Gene Page:GTF3C1
Summary?
| GeneID | 2975 |
| Symbol | GTF3C1 |
| Synonyms | TFIIIC|TFIIIC220|TFIIICalpha |
| Description | general transcription factor IIIC subunit 1 |
| Reference | MIM:603246|HGNC:HGNC:4664|Ensembl:ENSG00000077235|HPRD:07540|Vega:OTTHUMG00000176805 |
| Gene type | protein-coding |
| Map location | 16p12 |
| Pascal p-value | 0.025 |
| Sherlock p-value | 0.435 |
| eGene | Cerebellum |
| Support | CompositeSet Darnell FMRP targets Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_IIE | Genome scan meta-analysis (European-ancestry samples) | Psr: 0.01775 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| HIGD1A | 0.86 | 0.86 |
| CD59 | 0.85 | 0.84 |
| GSTO1 | 0.83 | 0.83 |
| IFIT1 | 0.83 | 0.85 |
| NDUFA4 | 0.82 | 0.81 |
| CTBS | 0.81 | 0.77 |
| HERC6 | 0.81 | 0.83 |
| TMEM22 | 0.81 | 0.87 |
| C1orf57 | 0.80 | 0.66 |
| HOPX | 0.80 | 0.78 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| KIAA1949 | -0.53 | -0.68 |
| VAV2 | -0.52 | -0.65 |
| AXIN1 | -0.52 | -0.62 |
| UPF3A | -0.51 | -0.70 |
| SH3BP2 | -0.51 | -0.74 |
| ZNF311 | -0.51 | -0.63 |
| MARCKSL1 | -0.51 | -0.64 |
| VASH1 | -0.51 | -0.64 |
| RTF1 | -0.51 | -0.61 |
| GMIP | -0.51 | -0.55 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003677 | DNA binding | IC | 17409385 | |
| GO:0003709 | RNA polymerase III transcription factor activity | IC | 17409385 | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0042797 | tRNA transcription from RNA polymerase III promoter | IC | 17409385 | |
| GO:0042791 | 5S class rRNA transcription | IC | 17409385 | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0000127 | transcription factor TFIIIC complex | IDA | 17409385 | |
| GO:0005634 | nucleus | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| AKTIP | FT1 | FTS | AKT interacting protein | Two-hybrid | BioGRID | 16169070 |
| ASCC2 | ASC1p100 | activating signal cointegrator 1 complex subunit 2 | Two-hybrid | BioGRID | 16169070 |
| C8orf30A | FLJ40907 | chromosome 8 open reading frame 30A | Two-hybrid | BioGRID | 16169070 |
| CHN1 | ARHGAP2 | CHN | DURS2 | RHOGAP2 | chimerin (chimaerin) 1 | Two-hybrid | BioGRID | 16169070 |
| CPE | - | carboxypeptidase E | Two-hybrid | BioGRID | 16169070 |
| EZH2 | ENX-1 | EZH1 | KMT6 | MGC9169 | enhancer of zeste homolog 2 (Drosophila) | Two-hybrid | BioGRID | 16169070 |
| FGFR3 | ACH | CD333 | CEK2 | HSFGFR3EX | JTK4 | fibroblast growth factor receptor 3 | Two-hybrid | BioGRID | 16169070 |
| GTF3C4 | FLJ21002 | KAT12 | MGC138450 | TFIII90 | TFIIIC90 | TFIIICdelta | TFiiiC2-90 | general transcription factor IIIC, polypeptide 4, 90kDa | - | HPRD,BioGRID | 10523658 |
| IGFBP3 | BP-53 | IBP3 | insulin-like growth factor binding protein 3 | Two-hybrid | BioGRID | 16169070 |
| KLF6 | BCD1 | COPEB | CPBP | DKFZp686N0199 | GBF | PAC1 | ST12 | ZF9 | Kruppel-like factor 6 | Two-hybrid | BioGRID | 16169070 |
| MAPK10 | FLJ12099 | FLJ33785 | JNK3 | JNK3A | MGC50974 | PRKM10 | p493F12 | p54bSAPK | mitogen-activated protein kinase 10 | Two-hybrid | BioGRID | 16169070 |
| NHP2L1 | 15.5K | FA-1 | FA1 | NHPX | OTK27 | SNU13 | SPAG12 | SSFA1 | NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) | Two-hybrid | BioGRID | 16169070 |
| POLR3C | RPC3 | RPC62 | polype DNA聚合酶(RNA) III(指导)ptide C (62kD) | Affinity Capture-Western | BioGRID | 10373544 |
| PRPF38A | FLJ14936 | MGC3320 | RP5-965L7.1 | PRP38 pre-mRNA processing factor 38 (yeast) domain containing A | Two-hybrid | BioGRID | 16169070 |
| RBM23 | CAPERbeta | FLJ10482 | MGC4458 | PP239 | RNPC4 | RNA binding motif protein 23 | Two-hybrid | BioGRID | 16169070 |
| TBC1D17 | FLJ12168 | TBC1 domain family, member 17 | Two-hybrid | BioGRID | 16169070 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| HOLLMANN APOPTOSIS VIA CD40 DN | 267 | 178 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS BASAL UP | 380 | 215 | All SZGR 2.0 genes in this pathway |
| WANG ESOPHAGUS CANCER VS NORMAL DN | 101 | 66 | All SZGR 2.0 genes in this pathway |
| EBAUER TARGETS OF PAX3 FOXO1 FUSION DN | 48 | 31 | All SZGR 2.0 genes in this pathway |
| GRUETZMANN PANCREATIC CANCER DN | 203 | 134 | All SZGR 2.0 genes in this pathway |
| YANG BREAST CANCER ESR1 LASER UP | 34 | 25 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | All SZGR 2.0 genes in this pathway |
| MANTOVANI NFKB TARGETS UP | 43 | 33 | All SZGR 2.0 genes in this pathway |
| MANTOVANI VIRAL GPCR SIGNALING UP | 86 | 54 | All SZGR 2.0 genes in this pathway |
| BYSTROEM CORRELATED WITH IL5 UP | 51 | 30 | All SZGR 2.0 genes in this pathway |
| POMEROY MEDULLOBLASTOMA PROGNOSIS UP | 47 | 30 | All SZGR 2.0 genes in this pathway |
| KLEIN PRIMARY EFFUSION LYMPHOMA UP | 51 | 29 | All SZGR 2.0 genes in this pathway |
| PENG RAPAMYCIN RESPONSE DN | 245 | 154 | All SZGR 2.0 genes in this pathway |
| THEILGAARD NEUTROPHIL AT SKIN WOUND DN | 225 | 163 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 | 482 | 296 | All SZGR 2.0 genes in this pathway |
| SANSOM APC MYC TARGETS | 217 | 138 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS DN | 668 | 419 | All SZGR 2.0 genes in this pathway |
| KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP | 756 | 494 | All SZGR 2.0 genes in this pathway |
| KIM ALL DISORDERS DURATION CORR DN | 146 | 90 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 3 UP | 170 | 97 | All SZGR 2.0 genes in this pathway |