Gene Page:HDAC1
概括?
GeneID | 3065 |
象征 | HDAC1 |
Synonyms | gon-10 | hd1 | rpd3 | rpd3l1 |
Description | histone deacetylase 1 |
Reference | MIM:601241|HGNC:HGNC:4852|Ensembl:ENSG00000116478|HPRD:03143|Vega:Otthumg00000007529 |
基因类型 | protein-coding |
Map location | 1p34 |
Pascal p-value | 0.59 |
Fetal beta | 0.69 |
eGene | Myers' cis & trans |
Support | Ascano FMRP targets Chromatin Remodeling Genes |
Gene in Data Sources
基因集名称 | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
PMID:cooccur | High-throughput literature-search | PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。 | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenics,schizophrenias | 点击to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | 染色体 | 位置 | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs4501739 | Chrx | 35960848 | HDAC1 | 3065 | 0.03 | 反式 |
Section II. Transcriptome annotation
General gene expression (GTEx)
![Not available](http://www.tjghsg.com/bioinfo/SZGR/GeneImg/HDAC1_DE_GTEx.png)
Gene expression during devlopment (BrainCloud)
脚注:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达(brainspan)
脚注:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25%和上层25%。
大脑区域的顶级共表达基因
前10名positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
MAMDC4 | 0.90 | 0.78 |
AC135050.2 | 0.89 | 0.76 |
CNKSR1 | 0.89 | 0.78 |
ZNF692 | 0.89 | 0.81 |
VWCE | 0.89 | 0.77 |
MST1 | 0.88 | 0.77 |
MYO19 | 0.88 | 0.76 |
VARS2 | 0.88 | 0.70 |
CTRL | 0.88 | 0.78 |
GAL3ST4 | 0.88 | 0.67 |
前10名negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
ABCG2 | -0.51 | -0.64 |
HLA-C | -0.49 | -0.51 |
FBXO2 | -0.47 | -0.50 |
PLA2G4A | -0.46 | -0.58 |
ITM2B | -0.46 | -0.53 |
AIFM3 | -0.45 | -0.46 |
ALDOC | -0.45 | -0.45 |
RGS5 | -0.45 | -0.57 |
SLC39A8 | -0.45 | -0.54 |
HLA-F | -0.45 | -0.40 |
Section III. Gene Ontology annotation
Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0003700 | 转录factor activity | TAS | 8646880 | |
GO:0004407 | 组蛋白脱乙酰基酶活性 | TAS | 12711221 | |
GO:0016787 | 水解酶活性 | IEA | - | |
GO:0008134 | 转录因子结合 | IPI | 15509593 | |
GO:0008134 | 转录因子结合 | TAS | 12711221 | |
GO:0042802 | identical protein binding | IPI | 9150135 | |
GO:0019899 | enzyme binding | IPI | 11062478|11136718 | |
Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
GO:0006355 | regulation of transcription, DNA-dependent | IEA | - | |
GO:0006350 | 转录 | IEA | - | |
GO:0006916 | 抗凋亡 | TAS | 10777477 | |
GO:0016568 | chromatin modification | TAS | 12711221 | |
GO:0016575 | 组蛋白脱乙酰作用 | IEA | - | |
Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
去:0000118 | histone deacetylase complex | TAS | 12711221 | |
去:0005634 | nucleus | IDA | 10846170 | |
去:0005634 | nucleus | TAS | 12711221 | |
GO:0005737 | 细胞质 | TAS | 12711221 |
Section IV. Protein-protein interaction annotation
互动者 | 别名b | 官方全名b | Experimental | 资源 | PubMed ID |
---|---|---|---|---|---|
AOF2 | BHC110 |KDM1 |KIAA0601 |LSD1 | amine oxidase (flavin containing) domain 2 | - | HPRD,BioGRID | 12493763 |
AR | AIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM | androgen receptor | - | HPRD,BioGRID | 11994312 |
ARID4A | RBBP1 |RBP-1 |RBP1 | AT rich interactive domain 4A (RBP1-like) | - | HPRD | 10490602 |
ARID4B | BCAA |brcaa1 |dkfzp313m2420 |MGC163290 |rbbp1l1 |RBP1L1 |SAP180 | AT rich interactive domain 4B (RBP1-like) | Affinity Capture-Western | BioGRID | 12724404 |
ATR | frp1 |mec1 |sckl |SCKL1 | ataxia telangiectasia and Rad3 related | Affinity Capture-Western | BioGRID | 10545197 |
ATRX | ATR2 | MGC2094 | MRXHF1 | RAD54 | RAD54L | SFM1 | SHS | XH2 | XNP | ZNF-HX | alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) | - | HPRD | 14645126 |
BAZ2A | DKFZP781B109 |FLJ13768 |FLJ13780 |FLJ45876 |KIAA0314 |tip5 |WALP3 | bromodomain adjacent to zinc finger domain, 2A | - | HPRD | 12198165 |
Bcl3 | BCL4 | D19S37 | B细胞CLL/淋巴瘤3 | HDAC1interacts with BCL-3. | 绑定 | 15469820 |
Bcl6 | BCL5 | BCL6A | LAZ3 | ZBTB27 | ZNF51 | B细胞CLL/淋巴瘤6 | Affinity Capture-Western | BioGRID | 9627120 |
BCOR | ANOP2 | FLJ20285 | FLJ38041 | KIAA1575 | MAA2 | MCOPS2 | MGC131961 | MGC71031 | Bcl6co-repressor | - | HPRD,BioGRID | 10898795 |
BRCA1 | Brcai |BRCC1 |虹膜|PSCP |RNF53 | breast cancer 1, early onset | BRCA1与HDAC1相互作用 | 绑定 | 10220405 |
BRCA1 | Brcai |BRCC1 |虹膜|PSCP |RNF53 | breast cancer 1, early onset | - | HPRD,BioGRID | 10220405 |
bub1 | bub1A | BUB1L | hBUB1 | 苯二咪唑1同源物(酵母)不受抑制的萌芽 | Affinity Capture-Western Co-purification |
BioGRID | 15388328 |
bub1B | bub1beta |bubr1 |bub1a |mad3l |SSK1 |HBUBR1 | 苯二咪唑1同源β(酵母)不受抑制的萌芽 | Affinity Capture-Western Co-purification |
BioGRID | 15388328 |
bub3 | bub3l |HBUB3 | budding uninhibited by benzimidazoles 3 homolog (yeast) | Affinity Capture-Western Co-purification |
BioGRID | 15388328 |
CABIN1 | CAIN | KIAA0330 | PPP3IN | 钙调蛋白结合蛋白1 | - | HPRD,BioGRID | 10933397 |
CBFA2T3 | ETO2 | MTG16 | MTGR2 | ZMYND4 | 核心结合因子,runt域,α亚基2;易位到3 | - | HPRD,BioGRID | 12242670 |
CBX5 | HP1 |HP1A | Chromobox同源物5(HP1 Alpha同源物,果蝇) | Affinity Capture-Western | BioGRID | 12242305 |
CDC20 | CDC20A |MGC102824 |BA276H19.3 |p55cdc | cell division cycle 20 homolog (S. cerevisiae) | Affinity Capture-Western Co-purification |
BioGRID | 15388328 |
CDH1 | Arc-1 | CD324 | CDHE | ECAD | LCAM | UVO | cadherin 1, type 1, E-cadherin (epithelial) | Affinity Capture-Western Co-purification |
BioGRID | 15388328 |
CDKN1A | CAP20 |CDKN1 |CIP1 |MDA-6 |p21 |SDI1 |WAF1 |P21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | HDAC1interacts with the p21 promoter. | 绑定 | 15710329 |
CDKN1A | CAP20 |CDKN1 |CIP1 |MDA-6 |p21 |SDI1 |WAF1 |P21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | HDAC1与CDKN1A(P21)启动子相互作用。 | 绑定 | 15674334 |
CDYL | CDYL1 | DKFZp586C1622 | MGC131936 | chromodomain protein, Y-like | - | HPRD,BioGRID | 12947414 |
CHD1 | DKFZp686E2337 | chromodomain helicase DNA binding protein 1 | - | HPRD,BioGRID | 12890497 |
CHD3 | Mi-2a | Mi2-ALPHA | ZFH | chromodomain helicase DNA binding protein 3 | - | HPRD,BioGRID | 9804427 |
CHD4 | DKFZp686E06161 | Mi-2b | Mi2-BETA | chromodomain helicase DNA binding protein 4 | Affinity Capture-MS Affinity Capture-Western |
BioGRID | 9804427|10220385 |12920132 |
CTBP1 | 酒吧|MGC104684 | C-terminal binding protein 1 | - | HPRD,BioGRID | 9650586 |
DAXX | BING2 | DAP6 | EAP1 | MGC126245 | MGC126246 | death-domain associated protein | - | HPRD,BioGRID | 10669754 |
DDB2 | DDBB |FLJ34321 |UV-DDB2 | damage-specific DNA binding protein 2, 48kDa | - | HPRD | 8602529 |
DDX17 | DKFZP761H2016 |P72 |RH70 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 | - | HPRD,BioGRID | 15298701 |
DDX5 | DKFZP686J01190 |G17P1 |HLR1 |hump68 |P68 | 死亡(ASP-GLU-ALA-ASP)盒多肽5 | Affinity Capture-Western | BioGRID | 15298701 |
DNMT1 | AIM | CXXC9 | DNMT | FLJ16293 | MCMT | MGC104992 | DNA (cytosine-5-)-methyltransferase 1 | Co-fractionation | BioGRID | 10888886 |
DNMT1 | AIM | CXXC9 | DNMT | FLJ16293 | MCMT | MGC104992 | DNA (cytosine-5-)-methyltransferase 1 | - | HPRD | 10615135 |
DNMT3A | DNMT3A2 | M.HsaIIIA | DNA (cytosine-5-)-methyltransferase 3 alpha | - | HPRD,BioGRID | 11350943 |
DNMT3B | ICF |M.Hsaiiib | DNA(胞嘧啶-5-) - 甲基转移酶3β | Co-purification | BioGRID | 15148359 |
DNMT3B | ICF |M.Hsaiiib | DNA(胞嘧啶-5-) - 甲基转移酶3β | - | HPRD | 12202768 |
DNMT3B | ICF |M.Hsaiiib | DNA(胞嘧啶-5-) - 甲基转移酶3β | DNMT3Binteracts with HDAC1. | 绑定 | 15120635 |
DNMT3L | MGC1090 | DNA (cytosine-5-)-methyltransferase 3-like | - | HPRD,BioGRID | 12177302|12202768 |
E2F1 | E2F-1 | RBAP1 | RBBP3 | RBP3 | E2F transcription factor 1 | Affinity Capture-Western | BioGRID | 10734134 |
E2F4 | E2F-4 | E2F转录因子4,P107/P130结合 | - | HPRD,BioGRID | 9724731 |
EED | HEED | WAIT1 | 胚胎外胚层开发 | - | HPRD,BioGRID | 10581039 |
EFCAB6 | DJBP | FLJ23588 | HSCBCIP1 | KIAA1672 | dJ185D5.1 | EF-hand calcium binding domain 6 | Affinity Capture-Western | BioGRID | 12612053 |
EID2 | CRI2 | EID-2 | MGC20452 | EP300 interacting inhibitor of differentiation 2 | - | HPRD | 12586827 |
ESR1 | DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 | 雌激素受体1 | 和HDAC1 ER-alpha交互。 | 绑定 | 14506733 |
EVI1 | AML1-EVI-1 | EVI-1 | MDS1-EVI1 | MGC163392 | PRDM3 | ecotropic viral integration site 1 | - | HPRD,BioGRID | 11568182 |
EZH2 | ENX-1 | EZH1 | KMT6 | MGC9169 | enhancer of zeste homolog 2 (Drosophila) | - | HPRD,BioGRID | 10581039 |
FKBP3 | FKBP-25 | PPIase | FK506 binding protein 3, 25kDa | - | HPRD,BioGRID | 11532945 |
FOXG1 | BF1 | BF2 | FHKL3 | FKH2 | FKHL1 | FKHL2 | FKHL3 | FKHL4 | FOXG1A | FOXG1B | FOXG1C | HBF-1 | HBF-2 | HBF-3 | HBF-G2 | HBF2 | HFK1 | HFK2 | HFK3 | KHL2 | QIN | forkhead box G1 | - | HPRD | 11238932 |
GATA1 | ERYF1 | GF-1 | GF1 | NFE1 | GATA binding protein 1 (globin transcription factor 1) | Affinity Capture-Western | BioGRID | 14668799 |
GATAD2B | FLJ37346 | KIAA1150 | MGC138257 | MGC138285 | P66beta | RP11-216N14.6 | GATA zinc finger domain containing 2B | Affinity Capture-Western | BioGRID | 11756549 |
gtf2i | BAP-135 | BAP135 | BTKAP1 | DIWS | FLJ38776 | FLJ56355 | IB291 | SPIN | TFII-I | WBS | WBSCR6 | 一般转录因子II,I | Affinity Capture-Western | BioGRID | 12393887 |
HBP1 | FLJ16340 | HMG-box transcription factor 1 | - | HPRD,BioGRID | 15235594 |
HCFC1 | CFF | HCF-1 | HCF1 | HFC1 | MGC70925 | VCAF | 宿主细胞因子C1(VP16-辅助蛋白) | Affinity Capture-MS Affinity Capture-Western |
BioGRID | 12670868 |
HDAC1 | DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1 | histone deacetylase 1 | Affinity Capture-MS | BioGRID | 12920132 |
HDAC2 | RPD3 |YAF1 | histone deacetylase 2 | - | HPRD,BioGRID | 9520398 |
HDAC3 | HD3 |RPD3 |RPD3-2 | histone deacetylase 3 | - | HPRD | 10944117|11302704 |
HDAC9 | DKFZp779K1053 | HD7 | HDAC | HDAC7 | HDAC7B | HDAC9B | HDAC9FL | HDRP | KIAA0744 | MITR | histone deacetylase 9 | Affinity Capture-Western | BioGRID | 10655483 |
HDAC9 | DKFZp779K1053 | HD7 | HDAC | HDAC7 | HDAC7B | HDAC9B | HDAC9FL | HDRP | KIAA0744 | MITR | histone deacetylase 9 | An unspecified isoform of HDAC9 (MITR) interacts with HDAC1. This interaction was modelled on a demonstrated interaction between an unspecified isoform of human HDAC9 and HDAC1 from an unspecified species. | 绑定 | 15711539 |
HDAC9 | DKFZp779K1053 | HD7 | HDAC | HDAC7 | HDAC7B | HDAC9B | HDAC9FL | HDRP | KIAA0744 | MITR | histone deacetylase 9 | - | HPRD | 12590135 |
HEY2 | CHF1 | GRIDLOCK | GRL | HERP1 | HESR2 | HRT2 | MGC10720 | bHLHb32 | 与YRPW图案2相关的毛茸茸/增强子2 | - | HPRD,BioGRID | 11486045 |
Hic1 | ZBTB29 |HIC-1 | hypermethylated in cancer 1 | - | HPRD | 12052894 |
hif1a | HIF-1alpha |HIF1 | HIF1-ALPHA | MOP1 | PASD8 | 低氧诱导因子1,α亚基(基本螺旋 - 环螺旋转录因子) | Reconstituted Complex | BioGRID | 11641274 |
hif1an | DKFZp762F1811 | FIH1 | FLJ20615 | FLJ22027 | hypoxia-inducible factor 1, alpha subunit inhibitor | - | HPRD,BioGRID | 11641274 |
HMG20B | BRAF25 | BRAF35 | FLJ26127 | HMGX2 | PP7706 | SMARCE1r | SOXL | pp8857 | high-mobility group 20B | Affinity Capture-Western Co-purification |
BioGRID | 12032298 |
HR | alunc |au |HSA277165 | 无毛同源物(鼠标) | - | HPRD,BioGRID | 11641275 |
HSPA4 | APG-2 | HS24/P52 | MGC131852 | RY | hsp70 | hsp70RY | heat shock 70kDa protein 4 | Affinity Capture-Western | BioGRID | 11777905 |
HSPD1 | CPN60 |凹槽|HSP60 |HSP65 |hucha60 |SPG13 | 热休克60KDA蛋白1(伴侣蛋白) | Affinity Capture-Western | BioGRID | 11777905 |
HUS1 | - | HUS1检查点同源物(S. Pombe) | - | HPRD,BioGRID | 10846170 |
IFRD1 | PC4 |TIS7 | 干扰素相关的发育调节剂1 | Affinity Capture-Western | BioGRID | 12198164 |
IKZF1 | Hs.54452 | IK1 | IKAROS | LYF1 | PRO0758 | ZNFN1A1 | hIk-1 | Ikaros家庭锌指1(Ikaros) | Affinity Capture-Western | BioGRID | 10357820|12015313 |
ING1 | p24ING1c | p33 | p33ING1 | p33ING1b | p47 | p47ING1a | inhibitor of growth family, member 1 | Affinity Capture-MS Affinity Capture-Western |
BioGRID | 11784859|12015309 |
KAT5 | ESA1 | HTATIP | HTATIP1 | PLIP | TIP | TIP60 | cPLA2 | K(lysine) acetyltransferase 5 | - | HPRD | 11994312 |
KLF11 | fklf |FKLF1 |Mody7 |tieg2 |扎格3 | Kruppel-like factor 11 | - | HPRD,BioGRID | 11438660 |
MAD1L1 | HSMAD1 |Mad1 |PIG9 |TP53I9 |TXBP181 | MAD1 mitotic arrest deficient-like 1 (yeast) | Affinity Capture-Western Co-purification |
BioGRID | 15388328 |
MAP3K7IP2 | FLJ21885 | KIAA0733 | TAB2 | mitogen-activated protein kinase kinase kinase 7 interacting protein 2 | Reconstituted Complex | BioGRID | 12150997 |
MBD2 | DKFZp586O0821 | DMTase | NY-CO-41 | methyl-CpG binding domain protein 2 | - | HPRD,BioGRID | 10471499 |
MBD3 | - | methyl-CpG binding domain protein 3 | - | HPRD,BioGRID | 12124384 |
MBD3 | - | methyl-CpG binding domain protein 3 | MBD3 interacts with HDAC1. | 绑定 | 12124384 |
MBD3L1 | MBD3L |MGC138263 |MGC138269 | methyl-CpG binding domain protein 3-like 1 | Affinity Capture-Western | BioGRID | 15456747 |
MDM2 | HDMX | MGC71221 | hdm2 | Mdm2 p53 binding protein homolog (mouse) | - | HPRD,BioGRID | 12426395 |
MDS1 | MDS1-EVI1 | PRDM3 | myelodysplasia syndrome 1 | - | HPRD,BioGRID | 11552981 |
MIER1 | DKFZP781G0451 |ER1 |KIAA1610 |MGC131940 |MGC150640 |MGC150641 |Mi-er1 |RP5-944N15.1 |HMI-ER1 | mesoderm induction early response 1 homolog (Xenopus laevis) | - | HPRD,BioGRID | 12482978 |
MIZF | DKFZp434F162 | HiNF-P | ZNF743 | MBD2-interacting zinc finger | Affinity Capture-Western | BioGRID | 12665568 |
MLL | ALL-1 | CXXC7 | FLJ11783 | HRX | HTRX1 | KMT2A | MLL/GAS7 | MLL1A | TET1-MLL | TRX1 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) | Affinity Capture-Western Reconstituted Complex |
BioGRID | 12829790 |
MORF4L2 | KIAA0026 | MORFL2 | MRGX | mortality factor 4 like 2 | - | HPRD | 14506250 |
MT1G | MGC12386 |MT1 |MT1K | metallothionein 1G | HDAC1interacts with the MT1G promoter. | 绑定 | 15735762 |
MTA1 | - | metastasis associated 1 | - | HPRD,BioGRID | 10840944|11146623 |
MTA2 | DKFZp686F2281 | MTA1L1 | PID | metastasis associated 1 family, member 2 | Affinity Capture-MS Affinity Capture-Western Co-purification |
BioGRID | 10444591|11171972 |12374985|12920132 |
MXD1 | MAD | MAD1 | MGC104659 | MAX dimerization protein 1 | - | HPRD | 9150133|9150134 |
MXD1 | MAD | MAD1 | MGC104659 | MAX dimerization protein 1 | Reconstituted Complex | BioGRID | 11101889 |
MYOD1 | MYF3 | MYOD | PUM | bHLHc1 | myogenic differentiation 1 | - | HPRD,BioGRID | 11285237|11684023 |
NCOR2 | CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1 | nuclear receptor co-repressor 2 | Affinity Capture-Western Co-purification |
BioGRID | 11013263|11739383 |
nfix | NF1A | nuclear factor I/X (CCAAT-binding transcription factor) | Affinity Capture-Western | BioGRID | 11896613 |
NFKB1 | DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | - | HPRD,BioGRID | 11931769 |
NFKBIA | IKBA | MAD-3 | NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | HDAC1interacts with I-kappa-B-alpha. | 绑定 | 12972430 |
NR2F2 | ARP1 | COUP-TFII | COUPTFB | MGC117452 | SVP40 | TFCOUP2 | nuclear receptor subfamily 2, group F, member 2 | - | HPRD,BioGRID | 10704340 |
NRIP1 | FLJ77253 |RIP140 | nuclear receptor interacting protein 1 | - | HPRD | 11006275|11285237 |
PCNA | MGC8367 | 增殖细胞核抗原 | - | HPRD,BioGRID | 11929879 |
PEX14 | MGC12767 | NAPP2 | Pex14p | dJ734G22.2 | 过氧化物酶体生物发生因子14 | - | HPRD | 11909966 |
PHB | PHB1 | prohibitin | - | HPRD,BioGRID | 12466959 |
PHF12 | FLJ34122 | KIAA1523 | MGC131914 | PF1 | PHD finger protein 12 | - | HPRD,BioGRID | 11390640 |
PHF21A | BHC80 |BM-006 |KIAA1696 | PHD finger protein 21A | - | HPRD,BioGRID | 15325272 |
PIAS3 | FLJ14651 |Zmiz5 | protein inhibitor of activated STAT, 3 | - | HPRD | 14691252 |
PML | MYL | PP8675 | RNF71 | TRIM19 | promyelocytic leukemia | - | HPRD,BioGRID | 11259576|11430826 |
PPARD | FAAR | MGC3931 | NR1C2 | NUC1 | NUCI | NUCII | PPAR-beta | PPARB | peroxisome proliferator-activated receptor delta | - | HPRD,BioGRID | 11867749 |
PTMA | MGC104802 | TMSA | prothymosin, alpha | - | HPRD,BioGRID | 12634383 |
rad9a | RAD9 | RAD9同源物A(S。Pombe) | - | HPRD,BioGRID | 10846170 |
兰布 | 哈普|NR1B2 |RRB2 | 视黄酸受体,β | HDAC1interacts with RARB (RAR-beta-2) gene promoter sequences. | 绑定 | 15688037 |
RB1 | OSRC | RB | p105-Rb | pRb | pp110 | retinoblastoma 1 | RB互动s with HDAC1. | 绑定 | 11447271 |
RB1 | OSRC | RB | p105-Rb | pRb | pp110 | retinoblastoma 1 | - | HPRD | 9491888|10888886 |11896613|11909966 |
RB1 | OSRC | RB | p105-Rb | pRb | pp110 | retinoblastoma 1 | The Retinoblastoma protein interacts with Histone Deacetylase 1. | 绑定 | 10734134 |
RB1 | OSRC | RB | p105-Rb | pRb | pp110 | retinoblastoma 1 | Affinity Capture-Western Reconstituted Complex |
BioGRID | 9491888|9724731 |10490602|10615135 |10779361|11684023 |12466959 |
RBBP4 | NURF55 |RBAP48 | 视网膜母细胞瘤结合蛋白4 | RBAP48与HDAC1相互作用 | 绑定 | 10734134 |
RBBP4 | NURF55 |RBAP48 | 视网膜母细胞瘤结合蛋白4 | - | HPRD | 10734134|11302704 |12091390|12943729 |
RBBP4 | NURF55 |RBAP48 | 视网膜母细胞瘤结合蛋白4 | Affinity Capture-Western Co-purification Reconstituted Complex |
BioGRID | 9150133|9150135 |9520398|10220385 |10444591|10471499 |11171972|11470869 |12091390|12920132 |12943729 |
RBBP7 | MGC138867 | MGC138868 | RbAp46 | 视网膜母细胞瘤结合蛋白7 | Affinity Capture-Western Co-purification |
BioGRID | 9150135|10444591 |10471499|12920132 |
RBL1 | CP107 | MGC40006 | PRB1 | p107 | retinoblastoma-like 1 (p107) | - | HPRD,BioGRID | 9724731 |
RBL2 | FLJ26459 | P130 | Rb2 | retinoblastoma-like 2 (p130) | - | HPRD,BioGRID | 10969803 |
rcor1 | Corest |KIAA0071 |rcor | REST corepressor 1 | Affinity Capture-MS Affinity Capture-Western Co-purification |
BioGRID | 11171972|12032298 |
RECQL4 | RECQ4 | RecQ protein-like 4 | HDAC1interacts with the RECQL4 (RECQ4) promoter. | 绑定 | 15674334 |
RELA | MGC131774 |NFKB3 |P65 | V-REL网状内皮症病毒性癌基因同源物A(Avian) | - | HPRD,BioGRID | 11564889 |
RFC1 | A1 | MGC51786 | MHCBFB | PO-GA | RECC1 | RFC | RFC140 | 复制因子C(激活剂1)1,145KDA | - | HPRD,BioGRID | 12045192 |
RFC4 | A1 | MGC27291 | RFC37 | replication factor C (activator 1) 4, 37kDa | - | HPRD | 12045192 |
runx1t1 | AML1T1 | CBFA2T1 | CDR | ETO | MGC2796 | MTG8 | MTG8b | ZMYND2 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | Affinity Capture-Western | BioGRID | 11533236 |
runx1t1 | AML1T1 | CBFA2T1 | CDR | ETO | MGC2796 | MTG8 | MTG8b | ZMYND2 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | ETO interacts with HDAC1. | 绑定 | 15333839 |
RUNX3 | AML2 | CBFA3 | FLJ34510 | MGC16070 | PEBP2aC | runt-related transcription factor 3 | - | HPRD | 15138260 |
RUVBL2 | CGI-46 | ECP51 | INO80J | REPTIN | RVB2 | TIH2 | TIP48 | TIP49B | RuvB-like 2 (E. coli) | RUVBL2 (reptin) interacts with HDAC1. | 绑定 | 15829968 |
sall1 | HSAL1 | TBS | ZNF794 | sal-like 1 (Drosophila) | - | HPRD | 11836251 |
SAP130 | FLJ12761 | Sin3A-associated protein, 130kDa | Affinity Capture-Western | BioGRID | 12724404 |
SAP18 | 2HOR0202 | MGC27131 | SAP18p | SIN3A相关蛋白,18KDA | - | HPRD | 9150135 |
SAP30 | - | Sin3A-associated protein, 30kDa | - | HPRD,BioGRID | 9651585 |
SATB1 | - | SATB homeobox 1 | - | HPRD,BioGRID | 12374985 |
SETDB1 | ESET | KG1T | KIAA0067 | KMT1E | 设定域,分叉1 | - | HPRD | 12398767 |
sin3a | DKFZp434K2235 | FLJ90319 | KIAA0700 | SIN3 homolog A, transcription regulator (yeast) | The transcriptional repressor mSin3A interacts with the histone deacetylase 1 protein. | 绑定 | 9150133|9150134 |
sin3a | DKFZp434K2235 | FLJ90319 | KIAA0700 | SIN3 homolog A, transcription regulator (yeast) | Affinity Capture-MS Affinity Capture-Western Co-fractionation Co-purification |
BioGRID | 9520398|9804427 |10220385|10444591 |10640275|11171972 |11784859|11931768 |12091390|12374985 |12398767|12724404 |12920132|12943729 |
sin3a | DKFZp434K2235 | FLJ90319 | KIAA0700 | SIN3 homolog A, transcription regulator (yeast) | - | HPRD | 11013263 |
SIN3B | KIAA0700 | SIN3 homolog B, transcription regulator (yeast) | - | HPRD | 11959842 |
SIN3B | KIAA0700 | SIN3 homolog B, transcription regulator (yeast) | Affinity Capture-Western Co-purification |
BioGRID | 10357820|10444591 |
SMAD2 | JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2 | SMAD家庭成员2 | - | HPRD,BioGRID | 10199400 |
SMARCA2 | BAF190 |BRM |FLJ36757 |MGC74511 |SNF2 |snf2l2 |snf2la |swi2 |sth1p |hbrm | hSNF2a | SWI/SNF相关,矩阵相关,染色质的肌动蛋白依赖性调节剂,亚家族A,成员2 | Co-purification | BioGRID | 11238380 |
SMARCB1 | BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFS | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | Co-purification | BioGRID | 11238380 |
SP1 | - | Sp1 transcription factor | Affinity Capture-Western | BioGRID | 11896613|12091390 |12176973|12847090 |
SP1 | - | Sp1 transcription factor | - | HPRD | 11896613|11909966 |
SP3 | DKFZp686O1631 | SPR-2 | Sp3 transcription factor | - | HPRD,BioGRID | 12176973 |
spen | KIAA0929 | MINT | RP1-134O19.1 | SHARP | SPEN同源物,转录调节剂(果蝇) | - | HPRD,BioGRID | 11331609 |
STAT3 | APRF | FLJ20882 | HIES | MGC16063 | signal transducer and activator of transcription 3 (acute-phase response factor) | STAT3与HDAC1相互作用。 | 绑定 | 15653507 |
SUDS3 | FLJ00052 | MGC104711 | SAP45 | SDS3 | suppressor of defective silencing 3 homolog (S. cerevisiae) | Affinity Capture-Western | BioGRID | 11909966|12724404 |
SUV39H1 | KMT1A | MG44 | SUV39H | suppressor of variegation 3-9 homolog 1 (Drosophila) | - | HPRD,BioGRID | 11788710 |
tal1 | SCL | TCL5 | bHLHa17 | tal-1 | T-cell acute lymphocytic leukemia 1 | - | HPRD | 10688671 |
tal1 | SCL | TCL5 | bHLHa17 | tal-1 | T-cell acute lymphocytic leukemia 1 | Affinity Capture-MS | BioGRID | 16407974 |
TGIF1 | HPE4 | MGC39747 | MGC5066 | TGIF | TGFB-induced factor homeobox 1 | Affinity Capture-Western | BioGRID | 10995736|11427533 |
TGIF2 | - | TGFB-induced factor homeobox 2 | - | HPRD,BioGRID | 11427533 |
TLE4 | BCE-1 |BCE1 |E(SPI)|ESG |ESG4 |GRG4 | 反式ducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | Affinity Capture-Western | BioGRID | 11266540 |
TNFSF10 | APO2L | Apo-2L | CD253 | TL2 | TRAIL | 肿瘤坏死因子(配体)超家族,成员10 | HDAC1interacts with the TNFSF10 promoter. | 绑定 | 15619633 |
TOP2A | top2 |TP2A | 拓扑异构酶(DNA)II alpha 170KDA | - | HPRD,BioGRID | 11136718 |
TOP2B | TOPIIB | top2beta | 拓扑异构酶(DNA)II Beta 180KDA | Affinity Capture-Western Reconstituted Complex Two-hybrid |
BioGRID | 11062478|11136718 |
TP53 | FLJ92943 |LFS1 |trp53 |p53 | 肿瘤蛋白p53 | Affinity Capture-Western | BioGRID | 12426395 |
TPD52L1 | D53 | MGC8556 | TPD52L2 | hD53 | tumor protein D52-like 1 | Two-hybrid | BioGRID | 16169070 |
TRIM27 | RFP |RNF76 | 三方基序27 | - | HPRD | 14530259 |
TXNIP | EST01027 |HHCPA78 |thif |VDUP1 | thioredoxin interacting protein | - | HPRD,BioGRID | 12821938 |
VHL | HRCA1 |RCA1 |VHL1 | von Hippel-Lindau tumor suppressor | Reconstituted Complex | BioGRID | 11641274 |
YY1 | delta |INO80S |NF-E1 |UCRBP |阴阳1 | YY1 transcription factor | Reconstituted Complex | BioGRID | 9346952 |
ZBTB16 | PLZF | ZNF145 | zinc finger and BTB domain containing 16 | - | HPRD | 9627120|15467736 |
ZBTB16 | PLZF | ZNF145 | zinc finger and BTB domain containing 16 | Affinity Capture-Western Reconstituted Complex |
BioGRID | 9627120|9765306 |15467736 |
ZBTB16 | PLZF | ZNF145 | zinc finger and BTB domain containing 16 | HDAC1interacts with PLZF. This interaction was modelled on a demonstrated interaction between HDAC1 and PLZF from unspecified species. | 绑定 | 9486654 |
Section V. Pathway annotation
Section VI. microRNA annotation
mirna家族 | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
mir-410 | 90 | 96 | 1A | hsa-miR-410 | aauauaacacagauggcugu |