Gene Page:HIST1H1B
Summary?
| GeneID | 3009 |
| Symbol | HIST1H1B |
| Synonyms | H1|H1.5|H1B|H1F5|H1s-3 |
| Description | histone cluster 1, H1b |
| Reference | MIM:142711|HGNC:HGNC:4719|运用:ENSG00000184357|HPRD:00821|Vega:OTTHUMG00000016139 |
| Gene type | protein-coding |
| Map location | 6p22.1 |
| Pascal p-value | 1E-12 |
| Fetal beta | 0.236 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | 系统的年代earch in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.033 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16836102 | chr4 | 4716366 | HIST1H1B | 3009 | 0.19 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AGBL4 | 0.64 | 0.67 |
| VSNL1 | 0.64 | 0.67 |
| ARNTL | 0.63 | 0.69 |
| SLC7A8 | 0.63 | 0.68 |
| FAM47E | 0.63 | 0.63 |
| BMPER | 0.62 | 0.69 |
| RPH3A | 0.62 | 0.70 |
| STBD1 | 0.62 | 0.67 |
| GRIA4 | 0.62 | 0.66 |
| C4orf18 | 0.62 | 0.63 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SH2D2A | -0.37 | -0.43 |
| KIAA1949 | -0.36 | -0.32 |
| CARHSP1 | -0.36 | -0.45 |
| MYCN | -0.35 | -0.17 |
| SH3BP2 | -0.35 | -0.38 |
| ZNF300 | -0.35 | -0.22 |
| VASH2 | -0.35 | -0.22 |
| AC005393.1 | -0.35 | -0.31 |
| SLA | -0.35 | -0.18 |
| RPL18 | -0.34 | -0.47 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003677 | DNA binding | NAS | - | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0006334 | nucleosome assembly | NAS | - | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0000786 | nucleosome | NAS | - | |
| GO:0005634 | nucleus | IEA | - | |
| GO:0005694 | chromosome | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | 13 | 10 | All SZGR 2.0 genes in this pathway |
| REACTOME APOPTOSIS | 148 | 94 | All SZGR 2.0 genes in this pathway |
| REACTOME APOPTOTIC EXECUTION PHASE | 54 | 37 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 6HR DN | 514 | 330 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY E2F4 UNSTIMULATED | 728 | 415 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 | 1069 | 729 | All SZGR 2.0 genes in this pathway |
| WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN | 374 | 217 | All SZGR 2.0 genes in this pathway |
| RAO BOUND BY SALL4 ISOFORM B | 517 | 302 | All SZGR 2.0 genes in this pathway |