Gene Page:HEXA

Summary?
GeneID 3073
Symbol HEXA
Synonyms TSD
Description hexosaminidase subunit alpha
Reference MIM:606869|HGNC:HGNC:4878|HPRD:06040|
Gene type protein-coding
Map location 15q24.1
Pascal p-value 0.083
eGene Caudate basal ganglia
Myers' cis & trans

基因数据来源
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症Co-occurance关键字s: schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 支安打与neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs928641 chr9 119927509 HEXA 3073 0.19 trans
snp_a-2231055 0 HEXA 3073 0.16 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NCBP1 0.96 0.95
WDR3 0.95 0.95
PAPOLG 0.95 0.95
ZMYM4 0.95 0.95
KIAA1429 0.95 0.95
CAPRIN1 0.95 0.95
XRCC5 0.95 0.96
SMEK2 0.95 0.95
TAF2 0.95 0.95
EPRS 0.95 0.95
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.72 -0.86
AF347015.31 -0.71 -0.85
IFI27 -0.71 -0.85
FXYD1 -0.71 -0.84
HLA-F -0.70 -0.76
AF347015.33 -0.70 -0.83
AF347015.27 -0.69 -0.81
C5orf53 -0.69 -0.71
AC018755.7 -0.68 -0.73
MT-CYB -0.68 -0.82

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0004563 beta-N-acetylhexosaminidase activity IEA -
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA -
GO:0043169 cation binding IEA -
GO:0046982 protein heterodimerization activity IDA 6230359
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0042552 myelination IEA neuron, axon, Brain, oligodendrocyte (GO term level: 13) -
GO:0001501 skeletal system development IEA -
GO:0005975 carbohydrate metabolic process IEA -
GO:0008152 metabolic process IEA -
GO:0019953 sexual reproduction IEA -
GO:0007628 adult walking behavior IEA -
GO:0007626 locomotory behavior IEA -
GO:0007605 sensory perception of sound IEA -
去:0019915 sequestering of lipid IEA -
GO:0007040 lysosome organization IEA -
GO:0006689 ganglioside catabolic process IEA -
GO:0030203 glycosaminoglycan metabolic process IEA -
GO:0050885 neuromuscular process controlling balance IEA -
GO:0050884 neuromuscular process controlling posture IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005764 lysosome IEA -
GO:0016020 membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG OTHER GLYCAN DEGRADATION 16 12 All SZGR 2.0 genes in this pathway
KEGG AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM 44 30 All SZGR 2.0 genes in this pathway
KEGG GLYCOSAMINOGLYCAN DEGRADATION 21 14 All SZGR 2.0 genes in this pathway
KEGG GLYCOSPHINGOLIPID BIOSYNTHESIS GLOBO SERIES 14 12 All SZGR 2.0 genes in this pathway
KEGG GLYCOSPHINGOLIPID BIOSYNTHESIS GANGLIO SERIES 15 9 All SZGR 2.0 genes in this pathway
KEGG LYSOSOME 121 83 All SZGR 2.0 genes in this pathway
REACTOME GLYCOSPHINGOLIPID METABOLISM 38 22 All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM 198 112 All SZGR 2.0 genes in this pathway
REACTOME CS DS DEGRADATION 12 9 All SZGR 2.0 genes in this pathway
REACTOME HYALURONAN UPTAKE AND DEGRADATION 10 7 All SZGR 2.0 genes in this pathway
REACTOME HYALURONAN METABOLISM 14 7 All SZGR 2.0 genes in this pathway
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 49 33 All SZGR 2.0 genes in this pathway
REACTOME KERATAN SULFATE KERATIN METABOLISM 30 21 All SZGR 2.0 genes in this pathway
REACTOME KERATAN SULFATE DEGRADATION 11 7 All SZGR 2.0 genes in this pathway
REACTOME GLYCOSAMINOGLYCAN METABOLISM 111 69 All SZGR 2.0 genes in this pathway
REACTOME SPHINGOLIPID METABOLISM 69 40 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES 247 154 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA DN 104 59 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP 306 188 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D DN 143 83 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329 219 All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN 185 115 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP 162 104 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP 147 101 All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP 146 104 All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217 143 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM1 229 137 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
LAMB CCND1 TARGETS 19 14 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398 262 All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER UP 49 36 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
APPEL IMATINIB RESPONSE 33 22 All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 108 71 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE UP 45 33 All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 3HR 74 47 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
HOFFMANN PRE BI TO LARGE PRE BII LYMPHOCYTE DN 75 61 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G6 UP 65 43 All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368 247 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237 159 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS DN 306 191 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216 130 All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242 159 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway