrid | 8764099|8776723 |9506989|12697834 |
| INSR | CD220 | HHF5 | 胰岛素受体 | GRB10与IR相互作用。 | 绑定 | 9506989 |
| INSR | CD220 | HHF5 | 胰岛素受体 | - | HPRD,BioGRID | 7479769|8621530 |
| IRS1 | HIRS-1 | 胰岛素受体substrate 1 | 重构的复合物 | Biogrid | 8621530 |
| JAK2 | JTK10 | Janus kinase 2 (a protein tyrosine kinase) | - | HPRD,BioGRID | 9632636 |
| KDR | CD309 |flk1 |VEGFR |VEGFR2 | 激酶插入结构域受体（III型受体酪氨酸激酶） | - | HPRD,BioGRID | 11494124 |
| KIT | c-kit |CD117 |PBT |scfr | V-Kit Hardy-Zuckerman 4猫肉瘤病毒性癌基因同源物 | - | HPRD,BioGRID | 11809791 |
| MAP2K1 | mapkk1 |MEK1 |MKK1 |prkmk1 | mitogen-activated protein kinase kinase 1 | - | HPRD,BioGRID | 9553107 |
| MEGF10 | DKFZp781K1852 | FLJ41574 | KIAA1780 | 多个EGF样域10 | - | HPRD | 12421765 |
| NEDD4 | KIAA0093 | MGC176705 | NEDD4-1 | RPF1 | 神经前体细胞表达，发育下调4 | - | HPRD | 12697834 |
| NEDD4 | KIAA0093 | MGC176705 | NEDD4-1 | RPF1 | 神经前体细胞表达，发育下调4 | - | HPRD | 10446181|12697834 | 12697834 |
| PDGFRB | CD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1 | platelet-derived growth factor receptor, beta polypeptide | - | HPRD | 9006901 |
| RAF1 | 克拉夫|NS5 |RAF-1 |C-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 | - | HPRD,BioGRID | 9553107|10585452 |
| ret | CDHF12 |HSCR1 |men2a |men2b |mtc1 |PTC |ret-ele1 |RET51 | ret原癌基因 | - | HPRD,BioGRID | 7665556 |
| src | ASV | SRC1 | c-SRC | p60-Src | V-SRC肉瘤（Schmidt-Ruppin A-2）病毒癌基因同源物（Avian） | 生化活动 | Biogrid | 10871840 |
Section V. Pathway annotation
Section VI. microRNA annotation
| mirna家族 | Target position | miRNA ID | mirna seq | ||
|---|---|---|---|---|---|
| UTR开始 | UTR结束 | 匹配方法 | |||
| miR-125/351 | 2338 | 2344 | M8 | hsa-miR-125bbrain | ucccugagacccuaacuuguga |
| hsa-miR-125abrain | ucccugagacccuuaaccugug | ||||
| miR-181 | 2320 | 2327 | 1A，M8 | HSA-MIR-181Abrain | AACAUUCAACGCUGUCGGUGAGU |
| HSA-MIR-181BSZ | AACAUUCAUUGCUGUCGGUGGG | ||||
| HSA-MIR-181Cbrain | AACAUUCAACCUGUCGGUGAGU | ||||
| HSA-MIR-181Dbrain | AACAUUCAUUGUUGUCGGUGGGUU | ||||
| miR-199 | 39 | 46 | 1A，M8 | HSA-MIR-199A | CCCAGUGUUCAGACUACCUGUUC |
| HSA-MIR-199B | cccaguguuuagacuaucuuc | ||||
| mir-30-5p | 367 | 373 | M8 | HSA-MIR-30A-5P | UGUAAACAUCCUCGACUGGAAG |
| hsa-miR-30cbrain | UGUAAACAUCCUACACUCUCAGC | ||||
| hsa-miR-30dSZ | UGUAAACAUCCCCGACUGGAAG | ||||
| hsa-miR-30bSZ | uguaaacauccuaccucucagcu | ||||
| hsa-miR-30e-5p | UGUAAACAUCCUUGACUGGA | ||||