Gene Page:GRM7

Summary？
基因 2917
象征 GRM7
Synonyms GLUR7|GPRC1G|MGLU7|MGLUR7|PPP1R87
Description glutamate receptor, metabotropic 7
Reference MIM:604101|HGNC:HGNC:4599|ENSEMBL：ENSG00000196277|HPRD：04979|Vega:OTTHUMG00000125549
基因类型 蛋白质编码
Map location 3P26.1-P25.1
Pascal p-value 0.069
Sherlock p-value 0.1
胎儿β -0.798
DMG 1(# studies)
Support GPCR信号传导
G2Cdb.humanPSD
G2Cdb.humanPSP
潜在的突触基因

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:GWASdb Genome-wide Association Studies 精神分裂症的GWASDB记录
CV:PGCnp Genome-wide Association Study GWAS
DMG：Wockner_2014 全基因组DNA甲基化分析 该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。 1
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
协会 A combined odds ratio method (Sun等。2008), association studies 2 Link to SZGene
Literature High-throughput literature-search 与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症 点击显示详细信息
go_annotation 将与神经相关的关键字映射到基因本体论注释 与神经相关关键字的命中：3
Network Shortest path distance of core genes in the Human protein-protein interaction network PPI网络中最短路径的贡献：0.0018

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe 染色体 位置 最近的基因 p（dis） Beta (dis) fdr（dis） 学习
cg12479516 3 7098132 GRM7 3.895E-4 0.539 0.043 DMG：Wockner_2014


第二节。转录组注释

一般基因表达（GTEX）

Not available

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene Pearson's Correlation 斯皮尔曼的相关性
sema3b 0.94 0.87
PCTK3 0.93 0.93
ATPGD1 0.93 0.91
杂志 0.93 0.92
TMC6 0.92 0.91
LDB3 0.92 0.90
chadl 0.92 0.90
CYP27A1 0.92 0.90
ERBB3 0.91 0.90
S1PR5 0.91 0.91
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 斯皮尔曼的相关性
Med19 -0.60 -0.72
NKIRAS2 -0.60 -0.65
NR2C2AP -0.60 -0.74
STMN1 -0.59 -0.71
TRNAU1AP -0.59 -0.69
KIAA1949 -0.58 -0.64
POLB -0.58 -0.72
tubb2b -0.58 -0.67
ING4 -0.58 -0.69
ZNF821 -0.58 -0.65

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
GO:0004872 受体活性 IEA -
去：0005245 voltage-gated calcium channel activity IEA -
去：0005246 钙通道调节剂活性 IEA -
GO:0030165 PDZ domain binding TAS 12052533
生物过程 去学期 证据 神经关键字 PubMed ID
去：0007268 synaptic transmission TAS 神经元，突触，神经递质（GO期限：6） 9473604
GO:0001662 行为恐惧反应 IEA -
GO:0001661 条件味道厌恶 IEA -
GO:0007186 G蛋白偶联受体蛋白信号通路 IEA -
GO:0007194 腺苷酸环化酶活性的阴性调节 TAS 9473604
GO:0007165 信号转导 IEA -
去：0007608 sensory perception of smell IEA -
GO：0050896 对刺激的反应 IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
GO:0048787 presynaptic active zone membrane TAS 突触，神经递质（GO期限：6） 12052533
GO:0045211 postsynaptic membrane TAS 突触，神经递质（GO期限：5） 12052533
去：0005886 plasma membrane IEA -
去：0005887 integral to plasma membrane TAS 9473604

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
CALM1 CALML2 | CAMI | DD132 | PHKD 钙调蛋白1（磷酸化酶激酶，三角洲） - HPRD 10488094|11953448
CALM2 camii |PHKD |PHKD2 钙调蛋白2（磷酸化酶激酶，三角洲） - HPRD 11953448
CALM3 PHKD |PHKD3 calmodulin 3 (phosphorylase kinase, delta) - HPRD 11953448
GNAQ G-ALPHA-q | GAQ 鸟嘌呤核苷酸结合蛋白（G蛋白），Q多肽 - HPRD,BioGRID 10550060
GRIP1 GRIP 谷氨酸受体相互作用蛋白1 握把与mglur7b相互作用。这种相互作用是在未指定物种和人类MGLUR7B的抓地力之间的相互作用上建模的。 绑定 11891216
Pick1 MGC15204 |选择|prkcabp protein interacting with PRKCA 1 Pick1interacts with mGluR7b. This interaction was modeled on a demonstrated interaction between PICK1 from an unspecified species and human mGluR7b. 绑定 11891216
Pick1 MGC15204 |选择|prkcabp protein interacting with PRKCA 1 亲和力捕获 - 韦斯特恩
生化活动
重构的复合物
Two-hybrid		 Biogrid 11007882
prkca AAG6 |MGC129900 |MGC129901 |PKC-Alpha |PKCA |Prkaca protein kinase C, alpha 亲和力捕获 - 韦斯特恩 Biogrid 11007882
SDCBP MDA-9 |ST1 |SYCL |Tacip18 联合结合蛋白（同步） Syntenin interacts with mGluR7b. This interaction was modeled on a demonstrated interaction between GRIP from an unspecified species and human mGluR7b. 绑定 11891216
tuba1a B-ALPHA-1 | FLJ25113 | LIS3 | TUBA3 tubulin, alpha 1a - HPRD 11953448
tuba1b K-Alpha-1 tubulin, alpha 1b - HPRD 11953448
tuba3c TUBA2 | bA408E5.3 tubulin, alpha 3c - HPRD 11953448
tuba4a FLJ30169 |H2-Alpha |tuba1 tubulin, alpha 4a - HPRD 11953448
tuba8 TUBAL2 微管蛋白，α8 - HPRD 11953448


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
Reactome C类C 3代谢型谷氨酸信息素受体 15 11 All SZGR 2.0 genes in this pathway
Reactome GPCR配体结合 408 246 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456 228 All SZGR 2.0 genes in this pathway
ODONNELL TARGETS OF MYC AND TFRC UP 83 50 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
Hatada甲基化在肺癌中 390 236 All SZGR 2.0 genes in this pathway
SCHLESINGER H3K27ME3 IN NORMAL AND METHYLATED IN CANCER 28 21 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
Benporath EED目标 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
Benporath PRC2目标 652 441 All SZGR 2.0 genes in this pathway
康（Kang）由tert dn永生 102 67 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412 249 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
Meissner NPC HCP带有H3K27Me3 79 59 All SZGR 2.0 genes in this pathway
Mikkelsen NPC HCP带有H3K27ME3 341 243 All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS DN 115 73 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 DN 180 116 All SZGR 2.0 genes in this pathway
Servitja Islet HNF1A靶向 163 111 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-130/301 397 403 M8 hsa-miR-130abrain cagugcaauguaaaaggggau
hsa-miR-301 cagugcaauaugucaaagc
hsa-miR-130bbrain Cagugcaaugaagggauggau
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-142-5p 176 182 M8 HSA-MIR-142-5P cauaaaguagaaagcacuac
miR-15/16/195/424/497 1001 1007 M8 HSA-MIR-15Abrain uagcagcacauaugguugug
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
HSA-MIR-15Bbrain UAGCAGCACAUCAUGGUUUACA
HSA-MIR-195SZ uagcagaaaaauauuggc
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
HSA-MIR-497 cagcagcacacuguguuugu
miR-17-5p/20/93.mr/106/519.d 399 405 M8 HSA-MIR-17-5P caaagugcuuacugcagguagu
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
HSA-MIR-519D caaagugccucccuuuagugugu
miR-181 1092 1098 1a HSA-MIR-181Abrain AACAUUCAACGCUGUCGGUGAGU
HSA-MIR-181BSZ AACAUUCAUUGCUGUCGGUGGG
HSA-MIR-181Cbrain AACAUUCAACCUGUCGGUGAGU
HSA-MIR-181Dbrain aacauucauuguugucggggguggguu
miR-19 396 402 M8 HSA-MIR-19A ugugcaaauaugauaugaaaacuga
HSA-MIR-19B UGUGCAAAUCCAUGCAAAACUGA
mir-25/32/92/363/367 837 843 1a hsa-miR-25brain Cauugcacuugucucggucuga
hsa-miR-32 uauugcacauacuaaguugc
HSA-MIR-92 uauugcacuugucccgcgcug
HSA-MIR-367 Aauugcacuuuagcaaugga
HSA-MIR-92BSZ uauugcacucgucccgcgcuc
mir-30-3p 1042 1048 1a HSA-MIR-30A-3P CUUUCAGUCGGAUGUUUGCAGC
HSA-MIR-30E-3P cuuucagucggauguauacagc
miR-34/449 210 217 1A，M8 hsa-miR-34abrain uggcaguguuaguguguuuu
hsa-miR-34c Aggcaguguaguagcugauugc
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
HSA-MIR-449B AGGCAGUGUAUUGUUAGCUGGC
mir-346 532 538 M8 hsa-miR-346brain UGUCUGCCCGCAUGCCUGCCUCU
miR-495 434 440 M8 HSA-MIR-495brain Aaacaaacauggugcacuuuuu