Gene Page:GRM1

Summary?
GeneID 2911
Symbol GRM1
Synonyms GPRC1A|MGLU1|MGLUR1|PPP1R85|SCAR13
Description glutamate receptor, metabotropic 1
Reference MIM:604473|HGNC:HGNC:4593|Ensembl:ENSG00000152822|HPRD:05129|Vega:OTTHUMG00000015752
Gene type protein-coding
Map location 6q24
Pascal p-value 0.091
Sherlock p-value 0.161
Fetal beta -0.93
DMG 1 (# studies)
eGene 元
Support GPCR SIGNALLING
METABOTROPIC GLUTAMATE RECEPTOR
G2Cdb.humanNRC
G2Cdb.humanPSD
G2Cdb.humanPSP
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search 系统搜索PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0024

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg13371951 6 146350041 GRM1 1.807E-4 0.445 0.034 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004872 receptor activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007268 synaptic transmission TAS neuron, Synap, Neurotransmitter (GO term level: 6) 9076744
GO:0007186 G-protein coupled receptor protein signaling pathway IEA -
GO:0007186 G-protein coupled receptor protein signaling pathway TAS 7476890
GO:0007165 signal transduction IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0016021 integral to membrane IEA -
GO:0005886 plasma membrane IEA -
GO:0005887 integral to plasma membrane TAS 7476890

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CALCIUM SIGNALING PATHWAY 178 134 All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION 90 68 All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION 70 57 All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 70 53 All SZGR 2.0 genes in this pathway
BIOCARTA CK1 PATHWAY 17 17 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 15 11 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN 261 183 All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS 90 71 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN 238 145 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA NEURAL 129 85 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 1019 1025 1A hsa - mir - 101 UACAGUACUGUGAUAACUGAAG
miR-124.1 151 158 1A,m8 保险公司-miR-124a UUAAGGCACGCGGUGAAUGCCA
保险公司-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 151 157 1A 保险公司-miR-506 UAAGGCACCCUUCUGAGUAGA
保险公司-miR-124brain UAAGGCACGCGGUGAAUGCC
保险公司-miR-506 UAAGGCACCCUUCUGAGUAGA
保险公司-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-139 1020 1026 m8 保险公司-miR-139brain UCUACAGUGCACGUGUCU
miR-144 1019 1025 1A 保险公司-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-204/211 245 252 1A,m8 保险公司-miR-204brain UUCCCUUUGUCAUCCUAUGCCU
保险公司-miR-211 UUCCCUUUGUCAUCCUUCGCCU
miR-218 261 268 1A,m8 保险公司-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-221/222 1022 1028 1A 保险公司-miR-221brain AGCUACAUUGUCUGCUGGGUUUC
hsa - mir - 222brain AGCUACAUCUGGCUACUGGGUCUC
miR-34b 2746 2752 m8 保险公司-miR-34b UAGGCAGUGUCAUUAGCUGAUUG
miR-381 1229 1236 1A,m8 保险公司-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-539 2025 2032 1A,m8 保险公司-miR-539 GGAGAAAUUAUCCUUGGUGUGU
miR-96 949 955 m8 保险公司-miR-96brain UUUGGCACUAGCACAUUUUUGC