Gene Page:grin2a
Summary？
| GeneID | 2903 |
| Symbol | grin2a |
| Synonyms | EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A |
| Description | 谷氨酸离子受体NMDA型亚基2A |
| 参考erence | MIM:138253|HGNC:HGNC:4585|Ensembl:ENSG00000183454|HPRD:00698|Vega:OTTHUMG00000129721 |
| 基因类型 | 蛋白质编码 |
| Map location | 16p13.2 |
| pascal p-value | 2。298E-5 |
| TADA p-value | 0.024 |
| DMG | 2(# studies) |
| Support | 配体门控离子信号传导 G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-FULL G2CDB.HUMAN_BAYES-COLLINS-MOUSE-PSD-CONSUS G2Cdb.human_mGluR5 G2CDB.HUMAN_TAP-PSD-95核 G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Darnell FMRP targets 潜在的突触基因 |
Gene in Data Sources
| 基因集名称 | Method of gene set | Description | 信息 |
|---|---|---|---|
| 简历：Gwascat | Genome-wide Association Studies | This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb. | |
| CV:GWASdb | Genome-wide Association Studies | 精神分裂症的GWASDB记录 | |
| CV:PGC128 | Genome-wide Association Study | 一个multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG：JAFFE_2016 | 全基因组DNA甲基化分析 | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 2 |
| DMG：Wockner_2014 | 全基因组DNA甲基化分析 | 该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。 | 2 |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | 这项研究报道了WES对623个精神分裂症三重奏的研究，该研究使用基因组DNA报告了DNM。 | |
| PMID：cooccur | High-throughput literature-search | PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。 | |
| 一个ssociation | 一个combined odds ratio method (Sun等。2008), association studies | 1 | Link to SZGene |
| Literature | High-throughput literature-search | 与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症，精神分裂症 | 点击显示详细信息 |
| GO_Annotation | 将与神经相关的关键字映射到基因本体论注释 | 支安打与neuro-related关键词:15 |
Section I. Genetics and epigenetics annotation
CV:PGC128
CV:PGC128| SNP ID | 染色体 | 位置 | 一个llele | p | Function | Gene | 向上/向下距离 |
|---|---|---|---|---|---|---|---|
| rs9922678 | chr16 | 9946319 | Ag | 6.721E-9 | intronic | grin2a |
DNM表
| Gene | 染色体 | 位置 | 参考 | alt | 成绩单 | 一个一个change | Mutation type | Sift | CG46 | 特征 | 学习 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| grin2a | chr16 | 9857517 | 一个 | G | NM_000833 NM_001134407 NM_001134408 |
p.1295i> t p.1295i> t 。 |
missense missense intronic |
Schizophrenia | DNM:Fromer_2014 |
Differentially methylated gene
| probe | 染色体 | 位置 | Nearest gene | p（dis） | Beta (dis) | fdr（dis） | 学习 |
|---|---|---|---|---|---|---|---|
| cg15134033 | 16 | 10274415 | grin2a | 1。887E-4 | 0.24 | 0.034 | DMG：Wockner_2014 |
| cg03764381 | 16 | 10275410 | grin2a | 1.61 e-8 | -0.009 | 5.96E-6 | DMG：JAFFE_2016 |
第二节。转录组注释
一般基因表达（GTEX）
时间变化的基因表达（brainspan）
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。
大脑区域的顶级共表达基因
| Top 10 positively co-expressed genes | ||
| Gene | pearson's Correlation | Spearman's Correlation |
| ZFP36 | 0.64 | 0.67 |
| MT2A | 0.62 | 0.61 |
| CXCL1 | 0.61 | 0.53 |
| SAT1 | 0.61 | 0.58 |
| G一个DD45B | 0.59 | 0.60 |
| FOSL1 | 0.59 | 0.52 |
| MT1F | 0.59 | 0.50 |
| TLCD1 | 0.59 | 0.59 |
| MT1G | 0.59 | 0.57 |
| FXYD1 | 0.58 | 0.60 |
| Top 10 negatively co-expressed genes | ||
| Gene | pearson's Correlation | Spearman's Correlation |
| CSRP2BP | -0.54 | -0.55 |
| ppp2R2D | -0.53 | -0.57 |
| arfgap2 | -0.53 | -0.53 |
| pNMA1 | -0.53 | -0.56 |
| WRNIP1 | -0.52 | -0.54 |
| RAB1A | -0.52 | -0.57 |
| PSMD1 | -0.52 | -0.50 |
| AC119673.2 | -0.52 | -0.51 |
| FAM50B | -0.52 | -0.54 |
| Bcl2l1 | -0.52 | -0.56 |
第三节。基因本体论注释
| 分子功能 | 去学期 | 证据 | 神经关键字 | pubMed ID |
|---|---|---|---|---|
| GO:0004972 | N-甲基-D-天冬氨酸选择性谷氨酸受体活性 | TAS | glutamate (GO term level: 8) | 8768735 |
| GO:0004970 | ionotropic glutamate receptor activity | IEA | glutamate (GO term level: 7) | - |
| 去：0005234 | 细胞外谷氨酸门控离子通道活性 | IEA | glutamate (GO term level: 11) | - |
| GO：0035254 | glutamate receptor binding | IEA | 谷氨酸（GO期限：5） | - |
| 去：0000287 | magnesium ion binding | IEA | - | |
| GO:0004872 | receptor activity | IEA | - | |
| 去：0005509 | calcium ion binding | IEA | - | |
| 去：0005515 | 蛋白质结合 | IPI | 17997397 | |
| GO:0005262 | calcium channel activity | IEA | - | |
| 去：0005216 | ion channel activity | IEA | - | |
| Biological process | 去学期 | 证据 | 神经关键字 | pubMed ID |
| GO:0022008 | neurogenesis | IEA | 神经发生（GO期限：6） | - |
| 去：0060079 | regulation of excitatory postsynaptic membrane potential | IEA | 神经元，突触（GO期限：10） | - |
| GO：0048167 | 突触可塑性的调节 | IEA | 突触（GO期限：8） | - |
| 去：0007215 | 谷氨酸信号通路 | TAS | glutamate (GO term level: 7) | 8768735 |
| GO:0030431 | 睡觉 | IEA | 大脑（GO期限：3） | - |
| GO：0042428 | 5-羟色胺代谢过程 | IEA | 5-羟色胺，神经递质（GO期限：8） | - |
| GO：0042417 | dopamine metabolic process | IEA | Neurotransmitter, dopamine (GO term level: 8) | - |
| GO:0001964 | 惊吓反应 | IEA | - | |
| GO:0001975 | 反应to amphetamine | IEA | - | |
| 去：0008542 | visual learning | IEA | - | |
| GO:0009611 | 对伤害的反应 | IEA | - | |
| 去：0007613 | memory | IEA | - | |
| GO:0008104 | protein localization | IEA | - | |
| 去：0006816 | 钙离子传输 | IEA | - | |
| 去：0006811 | ion transport | IEA | - | |
| GO:0042177 | negative regulation of protein catabolic process | IEA | - | |
| GO:0033058 | 方向运动 | IEA | - | |
| GO:0042493 | 反应to drug | IEA | - | |
| GO:0045471 | 反应to ethanol | IDA | 18445116 | |
| GO:0051930 | regulation of sensory perception of pain | IEA | - | |
| Cellular component | 去学期 | 证据 | 神经关键字 | pubMed ID |
| GO：0042734 | presynaptic membrane | IEA | 神经元，轴突，突触（GO术语级别：5） | - |
| GO：0014069 | 突触后密度 | IEA | 突触（GO期限：10） | - |
| GO：0019717 | 突触体 | IEA | Synap, Brain (GO term level: 7) | - |
| GO：0017146 | N-methyl-D-aspartate selective glutamate receptor complex | IDA | 谷氨酸，突触（GO期限：10） | 10480938 |
| GO:0045211 | postsynaptic membrane | IEA | 突触，神经递质（GO期限：5） | - |
| GO:0045202 | 突触 | IEA | neuron, Synap, Neurotransmitter, Glial (GO term level: 2) | - |
| 去：0005737 | cytoplasm | IDA | 18029348 | |
| GO:0016021 | 膜不可或缺 | IEA | - | |
| 去：0005886 | plasma membrane | IEA | - | |
| 去：0005887 | integral to plasma membrane | TAS | 8768735 | |
| GO:0030054 | cell junction | IEA | - |
Section IV. Protein-protein interaction annotation
| 互动者 | 别名b | 官方全名b | 实验 | Source | pubMed ID |
|---|---|---|---|---|---|
| 一个CTN1 | FLJ40884 | 肌动蛋白，alpha 1 | - | HPRD | 11854440 |
| DLG1 | DKFZP761P0818 |DKFZP781B0426 |dlgh1 |SAP97 |DJ1061C18.1.1 |HDLG | discs, large homolog 1 (Drosophila) | - | HPRD,BioGRID | 12933808 |
| DLG2 | DKFZP781D1854 |DKFZP781E0954 |FLJ37266 |MGC131811 |PSD-93 | discs, large homolog 2, chapsyn-110 (Drosophila) | - | HPRD | 10648730 |
| DLG2 | DKFZP781D1854 |DKFZP781E0954 |FLJ37266 |MGC131811 |PSD-93 | discs, large homolog 2, chapsyn-110 (Drosophila) | Two-hybrid | Biogrid | 9278515 |
| DLG3 | KIAA1232 |MRX |MRX90 |NE-DLG |nedlg |SAP102 | 圆盘，大型同源物3（果蝇神经内分泌-DLG，果蝇） | 体外 in vivo Two-hybrid |
Biogrid | 9278515|11937501 |
| DLG3 | KIAA1232 |MRX |MRX90 |NE-DLG |nedlg |SAP102 | 圆盘，大型同源物3（果蝇神经内分泌-DLG，果蝇） | - | HPRD | 11937501|12070168 |
| DLG4 | FLJ97752 | FLJ98574 | PSD95 | SAP90 | 圆盘，大型同源物4（果蝇） | - | HPRD | 7569905|11937501 |12419528 |
| DLG4 | FLJ97752 | FLJ98574 | PSD95 | SAP90 | 圆盘，大型同源物4（果蝇） | 亲和力捕获 - 韦斯特恩 体外 in vivo 重构的复合物 Two-hybrid |
Biogrid | 7569905|9278515 |9286858|10648730 |11937501|12419528 |
| DLGAP1 | DAP-1 | DAP-1-ALPHA | DAP-1-BETA | GKAP | MGC88156 | SAPAP1 | hGKAP | 圆盘，大（果蝇）同源物相关蛋白1 | - | HPRD,BioGRID | 9286858 |
| FYN | MGC45350 | SLK | SYN | Fyn Oncogene与SRC，FGR，是的 | 亲和力捕获 - 韦斯特恩 重构的复合物 |
Biogrid | 9892651|10458595 |12419528|12932824 |
| FYN | MGC45350 | SLK | SYN | Fyn Oncogene与SRC，FGR，是的 | - | HPRD | 10458595|12932824 |
| GRIN1 | NMDA1 | NMDAR1 | NR1 | 谷氨酸受体，离子型，N-甲基D-天冬氨酸1 | NR1A与NR2A相互作用。 | 绑定 | 11279200 |
| GRIN1 | NMDA1 | NMDAR1 | NR1 | 谷氨酸受体，离子型，N-甲基D-天冬氨酸1 | - | HPRD | 8139656|10862698 |11803122|12068077 |12191494|12893641 |14732708 |
| GRIN1 | NMDA1 | NMDAR1 | NR1 | 谷氨酸受体，离子型，N-甲基D-天冬氨酸1 | 亲和力捕获 - 韦斯特恩 | Biogrid | 12391275 |
| grin3b | NR3B | glutamate receptor, ionotropic, N-methyl-D-aspartate 3B | 亲和力捕获 - 韦斯特恩 | Biogrid | 12008020 |
| IL16 | FLJ16806 |FLJ42735 |FLJ44234 |HST19289 |IL-16 |LCF |Pril-16 | 白介素16（淋巴细胞趋化因子） | NPRO-IL-16与NR2A相互作用。 | 绑定 | 12923170 |
| IL16 | FLJ16806 |FLJ42735 |FLJ44234 |HST19289 |IL-16 |LCF |Pril-16 | 白介素16（淋巴细胞趋化因子） | - | HPRD,BioGRID | 10479680 |
| inadl | Cipp | FLJ26982 | InaD-like | PATJ | 类似果蝇（果蝇） | - | HPRD | 9647694 |
| pTK2B | Cadtk |cakb |fadk2 |fak2 |frnk |PKB |PTK |pyk2 |筏 | pTK2B protein tyrosine kinase 2 beta | - | HPRD,BioGRID | 11478920 |
| pTPN4 | pTPMEG | PTPMEG1 | 蛋白质酪氨酸磷酸酶，非受体4型（巨核细胞） | - | HPRD,BioGRID | 10748123 |
| RICS | GC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAP | Rho GTPase激活蛋白 | - | HPRD | 12531901 |
| SRC | 一个SV | SRC1 | c-SRC | p60-Src | V-SRC肉瘤（Schmidt-Ruppin A-2）病毒癌基因同源物（Avian） | 亲和力捕获 - 韦斯特恩 重构的复合物 |
Biogrid | 10458595|12932824 |
| SRC | 一个SV | SRC1 | c-SRC | p60-Src | V-SRC肉瘤（Schmidt-Ruppin A-2）病毒癌基因同源物（Avian） | - | HPRD | 10458595|10884433 |12932824 |
Section V. Pathway annotation
| 路径名 | 路径大小 | # SZGR 2.0 genes in pathway | 信息 |
|---|---|---|---|
| kegg钙信号通路 | 178 | 134 | 一个ll SZGR 2.0 genes in this pathway |
| KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION | 272 | 195 | 一个ll SZGR 2.0 genes in this pathway |
| KEGG LONG TERM POTENTIATION | 70 | 57 | 一个ll SZGR 2.0 genes in this pathway |
| KEGG ALZHEIMERS DISEASE | 169 | 110 | 一个ll SZGR 2.0 genes in this pathway |
| KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS | 53 | 43 | 一个ll SZGR 2.0 genes in this pathway |
| kegg系统性狼疮红斑 | 140 | 100 | 一个ll SZGR 2.0 genes in this pathway |
| BIOCARTA NOS1 PATHWAY | 24 | 21 | 一个ll SZGR 2.0 genes in this pathway |
| pID REELIN PATHWAY | 29 | 29 | 一个ll SZGR 2.0 genes in this pathway |
| REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | 186 | 155 | 一个ll SZGR 2.0 genes in this pathway |
| REACTOME NEURONAL SYSTEM | 279 | 221 | 一个ll SZGR 2.0 genes in this pathway |
| 反应组神经递质受体结合和突触后细胞中的下游传播 | 137 | 110 | 一个ll SZGR 2.0 genes in this pathway |
| REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | 17 | 15 | 一个ll SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS | 37 | 32 | 一个ll SZGR 2.0 genes in this pathway |
| REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS | 27 | 23 | 一个ll SZGR 2.0 genes in this pathway |
| 反应组后NMDA受体激活事件 | 33 | 28 | 一个ll SZGR 2.0 genes in this pathway |
| NMDA受体谷氨酸结合和激活的反应组释放 | 15 | 14 | 一个ll SZGR 2.0 genes in this pathway |
| Reactome Creb通过CAMKII的激活来磷酸化 | 15 | 14 | 一个ll SZGR 2.0 genes in this pathway |
| Sengupta鼻咽癌与LMP1 DN | 175 | 82 | 一个ll SZGR 2.0 genes in this pathway |
| 周的炎症反应生活 | 485 | 293 | 一个ll SZGR 2.0 genes in this pathway |
| GOZGIT ESR1 TARGETS DN | 781 | 465 | 一个ll SZGR 2.0 genes in this pathway |
| 一个MUNDSON GENOTOXIC SIGNATURE | 105 | 68 | 一个ll SZGR 2.0 genes in this pathway |
| HATADA METHYLATED IN LUNG CANCER UP | 390 | 236 | 一个ll SZGR 2.0 genes in this pathway |
| Wong IFNA2电阻DN | 34 | 20 | 一个ll SZGR 2.0 genes in this pathway |
| pENG GLUTAMINE DEPRIVATION DN | 337 | 230 | 一个ll SZGR 2.0 genes in this pathway |
| LU AGING BRAIN DN | 153 | 120 | 一个ll SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | 一个ll SZGR 2.0 genes in this pathway |
| LABBE WNT3A TARGETS DN | 97 | 53 | 一个ll SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3 UNMETHYLATED | 536 | 296 | 一个ll SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | 一个ll SZGR 2.0 genes in this pathway |
| Kim所有疾病Calb1 Corr Up | 548 | 370 | 一个ll SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | 一个ll SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
| mirna家族 | Target position | miRNA ID | mirna seq | ||
|---|---|---|---|---|---|
| UTR开始 | UTR结束 | 匹配方法 | |||
| miR-125/351 | 904 | 910 | M8 | hsa-miR-125bbrain | ucccugagacccuaacuuguga |
| hsa-miR-125abrain | UCCCUGAGACCCUUUAACCUGUG | ||||
| miR-137 | 416 | 423 | 1A，M8 | HSA-MIR-137 | uauugcuuaagaauacgcguag |
| miR-19 | 142 | 149 | 1A，M8 | HSA-MIR-19A | UGUGCAAAUCUAUGCAAAACUGA |
| HSA-MIR-19B | UGUGCAAAUCCAUGCAAAACUGA | ||||
| miR-381 | 911 | 917 | 1一个 | HSA-MIR-381 | UAUACAAGGGCAAGCUCUCUGU |
| mir-431 | 656 | 662 | 1一个 | hsa-miR-431 | uguugcaggccguauga |
| mir-7 | 166 | 172 | 1一个 | hsa-miR-7SZ | UGGAAGACUAGUGAUUUUGUUG |