Gene Page:CNOT7

Summary?
GeneID 29883
Symbol CNOT7
Synonyms CAF1 | Caf1a | hCAF-1
Description CCR4-NOT transcription complex subunit 7
Reference MIM:604913|HGNC:HGNC:14101|Ensembl:ENSG00000198791|Vega:OTTHUMG00000096971
Gene type protein-coding
Map location 8p22-p21.3
Pascal p-value 1.56E-6
Sherlock p-value 0.241
eGene Cerebellum
Meta

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_I 基因组扫描分析 Psr: 0.031
GSMA_IIA 基因组扫描分析(All samples) Psr: 0.03086
GSMA_IIE 基因组扫描分析(European-ancestry samples) Psr: 0.00057

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg17548406 8 17104535 VPS37A;CNOT7 4.33E-4 -0.372 0.045 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004871 signal transducer activity TAS 9820826
GO:0003676 nucleic acid binding IEA -
GO:0003700 transcription factor activity TAS 9820826
GO:0005515 protein binding IEA -
GO:0005515 protein binding 新闻学会 9820826
GO:0016563 transcription activator activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006355 regulation of transcription, DNA-dependent IEA -
GO:0006350 transcription IEA -
GO:0005975 carbohydrate metabolic process TAS 9820826
GO:0007165 signal transduction TAS 9820826
GO:0045944 积极的regulation of transcription from RNA polymerase II promoter IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IDA 9820826
GO:0005634 nucleus IEA -
GO:0030014 CCR4-NOT complex IEA -
GO:0030014 CCR4-NOT complex NAS 9820826

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
BTG1 - B-cell translocation gene 1, anti-proliferative - HPRD,BioGRID 9820826|11136725
|11429045
BTG2 MGC126063 | MGC126064 | PC3 | TIS21 BTG family, member 2 Reconstituted Complex BioGRID 11136725
BTG2 MGC126063 | MGC126064 | PC3 | TIS21 BTG family, member 2 - HPRD 9712883
BTG3 ANA | MGC8928 | TOB5 | TOB55 | TOFA BTG family, member 3 - HPRD 11429045
CDC2 CDC28A | CDK1 | DKFZp686L20222 | MGC111195 cell division cycle 2, G1 to S and G2 to M - HPRD,BioGRID 10602502
CDK2 p33(CDK2) cyclin-dependent kinase 2 - HPRD,BioGRID 10602502
CDK4 CMM3 | MGC14458 | PSK-J3 cyclin-dependent kinase 4 - HPRD,BioGRID 10602502
CDK6 MGC59692 | PLSTIRE | STQTL11 cyclin-dependent kinase 6 - HPRD 10602502
CNOT6 CCR4 | KIAA1194 CCR4-NOT transcription complex, subunit 6 - HPRD 10637334
PABPC1 PAB1 | PABP | PABP1 | PABPC2 | PABPL1 poly(A) binding protein, cytoplasmic 1 Affinity Capture-Western
Reconstituted Complex		 BioGRID 18056425
TOB1 APRO6 | MGC104792 | MGC34446 | PIG49 | TOB | TROB | TROB1 transducer of ERBB2, 1 Affinity Capture-Western
Reconstituted Complex		 BioGRID 10602502|18056425
TOB2 TOB4 | TOBL | TROB2 transducer of ERBB2, 2 - HPRD,BioGRID 10602502


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG RNA DEGRADATION 59 37 All SZGR 2.0 genes in this pathway
REACTOME DEADENYLATION OF MRNA 22 14 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284 128 All SZGR 2.0 genes in this pathway
REACTOME DEADENYLATION DEPENDENT MRNA DECAY 48 29 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330 155 All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP 201 125 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL UP 94 59 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431 263 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN 320 184 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION 6HR 40 23 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514 319 All SZGR 2.0 genes in this pathway
GROSS ELK3 TARGETS DN 32 17 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A UP 142 104 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 DN 176 104 All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 DN 64 47 All SZGR 2.0 genes in this pathway
MOOTHA VOXPHOS 87 51 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 AND CD2 UP 89 51 All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX UP 83 66 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
MATZUK SPERMATOCYTE 72 55 All SZGR 2.0 genes in this pathway
MATZUK SPERMATOZOA 114 77 All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE 242 168 All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429 260 All SZGR 2.0 genes in this pathway
MOOTHA PGC 420 269 All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447 277 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277 172 All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS 77 62 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553 343 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 209 215 1A hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-128 1175 1181 1A hsa-miR-128a UCACAGUGAACCGGUCUCUUUU
hsa-miR-128b UCACAGUGAACCGGUCUCUUUC
miR-130/301 424 430 m8 hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-136 1032 1039 1A,m8 hsa-miR-136 ACUCCAUUUGUUUUGAUGAUGGA
miR-17-5p/20/93.mr/106/519.d 426 433 1A,m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-19 423 429 m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-200bc/429 517 523 m8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-27 1175 1182 1A,m8 hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-320 721 728 1A,m8 hsa-miR-320 AAAAGCUGGGUUGAGAGGGCGAA
miR-363 557 563 1A hsa-miR-363 AUUGCACGGUAUCCAUCUGUAA
miR-377 239 245 m8 hsa-miR-377 AUCACACAAAGGCAACUUUUGU
miR-381 43 50 1A,m8 hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-410 1154 1160 1A hsa-miR-410 AAUAUAACACAGAUGGCCUGU
miR-490 196 202 1A hsa-miR-490 CAACCUGGAGGACUCCAUGCUG
miR-544 1194 1200 m8 hsa-miR-544 AUUCUGCAUUUUUAGCAAGU
miR-9 947 953 1A hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA