Gene Page:gria3

Summary？
基因 2892
象征 gria3
Synonyms GLUR-C|GLUR-K3|GLUR3|GLURC|GluA3|MRX94
Description 谷氨酸离子受体AMPA型亚基3
Reference MIM:305915|HGNC:HGNC:4573|Ensembl:ENSG00000125675|HPRD：02378|Vega：Otthumg0000000022685
基因类型 蛋白质编码
Map location Xq25
胎儿β -1.74
Support 配体门控离子信号传导
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-FULL
G2CDB.HUMAN_BAYES-COLLINS-MOUSE-PSD-CONSUS
G2CDB.HUMAN_TAP-PSD-95核
G2Cdb.humanARC
g2cdb.humanpsd
G2CDB.HUMANPSP
CompositeSet
潜在的突触基因

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp 全基因组协会研究 GWAS
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
协会 A combined odds ratio method (Sun等。2008), association studies 1 Link to SZGene
Literature High-throughput literature-search 与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症 点击显示详细信息
go_annotation 将与神经相关的关键字映射到基因本体论注释 与神经相关关键字的命中：4

Section I. Genetics and epigenetics annotation


第二节。转录组注释

一般基因表达（GTEX）

无法使用

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene Pearson's Correlation 斯皮尔曼的相关性
ACACA 0.94 0.95
PIP5K2B 0.94 0.95
NCOR1 0.93 0.94
kif1b 0.93 0.94
GSK3B 0.93 0.94
TP53BP1 0.93 0.94
NSD1 0.92 0.95
ABL2 0.92 0.94
Zranb1 0.92 0.93
jakmip2 0.92 0.93
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 斯皮尔曼的相关性
AF347015.31 -0.76 -0.82
FXYD1 -0.75 -0.80
MT-CO2 -0.74 -0.81
HIGD1B -0.73 -0.83
AC021016.1 -0.72 -0.79
ifi27 -0.72 -0.78
AF347015.21 -0.71 -0.83
AF347015.27 -0.71 -0.77
AF347015.33 -0.71 -0.75
mt-cyb -0.70 -0.76

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
GO:0004970 离子型谷氨酸受体活性 IEA glutamate (GO term level: 7) -
去：0005234 细胞外谷氨酸门控离子通道活性 IEA glutamate (GO term level: 11) -
GO:0004872 受体活性 IEA -
去：0005216 ion channel activity IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
去：0007215 谷氨酸信号通路 TAS glutamate (GO term level: 7) 1709304
去：0006811 ion transport IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
GO:0045211 postsynaptic membrane IEA 突触，神经递质（GO期限：5） -
GO:0045202 突触 IEA neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
GO：0016021 膜不可或缺 IEA -
去：0005886 plasma membrane TAS 1709304
GO:0030054 cell junction IEA -

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG神经活性配体受体相互作用 272 195 All SZGR 2.0 genes in this pathway
KEGG长期抑郁症 70 53 All SZGR 2.0 genes in this pathway
跨化学突触的反应组传播 186 155 All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279 221 All SZGR 2.0 genes in this pathway
反应组神经递质受体结合和突触后细胞中的下游传播 137 110 All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF AMPA RECEPTORS 28 23 All SZGR 2.0 genes in this pathway
含有AMPA受体的GLUR2的Reactome贩运 16 11 All SZGR 2.0 genes in this pathway
NMDA受体在谷氨酸结合和突触后事件上的反应组激活 37 32 All SZGR 2.0 genes in this pathway
NMDA受体谷氨酸结合和激活的反应组释放 15 14 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423 283 All SZGR 2.0 genes in this pathway
SILIGAN受EWS FLT1融合 47 34 All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向神经上皮 176 111 All SZGR 2.0 genes in this pathway
Sheth肝癌与TXNIP损失PAM2 153 102 All SZGR 2.0 genes in this pathway
co牛MYCN目标 43 27 All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT UP 89 61 All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP 214 133 All SZGR 2.0 genes in this pathway
伊万诺娃造血早期祖先 532 309 All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn 1237 837 All SZGR 2.0 genes in this pathway
Browne HCMV感染24小时DN 148 102 All SZGR 2.0 genes in this pathway
CUI TCF21目标2向上 428 266 All SZGR 2.0 genes in this pathway
Lein神经元标记 69 45 All SZGR 2.0 genes in this pathway
Zheng由Foxp3绑定 491 310 All SZGR 2.0 genes in this pathway
Boquest干细胞向上 260 174 All SZGR 2.0 genes in this pathway
LIN NPAS4靶向 163 100 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
黄成人组织STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
Mikkelsen ES ICP与H3K4Me3 718 401 All SZGR 2.0 genes in this pathway
Browne HCMV感染30分钟DN 150 99 All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3靶向 387 225 All SZGR 2.0 genes in this pathway
Bruins通过TP53组B响应UVC响应 549 316 All SZGR 2.0 genes in this pathway
BAKKER FOXO3 TARGETS UP 61 41 All SZGR 2.0 genes in this pathway
Durand Stroma S向上 297 194 All SZGR 2.0 genes in this pathway
Zwang仅通过第二EGF脉冲瞬时向上 1725 838 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-1/206 1605 1611 1a HSA-MIR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ Uggaauguaaggaagugugugg
HSA-MIR-613 AGGAAUGUUCCUUCUUUGCC
mir-124.1 167 173 M8 HSA-MIR-124A UUAAGGCACGCGGUGAAUGCCA
miR-124/506 166 173 1A，M8 hsa-miR-506 uaaggcacccuucugugaguaga
HSA-MIR-124brain UAAGGCACGCGGUGAAUGCC
miR-128 981 987 M8 HSA-MIR-128a ucacagugaaccggucuuuu
HSA-MIR-128b ucacagugaaccggucuuc
HSA-MIR-128a ucacagugaaccggucuuuu
HSA-MIR-128b ucacagugaaccggucuuc
miR-135 322 328 M8 HSA-MIR-135A UAUGGCUUUUUAUUCCUAUGUGA
HSA-MIR-135B Uauggcuuuucauuccuaugug
miR-146 1080 1087 1A，M8 HSA-MIR-146A ugagaacugaauuccaugggug
HSA-MIR-146Bbrain ugagaacugaauuccauaggcu
miR-181 619 625 1a HSA-MIR-181Abrain AACAUUCAACGCUGUCGGUGAGU
HSA-MIR-181BSZ aacauucauugcugucggggg
HSA-MIR-181Cbrain AACAUUCAACCUGUCGGUGAGU
HSA-MIR-181Dbrain aacauucauuguugucggggguggguu
miR-182 2079 2085 M8 HSA-MIR-182 uuuggcaaugguagaacucaca
miR-186 327 333 M8 HSA-MIR-186 caaagaauuuugggcuu
miR-187 102 108 1a HSA-MIR-187 UCGUGUCUUGUGUUGCAGCCG
miR-24 67 74 1A，M8 hsa-miR-24SZ uggcucucagagcaggaagag
mir-25/32/92/363/367 121 127 M8 hsa-miR-25brain Cauugcacuugucucggucuga
hsa-miR-32 uauugcacauacuaaguugc
HSA-MIR-92 uauugcacuugucccgcgcug
HSA-MIR-367 Aauugcacuuuagcaaugga
HSA-MIR-92BSZ uauugcacucgucccgcgcuc
miR-27 1712 1718 M8 HSA-MIR-27Abrain uucacaguggcuaaguuccgc
HSA-MIR-27Bbrain uucacaguggcuaaguucugc
mir-329 768 774 1a hsa-miR-329brain aacacaccugguaaccucuuu
miR-33 196 203 1A，M8 hsa-miR-33 Gugcauuguuguugcauug
hsa-miR-33b GUGCAUUGCUGUUGCAUUGCA
mir-330 223 229 M8 hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
miR-362 59 65 M8 HSA-MIR-362 aauccuuggaaccuaggugugugugugugagu
miR-384 138 144 1a HSA-MIR-384 auuccuagaaauuguucaua
mir-433-3p 1705 1711 1a hsa-miR-433brain aucaugauggggcuccucggugu
mir-452 199 205 M8 hsa-miR-452 UGUUUGCAGAGGAAACUGAGAC
miR-493-5p 2159 2165 1a HSA-MIR-493-5p uuguacaugguaggcuuucauu
miR-495 1914年 1921年 1A，M8 HSA-MIR-495brain Aaacaaacauggugcacuuuuu
miR-496 621 627 1a HSA-MIR-496 Auuacauggccaaucuc
mir-500 120 126 1a hsa-miR-500 augcaccuggggaggagauucug