基因页：HAGH
Summary？
| 基因 | 3029 |
| 象征 | HAGH |
| Synonyms | GLO2|GLX2|GLXII|HAGH1 |
| Description | 羟基戊二酸水解酶 |
| Reference | MIM:138760|HGNC：HGNC：4805|HPRD:00731| |
| 基因类型 | 蛋白质编码 |
| Map location | 16p13.3 |
| Pascal p-value | 0.009 |
| Sherlock p-value | 0.371 |
| 胎儿β | -0.985 |
| DMG | 1 (# studies) |
| 主持人 | 尾状基底神经节 Cerebellar Hemisphere 小脑 皮质 Frontal Cortex BA9 Hypothalamus 伏隔核基底神经节 Putamen basal ganglia 元 |
Gene in Data Sources
| 基因集名称 | Method of gene set | Description | 信息 |
|---|---|---|---|
| 简历:PGCnp | 全基因组协会研究 | GWAS | |
| DMG：Wockner_2014 | 全基因组DNA甲基化分析 | 该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。 | 2 |
| PMID：cooccur | High-throughput literature-search | PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | 点击显示详细信息 |
Section I. Genetics and epigenetics annotation
差异甲基化基因
差异甲基化基因| Probe | 染色体 | 位置 | 最近的基因 | p（dis） | Beta (dis) | fdr（dis） | 学习 |
|---|---|---|---|---|---|---|---|
| CG06782493 | 16 | 1876874 | hagh; fahd1 | 1.97E-5 | -0.24 | 0.016 | DMG：Wockner_2014 |
| CG09038527 | 16 | 1860756 | HAGH | 2.942E-4 | 0.279 | 0.039 | DMG：Wockner_2014 |
EQTL注释
| SNP ID | 染色体 | 位置 | 主持人 | Gene Entrez ID | PVALUE | QVALUE | TSS距离 | EQTL类型 |
|---|---|---|---|---|---|---|---|---|
| RS13339350 | 16 | 1825774 | HAGH | ENSG00000063854.8 | 1.237E-6 | 0 | 47264 | gtex_brain_putamen_basal |
| RS9929680 | 16 | 1826023 | HAGH | ENSG00000063854.8 | 1.158E-6 | 0 | 47015 | gtex_brain_putamen_basal |
| RS13332165 | 16 | 1827522 | HAGH | ENSG00000063854.8 | 8.034e-7 | 0 | 45516 | gtex_brain_putamen_basal |
| RS2272977 | 16 | 1838037 | HAGH | ENSG00000063854.8 | 6.258e-8 | 0 | 35001 | gtex_brain_putamen_basal |
| rs28568973 | 16 | 1838337 | HAGH | ENSG00000063854.8 | 6.1E-8 | 0 | 34701 | gtex_brain_putamen_basal |
| RS33988059 | 16 | 1840362 | HAGH | ENSG00000063854.8 | 8.667E-7 | 0 | 32676 | gtex_brain_putamen_basal |
| RS3829563 | 16 | 1845190 | HAGH | ENSG00000063854.8 | 1.029E-6 | 0 | 27848 | gtex_brain_putamen_basal |
| RS45449099 | 16 | 1845630 | HAGH | ENSG00000063854.8 | 1.034E-6 | 0 | 27408 | gtex_brain_putamen_basal |
| rs344352 | 16 | 1846476 | HAGH | ENSG00000063854.8 | 5.604E-7 | 0 | 26562 | gtex_brain_putamen_basal |
| rs344354 | 16 | 1846754 | HAGH | ENSG00000063854.8 | 1.883E-7 | 0 | 26284 | gtex_brain_putamen_basal |
| RS9933403 | 16 | 1850194 | HAGH | ENSG00000063854.8 | 1.474E-7 | 0 | 22844 | gtex_brain_putamen_basal |
| rs2575340 | 16 | 1853701 | HAGH | ENSG00000063854.8 | 3.734e-8 | 0 | 19337年 | gtex_brain_putamen_basal |
| rs2575339 | 16 | 1853859 | HAGH | ENSG00000063854.8 | 1.035E-7 | 0 | 19179 | gtex_brain_putamen_basal |
| RS2745192 | 16 | 1853870 | HAGH | ENSG00000063854.8 | 1.056E-7 | 0 | 19168 | gtex_brain_putamen_basal |
| RS2745193 | 16 | 1853959 | HAGH | ENSG00000063854.8 | 1.045E-6 | 0 | 19079 | gtex_brain_putamen_basal |
| RS2745194 | 16 | 1854038 | HAGH | ENSG00000063854.8 | 6.465e-8 | 0 | 19000 | gtex_brain_putamen_basal |
| rs113041534 | 16 | 1856368 | HAGH | ENSG00000063854.8 | 7.185e-8 | 0 | 16670 | gtex_brain_putamen_basal |
| RS8047464 | 16 | 1856440 | HAGH | ENSG00000063854.8 | 5.797E-7 | 0 | 16598 | gtex_brain_putamen_basal |
| RS200327289 | 16 | 1864926 | HAGH | ENSG00000063854.8 | 6.386E-8 | 0 | 8112 | gtex_brain_putamen_basal |
| RS2268669 | 16 | 1871727 | HAGH | ENSG00000063854.8 | 3.7E-8 | 0 | 1311 | gtex_brain_putamen_basal |
| RS238678 | 16 | 1872722 | HAGH | ENSG00000063854.8 | 1.522E-7 | 0 | 316 | gtex_brain_putamen_basal |
| RS2437728 | 16 | 1874232 | HAGH | ENSG00000063854.8 | 1.571E-6 | 0 | -1194 | gtex_brain_putamen_basal |
| rs7187048 | 16 | 1876261 | HAGH | ENSG00000063854.8 | 1.277E-8 | 0 | -3223 | gtex_brain_putamen_basal |
| RS116869551 | 16 | 1876619 | HAGH | ENSG00000063854.8 | 3.887E-8 | 0 | -3581 | gtex_brain_putamen_basal |
| RS7188401 | 16 | 1876949 | HAGH | ENSG00000063854.8 | 1.182E-7 | 0 | -3911 | gtex_brain_putamen_basal |
| rs3743852 | 16 | 1877698 | HAGH | ENSG00000063854.8 | 4.597E-8 | 0 | -4660 | gtex_brain_putamen_basal |
| RS13166 | 16 | 1877913 | HAGH | ENSG00000063854.8 | 4.597E-8 | 0 | -4875 | gtex_brain_putamen_basal |
| RS7185299 | 16 | 1879423 | HAGH | ENSG00000063854.8 | 4.597E-8 | 0 | -6385 | gtex_brain_putamen_basal |
| RS111646775 | 16 | 1880431 | HAGH | ENSG00000063854.8 | 4.597E-8 | 0 | -7393 | gtex_brain_putamen_basal |
| RS8044343 | 16 | 1881145 | HAGH | ENSG00000063854.8 | 1.735E-7 | 0 | -8107 | gtex_brain_putamen_basal |
| rs9944346 | 16 | 1881197 | HAGH | ENSG00000063854.8 | 4.597E-8 | 0 | -8159 | gtex_brain_putamen_basal |
| RS238677 | 16 | 1883279 | HAGH | ENSG00000063854.8 | 1.33E-6 | 0 | -10241 | gtex_brain_putamen_basal |
| RS171162 | 16 | 1884501 | HAGH | ENSG00000063854.8 | 1.521E-7 | 0 | -11463 | gtex_brain_putamen_basal |
| RS186938 | 16 | 1885537 | HAGH | ENSG00000063854.8 | 1.923E-6 | 0 | -12499 | gtex_brain_putamen_basal |
| RS13332303 | 16 | 1885632 | HAGH | ENSG00000063854.8 | 4.597E-8 | 0 | -12594 | gtex_brain_putamen_basal |
| rs12325217 | 16 | 1887108 | HAGH | ENSG00000063854.8 | 4.933E-8 | 0 | -14070 | gtex_brain_putamen_basal |
| RS143636881 | 16 | 1887201 | HAGH | ENSG00000063854.8 | 4.152E-8 | 0 | -14163 | gtex_brain_putamen_basal |
| RS199575059 | 16 | 1891184 | HAGH | ENSG00000063854.8 | 1.127E-7 | 0 | -18146 | gtex_brain_putamen_basal |
| RS112539690 | 16 | 1891309 | HAGH | ENSG00000063854.8 | 5.902E-8 | 0 | -18271 | gtex_brain_putamen_basal |
| rs116215052 | 16 | 1893312 | HAGH | ENSG00000063854.8 | 5.902E-8 | 0 | -20274 | gtex_brain_putamen_basal |
| rs56934115 | 16 | 1893596 | HAGH | ENSG00000063854.8 | 5.902E-8 | 0 | -20558 | gtex_brain_putamen_basal |
| RS3848350 | 16 | 1893882 | HAGH | ENSG00000063854.8 | 5.902E-8 | 0 | -20844 | gtex_brain_putamen_basal |
| RS9806826 | 16 | 1894912 | HAGH | ENSG00000063854.8 | 3.463E-7 | 0 | -21874 | gtex_brain_putamen_basal |
| RS3848352 | 16 | 1895297 | HAGH | ENSG00000063854.8 | 1.348E-6 | 0 | -22259 | gtex_brain_putamen_basal |
| RS9931865 | 16 | 1897201 | HAGH | ENSG00000063854.8 | 6.181E-8 | 0 | -24163 | gtex_brain_putamen_basal |
| rs1742414 | 16 | 1898097 | HAGH | ENSG00000063854.8 | 1.481E-6 | 0 | -25059 | gtex_brain_putamen_basal |
| RS111688244 | 16 | 1898638 | HAGH | ENSG00000063854.8 | 5.902E-8 | 0 | -25600 | gtex_brain_putamen_basal |
| RS142077410 | 16 | 1899106 | HAGH | ENSG00000063854.8 | 5.902E-8 | 0 | -26068 | gtex_brain_putamen_basal |
| RS61589779 | 16 | 1899115 | HAGH | ENSG00000063854.8 | 5.902E-8 | 0 | -26077 | gtex_brain_putamen_basal |
| rs1742417 | 16 | 1900705 | HAGH | ENSG00000063854.8 | 3.036E-7 | 0 | -27667 | gtex_brain_putamen_basal |
| RS9921618 | 16 | 1901721 | HAGH | ENSG00000063854.8 | 5.425e-8 | 0 | -28683 | gtex_brain_putamen_basal |
| RS2492883 | 16 | 1902105 | HAGH | ENSG00000063854.8 | 2.459E-7 | 0 | -29067 | gtex_brain_putamen_basal |
| RS7187251 | 16 | 1902901 | HAGH | ENSG00000063854.8 | 5.872E-8 | 0 | -29863 | gtex_brain_putamen_basal |
| RS10500322 | 16 | 1904239 | HAGH | ENSG00000063854.8 | 1.484E-6 | 0 | -31201 | gtex_brain_putamen_basal |
| rs5006376 | 16 | 1905201 | HAGH | ENSG00000063854.8 | 1.053E-6 | 0 | -32163 | gtex_brain_putamen_basal |
| RS57407778 | 16 | 1906017 | HAGH | ENSG00000063854.8 | 4.901E-8 | 0 | -32979 | gtex_brain_putamen_basal |
| RS9746488 | 16 | 1906233 | HAGH | ENSG00000063854.8 | 3.57E-7 | 0 | -33195 | gtex_brain_putamen_basal |
| RS10500323 | 16 | 1907558 | HAGH | ENSG00000063854.8 | 5.902E-8 | 0 | -34520 | gtex_brain_putamen_basal |
| RS2437745 | 16 | 1908431 | HAGH | ENSG00000063854.8 | 3.463E-7 | 0 | -35393 | gtex_brain_putamen_basal |
| RS2437744 | 16 | 1908451 | HAGH | ENSG00000063854.8 | 3.463E-7 | 0 | -35413 | gtex_brain_putamen_basal |
| RS11863172 | 16 | 1909083 | HAGH | ENSG00000063854.8 | 3.036E-6 | 0 | -36045 | gtex_brain_putamen_basal |
| RS413308 | 16 | 1909484 | HAGH | ENSG00000063854.8 | 3.463E-7 | 0 | -36446 | gtex_brain_putamen_basal |
| RS388928 | 16 | 1909657 | HAGH | ENSG00000063854.8 | 3.463E-7 | 0 | -36619 | gtex_brain_putamen_basal |
| rs7191695 | 16 | 1909971 | HAGH | ENSG00000063854.8 | 5.902E-8 | 0 | -36933 | gtex_brain_putamen_basal |
| RS7202283 | 16 | 1910015 | HAGH | ENSG00000063854.8 | 5.902E-8 | 0 | -36977 | gtex_brain_putamen_basal |
| rs1742438 | 16 | 1911134 | HAGH | ENSG00000063854.8 | 1.281E-7 | 0 | -38096 | gtex_brain_putamen_basal |
| RS1657125 | 16 | 1912021 | HAGH | ENSG00000063854.8 | 4.234E-7 | 0 | -38983 | gtex_brain_putamen_basal |
| RS1657126 | 16 | 1912205 | HAGH | ENSG00000063854.8 | 1.28e-7 | 0 | -39167 | gtex_brain_putamen_basal |
| rs28460464 | 16 | 1912616 | HAGH | ENSG00000063854.8 | 5.902E-8 | 0 | -39578 | gtex_brain_putamen_basal |
| RS28610155 | 16 | 1912695 | HAGH | ENSG00000063854.8 | 5.902E-8 | 0 | -39657 | gtex_brain_putamen_basal |
| RS2983907 | 16 | 1913336 | HAGH | ENSG00000063854.8 | 3.463E-7 | 0 | -40298 | gtex_brain_putamen_basal |
| RS392913 | 16 | 1913520 | HAGH | ENSG00000063854.8 | 1.324E-6 | 0 | -40482 | gtex_brain_putamen_basal |
| RS199576536 | 16 | 1913752 | HAGH | ENSG00000063854.8 | 1.462E-7 | 0 | -40714 | gtex_brain_putamen_basal |
| RS147632179 | 16 | 1913753 | HAGH | ENSG00000063854.8 | 1.5e-7 | 0 | -40715 | gtex_brain_putamen_basal |
| rs7188124 | 16 | 1915360 | HAGH | ENSG00000063854.8 | 5.902E-8 | 0 | -42322 | gtex_brain_putamen_basal |
| rs2917521 | 16 | 1915585 | HAGH | ENSG00000063854.8 | 6.552E-8 | 0 | -42547 | gtex_brain_putamen_basal |
| rs58422887 | 16 | 1915886 | HAGH | ENSG00000063854.8 | 5.902E-8 | 0 | -42848 | gtex_brain_putamen_basal |
| RS9928722 | 16 | 1916336 | HAGH | ENSG00000063854.8 | 5.902E-8 | 0 | -43298 | gtex_brain_putamen_basal |
| RS78268797 | 16 | 1918094 | HAGH | ENSG00000063854.8 | 6.109E-8 | 0 | -45056 | gtex_brain_putamen_basal |
| RS9934984 | 16 | 1919102 | HAGH | ENSG00000063854.8 | 6.105E-8 | 0 | -46064 | gtex_brain_putamen_basal |
| RS2437747 | 16 | 1919665 | HAGH | ENSG00000063854.8 | 1.521E-6 | 0 | -46627 | gtex_brain_putamen_basal |
| RS12719796 | 16 | 1921197 | HAGH | ENSG00000063854.8 | 3.327E-7 | 0 | -48159 | gtex_brain_putamen_basal |
| RS71384658 | 16 | 1922216 | HAGH | ENSG00000063854.8 | 1.006E-6 | 0 | -49178 | gtex_brain_putamen_basal |
| RS201703905 | 16 | 1966608 | HAGH | ENSG00000063854.8 | 8.482e-7 | 0 | -93570 | gtex_brain_putamen_basal |
第二节。转录组注释
一般基因表达（GTEX）
Devlopment期间的基因表达（BrainCloud）
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达（brainspan）
Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。
大脑区域的顶级共表达基因
| 前10个积极共表达的基因 | ||
| Gene | 皮尔逊的相关性 | 斯皮尔曼的相关性 |
| AC104389.5 | 0.92 | 0.73 |
| HBG2 | 0.91 | 0.74 |
| HBA1 | 0.87 | 0.70 |
| HBA2 | 0.85 | 0.63 |
| HBZ | 0.82 | 0.66 |
| HBG1 | 0.78 | 0.70 |
| 阿拉夫 | 0.76 | 0.68 |
| GPC4 | 0.74 | 0.37 |
| alas2 | 0.73 | 0.67 |
| HK2 | 0.73 | 0.48 |
| 前10个负共表达基因 | ||
| Gene | 皮尔逊的相关性 | 斯皮尔曼的相关性 |
| HLA-F | -0.41 | -0.66 |
| C5orf53 | -0.41 | -0.60 |
| FBXO2 | -0.40 | -0.62 |
| LHPP | -0.40 | -0.54 |
| TNFSF12 | -0.40 | -0.56 |
| apol1 | -0.40 | -0.68 |
| AIFM3 | -0.40 | -0.65 |
| HEPN1 | -0.39 | -0.64 |
| SLC16A11 | -0.39 | -0.56 |
| aldoc | -0.39 | -0.62 |