Gene Page:GRM3

概括?
基因 2913
Symbol GRM3
Synonyms GLUR3|GPRC1C|MGLUR3|mGlu3
Description glutamate receptor, metabotropic 3
Reference MIM:601115|HGNC:HGNC:4595|Ensembl:ENSG00000198822|HPRD:03070|Vega:OTTHUMG00000022884
Gene type protein-coding
Map location 7q21.1-q21.2
Pascal p-value 7.599E-5
Sherlock p-value 0.941
Fetal beta -0.539
eGene Cerebellum
Support GPCR SIGNALLING
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.humanPSD
G2Cdb.humanPSP
Potential synaptic genes

数据源中的基因
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies 该数据集包括与精神分裂症相关的560个SNP。总共将486个基因映射到50kb内的这些SNP。
CV:PGC128 Genome-wide Association Study A multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMed co-o基因ccurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 2 Link to SZGene
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关关键字的命中：7
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 31

Section I. Genetics and epigenetics annotation

@CV:PGC128

SNP ID Chromosome Position Allele P Function Gene Up/Down Distance
rs12704290 chr7 86427626 AG 1.037E-10 intronic GRM3


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0001641 group II metabotropic glutamate receptor activity IEA glutamate (GO term level: 8) -
GO:0004872 receptor activity IEA -
GO:0005246 calcium channel regulator activity IEA -
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0007268 synaptic transmission TAS neuron, Synap, Neurotransmitter (GO term level: 6) 8840013
GO:0007186 G-protein coupled receptor protein signaling pathway IEA -
GO:0007194 negative regulation of adenylate cyclase activity TAS 8840013
GO:0007165 signal transduction IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0042734 突触前膜 IEA neuron, axon, Synap (GO term level: 5) -
GO:0014069 postsynaptic density IEA Synap (GO term level: 10) -
GO:0043197 dendritic spine IEA Synap, dendrite (GO term level: 7) -
GO:0030424 axon IEA neuron, axon, Neurotransmitter (GO term level: 6) -
GO:0045211 postsynaptic membrane IEA Synap, Neurotransmitter (GO term level: 5) -
GO：0016021 integral to membrane IEA -
GO:0005886 plasma membrane IEA -
GO:0005887 integral to plasma membrane TAS 8840013

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 该途径中的所有SZGR 2.0基因
REACTOME SIGNALING BY GPCR 920 449 该途径中的所有SZGR 2.0基因
REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 15 11 该途径中的所有SZGR 2.0基因
REACTOME GPCR LIGAND BINDING 408 246 该途径中的所有SZGR 2.0基因
BENPORATH EED TARGETS 1062 725 该途径中的所有SZGR 2.0基因
PTCH1和SUFU DN的Lee目标 83 69 该途径中的所有SZGR 2.0基因
JOSEPH RESPONSE TO SODIUM BUTYRATE DN 64 45 该途径中的所有SZGR 2.0基因
KONDO PROSTATE CANCER WITH H3K27ME3 196 93 该途径中的所有SZGR 2.0基因
RIZKI TUMOR INVASIVENESS 3D DN 270 181 该途径中的所有SZGR 2.0基因
Yoshimura mapk8靶向 1305 895 该途径中的所有SZGR 2.0基因
MIKKELSEN MEF ICP WITH H3K27ME3 206 108 该途径中的所有SZGR 2.0基因
MIKKELSEN IPS ICP WITH H3K4ME3 AND H327ME3 126 83 该途径中的所有SZGR 2.0基因
Mikkelsen ES ICP带有H3K4ME3和H3K27ME3 137 85 该途径中的所有SZGR 2.0基因
MIKKELSEN NPC ICP WITH H3K4ME3 445 257 该途径中的所有SZGR 2.0基因
VERHAAK GLIOBLASTOMA NEURAL 129 85 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-10 251 257 m8 hsa-miR-10a UACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10b UACCCUGUAGAACCGAAUUUGU
miR-30-5p 227 234 1A,m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain uguaaacauccuacucucucucucagc
hsa-miR-30dSZ uguaaacauccccgacuggaag
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-339 250 256 m8 hsa-miR-339 UCCCUGUCCUCCAGGAGCUCA
mir-376 359 365 1A hsa-miR-376a AUCAUAGAGGAAAAUCCACGU
hsa-miR-376b AUCAUAGAGGAAAAUCCAUGUU
miR-381 413 419 1A hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-504 252 258 m8 hsa-miR-504 AGACCCUGGUCUGCACUCUAU
miR-539 450 456 1A hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU