Gene Page:HINT1

Summary?
GeneID 3094
Symbol HINT1
Synonyms HINT|NMAN|PKCI-1|PRKCNH1
Description histidine triad nucleotide binding protein 1
Reference MIM:601314|HGNC:HGNC:4912|Ensembl:ENSG00000169567|HPRD:03204|Vega:OTTHUMG00000128995
Gene type protein-coding
Map location 5q31.2
Pascal p-value 0.664
Sherlock p-value 0.09
Fetal beta -0.288
DMG 1 (# studies)
Support INTRACELLULAR SIGNAL TRANSDUCTION

Gene in Data Sources
Gene set name Method of gene set Description Info
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.0032
Expression Meta-analysis of gene expression Pvalue: 2.914
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg08523029 5 130500466 HINT1 3.14E-5 -0.363 0.019 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ARHGAP24 0.47 0.33
CHRNA2 0.45 0.13
MRVI1 0.45 0.37
CHRNA6 0.45 0.22
EPN3 0.44 0.18
WIPI1 0.43 0.36
RP4-539M6.2 0.42 0.29
SUSD2 0.42 0.29
EPS8L2 0.42 0.35
CPT1A 0.42 0.41
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ARL4D -0.29 -0.28
GPM6A -0.28 -0.27
METTL9 -0.28 -0.32
RNF5 -0.27 -0.32
AC174470.1 -0.27 -0.35
IER5L -0.26 -0.28
VPS37D -0.26 -0.30
ARPC5 -0.26 -0.25
DRAP1 -0.26 -0.30
STMN1 -0.26 -0.26

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005080 protein kinase C binding TAS 9770345
GO:0016787 hydrolase activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007165 signal transduction TAS 8812426
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005856 cytoskeleton TAS 8812426
GO:0005634 nucleus TAS 9770345
GO:0005737 cytoplasm IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431 263 All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP 290 177 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN 180 101 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN 281 186 All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 DN 116 71 All SZGR 2.0 genes in this pathway
LUI THYROID CANCER PAX8 PPARG DN 45 29 All SZGR 2.0 genes in this pathway
LUI THYROID CANCER CLUSTER 3 28 16 All SZGR 2.0 genes in this pathway
LUI TARGETS OF PAX8 PPARG FUSION 34 23 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
CHESLER BRAIN HIGHEST EXPRESSION 40 29 All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA 176 122 All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN 87 57 All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN 141 99 All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND H2O2 39 29 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA DN 52 33 All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE UP 45 33 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER T4 94 69 All SZGR 2.0 genes in this pathway
RAY TUMORIGENESIS BY ERBB2 CDC25A UP 104 57 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374 247 All SZGR 2.0 genes in this pathway
PARK APL PATHOGENESIS UP 14 11 All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389 245 All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN 225 124 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
BAE BRCA1 TARGETS UP 75 47 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841 431 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517 302 All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL UP 146 75 All SZGR 2.0 genes in this pathway