Gene Page:GRM8

概括?
基因 2918
Symbol GRM8
Synonyms GLUR8|GPRC1H|MGLUR8|mGlu8
Description glutamate receptor, metabotropic 8
Reference MIM:601116|HGNC:HGNC:4600|Ensembl:ENSG00000179603|HPRD:03071|Vega:OTTHUMG00000022888
Gene type protein-coding
Map location 7q31.3-q32.1
Pascal p-value 0.018
Sherlock p-value 0.573
Fetal beta -1.686
DMG 1 (# studies)
eGene Cerebellum
Support GPCR SIGNALLING
Potential synaptic genes

数据源中的基因
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
CV:PheWAS Phenome-wide association studies (PheWAS) 157 SNPs associated with schizophrenia 1
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 1 Link to SZGene
Literature High-throughput literature-search Co-occurance与精神分裂症nia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关的关键字的命中：1

Section I. Genetics and epigenetics annotation

@CV:PheWAS

SNP ID Chromosome Position Allele P 功能 Gene Up/Down Distance
rs17864092 7 126639604 null 0.4378 GRM8 null

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg02409125 7 126889555 GRM8 1.881E-4 0.337 0.034 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PPP2R5E 0.97 0.97
DIS3 0.96 0.97
ZMYM4 0.96 0.97
WDR48 0.96 0.97
NUP133 0.96 0.97
WDR3 0.96 0.97
SUPT16H 0.95 0.96
EXOC2 0.95 0.97
STRN3 0.95 0.97
taf2 0.95 0.96
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.78 -0.88
MT-CO2 -0.78 -0.89
FXYD1 -0.76 -0.86
AF347015.27 -0.76 -0.85
AF347015.33 -0.76 -0.85
AF347015.8 -0.75 -0.87
MT-CYB -0.75 -0.85
IFI27 -0.74 -0.85
HIGD1B -0.73 -0.85
AF347015.15 -0.72 -0.85

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0001642 group III metabotropic glutamate receptor activity IEA glutamate (GO term level: 8) -
GO:0004872 receptor activity IEA -
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0007186 G蛋白偶联受体蛋白信号通路 IEA -
GO:0007194 negative regulation of adenylate cyclase activity TAS 9473604
GO:0007165 signal transduction IEA -
GO:0007608 sensory perception of smell IEA -
GO:0007601 visual perception TAS 9473604
GO:0050896 对刺激的反应 IEA -
GO:0030818 negative regulation of cAMP biosynthetic process IDA 11166323
Cellular component GO term Evidence Neuro keywords PubMed ID
GO：0016021 integral to membrane IEA -
GO:0005886 plasma membrane IEA -
GO:0005887 integral to plasma membrane TAS 9473604

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 该途径中的所有SZGR 2.0基因
REACTOME SIGNALING BY GPCR 920 449 该途径中的所有SZGR 2.0基因
REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 15 11 该途径中的所有SZGR 2.0基因
REACTOME GPCR LIGAND BINDING 408 246 该途径中的所有SZGR 2.0基因
WATANABE COLON CANCER MSI VS MSS DN 81 42 该途径中的所有SZGR 2.0基因
SABATES COLORECTAL ADENOMA UP 141 75 该途径中的所有SZGR 2.0基因
PEREZ TP53 TARGETS 1174 695 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 48HR DN 504 323 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 6HR DN 160 101 该途径中的所有SZGR 2.0基因
Acevedo肝癌，H3K27me3 UP 295 149 该途径中的所有SZGR 2.0基因
ACEVEDO METHYLATED IN LIVER CANCER DN 940 425 该途径中的所有SZGR 2.0基因
Yoshimura mapk8靶向 1305 895 该途径中的所有SZGR 2.0基因
MEISSNER NPC HCP WITH H3K4ME3 AND H3K27ME3 142 103 该途径中的所有SZGR 2.0基因
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 该途径中的所有SZGR 2.0基因
YAGI AML WITH T 8 21 TRANSLOCATION 368 247 该途径中的所有SZGR 2.0基因
MIKKELSEN IPS WITH HCP H3K27ME3 102 76 该途径中的所有SZGR 2.0基因
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-219 97 103 1A hsa-miR-219brain UGAUUGUCCAAACGCAAUUCU
miR-24 146 152 1A hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-33 446 452 1A hsa-miR-33 GUGCAUUGUAGUUGCAUUG
HSA-MIR-33B GUGCAUUGCUGUUGCAUUGCA
miR-339 2 8 1A hsa-miR-339 UCCCUGUCCUCCAGGAGCUCA
miR-342 340 346 1A HSA-MIR-342brain UCUCACACAGAAAUCGCACCCGUC
miR-381 375 382 1A,m8 hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-543 504 510 m8 hsa-miR-543 AAACAUUCGCGGUGCACUUCU
hsa-miR-543 AAACAUUCGCGGUGCACUUCU