Gene Page:CXCL2

Summary?
GeneID 2920
Symbol CXCL2
Synonyms CINC-2a|GRO2|GROb|MGSA-b|MIP-2a|MIP2|MIP2A|SCYB2
Description C-X-C motif chemokine ligand 2
Reference MIM:139110|HGNC:HGNC:4603|Ensembl:ENSG00000081041|HPRD:00741|Vega:OTTHUMG00000160865
Gene type protein-coding
Map location 4q21
Pascal p-value 0.935
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis 这dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg02741554 4 74965278 CXCL2 1.17E-8 -0.013 4.85E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10915489 chr1 4321466 CXCL2 2920 1.19E-6 trans
rs17105629 chr1 49799320 CXCL2 2920 0.19 trans
rs473019 chr1 72296394 CXCL2 2920 0.03 trans
rs2997198 chr1 80760865 CXCL2 2920 0.02 trans
rs1342707 chr1 147264296 CXCL2 2920 5.263E-5 trans
rs12076447 chr1 159552549 CXCL2 2920 0.08 trans
rs529346 chr1 160743808 CXCL2 2920 0.12 trans
rs10494571 chr1 183930700 CXCL2 2920 0.07 trans
rs2907143 chr1 243147434 CXCL2 2920 3.921E-4 trans
rs6760426 chr2 66175535 CXCL2 2920 0.03 trans
rs17546660 chr2 66218021 CXCL2 2920 0.01 trans
rs17541094 chr2 66266798 CXCL2 2920 0.02 trans
rs9677627 chr2 80471983 CXCL2 2920 0.08 trans
snp_a-2198363 0 CXCL2 2920 0.11 trans
rs16865891 chr2 225235339 CXCL2 2920 0.06 trans
rs4676558 chr3 40084233 CXCL2 2920 0.1 trans
snp_a-1974890 0 CXCL2 2920 0.01 trans
rs16847252 chr3 163481290 CXCL2 2920 2.108E-4 trans
rs4256179 chr3 169628328 CXCL2 2920 0.02 trans
rs9870311 chr3 169641061 CXCL2 2920 0.02 trans
rs16846456 chr3 172757337 CXCL2 2920 0 trans
rs591585 chr4 43424979 CXCL2 2920 0 trans
rs17052594 chr4 167698562 CXCL2 2920 0.11 trans
rs31304 chr5 52942082 CXCL2 2920 0.02 trans
rs7726346 chr5 80229097 CXCL2 2920 0.17 trans
rs10515260 chr5 97076547 CXCL2 2920 2.588E-5 trans
rs10515267 chr5 100128201 CXCL2 2920 0.07 trans
rs1550363 chr5 124480528 CXCL2 2920 0.16 trans
rs6863508 chr5 159131795 CXCL2 2920 0.13 trans
rs6920921 chr6 8884160 CXCL2 2920 0.18 trans
rs10498827 chr6 65470694 CXCL2 2920 0.19 trans
rs1587434 chr6 66615354 CXCL2 2920 0.04 trans
rs16869716 chr6 71743471 CXCL2 2920 0.07 trans
rs2072161 chr7 105662460 CXCL2 2920 0 trans
rs4726747 chr7 144883187 CXCL2 2920 0.11 trans
rs9325708 chr8 12402940 CXCL2 2920 0.02 trans
rs1451681 chr8 40491890 CXCL2 2920 0.19 trans
rs13282254 chr8 126625316 CXCL2 2920 0.06 trans
rs16909867 chr9 25899226 CXCL2 2920 0.01 trans
rs2082711 chr9 83109430 CXCL2 2920 0.01 trans
rs1507903 chr9 119185777 CXCL2 2920 0.05 trans
rs3802522 chr10 28341865 CXCL2 2920 1.085E-13 trans
rs10508730 chr10 28403391 CXCL2 2920 1.085E-13 trans
rs1913524 chr10 50227869 CXCL2 2920 0.16 trans
rs2254632 chr10 50236578 CXCL2 2920 0.12 trans
rs2466750 chr10 50240164 CXCL2 2920 0.01 trans
rs1240385 chr10 88727329 CXCL2 2920 0.02 trans
rs7089703 chr10 119182182 CXCL2 2920 0.01 trans
rs17096254 chr10 119207026 CXCL2 2920 0.06 trans
rs17101184 chr10 122712943 CXCL2 2920 0.07 trans
rs10743139 chr11 10425326 CXCL2 2920 8.9E-7 trans
rs936368 chr11 80971140 CXCL2 2920 0.18 trans
rs17139249 chr11 130155705 CXCL2 2920 0.14 trans
rs2512874 chr11 131461291 CXCL2 2920 8.082E-4 trans
rs11107750 chr12 95241256 CXCL2 2920 0.12 trans
rs7304048 chr12 95292947 CXCL2 2920 0.12 trans
rs4762419 chr12 95771835 CXCL2 2920 0 trans
rs1566556 chr12 101918977 CXCL2 2920 0.1 trans
rs9645995 chr13 47246048 CXCL2 2920 0.13 trans
rs9598109 chr13 60878618 CXCL2 2920 0.06 trans
rs8028951 chr15 27187231 CXCL2 2920 0.01 trans
rs16968806 chr15 39622447 CXCL2 2920 0.19 trans
rs2219618 chr15 54109136 CXCL2 2920 0.18 trans
rs17271500 chr15 62428608 CXCL2 2920 0.17 trans
rs12445121 chr16 73542119 CXCL2 2920 0.2 trans
rs16959765 chr16 83237750 CXCL2 2920 0.18 trans
rs4783332 chr16 83238773 CXCL2 2920 0.18 trans
rs4303487 chr16 90033254 CXCL2 2920 0.08 trans
rs2448755 chr18 65344801 CXCL2 2920 0.08 trans
rs7228544 chr18 75188991 CXCL2 2920 0.15 trans
rs10425739 chr19 29582202 CXCL2 2920 0 trans
snp_a-2138575 0 CXCL2 2920 0.06 trans
rs6076051 chr20 23306825 CXCL2 2920 0.06 trans
rs6076060 chr20 23345068 CXCL2 2920 0 trans
rs2148213 chr20 54798599 CXCL2 2920 0.01 trans
rs17342476 chrX 102243644 CXCL2 2920 5.439E-5 trans
rs17342483 chrX 102250155 CXCL2 2920 6.097E-4 trans
rs17342504 chrX 102272107 CXCL2 2920 5.439E-5 trans
snp_a-2138851 0 CXCL2 2920 5.439E-5 trans
snp_a-2059928 0 CXCL2 2920 5.439E-5 trans
rs12393459 chrX 118215731 CXCL2 2920 0.12 trans
rs3813932 chrX 118220719 CXCL2 2920 0.12 trans
rs6634857 chrX 131111922 CXCL2 2920 0.04 trans
rs5953544 chrX 140038593 CXCL2 2920 0.15 trans
rs7065915 chrX 140038729 CXCL2 2920 0.15 trans
rs5966028 chrX 145163390 CXCL2 2920 0.18 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ERAL1 0.90 0.87
TCF25 0.89 0.86
ATG4B 0.89 0.87
CPT1C 0.89 0.84
AAMP 0.89 0.86
C11orf49 0.88 0.85
MARS 0.88 0.85
TRAP1 0.88 0.85
TMUB2 0.88 0.85
RABGGTA 0.87 0.84
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.8 -0.78 -0.71
AF347015.21 -0.78 -0.74
AF347015.27 -0.77 -0.73
MT-CO2 -0.76 -0.69
AF347015.31 -0.76 -0.69
AF347015.2 -0.75 -0.70
MT-CYB -0.75 -0.68
AF347015.33 -0.74 -0.68
AF347015.15 -0.73 -0.67
MT-ATP8 -0.72 -0.75

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267 161 All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY 190 128 All SZGR 2.0 genes in this pathway
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY 62 47 All SZGR 2.0 genes in this pathway
ST GRANULE CELL SURVIVAL PATHWAY 27 23 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188 108 All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 All SZGR 2.0 genes in this pathway
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES 57 27 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195 114 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423 283 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455 304 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460 312 All SZGR 2.0 genes in this pathway
NEWMAN ERCC6 TARGETS UP 26 18 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP 306 188 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233 161 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN 142 90 All SZGR 2.0 genes in this pathway
PEPPER CHRONIC LYMPHOCYTIC LEUKEMIA UP 33 28 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN 242 165 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN 281 186 All SZGR 2.0 genes in this pathway
PAPASPYRIDONOS UNSTABLE ATEROSCLEROTIC PLAQUE UP 52 36 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA UP 141 75 All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS CML DIVIDING UP 23 13 All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP 57 33 All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN 95 57 All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP 66 47 All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 UP 64 46 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215 137 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
MUELLER METHYLATED IN GLIOBLASTOMA 40 22 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2 127 92 All SZGR 2.0 genes in this pathway
RASHI NFKB1 TARGETS 19 18 All SZGR 2.0 genes in this pathway
OXFORD RALA TARGETS UP 9 7 All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380 213 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203 134 All SZGR 2.0 genes in this pathway
GROSS ELK3 TARGETS DN 32 17 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN 156 106 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 ONLY UP 33 18 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769 437 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 120 HELA 69 47 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 60 MCF10A 39 24 All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 40 MCF10A 32 21 All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223 140 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN 169 102 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 3 DN 59 32 All SZGR 2.0 genes in this pathway
ONDER CDH1 SIGNALING VIA CTNNB1 83 58 All SZGR 2.0 genes in this pathway
ZUCCHI METASTASIS DN 44 29 All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS UP 145 91 All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC 182 116 All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP 83 56 All SZGR 2.0 genes in this pathway
ADDYA ERYTHROID DIFFERENTIATION BY HEMIN 73 47 All SZGR 2.0 genes in this pathway
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN 85 67 All SZGR 2.0 genes in this pathway
HEDVAT ELF4目标了 12 8 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 DN 77 48 All SZGR 2.0 genes in this pathway
HALMOS CEBPA TARGETS UP 52 34 All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION DN 128 90 All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND UP 77 52 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183 111 All SZGR 2.0 genes in this pathway
LIANG SILENCED BY METHYLATION 2 53 34 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 6M 74 47 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371 218 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT 51 41 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244 151 All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 3M 59 36 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD UP 222 139 All SZGR 2.0 genes in this pathway
KEEN RESPONSE TO ROSIGLITAZONE DN 106 68 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP 123 75 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP 148 96 All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A UP 81 52 All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G2 30 18 All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE 261 166 All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS 90 71 All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS 92 68 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195 135 All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE UP 56 41 All SZGR 2.0 genes in this pathway
AMBROSINI FLAVOPIRIDOL TREATMENT TP53 109 63 All SZGR 2.0 genes in this pathway
WORSCHECH TUMOR REJECTION UP 56 32 All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS DN 36 21 All SZGR 2.0 genes in this pathway
乳腺癌萧述三腔的DN 564 326 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476 285 All SZGR 2.0 genes in this pathway
GAURNIER PSMD4 TARGETS 73 55 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
CUI GLUCOSE DEPRIVATION 60 44 All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165 118 All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN 138 92 All SZGR 2.0 genes in this pathway
FERRARI RESPONSE TO FENRETINIDE UP 22 16 All SZGR 2.0 genes in this pathway
SPIRA SMOKERS LUNG CANCER UP 38 24 All SZGR 2.0 genes in this pathway
SOUCEK MYC TARGETS 8 6 All SZGR 2.0 genes in this pathway
SEKI INFLAMMATORY RESPONSE LPS UP 77 56 All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION A 67 52 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
CROONQUIST STROMAL STIMULATION UP 60 42 All SZGR 2.0 genes in this pathway
SCHOEN NFKB SIGNALING 34 26 All SZGR 2.0 genes in this pathway
KUROZUMI RESPONSE TO ONCOCYTIC VIRUS 44 30 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266 180 All SZGR 2.0 genes in this pathway
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN 37 26 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
TIAN TNF SIGNALING VIA NFKB 28 21 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718 401 All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G28 20 11 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR UP 61 44 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572 352 All SZGR 2.0 genes in this pathway
WINZEN DEGRADED VIA KHSRP 100 70 All SZGR 2.0 genes in this pathway
王MLL目标 289 188 All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418 245 All SZGR 2.0 genes in this pathway
PHONG TNF TARGETS UP 63 43 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL 160 106 All SZGR 2.0 genes in this pathway
ALTEMEIER RESPONSE TO LPS WITH MECHANICAL VENTILATION 128 81 All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP 289 184 All SZGR 2.0 genes in this pathway
GHANDHI DIRECT IRRADIATION UP 110 68 All SZGR 2.0 genes in this pathway
GHANDHI BYSTANDER IRRADIATION UP 86 54 All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222 159 All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344 197 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway