Gene Page:HIST1H1E

Summary?
GeneID 3008
Symbol HIST1H1E
Synonyms H1.4|H1E|H1F4|H1s-4|dJ221C16.5
Description histone cluster 1, H1e
Reference MIM:142220|HGNC:HGNC:4718|Ensembl:ENSG00000168298|HPRD:07513|Vega:OTTHUMG00000014422
Gene type protein-coding
Map location 6p21.3
Pascal p-value 1.887E-9
TADA p-value 7.86E-4
Fetal beta 0.622
Support G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DNM:Xu_2012 Whole Exome Sequencing analysis 新创突变s of 4 genes were identified by exome sequencing of 795 samples in this study
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.033
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
HIST1H1E chr6 26157173..26157175 CAA C NM_005321 . frameshift Schizophrenia DNM:Xu_2012


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003677 DNA binding NAS -
GO:0005515 protein binding 新闻学会 17540172
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006334 nucleosome assembly NAS -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0000786 nucleosome NAS -
GO:0005634 nucleus IEA -
GO:0005694 chromosome IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID HDAC CLASSIII PATHWAY 25 20 All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION 13 10 All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 148 94 All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC EXECUTION PHASE 54 37 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769 437 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514 330 All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA DN 39 29 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR 293 193 All SZGR 2.0 genes in this pathway
《图片报》极品致癌签名 261 166 All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS UP 88 47 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374 217 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324 193 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
BILANGES SERUM SENSITIVE VIA TSC2 39 25 All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418 245 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway