SZGR2 - Beplay体育中心

Summary？

基因	3014
象征	H2AFX
Synonyms	h2a.x \| h2a/x \| h2ax
Description	H2A组蛋白家庭成员X
Reference	MIM：601772\|HGNC：HGNC：4739\|Ensembl:ENSG00000188486\|HPRD：03465\|Vega：Otthumg00000166196
基因类型	蛋白质编码
Map location	11q23.3
Pascal p-value	0.035
Sherlock p-value	0.417
胎儿β	0.647
DMG	1(# studies)
主持人	Myers' cis & trans

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
DMG：Wockner_2014	全基因组DNA甲基化分析	该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。	1
GSMA_I	Genome scan meta-analysis	Psr: 0.006

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	染色体	位置	最近的基因	p（dis）	Beta (dis)	fdr（dis）	学习
CG06159435	11	118966351	H2AFX	9.9e-6	-0.461	0.013	DMG：Wockner_2014

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	EQTL类型
rs4706060	CHR6	79232160	H2AFX	3014		0.2		反式

第二节。转录组注释

一般基因表达（GTEX）

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0003684	DNA结合受损	IEA		-
去：0005515	蛋白质结合	IPI		17498979
生物过程	去学期	证据	神经关键字	PubMed ID
GO：0000724	double-strand break repair via homologous recombination	IEA		-
去：0006334	nucleosome assembly	nas		2587254
去：0006310	DNA recombination	IEA		-
GO:0007283	spermatogenesis	IEA		-
去：0006281	DNA repair	IEA		-
GO:0007049	cell cycle	IEA		-
去：0007126	meiosis	IEA		-
Cellular component	去学期	证据	神经关键字	PubMed ID
GO:0000786	nucleosome	nas		-
去：0005634	nucleus	IDA		11331621\|15604234
去：0005654	核质	经验		10959836\|12419185\|12556884
去：0005657	复制叉	IEA		-
去：0005694	chromosome	IEA		-

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
kegg系统性狼疮红斑	140	100	All SZGR 2.0 genes in this pathway
PID FANCONI PATHWAY	47	28	All SZGR 2.0 genes in this pathway
PID ATM路径	34	25	All SZGR 2.0 genes in this pathway
Reactome减数分裂	116	81	All SZGR 2.0 genes in this pathway
反应组细胞周期	421	253	All SZGR 2.0 genes in this pathway
Reactome RNA Pol I转录	89	64	All SZGR 2.0 genes in this pathway
REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	17	11	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION	210	127	All SZGR 2.0 genes in this pathway
Reactome Double Strand Break修复	24	14	All SZGR 2.0 genes in this pathway
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION	122	80	All SZGR 2.0 genes in this pathway
Reactome DNA修复	112	59	All SZGR 2.0 genes in this pathway
REACTOME CHROMOSOME MAINTENANCE	122	80	All SZGR 2.0 genes in this pathway
REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	64	43	All SZGR 2.0 genes in this pathway
REACTOME RNA POL I PROMOTER OPENING	62	49	All SZGR 2.0 genes in this pathway
Reactome减数分裂重组	86	62	All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC SYNAPSIS	73	57	All SZGR 2.0 genes in this pathway
REACTOME AMYLOIDS	83	63	All SZGR 2.0 genes in this pathway
REACTOME PACKAGING OF TELOMERE ENDS	48	40	All SZGR 2.0 genes in this pathway
Reactome端粒维护	75	57	All SZGR 2.0 genes in this pathway
Onken Uveal黑色素瘤	783	507	All SZGR 2.0 genes in this pathway
GAZDA钻石黑芬贫血红斑dn	493	298	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP	579	346	All SZGR 2.0 genes in this pathway
deurig t细胞促进性白血病	368	234	All SZGR 2.0 genes in this pathway
Horiuchi WTAP目标DN	310	188	All SZGR 2.0 genes in this pathway
Basaki YBX1靶向	290	177	All SZGR 2.0 genes in this pathway
Wang LMO4靶向	372	227	All SZGR 2.0 genes in this pathway
Senese HDAC3靶向DN	536	332	All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL QUIESCENT UP	87	45	All SZGR 2.0 genes in this pathway
Graham CML分割与正常静止	181	101	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
甲状腺癌	443	294	All SZGR 2.0 genes in this pathway
CHIARADONNA肿瘤转化喀斯特	126	72	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 UP	120	73	All SZGR 2.0 genes in this pathway
Markey RB1急性LOF DN	228	137	All SZGR 2.0 genes in this pathway
Kong E2F1目标	10	6	All SZGR 2.0 genes in this pathway
Kong E2F3目标	97	58	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN	800	473	All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP	207	128	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 4	61	34	All SZGR 2.0 genes in this pathway
罗斯蒂宫颈癌增殖簇	140	73	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
牛津拉拉或拉尔布靶向	48	23	All SZGR 2.0 genes in this pathway
Mohankumar TLX1靶向	414	287	All SZGR 2.0 genes in this pathway
Spielman淋巴细胞欧洲vs亚洲	479	299	All SZGR 2.0 genes in this pathway
Pujana乳腺癌点燃int网络	101	73	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络	1652	1023	All SZGR 2.0 genes in this pathway
Pujana BRCA2 PCC网络	423	265	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP	209	139	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
Buytaert光动力疗法应力DN	637	377	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
Benporath SOX2目标	734	436	All SZGR 2.0 genes in this pathway
Benporath EED目标	1062	725	All SZGR 2.0 genes in this pathway
Benporath Myc Max目标	775	494	All SZGR 2.0 genes in this pathway
Benporath循环基因	648	385	All SZGR 2.0 genes in this pathway
Amit EGF响应480 HELA	164	118	All SZGR 2.0 genes in this pathway
Shin B细胞淋巴瘤簇8	36	28	All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE UP	80	54	All SZGR 2.0 genes in this pathway
Mori大型BII淋巴细胞向上	86	49	All SZGR 2.0 genes in this pathway
Mori未成熟B淋巴细胞DN	90	55	All SZGR 2.0 genes in this pathway
Collis PrkDC底物	20	15	All SZGR 2.0 genes in this pathway
Kauffmann DNA修复基因	230	137	All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN	289	166	All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS UP	108	75	All SZGR 2.0 genes in this pathway
由E2F绑定的REN	61	40	All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP	203	130	All SZGR 2.0 genes in this pathway
Zhan V2晚分化基因	45	34	All SZGR 2.0 genes in this pathway
GREENBAUM E2A TARGETS UP	33	18	All SZGR 2.0 genes in this pathway
ly老龄过早的DN	30	17	All SZGR 2.0 genes in this pathway
Browne HCMV感染20小时	240	152	All SZGR 2.0 genes in this pathway
HU遗传毒性损伤24小时	35	22	All SZGR 2.0 genes in this pathway
PAL PRMT5靶向	203	135	All SZGR 2.0 genes in this pathway
Browne HCMV感染8小时	105	73	All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病	1691	1088	All SZGR 2.0 genes in this pathway
KIM胃癌化学敏感性	103	64	All SZGR 2.0 genes in this pathway
Rhodes未分化的癌症	69	44	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP	244	151	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 24HR	43	30	All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS PRENATAL	42	33	All SZGR 2.0 genes in this pathway
伯顿成生成4	48	32	All SZGR 2.0 genes in this pathway
SONG TARGETS OF IE86 CMV PROTEIN	60	42	All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN	88	58	All SZGR 2.0 genes in this pathway
LY AGING OLD DN	56	35	All SZGR 2.0 genes in this pathway
王顺铂响应和XPC向上	202	115	All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN	161	105	All SZGR 2.0 genes in this pathway
ly衰老的中间DN	16	10	All SZGR 2.0 genes in this pathway
HU遗传毒性损伤4小时	35	28	All SZGR 2.0 genes in this pathway
Sesto对UV C3的反应	20	15	All SZGR 2.0 genes in this pathway
由E2F4绑定的Marson未刺激	728	415	All SZGR 2.0 genes in this pathway
AMUNDSON GAMMA RADIATION RESPONSE	40	25	All SZGR 2.0 genes in this pathway
Sarrio上皮间质转变	180	114	All SZGR 2.0 genes in this pathway
Fujii YBX1靶向DN	202	132	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
阿塞维多肝肿瘤与正常的相邻组织向上	863	514	All SZGR 2.0 genes in this pathway
MATZUK精子细胞	72	55	All SZGR 2.0 genes in this pathway
怀特福德小儿癌标记	116	63	All SZGR 2.0 genes in this pathway
Chen Hoxa5目标9小时DN	41	17	All SZGR 2.0 genes in this pathway
Frasor对Serm或Fulvestrant DN的响应	50	29	All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE	346	192	All SZGR 2.0 genes in this pathway
Ruiz TNC靶向DN	142	79	All SZGR 2.0 genes in this pathway
CHANG CYCLING GENES	148	83	All SZGR 2.0 genes in this pathway
甜肺癌Kras DN	435	289	All SZGR 2.0 genes in this pathway
霍夫曼大到小淋巴细胞向上	163	102	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
CROONQUIST NRAS SIGNALING DN	72	47	All SZGR 2.0 genes in this pathway
Croonquist NRA与基质刺激DN	99	65	All SZGR 2.0 genes in this pathway
Kobayashi EGFR信令24小时DN	251	151	All SZGR 2.0 genes in this pathway
CHIARETTI T ALL RELAPSE PROGNOSIS	19	15	All SZGR 2.0 genes in this pathway
由MYC约束	1103	714	All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G5	12	8	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2	182	102	All SZGR 2.0 genes in this pathway
马滕斯三维诺蛋白响应DN	841	431	All SZGR 2.0 genes in this pathway
Wang对GSK3抑制剂SB216763 DN的响应	374	217	All SZGR 2.0 genes in this pathway
Dutertre雌二醇反应24小时	324	193	All SZGR 2.0 genes in this pathway
棕熊UVC响应迟到	1137	655	All SZGR 2.0 genes in this pathway
Linsley mir16目标	206	127	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
ERBB2同工型的Pedersen转移7	403	240	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway
IR响应6小时中的周细胞周期基因	85	49	All SZGR 2.0 genes in this pathway
24小时IR响应中的周细胞周期基因	128	73	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
miR-138	940	946	1a	HSA-MIR-138^brain	AGCUGGUGUUGUGAAUC
miR-145	992	999	1A，M8	HSA-MIR-145	guccaguuucccaggaaucccuu
miR-22	1004	1010	1a	hsa-miR-22^brain	Aagcugccaguugaagaacugu
miR-24	88	94	M8	hsa-miR-24^SZ	uggcucucagagcaggaagag
miR-24	88	94	M8	hsa-miR-24^SZ	uggcucucagagcaggaagag
mir-328	60	66	M8	hsa-miR-328^brain	cuggcccucugccuuccgu

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:H2AFX