Gene Page:GRIN2C
概括?
| 基因 | 2905 |
| 象征 | GRIN2C |
| Synonyms | GluN2C|NMDAR2C|NR2C |
| Description | glutamate ionotropic receptor NMDA type subunit 2C |
| Reference | MIM:138254|HGNC:HGNC:4587|Ensembl：ENSG00000161509|HPRD:00699|Vega:OTTHUMG00000044524 |
| Gene type | protein-coding |
| Map location | 17q25.1 |
| Pascal p-value | 0.937 |
| Sherlock p-value | 0.454 |
| Fetal beta | -1.591 |
| eGene | Myers' cis & trans |
| Support | LIGAND GATED ION SIGNALING Potential synaptic genes |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| PMID:cooccur | High-throughput literature-search | 系统搜索PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| 文学 | High-throughput literature-search | 与精神分裂症关键词共同存在：精神分裂症，精神分裂症 | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | 与神经相关的关键字：10 |
第一节遗传学和表观遗传学注释
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | EQTL类型 |
|---|---|---|---|---|---|---|---|---|
| rs16829545 | chr2 | 151977407 | GRIN2C | 2905 | 6.065E-15 | trans | ||
| rs3845734 | chr2 | 171125572 | GRIN2C | 2905 | 0 | trans | ||
| rs7584986 | chr2 | 184111432 | GRIN2C | 2905 | 2.232E-5 | trans | ||
| rs2183142 | chr4 | 159232695 | GRIN2C | 2905 | 0.03 | trans | ||
| rs1396222 | chr4 | 173279496 | GRIN2C | 2905 | 0.17 | trans | ||
| RS335980 | chr4 | 173329784 | GRIN2C | 2905 | 0.18 | trans | ||
| rs337984 | chr4 | 173411662 | GRIN2C | 2905 | 0.05 | trans | ||
| rs9461864 | chr6 | 33481468 | GRIN2C | 2905 | 0 | trans | ||
| rs16890367 | chr6 | 38078448 | GRIN2C | 2905 | 0.03 | trans | ||
| RS7787830 | chr7 | 98797019 | GRIN2C | 2905 | 0.06 | trans | ||
| rs3118341 | chr9 | 25185518 | GRIN2C | 2905 | 0 | trans | ||
| rs1126130 | chr9 | 25209346 | GRIN2C | 2905 | 0.15 | trans | ||
| rs9406868 | chr9 | 25223372 | GRIN2C | 2905 | 0.04 | trans | ||
| rs11139334 | chr9 | 84209393 | GRIN2C | 2905 | 0.06 | trans | ||
| rs16955618 | chr15 | 29937543 | GRIN2C | 2905 | 9.25 e-20 | trans | ||
| rs16945437 | chr17 | 11797650 | GRIN2C | 2905 | 0.09 | trans | ||
| rs11873184 | chr18 | 1584081 | GRIN2C | 2905 | 0.03 | trans | ||
| rs11882889 | chr19 | 19887684 | GRIN2C | 2905 | 0.12 | trans | ||
| rs1041786 | chr21 | 22617710 | GRIN2C | 2905 | 0 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SOSTDC1 | 0.80 | 0.52 |
| CLDN1 | 0.71 | 0.37 |
| PROM1 | 0.70 | 0.34 |
| WNT11 | 0.70 | 0.37 |
| myo16 | 0.68 | 0.41 |
| ADAMTSL3 | 0.67 | 0.44 |
| GDF10 | 0.67 | 0.58 |
| RASGEF1C | 0.65 | 0.39 |
| TAL2 | 0.63 | 0.21 |
| traf5 | 0.63 | 0.43 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| REEP6 | -0.35 | -0.24 |
| RHBDL3 | -0.32 | -0.35 |
| NFE2L2 | -0.31 | -0.15 |
| FAM162A | -0.28 | -0.09 |
| NPC2 | -0.28 | -0.13 |
| RENBP | -0.28 | -0.11 |
| AIF1L | -0.28 | -0.19 |
| HLA-F | -0.28 | -0.05 |
| QPRT | -0.28 | -0.11 |
| GM2A | -0.28 | -0.16 |
Section III. Gene Ontology annotation
| 分子功能 | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| 去：0004972 | N-methyl-D-aspartate selective glutamate receptor activity | IEA | glutamate (GO term level: 8) | - |
| 去：0004972 | N-methyl-D-aspartate selective glutamate receptor activity | TAS | glutamate (GO term level: 8) | 9798920 |
| GO:0005234 | extracellular-glutamate-gated ion channel activity | IEA | glutamate (GO term level: 11) | - |
| GO:0035254 | 谷氨酸受体结合 | IEA | glutamate (GO term level: 5) | - |
| GO:0000287 | magnesium ion binding | IEA | - | |
| 去：0004872 | receptor activity | IEA | - | |
| GO:0005509 | 钙离子结合 | IEA | - | |
| GO:0005515 | protein binding | IEA | - | |
| 去：0005261 | 阳离子通道活动 | IEA | - | |
| GO:0005216 | 离子通道活动 | IEA | - | |
| 生物过程 | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0060079 | 调节兴奋性突触后膜电位 | IEA | neuron, Synap (GO term level: 10) | - |
| GO:0048167 | regulation of synaptic plasticity | IEA | Synap (GO term level: 8) | - |
| GO:0007215 | glutamate signaling pathway | TAS | glutamate (GO term level: 7) | 9798920 |
| 去：0009611 | response to wounding | IEA | - | |
| GO:0008104 | 蛋白质定位 | IEA | - | |
| GO:0006811 | ion transport | IEA | - | |
| GO:0042177 | negative regulation of protein catabolic process | IEA | - | |
| GO:0042391 | regulation of membrane potential | IEA | - | |
| GO：0033058 | directional locomotion | IEA | - | |
| GO:0050885 | neuromuscular process controlling balance | IEA | - | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0014069 | postsynaptic density | IEA | Synap (GO term level: 10) | - |
| GO：0017146 | N-methyl-D-aspartate selective glutamate receptor complex | IEA | glutamate, Synap (GO term level: 10) | - |
| GO:0045211 | postsynaptic membrane | IEA | Synap, Neurotransmitter (GO term level: 5) | - |
| GO:0045202 | 突触 | IEA | neuron, Synap, Neurotransmitter, Glial (GO term level: 2) | - |
| GO：0016021 | integral to membrane | IEA | - | |
| GO:0005886 | plasma membrane | IEA | - | |
| GO:0005887 | integral to plasma membrane | TAS | 9798920 | |
| GO:0030054 | 细胞连接 | IEA | - |
V.途径注释
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CALCIUM SIGNALING PATHWAY | 178 | 134 | 该途径中的所有SZGR 2.0基因 |
| KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION | 272 | 195 | 该途径中的所有SZGR 2.0基因 |
| KEGG LONG TERM POTENTIATION | 70 | 57 | 该途径中的所有SZGR 2.0基因 |
| KEGG ALZHEIMERS DISEASE | 169 | 110 | 该途径中的所有SZGR 2.0基因 |
| KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS | 53 | 43 | 该途径中的所有SZGR 2.0基因 |
| Biocarta NOS1途径 | 24 | 21 | 该途径中的所有SZGR 2.0基因 |
| REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | 186 | 155 | 该途径中的所有SZGR 2.0基因 |
| REACTOME NEURONAL SYSTEM | 279 | 221 | 该途径中的所有SZGR 2.0基因 |
| REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL | 137 | 110 | 该途径中的所有SZGR 2.0基因 |
| REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | 17 | 15 | 该途径中的所有SZGR 2.0基因 |
| REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS | 37 | 32 | 该途径中的所有SZGR 2.0基因 |
| Reactome Creb通过RAS激活的磷酸化 | 27 | 23 | 该途径中的所有SZGR 2.0基因 |
| REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | 33 | 28 | 该途径中的所有SZGR 2.0基因 |
| REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | 15 | 14 | 该途径中的所有SZGR 2.0基因 |
| REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | 15 | 14 | 该途径中的所有SZGR 2.0基因 |
| ODONNELL TFRC TARGETS UP | 456 | 228 | 该途径中的所有SZGR 2.0基因 |
| NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON | 335 | 181 | 该途径中的所有SZGR 2.0基因 |
| NIKOLSKY MUTATED AND AMPLIFIED IN BREAST CANCER | 94 | 60 | 该途径中的所有SZGR 2.0基因 |
| BYSTRYKH造血干细胞QTL Trans | 882 | 572 | 该途径中的所有SZGR 2.0基因 |
| KAAB HEART ATRIUM VS VENTRICLE UP | 249 | 170 | 该途径中的所有SZGR 2.0基因 |
| WEST ADRENOCORTICAL TUMOR UP | 294 | 199 | 该途径中的所有SZGR 2.0基因 |
| MEISSNER NPC HCP WITH H3 UNMETHYLATED | 536 | 296 | 该途径中的所有SZGR 2.0基因 |
| MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 | 1069 | 729 | 该途径中的所有SZGR 2.0基因 |
| MIKKELSEN MCV6 HCP WITH H3K27ME3 | 435 | 318 | 该途径中的所有SZGR 2.0基因 |
| MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | 该途径中的所有SZGR 2.0基因 |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | 该途径中的所有SZGR 2.0基因 |