Gene Page:GRIA4

概括?
基因 2893
Symbol GRIA4
Synonyms GLUR4|GLUR4C|GLURD|GluA4
Description glutamate ionotropic receptor AMPA type subunit 4
Reference MIM:138246|HGNC:HGNC:4574|Ensembl:ENSG00000152578|HPRD:00694|Vega:OTTHUMG00000166236
Gene type protein-coding
Map location 11q22
Pascal p-value 0.113
Fetal beta -1.067
eGene Cerebellum
Myers' cis & trans
Support LIGAND GATED ION SIGNALING
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_TAP-PSD-95-CORE
G2Cdb.humanARC
G2Cdb.humanPSD
G2Cdb.humanPSP
Potential synaptic genes

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMed co-o基因ccurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 1 Link to SZGene
GSMA_I Genome scan meta-analysis PSR：0.006
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关关键字的命中：4
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0047

第一节遗传学和表观遗传学注释

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16829545 chr2 151977407 GRIA4 2893 0 trans
rs16955618 chr15 29937543 GRIA4 2893 0 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
去：0004970 ionotropic glutamate receptor activity IEA glutamate (GO term level: 7) -
GO:0005234 extracellular-glutamate-gated ion channel activity IEA glutamate (GO term level: 11) -
GO:0004872 receptor activity IEA -
GO:0005216 离子通道活动 IEA -
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0007215 glutamate signaling pathway TAS glutamate (GO term level: 7) 8589990
GO:0006811 ion transport IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0045211 postsynaptic membrane IEA Synap, Neurotransmitter (GO term level: 5) -
GO:0045202 synapse IEA neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
GO：0016021 integral to membrane IEA -
GO:0005886 plasma membrane TAS 8589990
GO:0030054 细胞连接 IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 该途径中的所有SZGR 2.0基因
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186 155 该途径中的所有SZGR 2.0基因
REACTOME NEURONAL SYSTEM 279 221 该途径中的所有SZGR 2.0基因
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137 110 该途径中的所有SZGR 2.0基因
REACTOME TRAFFICKING OF AMPA RECEPTORS 28 23 该途径中的所有SZGR 2.0基因
REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 16 11 该途径中的所有SZGR 2.0基因
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 37 32 该途径中的所有SZGR 2.0基因
REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION 15 14 该途径中的所有SZGR 2.0基因
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 该途径中的所有SZGR 2.0基因
SCHLESINGER H3K27ME3 IN NORMAL AND METHYLATED IN CANCER 28 21 该途径中的所有SZGR 2.0基因
Schaeffer前列腺开发6小时DN 514 330 该途径中的所有SZGR 2.0基因
MCCLUNG COCAINE REWARD 5D 79 62 该途径中的所有SZGR 2.0基因
LEIN NEURON MARKERS 69 45 该途径中的所有SZGR 2.0基因
KONDO PROSTATE CANCER HCP WITH H3K27ME3 97 72 该途径中的所有SZGR 2.0基因
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 21 28 1A,m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 20 27 1A,m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-218 1527 1534 1A,m8 hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-25/32/92/363/367 657 663 1A hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 Aauugcacuuuagcaaugga
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
miR-26 1230 1236 m8 hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ uucaaguaauucaggauagguu
miR-28 2244 2250 m8 hsa-miR-28brain AAGGAGCUCACAGUCUAUUGAG
miR-30-3p 570 576 m8 hsa-miR-30a-3p CUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3p cuuucagucggauguauacagc
mir-378 203 209 1A hsa-miR-378 CUCCUGACUCCAGGUCCUGUGU
mir-493-5p 911 917 1A hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
miR-505 2341 2347 1A hsa-miR-505 GUCAACACUUGCUGGUUUCCUC
mir-542-3p 755 761 1A hsa-miR-542-3p UGUGACAGAUUGAUAACUGAAA