Gene Page:一个BR

Summary?
GeneID 29
Symbol 一个BR
Synonyms MDB
Description active BCR-related
Reference MIM:600365|HGNC:HGNC:81|Ensembl:ENSG00000159842|HPRD:02649|Vega:OTTHUMG00000090313
Gene type protein-coding
Map location 17p13.3
Pascal p-value 0.391
Sherlock p-value 0.395
Fetal beta -1.119
DMG 2 (# studies)
Support CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 3
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg09732966 17 1083309 一个BR 3.846E-4 0.647 0.043 DMG:Wockner_2014
cg10687217 17 1085135 一个BR 4.866E-4 0.403 0.047 DMG:Wockner_2014
cg19816938 17 1082526 一个BR 6.11E-8 -0.008 1.53E-5 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
一个total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CPT1A 0.85 0.83
一个CSS1 0.85 0.83
FYCO1 0.85 0.86
TPCN1 0.84 0.79
ITPKB 0.84 0.80
CHDH 0.83 0.73
OPLAH 0.82 0.75
FAM38A 0.82 0.77
DOCK1 0.82 0.81
一个TP1A2 0.80 0.76
十大负面中的基因
Gene Pearson's Correlation Spearman's Correlation
VPS29 -0.49 -0.55
MED19 -0.49 -0.54
C12orf73 -0.49 -0.53
TAF9 -0.49 -0.52
NT5C3L -0.48 -0.55
PSMA6 -0.47 -0.58
POLB -0.47 -0.52
STMN1 -0.46 -0.48
TXNL1 -0.46 -0.51
DCUN1D5 -0.46 -0.48

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA -
GO:0005085 guanyl-nucleotide交换因素活动 IEA -
GO:0005096 GTPase activator activity TAS 8262969
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007420 brain development IEA Brain (GO term level: 7) -
GO:0007242 intracellular signaling cascade IEA -
GO:0007264 small GTPase mediated signal transduction TAS 8262969
GO:0035023 regulation of Rho protein signal transduction IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID RHOA REG PATHWAY 46 30 一个ll SZGR 2.0 genes in this pathway
PID RAC1 REG PATHWAY 38 25 一个ll SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY RHO GTPASES 113 81 一个ll SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 一个ll SZGR 2.0 genes in this pathway
REACTOME NRAGE SIGNALS DEATH THROUGH JNK 43 33 一个ll SZGR 2.0 genes in this pathway
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 60 43 一个ll SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING 81 61 一个ll SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 一个ll SZGR 2.0 genes in this pathway
REACTOME G ALPHA1213 SIGNALLING EVENTS 74 56 一个ll SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 一个ll SZGR 2.0 genes in this pathway
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE DN 92 51 一个ll SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 一个ll SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276 187 一个ll SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380 236 一个ll SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 一个ll SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 一个ll SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 一个ll SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 一个ll SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE DN 76 52 一个ll SZGR 2.0 genes in this pathway
ROSS ACUTE MYELOID LEUKEMIA CBF 82 57 一个ll SZGR 2.0 genes in this pathway
SMITH TERT TARGETS DN 87 69 一个ll SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366 238 一个ll SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544 307 一个ll SZGR 2.0 genes in this pathway
RAMALHO STEMNESS DN 74 55 一个ll SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 一个ll SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163 102 一个ll SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 一个ll SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368 247 一个ll SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351 238 一个ll SZGR 2.0 genes in this pathway
YOSHIOKA LIVER CANCER EARLY RECURRENCE DN 65 31 一个ll SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491 319 一个ll SZGR 2.0 genes in this pathway
GUTIERREZ CHRONIC LYMPHOCYTIC LEUKEMIA DN 56 39 一个ll SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN 225 124 一个ll SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548 370 一个ll SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 一个ll SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 一个ll SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 一个ll SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337 236 一个ll SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-122 101 107 1A hsa-miR-122a UGGAGUGUGACAAUGGUGUUUGU
miR-124.1 1161 1167 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 1161 1167 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-125/351 1637 1643 m8 hsa-miR-125bbrain UCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrain UCCCUGAGACCCUUUAACCUGUG
miR-145 133 140 1A,m8 hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
miR-19 2547 2554 1A,m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-299-5p 2498 2505 1A,m8 hsa-miR-299-5p UGGUUUACCGUCCCACAUACAU
miR-34/449 1194 1201 1A,m8 hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c 一个GGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b 一个GGCAGUGUAUUGUUAGCUGGC
miR-369-3p 2484 2490 1A hsa-miR-369-3p 一个一个UAAUACAUGGUUGAUCUUU
miR-370 2291 2297 m8 hsa-miR-370brain GCCUGCUGGGGUGGAACCUGG
miR-374 2484 2491 1A,m8 hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
miR-493-5p 164 170 1A hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
miR-496 2496 2502 1A hsa-miR-496 一个UUACAUGGCCAAUCUC
miR-543 2517 2523 1A hsa-miR-543 一个一个一个CAUUCGCGGUGCACUUCU
miR-544 284 290 1A hsa-miR-544 一个UUCUGCAUUUUUAGCAAGU