Gene Page:HLA-B

Summary?
GeneID 3106
Symbol HLA-B
Synonyms AS|Bw-47|Bw-50|HLAB|SPDA1
Description major histocompatibility complex, class I, B
Reference MIM:142830|HGNC:HGNC:4932|Ensembl:ENSG00000234745|Ensembl:ENST00000359635|Ensembl:ENST00000435618|Ensembl:ENST00000450871|HPRD:00828|Vega:OTTHUMG00000031153
Gene type protein-coding
Map location 6p21.3
Sherlock p-value 0.381
Fetal beta -0.622
eGene Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Frontal Cortex BA9
Hippocampus
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 体制matic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.033
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.5489

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs4081552 chr6 31353688 HLA-B 3106 0.16 cis
rs10495652 chr2 17139288 HLA-B 3106 0.04 trans
rs6531271 chr2 17139932 HLA-B 3106 0.04 trans
rs12620194 chr2 17148003 HLA-B 3106 0.04 trans
rs17503903 chr2 51039461 HLA-B 3106 0.1 trans
rs890527 chr3 140774852 HLA-B 3106 0.04 trans
rs1678893 chr5 31763244 HLA-B 3106 0.14 trans
rs7741955 chr6 84829621 HLA-B 3106 0.15 trans
rs12524136 chr6 84935440 HLA-B 3106 0.05 trans
rs9397692 chr6 154487314 HLA-B 3106 0.2 trans
rs10509151 chr10 63358651 HLA-B 3106 0.15 trans
rs6488258 chr12 10252207 HLA-B 3106 0.17 trans
rs4769240 chr13 23697920 HLA-B 3106 0.19 trans
rs16979927 chr20 55019249 HLA-B 3106 0 trans
rs2832206 chr21 30504653 HLA-B 3106 0.15 trans
rs17347454 chrX 23347700 HLA-B 3106 0.01 trans
rs689365 chrX 97074769 HLA-B 3106 0.15 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003674 molecular_function ND -
GO:0005515 protein binding 新闻学会 17353931
GO:0032393 MHC class I receptor activity NAS 518865|2715640|8420828
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I IEA -
GO:0019882 antigen processing and presentation IEA -
GO:0008150 biological_process ND 10203017
GO:0006955 immune response IEA -
GO:0006955 immune response NAS 518865|2715640|8420828
GO:0006952 defense response TAS 3011411
GO:0044419 interspecies interaction between organisms IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005575 cellular_component ND -
GO:0005624 membrane fraction TAS 3011411
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -
GO:0005886 plasma membrane EXP 15304001
GO:0005887 integral to plasma membrane NAS 518865|2715640|8420828
GO:0042612 MHC class I protein complex IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AHCY SAHH S-adenosylhomocysteine水解酶 Affinity Capture-MS BioGRID 17353931
B2M - beta-2-microglobulin - HPRD 2450918
CD8A CD8 | Leu2 | MAL | p32 CD8a molecule - HPRD,BioGRID 9331948|10809759|10809759
EZR CVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2 ezrin Affinity Capture-MS BioGRID 17353931
KIR3DL1 CD158E1 | KIR | MGC119726 | MGC119728 | MGC126589 | MGC126591 | NKAT3 | NKB1 | NKB1B killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 in vivo BioGRID 8046332
KIR3DL1 CD158E1 | KIR | MGC119726 | MGC119728 | MGC126589 | MGC126591 | NKAT3 | NKB1 | NKB1B killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 - HPRD 12134147
KIR3DS1 CD158E2 | KIR-123FM | KIR-G1 | MGC119726 | MGC119728 | MGC125316 | NKAT10 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1 Phenotypic Enhancement BioGRID 12134147
KLRD1 CD94 killer cell lectin-like receptor subfamily D, member 1 - HPRD 8046333
LILRB1 CD85 | CD85J | FLJ37515 | ILT2 | LIR-1 | LIR1 | MIR-7 | MIR7 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 - HPRD,BioGRID 12853576
LILRB2 CD85D | ILT4 | LILRA6 | LIR-2 | LIR2 | MIR-10 | MIR10 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 - HPRD,BioGRID 9531263|12853576
LILRB2 CD85D | ILT4 | LILRA6 | LIR-2 | LIR2 | MIR-10 | MIR10 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 - HPRD 12853576
MAGEA1 MAGE1 | MGC9326 melanoma antigen family A, 1 (directs expression of antigen MZ2-E) - HPRD,BioGRID 10363990
MSN - moesin Affinity Capture-MS BioGRID 17353931
PAICS ADE2 | ADE2H1 | AIRC | DKFZp781N1372 | MGC1343 | MGC5024 | PAIS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase Affinity Capture-MS BioGRID 17353931
PFAS FGAMS | FGARAT | KIAA0361 | PURL phosphoribosylformylglycinamidine synthase Affinity Capture-MS BioGRID 17353931
PLS3 T-plastin plastin 3 (T isoform) Affinity Capture-MS BioGRID 17353931
PSMD1 MGC133040 | MGC133041 | P112 | Rpn2 | S1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 Affinity Capture-MS BioGRID 17353931
RUVBL1 ECP54 | INO80H | NMP238 | PONTIN | Pontin52 | RVB1 | TIH1 | TIP49 | TIP49A RuvB-like 1 (E. coli) Affinity Capture-MS BioGRID 17353931
TARS MGC9344 | ThrRS threonyl-tRNA synthetase Affinity Capture-MS BioGRID 17353931
TRA@ FLJ22602 | MGC117436 | MGC22624 | MGC23964 | MGC71411 | TCRA | TCRD | TRA T cell receptor alpha locus - HPRD,BioGRID 12530975
TRIM28 FLJ29029 | KAP1 | RNF96 | TF1B | TIF1B tripartite motif-containing 28 Affinity Capture-MS BioGRID 17353931
VARS G7A | VARS1 | VARS2 valyl-tRNA synthetase Affinity Capture-MS BioGRID 17353931
VCP IBMPFD | MGC131997 | MGC148092 | MGC8560 | TERA | p97 valosin-containing protein Affinity Capture-MS BioGRID 17353931


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG ENDOCYTOSIS 183 132 All SZGR 2.0 genes in this pathway
KEGG CELL ADHESION MOLECULES CAMS 134 93 All SZGR 2.0 genes in this pathway
KEGG ANTIGEN PROCESSING AND PRESENTATION 89 65 All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 137 92 All SZGR 2.0 genes in this pathway
KEGG TYPE I DIABETES MELLITUS 44 38 All SZGR 2.0 genes in this pathway
KEGG AUTOIMMUNE THYROID DISEASE 53 49 All SZGR 2.0 genes in this pathway
KEGG ALLOGRAFT REJECTION 38 34 All SZGR 2.0 genes in this pathway
KEGG GRAFT VERSUS HOST DISEASE 42 31 All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS 73 58 All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION 76 48 All SZGR 2.0 genes in this pathway
REACTOME ENDOSOMAL VACUOLAR PATHWAY 9 7 All SZGR 2.0 genes in this pathway
REACTOME ER PHAGOSOME PATHWAY 61 40 All SZGR 2.0 genes in this pathway
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 70 37 All SZGR 2.0 genes in this pathway
REACTOME INTERFERON GAMMA SIGNALING 63 48 All SZGR 2.0 genes in this pathway
REACTOME INTERFERON ALPHA BETA SIGNALING 64 50 All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING 159 116 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 21 17 All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251 156 All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634 384 All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN 267 178 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN 116 79 All SZGR 2.0 genes in this pathway
LEE NEURAL CREST STEM CELL DN 118 79 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP 266 171 All SZGR 2.0 genes in this pathway
WIELAND UP BY HBV INFECTION 101 66 All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG UP 78 50 All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP 83 56 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207 145 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366 238 All SZGR 2.0 genes in this pathway
GALE APL WITH FLT3 MUTATED DN 17 10 All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA UP 71 49 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371 218 All SZGR 2.0 genes in this pathway
HU GENOTOXIN ACTION DIRECT VS INDIRECT 24HR 55 38 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487 303 All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419 273 All SZGR 2.0 genes in this pathway
MARCHINI TRABECTEDIN RESISTANCE DN 49 34 All SZGR 2.0 genes in this pathway
KIM LRRC3B TARGETS 30 24 All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN 49 38 All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299 167 All SZGR 2.0 genes in this pathway
CAMPS COLON CANCER COPY NUMBER DN 74 34 All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP 174 96 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE UP 126 92 All SZGR 2.0 genes in this pathway
GAURNIER PSMD4 TARGETS 73 55 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN 216 143 All SZGR 2.0 genes in this pathway
HUPER BREAST BASAL VS LUMINAL DN 59 44 All SZGR 2.0 genes in this pathway
WUNDER INFLAMMATORY RESPONSE AND CHOLESTEROL UP 58 38 All SZGR 2.0 genes in this pathway
HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE DN 50 33 All SZGR 2.0 genes in this pathway
LEE EARLY T LYMPHOCYTE DN 57 36 All SZGR 2.0 genes in this pathway
KUROKAWA LIVER CANCER EARLY RECURRENCE DN 7 6 All SZGR 2.0 genes in this pathway
STAMBOLSKY TARGETS OF MUTATED TP53 DN 50 24 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572 352 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP 140 94 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430 288 All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 403 240 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337 236 All SZGR 2.0 genes in this pathway