Gene Page:SPCS1
Summary?
| GeneID | 28972 |
| Symbol | SPCS1 |
| Synonyms | HSPC033|SPC1|SPC12|YJR010C-A |
| Description | signal peptidase complex subunit 1 |
| Reference | MIM:610358|HGNC:HGNC:23401|Ensembl:ENSG00000114902| |
| Gene type | protein-coding |
| Map location | 3p21.1 |
| Pascal p-value | 1.853E-7 |
| Sherlock p-value | 0.234 |
| Fetal beta | -0.66 |
| eGene | 元 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| LK:YES | Genome-wide Association Study | This data set included 99 genes mapped to the 22 regions. The 24 leading SNPs were also included in CV:Ripke_2013 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PROTEIN EXPORT | 24 | 16 | All SZGR 2.0 genes in this pathway |
| 反应OME TRANSLATION | 222 | 75 | All SZGR 2.0 genes in this pathway |
| 反应OME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | 179 | 53 | All SZGR 2.0 genes in this pathway |
| 反应OME INTEGRATION OF ENERGY METABOLISM | 120 | 84 | All SZGR 2.0 genes in this pathway |
| 反应OME DIABETES PATHWAYS | 133 | 91 | All SZGR 2.0 genes in this pathway |
| 反应OME METABOLISM OF PROTEINS | 518 | 242 | All SZGR 2.0 genes in this pathway |
| 反应OME REGULATION OF INSULIN SECRETION | 93 | 65 | All SZGR 2.0 genes in this pathway |
| 反应OME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | 16 | 11 | All SZGR 2.0 genes in this pathway |
| 反应OME SYNTHESIS SECRETION AND INACTIVATION OF GIP | 14 | 8 | All SZGR 2.0 genes in this pathway |
| 反应OME INCRETIN SYNTHESIS SECRETION AND INACTIVATION | 22 | 14 | All SZGR 2.0 genes in this pathway |
| 反应OME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | 19 | 12 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN MLL SIGNATURE 1 UP | 380 | 236 | All SZGR 2.0 genes in this pathway |
| LINDGREN BLADDER CANCER CLUSTER 1 DN | 378 | 231 | All SZGR 2.0 genes in this pathway |
| FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE DN | 98 | 59 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| PASQUALUCCI LYMPHOMA BY GC STAGE UP | 283 | 177 | All SZGR 2.0 genes in this pathway |
| MORI PLASMA CELL UP | 51 | 29 | All SZGR 2.0 genes in this pathway |
| CHESLER BRAIN QTL TRANS | 6 | 5 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
| ACEVEDO肝癌了 | 973 | 570 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | 863 | 514 | All SZGR 2.0 genes in this pathway |
| ALONSO METASTASIS UP | 198 | 128 | All SZGR 2.0 genes in this pathway |
| TOOKER GEMCITABINE RESISTANCE DN | 122 | 84 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 13 | 172 | 107 | All SZGR 2.0 genes in this pathway |