Gene Page:GRID1

Summary?
GeneID 2894
Symbol GRID1
Synonyms GluD1
Description glutamate ionotropic receptor delta type subunit 1
Reference MIM:610659|HGNC:HGNC:4575|Ensembl:ENSG00000182771|HPRD:17078|Vega:OTTHUMG00000018650
Gene type protein-coding
Map location 10q22
Pascal p-value 0.005
Fetal beta -0.811
DMG 1 (# studies)
eGene 元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 2 Link to SZGene
Expression 元-analysis of gene expression Pvalue: 1.428
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenics,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 3

部分即遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg01007305 10 88123687 GRID1 6.023E-4 0.296 0.05 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SPOCK1 0.80 0.87
MTMR7 0.80 0.86
PALM2-AKAP2 0.79 0.82
AHNAK2 0.77 0.83
SLC23A2 0.77 0.86
NLGN4X 0.77 0.83
CADPS 0.77 0.87
TNFRSF21 0.76 0.84
GABBR2 0.76 0.86
NRG3 0.76 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SAT1 -0.48 -0.64
ACSF2 -0.48 -0.60
AP002478.3 -0.47 -0.63
AC021016.1 -0.47 -0.58
HIGD1B -0.46 -0.61
FXYD1 -0.46 -0.55
C1orf54 -0.45 -0.64
AF347015.31 -0.45 -0.58
GNG11 -0.45 -0.60
AF347015.2 -0.45 -0.54

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004970 ionotropic glutamate receptor activity IEA glutamate (GO term level: 7) -
GO:0005234 extracellular-glutamate-gated ion channel activity IEA glutamate (GO term level: 11) -
GO:0004872 receptor activity IEA -
GO:0005515 protein binding IEA -
GO:0005216 ion channel activity IEA -
GO:0016491 oxidoreductase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0008152 metabolic process IEA -
GO:0006811 ion transport IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0045211 postsynaptic membrane IEA Synap, Neurotransmitter (GO term level: 5) -
GO:0045202 synapse IEA neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
GO:0016021 integral to membrane IEA -
GO:0005886 plasma membrane IEA -
GO:0030054 厘米/秒l junction IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION UP 119 66 All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 All SZGR 2.0 genes in this pathway
SILIGAN BOUND BY EWS FLT1 FUSION 47 34 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940 425 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 2172 2178 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 2663 2669 m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-136 156 162 m8 hsa-miR-136 ACUCCAUUUGUUUUGAUGAUGGA
miR-138 41 47 1A hsa-miR-138brain AGCUGGUGUUGUGAAUC
miR-181 2584 2590 1A hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-182 293 299 1A hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-330 2602 2608 m8 hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
miR-34/449 2169 2175 m8 hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC
miR-34b 2170 2176 m8 hsa-miR-34b UAGGCAGUGUCAUUAGCUGAUUG
miR-485-3p 224 231 1A,m8 hsa-miR-485-3p GUCAUACACGGCUCUCCUCUCU
miR-96 292 299 1A,m8 hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC