Gene Page:SLC2A8

Summary?
GeneID 29988
Symbol SLC2A8
Synonyms GLUT8|GLUTX1
Description solute carrier family 2 member 8
Reference MIM:605245|HGNC:HGNC:13812|Ensembl:ENSG00000136856|HPRD:05580|Vega:OTTHUMG00000020702
Gene type protein-coding
Map location 9q33.3
Pascal p-value 0.006
Sherlock p-value 0.875
Fetal beta -0.581
DMG 1 (# studies)
eGene Anterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Putamen basal ganglia
Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg03804985 9 130159694 SLC2A8 -0.027 0.91 DMG:Nishioka_2013

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs7044100 chr9 129742639 SLC2A8 29988 0.05 cis
rs12644099 0 SLC2A8 29988 0.11 trans
rs1138739 9 130164993 SLC2A8 ENSG00000136856.13 2.389E-6 0.02 5572 gtex_brain_ba24
rs1138740 9 130165995 SLC2A8 ENSG00000136856.13 1.55E-6 0.02 6574 gtex_brain_ba24
rs11788710 9 130166383 SLC2A8 ENSG00000136856.13 1.99E-6 0.02 6962 gtex_brain_ba24
rs11790936 9 130170526 SLC2A8 ENSG00000136856.13 4.052E-6 0.02 11105 gtex_brain_ba24
rs11790967 9 130170561 SLC2A8 ENSG00000136856.13 2.009E-6 0.02 11140 gtex_brain_ba24
rs11794990 9 130171020 SLC2A8 ENSG00000136856.13 2.02E-6 0.02 11599 gtex_brain_ba24
rs10987639 9 130172485 SLC2A8 ENSG00000136856.13 1.985E-6 0.02 13064 gtex_brain_ba24
rs11791288 9 130173224 SLC2A8 ENSG00000136856.13 2.009E-6 0.02 13803 gtex_brain_ba24
rs11791717 9 130173320 SLC2A8 ENSG00000136856.13 2.016E-6 0.02 13899 gtex_brain_ba24
rs7873847 9 130174444 SLC2A8 ENSG00000136856.13 2.18E-6 0.02 15023 gtex_brain_ba24
rs10987643 9 130175263 SLC2A8 ENSG00000136856.13 2.475E-6 0.02 15842 gtex_brain_ba24
rs4837147 9 130125645 SLC2A8 ENSG00000136856.13 1.169E-6 0 -33776 gtex_brain_putamen_basal
rs10987619 9 130131996 SLC2A8 ENSG00000136856.13 1.226E-6 0 -27425 gtex_brain_putamen_basal
rs1138739 9 130164993 SLC2A8 ENSG00000136856.13 1.961E-7 0 5572 gtex_brain_putamen_basal
rs1138740 9 130165995 SLC2A8 ENSG00000136856.13 1.496E-7 0 6574 gtex_brain_putamen_basal
rs11788710 9 130166383 SLC2A8 ENSG00000136856.13 7.95E-8 0 6962 gtex_brain_putamen_basal
rs11790936 9 130170526 SLC2A8 ENSG00000136856.13 5.43E-8 0 11105 gtex_brain_putamen_basal
rs11790967 9 130170561 SLC2A8 ENSG00000136856.13 2.845E-8 0 11140 gtex_brain_putamen_basal
rs11794990 9 130171020 SLC2A8 ENSG00000136856.13 2.845E-8 0 11599 gtex_brain_putamen_basal
rs151232558 9 130171848 SLC2A8 ENSG00000136856.13 2.301E-8 0 12427 gtex_brain_putamen_basal
rs28546643 9 130171859 SLC2A8 ENSG00000136856.13 4.992E-7 0 12438 gtex_brain_putamen_basal
rs10987639 9 130172485 SLC2A8 ENSG00000136856.13 2.845E-8 0 13064 gtex_brain_putamen_basal
rs11791288 9 130173224 SLC2A8 ENSG00000136856.13 2.838E-8 0 13803 gtex_brain_putamen_basal
rs11791717 9 130173320 SLC2A8 ENSG00000136856.13 2.835E-8 0 13899 gtex_brain_putamen_basal
rs7873847 9 130174444 SLC2A8 ENSG00000136856.13 2.81E-8 0 15023 gtex_brain_putamen_basal
rs10987643 9 130175263 SLC2A8 ENSG00000136856.13 2.782E-8 0 15842 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),圣2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 241 157 All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 89 54 All SZGR 2.0 genes in this pathway
REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS 12 10 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER WITH LOH IN CHR9Q 116 71 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM 302 191 All SZGR 2.0 genes in this pathway
XU GH1 EXOGENOUS TARGETS DN 120 69 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P2 79 55 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442 263 All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE DN 138 99 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211 131 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP 281 183 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway