Gene Page:SH3KBP1
Summary？
| 基因 | 30011 |
| 象征 | SH3KBP1 |
| Synonyms | CD2BP3|CIN85|GIG10|HSB-1|HSB1|MIG18 |
| Description | SH3核蛋白激酶结合蛋白1 |
| Reference | MIM:300374|HGNC:HGNC:13867|Ensembl:ENSG00000147010|HPRD:02301|Vega：Otthumg0000000021227 |
| 基因类型 | 蛋白质编码 |
| Map location | XP22.1-P21.3 |
| Sherlock p-value | 0.057 |
| 胎儿β | -0.887 |
| Support | G2CDB.HUMAN_BAYES-COLLINS-MOUSE-PSD-CONSUS G2Cdb.humanPSD G2Cdb.humanPSP 潜在的突触基因 |
Gene in Data Sources
| 基因集名称 | Method of gene set | Description | 信息 |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | 精神分裂症的GWASDB记录 | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GO_Annotation | 将与神经相关的关键字映射到基因本体论注释 | 与神经相关的关键字的命中：1 | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | PPI网络中最短路径的贡献：0.2206 |
Section I. Genetics and epigenetics annotation
第二节。转录组注释
一般基因表达（GTEX）
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达（brainspan）
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。
No co-expressed genes in brain regions
第三节。基因本体论注释
| 分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
|---|---|---|---|---|
| 去：0003674 | Molecular_Function | nd | - | |
| 去：0005515 | 蛋白质结合 | IPI | 12029088 | |
| GO：0017124 | SH3域结合 | IEA | - | |
| 去：0016301 | kinase activity | IEA | - | |
| 生物过程 | 去学期 | 证据 | 神经关键字 | PubMed ID |
| GO:0007267 | 细胞细胞信号传导 | nas | 10679202 | |
| GO:0006915 | 凋亡 | IEA | - | |
| 去：0006897 | 内吞作用 | IEA | - | |
| Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
| GO：0019717 | 突触体 | IEA | 突触，大脑（GO期限：7） | - |
| GO:0045202 | 突触 | IEA | neuron, Synap, Neurotransmitter, Glial (GO term level: 2) | - |
| GO:0005829 | 细胞质 | 经验 | 10567358|11894095|12218189 |15962011 |
|
| 去：0005856 | 细胞骨架 | IEA | - | |
| 去：0005634 | nucleus | IDA | 18029348 | |
| 去：0005730 | nucleolus | IDA | 18029348 | |
| 去：0005737 | cytoplasm | IEA | - | |
| 去：0005886 | plasma membrane | 经验 | 16407834 | |
| GO:0030054 | cell junction | IEA | - | |
| GO：0031410 | 细胞质囊泡 | IEA | - | |
| 去：0030659 | 细胞质囊泡膜 | IEA | - |
Section IV. Protein-protein interaction annotation
| 互动者 | 别名b | 官方全名b | 实验 | Source | PubMed ID |
|---|---|---|---|---|---|
| ABI2 | Abi-2 |ABI2B |AIP-1 |ablbp3 |SSH3BP2 |argbpia |argbpib | ABL Interactor 2 | - | HPRD,BioGRID | 10858458 |
| ARHGAP27 | CAMGAP1 | FLJ43547 | MGC120624 | Rho GTPase activating protein 27 | - | HPRD,BioGRID | 15147912 |
| ASAP1 | AMAP1 | CENTB4 | DDEF1 | KIAA1249 | PAG2 | PAP | ZG14P | 带有SH3结构域的ArfGap，Ankyrin重复和pH结构域1 | DDEF1 (AMAP1) interacts with SH3KBP1 (CIN85). | 绑定 | 15719014 |
| ASAP2 | AMAP2 | CENTB3 | DDEF2 | FLJ42910 | KIAA0400 | PAG3 | PAP | Pap-alpha | SHAG1 | 带有SH3结构域的ArfGap，Ankyrin重复和pH结构域2 | DDEF2（AMAP2）与SH3KBP1（CIN85）相互作用。 | 绑定 | 15719014 |
| BCAR1 | cas |cas1 |Cass1 |crkas |P130CAS | breast cancer anti-estrogen resistance 1 | 亲和力捕获 - 韦斯特恩 | Biogrid | 11071869 |
| BLNK | bash |blnk-s |Ly57 |MGC111051 |SLP-65 |SLP65 | B细胞链接器 | - | HPRD,BioGRID | 11071869 |
| CAPZA1 | CAPPA1 | CAPZ | CAZ1 | 上限蛋白（肌动蛋白丝）肌肉z线，alpha 1 | - | HPRD | 12690097 |
| CBL | C-CBL | CBL2 | RNF55 | CAS-BR-M（鼠）生态逆转录病毒转化序列 | - | HPRD,BioGRID | 11894095 |
| CBL | C-CBL | CBL2 | RNF55 | CAS-BR-M（鼠）生态逆转录病毒转化序列 | CIN85与CBL相互作用。 | 绑定 | 11894095 |
| CBLB | DKFZp686J10223 | DKFZp779A0729 | DKFZp779F1443 | FLJ36865 | FLJ41152 | Nbla00127 | RNF56 | CAS-BR-M（鼠）生态逆转录病毒转化序列b | - | HPRD,BioGRID | 12218189 |
| CD2 | SRBC |T11 | CD2 molecule | - | HPRD | 12690097 |
| CD2 | SRBC |T11 | CD2 molecule | - | HPRD,BioGRID | 9857189|12690097|12690097 |
| CD2 | SRBC |T11 | CD2 molecule | SETA interacts with CD2. This interaction was modelled on a demonstrated interaction between rat SETA and human CD2. | 绑定 | 11152963 |
| CLYBL | Clb |BA134O15.1 | 柠檬酸裂裂解酶类似 | 亲和力捕获 - 韦斯特恩 | Biogrid | 11894096 |
| CRK | crkii | v-crk sarcoma virus CT10 oncogene homolog (avian) | 亲和力捕获 - 韦斯特恩 | Biogrid | 11071869 |
| egfr | ERBB |ERBB1 |her1 |PIG61 |梅纳 | 表皮生长因子受体（红细胞性白血病病毒（V-ERB-B）癌基因同源物，鸟类） | 亲和力捕获 - 韦斯特恩 | Biogrid | 11894095|12177062 |
| GRB2 | 灰烬|EGFRBP-GRB2 |Grb3-3 |MST084 |MSTP084 | 生长因子受体结合蛋白2 | - | HPRD | 9507006|11152963 |
| GRB2 | 灰烬|EGFRBP-GRB2 |Grb3-3 |MST084 |MSTP084 | 生长因子受体结合蛋白2 | SETA与GRB2相互作用。这种相互作用是在大鼠seta和人类GRB2之间的相互作用上建模的 | 绑定 | 11152963 |
| GRB2 | 灰烬|EGFRBP-GRB2 |Grb3-3 |MST084 |MSTP084 | 生长因子受体结合蛋白2 | 重构的复合物 | Biogrid | 10921882|11152963 |
| KIT | c-kit |CD117 |PBT |scfr | V-Kit Hardy-Zuckerman 4猫肉瘤病毒性癌基因同源物 | 亲和力捕获 - 韦斯特恩 | Biogrid | 12177062 |
| 见面 | auts9 |HGFR |RCCP2 |C-MET | met proto-oncogene (hepatocyte growth factor receptor) | - | HPRD,BioGRID | 11894096 |
| NEDD4 | KIAA0093 | MGC176705 | NEDD4-1 | RPF1 | 神经前体细胞表达，发育下调4 | - | HPRD,BioGRID | 12218189 |
| PAK2 | Pak65 |Pakgamma | P21蛋白（CDC42/RAC）激活激酶2 | - | HPRD,BioGRID | 12829691 |
| PDCD6 | ALG-2 | FLJ46208 | MGC111017 | MGC119050 | MGC9123 | PEF1B | 程序性细胞死亡6 | - | HPRD,BioGRID | 10858458 |
| PDGFRB | CD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1 | platelet-derived growth factor receptor, beta polypeptide | - | HPRD,BioGRID | 12177062 |
| PIK3R1 | GRB1 | p85 | p85-ALPHA | 磷酸肌醇3-激酶，调节亚基1（alpha） | - | HPRD,BioGRID | 10921882 |
| SH3GL1 | CNSA1 |Een |MGC111371 |SH3D2B |SH3P8 | SH3-domain GRB2-like 1 | Endophilin A2 interacts with CIN85. This interaction was modeled on a demonstrated interaction between endophilin A2 from an unspecified species and human CIN85. | 绑定 | 11894096 |
| SH3GL2 | CNSA2 | EEN-B1 | FLJ20276 | FLJ25015 | SH3D2A | SH3P4 | SH3-domain GRB2-like 2 | - | HPRD,BioGRID | 12218189 |
| SH3GL2 | CNSA2 | EEN-B1 | FLJ20276 | FLJ25015 | SH3D2A | SH3P4 | SH3-domain GRB2-like 2 | CIN85 interacts with endophilin A1. This interaction was modeled on a demonstrated interaction between human CIN85 and mouse endophilin A1. | 绑定 | 11894095 |
| SH3GL3 | CNSA3 |een-2b-l3 |een-b2 |HST19371 |SH3D2C |SH3P13 | SH3-domain GRB2-like 3 | 内菲林A3与CIN85相互作用。 | 绑定 | 11894096 |
| SH3GL3 | CNSA3 |een-2b-l3 |een-b2 |HST19371 |SH3D2C |SH3P13 | SH3-domain GRB2-like 3 | 亲和力捕获 - 韦斯特恩 重构的复合物 Two-hybrid |
Biogrid | 11894096 |
| SH3GLB1 | Bif-1 | CGI-61 | KIAA0491 | dJ612B15.2 | SH3域grb2样内粒蛋白B1 | 重构的复合物 | Biogrid | 11894096 |
| SH3GLB2 | KIAA1848 | PP6569 | PP9455 | SH3膜GRB2样的内啡肽B2 | 重构的复合物 Two-hybrid |
Biogrid | 11894095|11894096 |
| SH3KBP1 | CIN85 | GIG10 | MIG18 | SH3核蛋白激酶结合蛋白1 | 亲和力捕获 - 韦斯特恩 Two-hybrid |
Biogrid | 11071869|11894095 |
| SHKBP1 | pp203 |SB1 | SH3KBP1 binding protein 1 | - | HPRD,BioGRID | 11152963 |
| SOS1 | GF1 |GGF1 |gingf |HGF |NS4 | 七个无同胞1的儿子（果蝇） | - | HPRD,BioGRID | 11071869 |
| synj1 | INPP5G | Synaptojanin 1 | 亲和力捕获 - 韦斯特恩 Far Western |
Biogrid | 12829691 |
| TAF6 | DKFZp781E21155 | MGC:8964 | TAF2E | TAFII70 | TAFII80 | TAFII85 | TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa | - | HPRD,BioGRID | 12829691 |
| TJP2 | MGC26306 |x104 |ZO-2 |ZO2 | 紧密连接蛋白2（Zona occludens 2） | - | HPRD,BioGRID | 12829691 |
Section V. Pathway annotation
| 路径名 | 路径大小 | # SZGR 2.0 genes in pathway | 信息 |
|---|---|---|---|
| KEGG内吞作用 | 183 | 132 | All SZGR 2.0 genes in this pathway |
| Biocarta CBL途径 | 13 | 10 | All SZGR 2.0 genes in this pathway |
| PID MET PATHWAY | 80 | 60 | All SZGR 2.0 genes in this pathway |
| PID ERBB1 INTERNALIZATION PATHWAY | 41 | 35 | All SZGR 2.0 genes in this pathway |
| EGFR在癌症中的反应组信号传导 | 109 | 80 | All SZGR 2.0 genes in this pathway |
| Reactome抗原激活B细胞受体，导致第二使者产生 | 29 | 24 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY THE B CELL RECEPTOR BCR | 126 | 90 | All SZGR 2.0 genes in this pathway |
| REACTOME EGFR DOWNREGULATION | 25 | 14 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| Reactome适应性免疫系统 | 539 | 350 | All SZGR 2.0 genes in this pathway |
| CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP | 146 | 86 | All SZGR 2.0 genes in this pathway |
| FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP | 579 | 346 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS BASAL DN | 455 | 304 | All SZGR 2.0 genes in this pathway |
| 乳腺癌腔与间充质DN | 460 | 312 | All SZGR 2.0 genes in this pathway |
| Horiuchi WTAP靶向 | 306 | 188 | All SZGR 2.0 genes in this pathway |
| WAMUNYOKOLI OVARIAN CANCER LMP UP | 265 | 158 | All SZGR 2.0 genes in this pathway |
| chebotaev gr目标dn | 120 | 73 | All SZGR 2.0 genes in this pathway |
| Lindgren膀胱癌簇1 DN | 378 | 231 | All SZGR 2.0 genes in this pathway |
| Graessmann血清剥夺DN的细胞凋亡 | 234 | 147 | All SZGR 2.0 genes in this pathway |
| 由阿霉素DN GRAESSMANN细胞凋亡 | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| Gaussmann MLL AF4融合靶向 | 191 | 128 | All SZGR 2.0 genes in this pathway |
| LINDGREN BLADDER CANCER CLUSTER 2B | 392 | 251 | All SZGR 2.0 genes in this pathway |
| Schaeffer前列腺开发48小时DN | 428 | 306 | All SZGR 2.0 genes in this pathway |
| GC期DN的pasqualucci淋巴瘤 | 165 | 104 | All SZGR 2.0 genes in this pathway |
| XU GH1 AUTOCRINE TARGETS UP | 268 | 157 | All SZGR 2.0 genes in this pathway |
| Zheng由Foxp3绑定 | 491 | 310 | All SZGR 2.0 genes in this pathway |
| 马丁内斯RB1靶向 | 673 | 430 | All SZGR 2.0 genes in this pathway |
| Martinez TP53靶向 | 602 | 364 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 AND TP53 TARGETS UP | 601 | 369 | All SZGR 2.0 genes in this pathway |
| Sarrio上皮间质转变 | 180 | 114 | All SZGR 2.0 genes in this pathway |
| IZADPANAH STEM CELL ADIPOSE VS BONE UP | 126 | 92 | All SZGR 2.0 genes in this pathway |
| HUANG DASATINIB RESISTANCE UP | 81 | 53 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| ROME INSULIN TARGETS IN MUSCLE UP | 442 | 263 | All SZGR 2.0 genes in this pathway |
| Mikkelsen MCV6 LCP带有H3K4Me3 | 162 | 80 | All SZGR 2.0 genes in this pathway |
| Mikkelsen MEF LCP带有H3K4ME3 | 128 | 68 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| Bruins通过TP53组A的UVC响应 | 898 | 516 | All SZGR 2.0 genes in this pathway |
| MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP | 259 | 159 | All SZGR 2.0 genes in this pathway |
| Huang Gata2靶向 | 149 | 96 | All SZGR 2.0 genes in this pathway |
| ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP | 289 | 184 | All SZGR 2.0 genes in this pathway |
第六节。microRNA注释
| mirna家族 | Target position | miRNA ID | mirna seq | ||
|---|---|---|---|---|---|
| UTR开始 | UTR结束 | 匹配方法 | |||
| miR-124/506 | 639 | 645 | M8 | hsa-miR-506 | UAAGGCACCCUUCUGAGUAGA |
| HSA-MIR-124brain | UAAGGCACGCGGUGAAUGCC | ||||
| miR-129-5p | 977 | 983 | M8 | HSA-MIR-129brain | cuuuuugcgguggggcuugc |
| HSA-MIR-129-5p | cuuuuugcgguggggcuugcu | ||||
| miR-142-5p | 362 | 368 | 1A | hsa - mir - 142-5p | cauaaaguagaaagcacuac |
| miR-153 | 509 | 515 | 1A | HSA-MIR-153 | UUGCAUAGUCACAAAAGUGA |
| miR-182 | 79 | 85 | 1A | HSA-MIR-182 | uuuggcaaugguagaacucaca |
| mir-218 | 144 | 150 | 1A | hsa-miR-218brain | UUGUGCUUGAUCUAACCAUGU |
| miR-22 | 681 | 687 | 1A | hsa-miR-22brain | Aagcugccaguugaagaacugu |
| miR-26 | 2 | 8 | M8 | HSA-MIR-26Abrain | UUCAAGUAAUCCAGGAUAGGC |
| HSA-MIR-26BSZ | UUCAAGUAAUUCAGGAUAGGUU | ||||
| miR-33 | 997 | 1003 | 1A | hsa-miR-33 | Gugcauuguuguugcauug |
| hsa-miR-33b | GUGCAUUGCUGUUGCAUUGCA | ||||
| mir-410 | 579 | 585 | 1A | hsa-miR-410 | aauauaacacagauggcugu |
| mir-448 | 962 | 968 | M8 | hsa-miR-448 | UUGCAUAUGUAGGAUGUCCCAU |
| hsa-miR-448 | UUGCAUAUGUAGGAUGUCCCAU | ||||
| mir-450 | 977 | 983 | 1A | hsa-miR-450 | UUUUUGCGAUGUGUUCCUAAUA |
| miR-542-3p | 394 | 400 | 1A | hsa-miR-542-3p | UGUGACAGAUUGAUAACUGAAA |
| mir-96 | 78 | 85 | 1A，M8 | hsa-miR-96brain | uuuggcacuagcacauuuuugc |