SZGR2 - Beplay体育中心

Summary？

基因	3091
象征	hif1a
Synonyms	HIF-1-alpha\|HIF-1A\|HIF-1alpha\|HIF1\|HIF1-ALPHA\|MOP1\|PASD8\|bHLHe78
Description	低氧诱导因子1α亚基
参考erence	MIM:603348\|HGNC：HGNC：4910\|Ensembl:ENSG00000100644\|HPRD：04517\|Vega：Otthumg00000140344
基因类型	蛋白质编码
Map location	14Q23.2
Pascal p-value	0.29
Sherlock p-value	0.907
TADA p-value	0.013
胎儿β	1.164
主持人	Myers' cis & trans

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
DNM：Gulsuner_2013	Whole Exome Sequencing analysis	155 DNMs identified by exome sequencing of quads or trios of schizophrenia individuals and their parents.
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	点击显示详细信息

Section I. Genetics and epigenetics annotation

DNM表

Gene	染色体	位置	参考	alt	成绩单	AA change	Mutation type	筛	CG46	特征	学习
hif1a	chr14	62203734	C	G	NM_001243084 NM_001530 NM_181054	p.410l> v p.386L>V p.386L>V	missense missense missense			Schizophrenia	DNM：Gulsuner_2013

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	EQTL类型
rs17139868	CHR7	117079228	hif1a	3091		0.13		反式

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
HLA-DRA	0.86	0.84
HLA-DMA	0.81	0.84
HLA-DPA1	0.80	0.81
CD74	0.78	0.81
tbxas1	0.77	0.77
CTSS	0.74	0.69
HLA-DRB1	0.74	0.77
CD86	0.73	0.64
RGS10	0.73	0.71
HLA-DQA1	0.73	0.71

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SH3BP2	-0.46	-0.62
KIAA1949	-0.44	-0.52
SH2B2	-0.44	-0.63
tubb2b	-0.42	-0.58
NASP	-0.42	-0.52
VAV2	-0.42	-0.48
ZNF311	-0.41	-0.45
ZBTB12	-0.41	-0.46
AL033532.1	-0.41	-0.48
ZNF300	-0.41	-0.44

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
Apex1	APE \| APE-1 \| APE1 \| APEN \| APEX \| APX \| HAP1 \| REF-1 \| REF1	APEX nuclease (multifunctional DNA repair enzyme) 1	-	HPRD,BioGRID	10594042
arnt	HIF-1beta \| HIF1B \| HIF1BETA \| TANGO \| bHLHe2	aryl hydrocarbon receptor nuclear translocator	-	HPRD,BioGRID	9079689
arnt	HIF-1beta \| HIF1B \| HIF1BETA \| TANGO \| bHLHe2	aryl hydrocarbon receptor nuclear translocator	HIF-1Alpha与HIF-1Beta相互作用	绑定	8663540
arnt	HIF-1beta \| HIF1B \| HIF1BETA \| TANGO \| bHLHe2	aryl hydrocarbon receptor nuclear translocator	HIF-1Alpha亚型1与HIF-1BETA亚型3相互作用3	绑定	8663540
arnt	HIF-1beta \| HIF1B \| HIF1BETA \| TANGO \| bHLHe2	aryl hydrocarbon receptor nuclear translocator	ARNT与HIF1-Alpha相互作用。	绑定	9704006
arnt	HIF-1beta \| HIF1B \| HIF1BETA \| TANGO \| bHLHe2	aryl hydrocarbon receptor nuclear translocator	HIF-1Alpha亚型2与HIF-1BETA亚型1相互作用1	绑定	8663540
arnt	HIF-1beta \| HIF1B \| HIF1BETA \| TANGO \| bHLHe2	aryl hydrocarbon receptor nuclear translocator	HIF-1Alpha亚型2与HIF-1BETA亚型3相互作用3	绑定	8663540
arntL	BMAL1 \|bmal1c \|JAP3 \|MGC47515 \|mop3 \|pasd3 \|抽动\|Bhlhe5	芳基碳氢化合物受体核转运剂样	-	HPRD,BioGRID	9576906
CDKN1A	CAP20 \|CDKN1 \|CIP1 \|MDA-6 \|p21 \|SDI1 \|WAF1 \|P21CIP1	细胞周期蛋白依赖性激酶抑制剂1a（P21，CIP1）	HIF-1alpha interacts with CDKN1A promoter.	绑定	15780936
CDKN2A	ARF \| CDK4I \| CDKN2 \| CMM2 \| INK4 \| INK4a \| MLM \| MTS1 \| TP16 \| p14 \| p14ARF \| p16 \| p16INK4 \| p16INK4a \| p19	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	p14ARF interacts with HIF-1alpha.	绑定	11382768
COPS5	CSN5 \|jab1 \|MGC3149 \|mov-34 \|SGN5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	JAB1与HIF-1Alpha相互作用。	绑定	11707426
克雷布	CBP \| KAT3A \| RSTS	CREB结合蛋白	-	HPRD,BioGRID	10202154
DAP3	DAP-3 \|DKFZP686G12159 \|MGC126058 \|MGC126059 \|MRP-S29 \|MRPS29 \|BMRP-10	death associated protein 3	-	HPRD,BioGRID	10903152
EGLN1	C1orf12 \| DKFZp761F179 \| ECYT3 \| HIFPH2 \| HPH2 \| PHD2 \| SM-20 \| SM20 \| ZMYND6	EGL九个同源物1（秀丽隐杆线虫）	HIF-1α与PHD2相互作用。	绑定	15721254
EGLN3	FLJ21620 \|hifph3 \|MGC125998 \|MGC125999 \|PHD3	EGL九个同源物3（秀丽隐杆线虫）	HIF-1 alpha interacts with PHD3.	绑定	15721254
EP300	kat3b \|P300	E1A binding protein p300	-	HPRD,BioGRID	11823643
EPO	EP \| MGC138142	红细胞生成素	hif1a(HIF-1-alpha) interacts with the EPO gene 3(prime) enhancer.	绑定	15674338
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	重构的复合物	Biogrid	11641274
HDAC2	RPD3 \|yaf1	histone deacetylase 2	重构的复合物	Biogrid	11641274
HDAC3	HD3 \|RPD3 \|RPD3-2	histone deacetylase 3	重构的复合物	Biogrid	11641274
hif1an	DKFZp762F1811 \| FIH1 \| FLJ20615 \| FLJ22027	hypoxia-inducible factor 1, alpha subunit inhibitor	-	HPRD,BioGRID	11641274
HIF3A	HIF-3A \| HIF-3A2 \| HIF-3A4 \| IPAS \| MOP7 \| PASD7 \| bHLHe17	低氧诱导因子3，α亚基	-	HPRD	11734856
HSP90AA1	FLJ31884 \|HSP86 \|HSP89A \|HSP90A \|HSP90N \|HSPC1 \|HSPCA \|HSPCAL1 \|HSPCAL4 \|HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	-	HPRD,BioGRID	9079689
六月	AP-1 \|AP1 \|C-Jun	jun oncogene	-	HPRD,BioGRID	11739718
MAPK3	ERK1 \|HS44KDAP \|Humker1a \|MGC20180 \|p44erk1 \|p44mapk \|prkm3	有丝分裂原激活的蛋白激酶3	-	HPRD	10551817
MDM2	HDMX \| MGC71221 \| hdm2	Mdm2 p53 binding protein homolog (mouse)	亲和力捕获 - 韦斯特恩生化活动重构的复合物	Biogrid	10640274\|12606552
MDM2	HDMX \| MGC71221 \| hdm2	Mdm2 p53 binding protein homolog (mouse)	-	HPRD	10640274 \| 12606552
NCOA1	F-SRC-1 \| KAT13A \| MGC129719 \| MGC129720 \| NCoA-1 \| RIP160 \| SRC-1 \| SRC1 \| bHLHe42	核受体共激活因子1	-	HPRD,BioGRID	10594042
OS9	-	在骨肉瘤中放大	HIF-1α与OS-9相互作用。	绑定	15721254
PER1	MGC88021 \| PER \| RIGUI \| hPER	时期同源物1（果蝇）	-	HPRD,BioGRID	11726537
PGK1	MGC117307 \| MGC142128 \| MGC8947 \| MIG10 \| PGKA	phosphoglycerate kinase 1	-	HPRD	8089148
PSMA7	C6 \|HSPC \|MGC3755 \|RC6-1 \|XAPC7	proteasome (prosome, macropain) subunit, alpha type, 7	-	HPRD,BioGRID	11389899
PSMC3	MGC8487 \|TBP1	proteasome (prosome, macropain) 26S subunit, ATPase, 3	-	HPRD,BioGRID	14556007
RB1	OSRC \|RB \|P105-RB \|PRB \|PP110	retinoblastoma 1	RB1(pRB) interacts with HIF1A (HIF-1-alpha).	绑定	15674338
SP1	-	Sp1 transcription factor	SP1与HIF-1Alpha相互作用。	绑定	15780936
SSX4	MGC119056 \|MGC12411	滑膜肉瘤，X断点4	Two-hybrid	Biogrid	16189514
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	肿瘤蛋白p53	亲和力捕获 - 韦斯特恩重构的复合物	Biogrid	9537326\|10640274 \|12124396\|12606552
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	肿瘤蛋白p53	-	HPRD	9537326 \| 12124396
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	肿瘤蛋白p53	p53 interacts with HIF-1 alpha.	绑定	15629713
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	肿瘤蛋白p53	HIF-1alpha interacts with p53	绑定	11593383
VEGFA	MGC70609 \| VEGF \| VEGF-A \| VPF	vascular endothelial growth factor A	hif1a(HIF-1-alpha) interacts with the VEGF promoter.	绑定	15674338
VHL	HRCA1 \| RCA1 \| VHL1	von Hippel-Lindau tumor suppressor	羟基化的HIF-1α与VHL相互作用。这种相互作用是建立在人类羟化HIF-1α与来自未指定物种的VHL的未指定同工型之间的相互作用的模型。	绑定	15721254
VHL	HRCA1 \| RCA1 \| VHL1	von Hippel-Lindau tumor suppressor	von Hippel-Lindau肿瘤抑制蛋白（PVHL）与缺氧诱导因子-Alpha（HIF-1α）相互作用	绑定	10823831
VHL	HRCA1 \| RCA1 \| VHL1	von Hippel-Lindau tumor suppressor	-	HPRD	11504942
VHL	HRCA1 \| RCA1 \| VHL1	von Hippel-Lindau tumor suppressor	hif1a(HIF-1alpha) interacts with VHL.	绑定	15750626
VHL	HRCA1 \| RCA1 \| VHL1	von Hippel-Lindau tumor suppressor	-	HPRD,BioGRID	10944113
VHLL	VLP	von Hippel-Lindau肿瘤抑制剂	-	HPRD	14757845
ZNF197	D3S1363E \| P18 \| VHLaK \| ZKSCAN9 \| ZNF166 \| ZNF20	zinc finger protein 197	亲和力捕获 - 韦斯特恩	Biogrid	12682018

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
kegg mtor信号通路	52	40	All SZGR 2.0 genes in this pathway
癌症中的KEGG途径	328	259	All SZGR 2.0 genes in this pathway
KEGG肾细胞癌	70	60	All SZGR 2.0 genes in this pathway
BIOCARTA EPONFKB PATHWAY	11	11	All SZGR 2.0 genes in this pathway
Biocarta P53Hypoxia途径	23	21	All SZGR 2.0 genes in this pathway
Biocarta HIF途径	15	12	All SZGR 2.0 genes in this pathway
BIOCARTA VEGF PATHWAY	29	18	All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY	70	60	All SZGR 2.0 genes in this pathway
PID HIF1A途径	19	12	All SZGR 2.0 genes in this pathway
PID VEGFR1 PATHWAY	26	23	All SZGR 2.0 genes in this pathway
PID HIF1 TFPathway	66	52	All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY	48	39	All SZGR 2.0 genes in this pathway
Reactome Notch1细胞内结构域调节转录	46	28	All SZGR 2.0 genes in this pathway
由NOTCH1 REACTOME信号	70	46	All SZGR 2.0 genes in this pathway
反应组对缺氧HIF的低氧诱导因子HIF调节	25	17	All SZGR 2.0 genes in this pathway
REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	18	12	All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN CLOCK	53	40	All SZGR 2.0 genes in this pathway
Notch的Reactome信号传导	103	64	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED UP	112	71	All SZGR 2.0 genes in this pathway
Mullighan MLL签名2 DN	281	186	All SZGR 2.0 genes in this pathway
ENK UV响应表皮DN	508	354	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL DN	186	107	All SZGR 2.0 genes in this pathway
MARKS HDAC TARGETS DN	15	11	All SZGR 2.0 genes in this pathway
贝克造血STAT3目标	16	12	All SZGR 2.0 genes in this pathway
MARTIN INTERACT WITH HDAC	44	31	All SZGR 2.0 genes in this pathway
Hernandez异常有丝分裂由Docetacel 4NM DN	7	6	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
Hasina NOL7目标	13	11	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN	382	224	All SZGR 2.0 genes in this pathway
里克曼肿瘤分化了井与中度DN	110	64	All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发48小时DN	428	306	All SZGR 2.0 genes in this pathway
Benporath MYC带Ebox的目标	230	156	All SZGR 2.0 genes in this pathway
Benporath循环基因	648	385	All SZGR 2.0 genes in this pathway
BENPORATH ES CORE NINE CORRELATED	100	68	All SZGR 2.0 genes in this pathway
Rozanov MMP14目标子集	33	20	All SZGR 2.0 genes in this pathway
Rozanov MMP14靶向	266	171	All SZGR 2.0 genes in this pathway
ROSS ACUTE MYELOID LEUKEMIA CBF	82	57	All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION UP	71	51	All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP	102	67	All SZGR 2.0 genes in this pathway
费尔南德斯（Fernandez）由迈克（Myc）约束	182	116	All SZGR 2.0 genes in this pathway
哈里斯缺氧	81	64	All SZGR 2.0 genes in this pathway
Sesto对UV C2的反应	54	39	All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN	228	146	All SZGR 2.0 genes in this pathway
大脑衰老	262	186	All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP	77	57	All SZGR 2.0 genes in this pathway
敏锐的回应罗格列酮DN	106	68	All SZGR 2.0 genes in this pathway
江缺氧正常	311	205	All SZGR 2.0 genes in this pathway
霍林引用1个目标1 dn	37	22	All SZGR 2.0 genes in this pathway
Zheng由Foxp3绑定	491	310	All SZGR 2.0 genes in this pathway
Zheng Foxp3目标胸腺	196	137	All SZGR 2.0 genes in this pathway
DE YY1 TARGETS DN	92	64	All SZGR 2.0 genes in this pathway
冬季缺氧metagene	242	168	All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN	264	159	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP	165	118	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN	175	103	All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP	71	49	All SZGR 2.0 genes in this pathway
罗斯白血病与MLL融合	78	49	All SZGR 2.0 genes in this pathway
Vantveer乳腺癌ESR1 DN	240	153	All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP	298	174	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP	491	316	All SZGR 2.0 genes in this pathway
甜Kras致癌签名	89	56	All SZGR 2.0 genes in this pathway
米利假足	518	299	All SZGR 2.0 genes in this pathway
VALK AML WITH 11Q23 REARRANGED	22	13	All SZGR 2.0 genes in this pathway
Sakai慢性肝炎与肝癌	83	63	All SZGR 2.0 genes in this pathway
Hoshida肝癌亚类S1	237	159	All SZGR 2.0 genes in this pathway
Zhan多发性骨髓瘤LB DN	44	23	All SZGR 2.0 genes in this pathway
由MYC约束	1103	714	All SZGR 2.0 genes in this pathway
YAO对孕酮簇的时间反应11	103	68	All SZGR 2.0 genes in this pathway
惠特菲尔德细胞周期M G1	148	95	All SZGR 2.0 genes in this pathway
Hirsch细胞转换签名	242	159	All SZGR 2.0 genes in this pathway
Dutertre雌二醇反应6小时	229	149	All SZGR 2.0 genes in this pathway
SMAD1和SMAD5 DN抑制Pangas肿瘤	157	106	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP	682	433	All SZGR 2.0 genes in this pathway
拉菲尔Vegfa的目标	9	8	All SZGR 2.0 genes in this pathway
IKEDA MIR133 TARGETS UP	43	27	All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF	516	308	All SZGR 2.0 genes in this pathway

Gene Page:hif1a