Gene Page:GRM4

概括?
GeneID 2914
Symbol GRM4
Synonyms GPRC1D|MGLUR4|mGlu4
Description glutamate receptor, metabotropic 4
参考 MIM:604100|HGNC:HGNC:4596|ENSEMBL：ENSG00000124493|HPRD:04978|
Gene type protein-coding
Map location 6p21.3
Pascal p-value 0.119
Sherlock P值 0.722
Fetal beta -0.155
eGene Cerebellar Hemisphere
迈尔斯的顺式和跨性别
Support GPCR SIGNALLING
COMPOSITESET
Darnell FMRP targets
Potential synaptic genes

数据源中的基因
Gene set name Method of gene set Description Info
CV：GWASDB 全基因组关联研究 GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur 高通量文献搜索 Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008），协会研究 1 Link to SZGene
GSMA_I 基因组扫描荟萃分析 PSR：0.033
GSMA_IIE 基因组扫描荟萃分析（欧洲官方样品） Psr: 0.04433
文学 高通量文献搜索 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 5
Network 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 Contribution to shortest path in PPI network: 0.0018

第一节遗传学和表观遗传学注释

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17392743 chr1 54764240 GRM4 2914 0.01 trans
rs6687849 chr1 175904808 GRM4 2914 0 trans
rs2481653 chr1 176044120 GRM4 2914 0.05 trans
RS2502827 chr1 176044216 GRM4 2914 1.129E-5 trans
rs12405921 chr1 206695730 GRM4 2914 0.03 trans
rs17572651 chr1 218943612 GRM4 2914 1.145E-4 trans
snp_a-1919794 0 GRM4 2914 0.19 trans
rs882011 chr2 22711668 GRM4 2914 0.06 trans
rs16829545 chr2 151977407 GRM4 2914 1.247E-5 trans
rs3845734 chr2 171125572 GRM4 2914 2.083E-4 trans
rs7584986 chr2 184111432 GRM4 2914 2.423E-9 trans
rs6807632 chr3 111395567 GRM4 2914 0 trans
rs7635430 chr3 180152035 GRM4 2914 0.02 trans
rs6828371 chr4 15757600 GRM4 2914 0.12 trans
rs6826731 chr4 72130691 GRM4 2914 0.06 trans
rs2115110 chr5 38193428 GRM4 2914 0.12 trans
rs17762315 chr5 76807576 GRM4 2914 0 trans
rs7729096 chr5 76835927 GRM4 2914 0 trans
rs10063752 chr5 109259572 GRM4 2914 0.08 trans
RS1368303 chr5 147672388 GRM4 2914 1.145E-7 trans
RS1929769 chr6 40765977 GRM4 2914 0.13 trans
rs2530313 chr7 148112233 GRM4 2914 0.17 trans
rs17079498 chr8 3018343 GRM4 2914 0.02 trans
rs4872540 chr8 22598980 GRM4 2914 0.05 trans
rs6989594 chr8 126303866 GRM4 2914 0.02 trans
RS7021724 chr9 2527899 GRM4 2914 0.13 trans
rs2766987 chr9 113667956 GRM4 2914 0.12 trans
RS17263352 chr9 124811572 GRM4 2914 0.02 trans
rs12716680 chr13 42196469 GRM4 2914 0.12 trans
RS7996604 chr13 42224412 GRM4 2914 0.07 trans
SNP_A-1880548 0 GRM4 2914 0.08 trans
RS1629937 chr14 77059671 GRM4 2914 0 trans
rs17104720 chr14 77127308 GRM4 2914 2.101E-6 trans
rs17104722 chr14 77138109 GRM4 2914 0.07 trans
rs17104782 chr14 77156735 GRM4 2914 0.07 trans
RS6574467 chr14 79179744 GRM4 2914 0.01 trans
rs10146003 chr14 79191170 GRM4 2914 0.01 trans
rs16955618 chr15 29937543 GRM4 2914 2.74E-23 trans
snp_a-1830894 0 GRM4 2914 6.868E-4 trans
rs16968252 chr17 31692447 GRM4 2914 0.08 trans
rs17823633 chr17 68851458 GRM4 2914 0.15 trans
rs17085767 chr18 69839397 GRM4 2914 0.1 trans
rs749043 chr20 46995700 GRM4 2914 0.2 trans
rs1041786 chr21 22617710 GRM4 2914 0.19 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TBC1D25 0.92 0.91
APBB1 0.91 0.90
AGAP3 0.91 0.89
AP2A2 0.91 0.91
EPN1 0.90 0.89
RTN1 0.90 0.88
CACNB3 0.89 0.89
SNAP47 0.89 0.84
MCOLN1 0.89 0.88
ASB6 0.89 0.89
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.78 -0.71
MT-CO2 -0.77 -0.66
AF347015.31 -0.77 -0.66
AF347015.8 -0.77 -0.67
MT-CYB -0.75 -0.65
AF347015.2 -0.74 -0.61
AF347015.26 -0.74 -0.63
AF347015.33 -0.74 -0.62
AF347015.27 -0.73 -0.66
AL139819.3 -0.72 -0.69

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
去：0004872 receptor activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007269 neurotransmitter secretion 塔斯 神经元，轴突，突触，5-羟色胺，神经递质，多巴胺（GO期限：8） 15102938
GO:0007268 突触传输 IEA neuron, Synap, Neurotransmitter (GO term level: 6) -
GO:0007268 突触传输 塔斯 neuron, Synap, Neurotransmitter (GO term level: 6) 8738157
去：0007196 metabotropic glutamate receptor, adenylate cyclase inhibiting pathway 小鬼 谷氨酸（GO期限：12） 15102938
GO:0043526 神经保护 塔斯 neuron (GO term level: 9) 15102938
GO:0000187 activation of MAPK activity IDA 15102938
GO:0007186 G-protein coupled receptor protein signaling pathway IEA -
GO:0007194 negative regulation of adenylate cyclase activity IEP 15102938
GO:0007165 signal transduction IEA -
GO:0007612 learning IEA -
GO:0043410 positive regulation of MAPKKK cascade IEP 15102938
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IDA 15102938
GO:0016021 integral to membrane IEA -
GO:0005886 plasma membrane IEA -
GO:0005887 质膜的积分 IDA 15102938
GO:0031410 cytoplasmic vesicle IDA 15102938

V.途径注释

Pathway name Pathway size ＃szgr 2.0基因 Info
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 该途径中的所有SZGR 2.0基因
KEGG TASTE TRANSDUCTION 52 28 该途径中的所有SZGR 2.0基因
GPCR的反应组信号传导 920 449 该途径中的所有SZGR 2.0基因
REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 15 11 该途径中的所有SZGR 2.0基因
REACTOME GPCR LIGAND BINDING 408 246 该途径中的所有SZGR 2.0基因
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 该途径中的所有SZGR 2.0基因
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position mirna id miRNA seq
UTR start UTR end Match method
miR-129-5p 668 674 1A hsa-miR-129脑 CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-203.1 937 943 m8 HSA-MIR-203 UGAAAUGUUUAGGACCACUAG
miR-29 122 128 m8 hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ uagcaccauuugaaaucaguguu
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU