Gene Page:HARS

Summary?
GeneID 3035
Symbol HARS
Synonyms CMT2W|HRS|USH3B
Description histidyl-tRNA synthetase
Reference MIM:142810|HGNC:HGNC:4816|Ensembl:ENSG00000170445|HPRD:00827|Vega:OTTHUMG00000129502
Gene type protein-coding
Map location 5q31.3
Pascal p-value 6.914E-6
Sherlock p-value 0.443
Fetal beta -0.749
eGene Cerebellum
Cortex
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.0032
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MAT2B 0.87 0.87
IDH3A 0.87 0.86
PPP3R1 0.87 0.87
GHITM 0.87 0.87
ARL8B 0.87 0.89
NKIRAS1 0.87 0.87
PCMT1 0.87 0.86
NAPG 0.87 0.87
CCNY 0.87 0.87
TSNAX 0.86 0.87
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.18 -0.48 -0.30
AC010300.1 -0.47 -0.46
MYLK2 -0.43 -0.40
AC100783.1 -0.42 -0.37
AC098691.2 -0.40 -0.33
C10orf108 -0.40 -0.41
AF347015.21 -0.39 -0.20
AL022328.1 -0.39 -0.43
AF347015.26 -0.39 -0.21
EGFL8 -0.39 -0.37

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0005524 ATP binding NAS -
GO:0004821 histidine-tRNA ligase activity NAS 1549469|7755634
GO:0016874 ligase activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006427 histidyl-tRNA aminoacylation IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm NAS -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG AMINOACYL TRNA BIOSYNTHESIS 41 33 All SZGR 2.0 genes in this pathway
REACTOME CYTOSOLIC TRNA AMINOACYLATION 24 19 All SZGR 2.0 genes in this pathway
REACTOME TRNA AMINOACYLATION 42 34 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557 331 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536 340 All SZGR 2.0 genes in this pathway
CEBALLOS TARGETS OF TP53 AND MYC UP 21 16 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL CIS 128 77 All SZGR 2.0 genes in this pathway
BYSTRYKH造血干细胞和大脑QTL CIS 65 38 All SZGR 2.0 genes in this pathway
WANG TARGETS OF MLL CBP FUSION DN 45 31 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C0 107 72 All SZGR 2.0 genes in this pathway
JAZAERI BREAST CANCER BRCA1 VS BRCA2 UP 49 28 All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425 253 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE DN 103 67 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway