Gene Page:GUCY2C
Summary?
| GeneID | 2984 |
| Symbol | GUCY2C |
| Synonyms | DIAR6|GUC2C|MECIL|MUCIL|STAR |
| Description | guanylate cyclase 2C |
| Reference | MIM:601330|HGNC:HGNC:4688|Ensembl:ENSG00000070019|HPRD:07529|Vega:OTTHUMG00000168732 |
| Gene type | protein-coding |
| Map location | 12p12 |
| Pascal p-value | 0.022 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| S100B | 0.53 | 0.60 |
| CTSH | 0.53 | 0.59 |
| MUSTN1 | 0.52 | 0.57 |
| SERPINB6 | 0.50 | 0.56 |
| RERGL | 0.50 | 0.53 |
| TNFSF10 | 0.49 | 0.57 |
| PPP1R14A | 0.48 | 0.57 |
| S100A13 | 0.48 | 0.55 |
| GSDMD | 0.48 | 0.54 |
| PSMB9 | 0.48 | 0.59 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NOC2L | -0.51 | -0.61 |
| STRN4 | -0.48 | -0.58 |
| RNF40 | -0.47 | -0.57 |
| GTF2F1 | -0.47 | -0.57 |
| DAZAP1 | -0.47 | -0.59 |
| PA2G4 | -0.47 | -0.58 |
| KIAA1967 | -0.47 | -0.56 |
| NEURL4 | -0.47 | -0.56 |
| MKRN1 | -0.47 | -0.56 |
| C7orf26 | -0.47 | -0.58 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PURINE METABOLISM | 159 | 96 | All SZGR 2.0 genes in this pathway |
| VECCHI GASTRIC CANCER EARLY UP | 430 | 232 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| ROVERSI GLIOMA LOH REGIONS | 44 | 30 | All SZGR 2.0 genes in this pathway |
| SHIPP DLBCL CURED VS FATAL DN | 45 | 30 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER WITH H3K27ME3 UP | 295 | 149 | All SZGR 2.0 genes in this pathway |
| FIRESTEIN PROLIFERATION | 175 | 125 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |