Gene Page:GRIA2

Summary?
GeneID 2891
Symbol GRIA2
Synonyms GLUR2|GLURB|GluA2|GluR-K2|HBGR2
Description glutamate ionotropic receptor AMPA type subunit 2
Reference MIM:138247|HGNC:HGNC:4572|Ensembl:ENSG00000120251|HPRD:04726|Vega:OTTHUMG00000133836
Gene type protein-coding
Map location 4q32.1
Pascal p-value 0.235
Sherlock p-value 0.755
Fetal beta -0.172
Support LIGAND GATED ION SIGNALING
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_TAP-PSD-95-CORE
G2Cdb.humanARC
G2Cdb.humanPSD
G2Cdb.humanPSP
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 6
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.6626

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TACC1 0.94 0.89
ZMAT3 0.93 0.88
FAM73A 0.92 0.81
CHIC1 0.91 0.80
MBNL2 0.90 0.87
EFR3A 0.90 0.79
DPP8 0.90 0.78
NAPEPLD 0.90 0.77
OXR1 0.89 0.79
ARAP2 0.89 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
BCL7C -0.48 -0.65
TBC1D10A -0.48 -0.44
TRAF4 -0.46 -0.63
AC006276.2 -0.46 -0.52
SH3BP2 -0.46 -0.57
SH2B2 -0.45 -0.56
RPL36 -0.45 -0.65
RPLP1 -0.45 -0.61
SIGIRR -0.45 -0.57
NR2C2AP -0.45 -0.50

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0004971 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity TAS glutamate (GO term level: 8) 8003671
GO:0004970 ionotropic glutamate receptor activity IEA glutamate (GO term level: 7) -
GO:0005234 extracellular-glutamate-gated ion channel activity IEA glutamate (GO term level: 11) -
GO:0015277 kainate selective glutamate receptor activity TAS glutamate (GO term level: 8) 8003671
GO:0004872 receptor activity IEA -
GO:0005216 ion channel activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007268 synaptic transmission TAS neuron, Synap, Neurotransmitter (GO term level: 6) 8003671
GO:0007165 signal transduction TAS 8003671
GO:0006811 ion transport IEA -
GO:0006810 transport IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0045211 postsynaptic membrane IEA Synap, Neurotransmitter (GO term level: 5) -
GO:0045202 synapse IEA neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -
GO:0005886 plasma membrane TAS 8003671
GO:0030054 cell junction IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CACNG2 MGC138502 | MGC138504 calcium channel, voltage-dependent, gamma subunit 2 Affinity Capture-Western BioGRID 11140673
DLG4 FLJ97752 | FLJ98574 | PSD95 | SAP90 discs, large homolog 4 (Drosophila) Affinity Capture-MS BioGRID 16990550
GRIA1 GLUH1 | GLUR1 | GLURA | HBGR1 | MGC133252 glutamate receptor, ionotropic, AMPA 1 Affinity Capture-Western BioGRID 10358037
GRID2 MGC117022 | MGC117023 | MGC117024 glutamate receptor, ionotropic, delta 2 Affinity Capture-Western BioGRID 12573530
GRIK2 EAA4 | GLR6 | GLUK6 | GLUR6 | MGC74427 | MRT6 glutamate receptor, ionotropic, kainate 2 Affinity Capture-Western BioGRID 8288598
GRIK5 EAA2 | GRIK2 | KA2 glutamate receptor, ionotropic, kainate 5 Affinity Capture-Western BioGRID 12573530
GRIP1 GRIP glutamate receptor interacting protein 1 Reconstituted Complex
Two-hybrid		 BioGRID 11891216
PICK1 MGC15204 | PICK | PRKCABP protein interacting with PRKCA 1 Reconstituted Complex
Two-hybrid		 BioGRID 11891216
SDCBP MDA-9 | ST1 | SYCL | TACIP18 syndecan binding protein (syntenin) Reconstituted Complex BioGRID 11891216
SPTAN1 (ALPHA)II-SPECTRIN | FLJ44613 | NEAS spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) Affinity Capture-Western
Far Western		 BioGRID 10576550
SPTBN1 ELF | SPTB2 | betaSpII spectrin, beta, non-erythrocytic 1 Far Western BioGRID 10576550


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION 70 57 All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 70 53 All SZGR 2.0 genes in this pathway
KEGG肌萎缩性脊髓侧索硬化肌萎缩性侧索硬化症 53 43 All SZGR 2.0 genes in this pathway
PID NCADHERIN PATHWAY 33 32 All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186 155 All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279 221 All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137 110 All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF AMPA RECEPTORS 28 23 All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 16 11 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 37 32 All SZGR 2.0 genes in this pathway
REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION 15 14 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL UP 94 59 All SZGR 2.0 genes in this pathway
GUENTHER GROWTH SPHERICAL VS ADHERENT UP 21 15 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
CHESLER BRAIN HIGHEST EXPRESSION 40 29 All SZGR 2.0 genes in this pathway
ABBUD LIF SIGNALING 1 DN 26 17 All SZGR 2.0 genes in this pathway
MCCLUNG DELTA FOSB TARGETS 8WK 47 38 All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS POSTNATAL 63 50 All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX UP 36 27 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS DN 74 55 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
LEIN NEURON MARKERS 69 45 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN 120 81 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430 288 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B UP 172 109 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE UP 149 85 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366 257 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293 203 All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN 134 83 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177 132 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 188 194 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 187 194 1A,m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-132/212 2343 2349 1A hsa-miR-212深圳 UAACAGUCUCCAGUCACGGCC
hsa-miR-132brain UAACAGUCUACAGCCAUGGUCG
miR-181 140 146 m8 hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181b深圳 AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-186 779 786 1A,m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-218 476 482 m8 hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-219 1988 1994 1A hsa-miR-219brain UGAUUGUCCAAACGCAAUUCU
miR-30-5p 2417 2424 1A,m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30d深圳 UGUAAACAUCCCCGACUGGAAG
hsa-miR-30b深圳 UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-335 456 462 1A hsa-miR-335brain UCAAGAGCAAUAACGAAAAAUGU
miR-374 1284 1290 1A hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
miR-410 2097 2103 m8 hsa-miR-410 AAUAUAACACAGAUGGCCUGU
miR-486 48 54 1A hsa-miR-486 UCCUGUACUGAGCUGCCCCGAG
miR-496 2090 2096 1A hsa-miR-496 AUUACAUGGCCAAUCUC
hsa-miR-496 AUUACAUGGCCAAUCUC
hsa-miR-496 AUUACAUGGCCAAUCUC
hsa-miR-496 AUUACAUGGCCAAUCUC
hsa-miR-496 AUUACAUGGCCAAUCUC