SZGR2 - Beplay体育中心

Summary？

GeneID	2902
Symbol	GRIN1
Synonyms	GluN1\|MRD8\|NMD-R1\|NMDA1\|NMDAR1\|NR1
Description	谷氨酸离子受体NMDA型亚基1
Reference	MIM:138249\|HGNC:HGNC:4584\|ENSEMBL：ENSG00000176884\|HPRD:15926\|Vega：Otthumg00000020976
基因类型	蛋白质编码
Map location	9Q34.3
Pascal p-value	0.108
Sherlock p-value	0.397
胎儿β	-1.27
主持人	Myers' cis & trans
Support	配体门控离子信号传导 G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-FULL G2CDB.HUMAN_BAYES-COLLINS-MOUSE-PSD-CONSUS G2Cdb.human_PocklingtonH1 G2CDB.HUMAN_TAP-PSD-95核 G2Cdb.humanNRC CompositeSet Darnell FMRP targets 潜在的突触基因

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Association	A combined odds ratio method (Sun等。2008), association studies	2	Link to SZGene
Literature	High-throughput literature-search	与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症，精神分裂症	点击显示详细信息
GO_Annotation	将与神经相关的关键字映射到基因本体论注释	Hits with neuro-related keywords: 15
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 7.9864

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	eQTL type
rs3823720	CHR7	42001170	GRIN1	2902		0.19		反式

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
共有269个时间点秘密策划,n = 38胎儿samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

中的基因在大脑区域

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AC021914.1	0.74	0.28
CLEC2B	0.64	0.35
CXCL2	0.61	0.53
AL050337.1	0.57	0.18
AC137766.1	0.56	0.37
C1orf61	0.55	0.34
C17orf84	0.54	0.03
OASL	0.53	0.33
C1orf54	0.52	0.31
IFITM1	0.51	0.47

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
DNAJC7	-0.51	-0.38
CHMP4B	-0.50	-0.35
ARFGAP2	-0.50	-0.40
nudc	-0.49	-0.40
NDUFS2	-0.48	-0.36
UBE2Q1	-0.48	-0.37
grpel1	-0.48	-0.40
C20orf43	-0.47	-0.36
SPG7	-0.47	-0.29
MRPS5	-0.47	-0.41

第三节。基因本体论注释

Molecular function	去学期	证据	神经关键字	PubMed ID
GO:0004972	N-甲基-D-天冬氨酸选择性谷氨酸受体活性	IDA	glutamate (GO term level: 8)	7679115\|7685113
GO:0004970	ionotropic glutamate receptor activity	IEA	glutamate (GO term level: 7)	-
去：0005234	细胞外谷氨酸门控离子通道活性	IEA	glutamate (GO term level: 11)	-
去：0016595	谷氨酸结合	IDA	谷氨酸（GO期限：5）	7685113
GO：0035254	glutamate receptor binding	ISS	谷氨酸（GO期限：5）	-
去：0000287	magnesium ion binding	IEA		-
GO:0004872	receptor activity	IEA		-
去：0005509	calcium ion binding	ISS		-
去：0005516	calmodulin binding	ISS		-
GO:0005262	calcium channel activity	IDA		7685113
去：0005216	ion channel activity	IEA		-
GO：0016594	甘氨酸结合	IDA		7685113
GO：0016594	甘氨酸结合	IMP		17047094
Biological process	去学期	证据	神经关键字	PubMed ID
去：0060079	regulation of excitatory postsynaptic membrane potential	ISS	神经元，突触（GO期限：10）	-
GO:0007268	synaptic transmission	ISS	神经元，突触，神经递质（GO期限：6）	-
GO:0035235	离子型谷氨酸受体信号通路	ISS	glutamate (GO term level: 8)	-
GO:0008542	visual learning	ISS		-
去：0006811	ion transport	IEA		-
去：0006812	阳离子运输	IDA		7685113
GO:0042391	regulation of membrane potential	IDA		7679115\|7685113\|17047094
GO：0045944	RNA聚合酶II启动子的转录阳性调节	ISS		-
GO:0045471	response to ethanol	IDA		18445116
GO:0055074	calcium ion homeostasis	ISS		-
Cellular component	去学期	证据	神经关键字	PubMed ID
GO:0008021	synaptic vesicle	ISS	突触，神经递质（GO期限：12）	-
GO：0014069	突触后密度	ISS	突触（GO期限：10）	-
GO：0019717	synaptosome	ISS	Synap, Brain (GO term level: 7)	-
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex	IDA	谷氨酸，突触（GO期限：10）	7679115\|10480938\|17047094
GO：0030425	树突	IDA	neuron, axon, dendrite (GO term level: 6)	10749211
GO:0045211	postsynaptic membrane	IEA	突触，神经递质（GO期限：5）	-
GO:0045211	postsynaptic membrane	ISS	突触，神经递质（GO期限：5）	-
GO:0045202	synapse	IEA	neuron, Synap, Neurotransmitter, Glial (GO term level: 2)	-
GO:0045202	synapse	ISS	neuron, Synap, Neurotransmitter, Glial (GO term level: 2)	-
GO:0016021	膜不可或缺	IEA		-
去：0005886	plasma membrane	IEA		-
去：0005887	integral to plasma membrane	IDA		7685113
GO:0030054	cell junction	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	别名b	官方全名b	实验	Source	PubMed ID
ACTN2	CMD1AA	肌动蛋白，alpha 2	-	HPRD	9009191\|9728925 \|9952395
ACTN2	CMD1AA	肌动蛋白，alpha 2	alpha-actinin-2 interacts with NR1A. This interaction was modeled on a demonstrated interaction between human alpha-actinin-2 and NR1A from an unspecified species.	绑定	9009191
AKAP9	AKAP350 \| AKAP450 \| CG-NAP \| HYPERION \| KIAA0803 \| MU-RMS-40.16A \| PRKA9 \| YOTIAO	激酶（PRKA）锚蛋白（Yotiao）9	-	HPRD	9482789\|10862698
AKAP9	AKAP350 \| AKAP450 \| CG-NAP \| HYPERION \| KIAA0803 \| MU-RMS-40.16A \| PRKA9 \| YOTIAO	激酶（PRKA）锚蛋白（Yotiao）9	-	HPRD	10862698
CACNG2	MGC138502 \| MGC138504	calcium channel, voltage-dependent, gamma subunit 2	Co-fractionation	Biogrid	11140673
CAMK2A	CAMKA \|KIAA0968	钙/钙调蛋白依赖性蛋白激酶IIα	-	HPRD	10862698
CANX	CNX \| FLJ26570 \| IP90 \| P90	calnexin	-	HPRD	11506858\|14732708
CDH2	CD325 \| CDHN \| CDw325 \| NCAD	cadherin 2, type 1, N-cadherin (neuronal)	-	HPRD	10862698
引用	CRIK \| KIAA0949 \| STK21	citron (rho-interacting, serine/threonine kinase 21)	-	HPRD	10862698
cltc	CHC \|CHC17 \|CLH-17 \|cltcl2 \|HC \|KIAA0034	网状蛋白，重链（HC）	-	HPRD	10862698
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	Catenin（cadherin相关蛋白），β1，88KDA	-	HPRD	10862698
DLG2	DKFZp781D1854 \| DKFZp781E0954 \| FLJ37266 \| MGC131811 \| PSD-93	discs, large homolog 2, chapsyn-110 (Drosophila)	-	HPRD	10862698
DLG3	KIAA1232 \|MRX \|MRX90 \|NE-DLG \|nedlg \|SAP102	圆盘，大型同源物3（果蝇神经内分泌-DLG，果蝇）	-	HPRD	10862698
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	圆盘，大型同源物4（果蝇）	-	HPRD	9009191\|9502803 \|11506858\|12068077 \|14732708\|15030493
DLGAP4	DAP4 \|KIAA0964 \|MGC131862 \|RP5-977B1.6 \|SAPAP4	圆盘，大（果蝇）同源物相关蛋白4	-	HPRD	10862698
DNM1	DNM	dynamin 1	-	HPRD	10862698
DRD1	dadr \|drd1a	dopamine receptor D1	-	HPRD	12408866
DUSP4	HVH2 \|MKP-2 \|mkp2 \|典型	双重特异性磷酸酶4	-	HPRD	10862698
EPHB2	CAPB \| DRT \| EPHT3 \| ERK \| Hek5 \| MGC87492 \| PCBC \| Tyro5	EPH receptor B2	-	HPRD	11754835
EPHB4	htk \|myk1 \|Tyro11	EPH receptor B4	-	HPRD	11136979
FUS	CHOP \| FUS-CHOP \| FUS1 \| TLS \| TLS/CHOP \| hnRNP-P2	fusion (involved in t(12;16) in malignant liposarcoma)	-	HPRD	10862698
grin2a	nmdar2a \|NR2A	谷氨酸受体，离子型，N-甲基D-天冬氨酸2A	NR1a interacts with NR2A.	绑定	11279200
grin2a	nmdar2a \|NR2A	谷氨酸受体，离子型，N-甲基D-天冬氨酸2A	-	HPRD	8139656\|10862698 \|11803122\|12068077 \|12191494\|12893641 \|14732708
grin2a	nmdar2a \|NR2A	谷氨酸受体，离子型，N-甲基D-天冬氨酸2A	亲和力捕获 - 韦斯特恩	Biogrid	12391275
grin2b	MGC142178 \|MGC142180 \|NMDAR2B \|NR2B \|HNR3	谷氨酸受体，离子型，N-甲基D-天冬氨酸2B	亲和力捕获 - 韦斯特恩	Biogrid	12391275
grin2b	MGC142178 \|MGC142180 \|NMDAR2B \|NR2B \|HNR3	谷氨酸受体，离子型，N-甲基D-天冬氨酸2B	-	HPRD	8139656\|12191494 \|15030493
Grin2d	EB11 \| NMDAR2D	谷氨酸受体，离子型，N-甲基D-天冬氨酸2D	-	HPRD	12191494
格林3A	FLJ45414 \|nmdar-l \|NR3A	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	亲和力捕获 - 韦斯特恩	Biogrid	12391275
格林3A	FLJ45414 \|nmdar-l \|NR3A	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	-	HPRD	9620802\|11160393 \|11588171
grin3b	NR3B	glutamate receptor, ionotropic, N-methyl-D-aspartate 3B	亲和力捕获 - 韦斯特恩	Biogrid	12008020
hnrnpu	hnrpu \|SAF-A \|U21.1	异质核核糖核蛋白U（支架附着因子A）	-	HPRD	10862698
HRAS	C-BAS/HAS \| C-H-RAS \| C-HA-RAS1 \| CTLO \| H-RASIDX \| HAMSV \| HRAS1 \| K-RAS \| N-RAS \| RASH1	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	-	HPRD	10862698
HSPA1A	FLJ54303 \| FLJ54370 \| FLJ54392 \| FLJ54408 \| FLJ75127 \| HSP70-1 \| HSP70-1A \| HSP70I \| HSP72 \| HSPA1 \| HSPA1B	heat shock 70kDa protein 1A	-	HPRD	10862698
INA	FLJ18662 \|FLJ57501 \|MGC12702 \|nef5 \|NF-66 \|TXBP-1	internexin neuronal intermediate filament protein, alpha	-	HPRD	10862698
KAT5	ESA1 \| HTATIP \| HTATIP1 \| PLIP \| TIP \| TIP60 \| cPLA2	K（赖氨酸）乙酰转移酶5	-	HPRD	10862698
MAP2	DKFZp686I2148 \| MAP2A \| MAP2B \| MAP2C	microtubule-associated protein 2	-	HPRD	10862698
MAP2K2	FLJ26075 \| MAPKK2 \| MEK2 \| MKK2 \| PRKMK2	mitogen-activated protein kinase kinase 2	-	HPRD	10862698
MYH9	DFNA17 \|EPSTS \|ftns \|MGC104539 \|MHA \|NMHC-II-A \|nmmhca	myosin, heavy chain 9, non-muscle	-	HPRD	10862698
NANOS1	NOS1	纳米同源物1（果蝇）	-	HPRD	10862698
ND2	MTND2	NADH dehydrogenase, subunit 2 (complex I)	亲和力捕获 - 韦斯特恩	Biogrid	15069201
NEFL	CMT1F \| CMT2E \| FLJ53642 \| NF-L \| NF68 \| NFL	neurofilament, light polypeptide	-	HPRD	9425014
NF1	DKFZp686J1293 \| FLJ21220 \| NFNS \| VRNF \| WSS	神经纤维蛋白1	-	HPRD	10862698
PLAT	DKFZp686I03148 \| T-PA \| TPA	plasminogen activator, tissue	-	HPRD	15448144
PPP2R1A	MGC786 \| PR65A	蛋白质磷酸酶2（以前为2A），调节亚基A，α同工型	-	HPRD	10862698
PPP2R2A	B55-Alpha \|B55A \|FLJ26613 \|MGC52248 \|Pr52a \|PR55A	蛋白质磷酸酶2（以前为2A），调节亚基B，α同工型	-	HPRD	10862698
Prkcb	MGC41878 \|pkc-beta \|PKCB \|prkcb1 \|PRKCB2	蛋白激酶C，β	-	HPRD	10862698
prkce	MGC125656 \| MGC125657 \| PKCE \| nPKC-epsilon	protein kinase C, epsilon	-	HPRD	10862698
Prkcg	MGC57564 \|PKC-Gamma \|PKCC \|PKCG \|SCA14	protein kinase C, gamma	-	HPRD	10862698
RAP2A	K-REV \| KREV \| RAP2 \| RbBP-30	RAP2A，Ras Oncogene家族的成员	-	HPRD	10862698
RPS6KA3	CLS \| HU-3 \| ISPK-1 \| MAPKAPK1B \| MRX19 \| RSK \| RSK2 \| S6K-alpha3 \| p90-RSK2 \| pp90RSK2	ribosomal protein S6 kinase, 90kDa, polypeptide 3	-	HPRD	10862698
SP1	-	Sp1 transcription factor	-	HPRD	14970236
SP3	DKFZp686O1631 \| SPR-2	Sp3 transcription factor	-	HPRD	14970236
SPTAN1	（alpha）ii-spectrin \|FLJ44613 \|Neas	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	-	HPRD	9670010\|10862698
syngap1	DKFZP761G1421 \|KIAA1938 \|rasa1 \|rasa5 \|syngap	synaptic Ras GTPase activating protein 1 homolog (rat)	-	HPRD	10862698
TIAM1	FLJ36302	T细胞淋巴瘤侵袭和转移1	Tiam1 interacts with NMDA subunit NR1. This interaction was modelled on a demonstrated interaction between human Tiam1 and NR1 from an unspecified species.	绑定	15721239
TJP1	DKFZP686M05161 \|MGC133289 \|zo-1	tight junction protein 1 (zona occludens 1)	-	HPRD	10862698
TRAF3	CAP-1 \|CD40BP \|craf1 \|LAP1	TNF receptor-associated factor 3	-	HPRD	10862698
tuba4b	FLJ13940 \|tuba4	tubulin, alpha 4b (pseudogene)	-	HPRD	10862698

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
kegg钙信号通路	178	134	All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION	272	195	All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION	70	57	All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE	169	110	All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS	53	43	All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE	185	109	All SZGR 2.0 genes in this pathway
BIOCARTA EPONFKB PATHWAY	11	11	All SZGR 2.0 genes in this pathway
BIOCARTA NOS1 PATHWAY	24	21	All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	186	155	All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM	279	221	All SZGR 2.0 genes in this pathway
反应组神经递质受体结合和突触后细胞中的下游传播	137	110	All SZGR 2.0 genes in this pathway
REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	17	15	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS	37	32	All SZGR 2.0 genes in this pathway
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	27	23	All SZGR 2.0 genes in this pathway
反应组后NMDA受体激活事件	33	28	All SZGR 2.0 genes in this pathway
REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	15	14	All SZGR 2.0 genes in this pathway
Reactome Creb通过CAMKII的激活来磷酸化	15	14	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL DN	186	107	All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP	207	128	All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3	1118	744	All SZGR 2.0 genes in this pathway
CHIARETTI ACUTE LYMPHOBLASTIC LEUKEMIA ZAP70	67	33	All SZGR 2.0 genes in this pathway
McClung Delta FOSB目标8WK	47	38	All SZGR 2.0 genes in this pathway
ULE SPLICING VIA NOVA2	43	38	All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN	88	58	All SZGR 2.0 genes in this pathway
MARIADASON RESPONSE TO BUTYRATE SULINDAC 6	52	32	All SZGR 2.0 genes in this pathway
iwanaga癌变由Kras Pten Up	181	112	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP	210	124	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
米凯尔森NPC HCP WITH H3K27ME3	341	243	All SZGR 2.0 genes in this pathway
Browne HCMV感染1小时DN	222	147	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP	857	456	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	mirna seq
miRNA family	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
miR-15/16/195/424/497	58	64	M8	HSA-MIR-15A^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				HSA-MIR-15B^brain	UAGCAGCACAUCAUGGUUUACA
				HSA-MIR-195^SZ	uagcagaaaaauauuggc
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				HSA-MIR-497	CAGCAGCACACUGUGGUUUGU
mir-214	56	62	M8	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Clickhere查看与大脑相关的miRNA列表。

Gene Page:GRIN1