Gene Page:HLA-DPB1
Summary?
基因 | 3115 |
象征 | HLA-DPB1 |
Synonyms | dpb1 | hla-dp | hla-dp1b | hla-dpb |
Description | 主要的组织相容性复合物,II类,DP Beta 1 |
Reference | MIM:142858|HGNC:HGNC:4940|HPRD:00832| |
基因类型 | 蛋白质编码 |
Map location | 6p21.3 |
Pascal p-value | 1.1E-5 |
Sherlock p-value | 0.044 |
胎儿β | -1.06 |
主持人 | Caudate basal ganglia Cerebellar Hemisphere 小脑 皮质 海马 Hypothalamus 伏隔核基底神经节 Putamen basal ganglia Myers' cis & trans 元 |
Gene in Data Sources
基因集名称 | Method of gene set | Description | 信息 |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
PMID:cooccur | High-throughput literature-search | PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。 | |
GSMA_I | Genome scan meta-analysis | Psr: 0.033 | |
Literature | High-throughput literature-search | 与精神分裂症关键词共同存在:精神分裂症,精神分裂症,精神分裂症 | 点击显示详细信息 |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | 染色体 | 位置 | 主持人 | Gene Entrez ID | pvalue | QVALUE | TSS距离 | EQTL类型 |
---|---|---|---|---|---|---|---|---|
rs11216730 | Chr11 | 117918701 | HLA-DPB1 | 3115 | 0.13 | 反式 | ||
rs9277376 | 6 | 3.3.050196 | HLA-DPB1 | ENSG00000223865.6 | 9.011E-7 | 0.01 | 6493 | gtex_brain_putamen_basal |
rs9277377 | 6 | 33050203 | HLA-DPB1 | ENSG00000223865.6 | 9.011E-7 | 0.01 | 6500 | gtex_brain_putamen_basal |
rs9277392 | 6 | 33050829 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 7126 | gtex_brain_putamen_basal |
rs9277393 | 6 | 33050877 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 7174 | gtex_brain_putamen_basal |
rs9277394 | 6 | 33050970 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 7267 | gtex_brain_putamen_basal |
rs9277395 | 6 | 33051051 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 7348 | gtex_brain_putamen_basal |
rs9277396 | 6 | 3.3.051139 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 7436 | gtex_brain_putamen_basal |
RS9277401 | 6 | 33051394 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 7691 | gtex_brain_putamen_basal |
RS9277402 | 6 | 3.3.051460 | HLA-DPB1 | ENSG00000223865.6 | 3.218e-7 | 0.01 | 7757 | gtex_brain_putamen_basal |
RS9277406 | 6 | 33051554 | HLA-DPB1 | ENSG00000223865.6 | 4.173E-7 | 0.01 | 7851 | gtex_brain_putamen_basal |
RS9277407 | 6 | 33051558 | HLA-DPB1 | ENSG00000223865.6 | 4.173E-7 | 0.01 | 7855 | gtex_brain_putamen_basal |
RS9277408 | 6 | 33051562 | HLA-DPB1 | ENSG00000223865.6 | 4.18E-7 | 0.01 | 7859 | gtex_brain_putamen_basal |
RS9277409 | 6 | 33051624 | HLA-DPB1 | ENSG00000223865.6 | 4.116E-7 | 0.01 | 7921 | gtex_brain_putamen_basal |
RS9277410 | 6 | 33051640 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 7937 | gtex_brain_putamen_basal |
RS9277411 | 6 | 33051683 | HLA-DPB1 | ENSG00000223865.6 | 4.083E-7 | 0.01 | 7980 | gtex_brain_putamen_basal |
RS9277412 | 6 | 33051689 | HLA-DPB1 | ENSG00000223865.6 | 4.083E-7 | 0.01 | 7986 | gtex_brain_putamen_basal |
RS9277420 | 6 | 33051790 | HLA-DPB1 | ENSG00000223865.6 | 1.607E-7 | 0.01 | 8087 | gtex_brain_putamen_basal |
RS9282411 | 6 | 33051827 | HLA-DPB1 | ENSG00000223865.6 | 1.609E-7 | 0.01 | 8124 | gtex_brain_putamen_basal |
RS9277423 | 6 | 33051845 | HLA-DPB1 | ENSG00000223865.6 | 1.607E-7 | 0.01 | 8142 | gtex_brain_putamen_basal |
RS9277424 | 6 | 33051865 | HLA-DPB1 | ENSG00000223865.6 | 1.607E-7 | 0.01 | 8162 | gtex_brain_putamen_basal |
rs142975055 | 6 | 33051896 | HLA-DPB1 | ENSG00000223865.6 | 1.626E-7 | 0.01 | 8193 | gtex_brain_putamen_basal |
RS9277426 | 6 | 33051910 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 8207 | gtex_brain_putamen_basal |
RS9277427 | 6 | 33051969 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 8266 | gtex_brain_putamen_basal |
RS9277428 | 6 | 33051976 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 8273 | gtex_brain_putamen_basal |
RS9277431 | 6 | 3.3.052028 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 8325 | gtex_brain_putamen_basal |
RS9277432 | 6 | 3.3.052072 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 8369 | gtex_brain_putamen_basal |
RS9277433 | 6 | 33052128 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 8425 | gtex_brain_putamen_basal |
RS10536191 | 6 | 3.3.052167 | HLA-DPB1 | ENSG00000223865.6 | 3..168E-7 | 0.01 | 8464 | gtex_brain_putamen_basal |
RS9277437 | 6 | 3.3.052250 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 8547 | gtex_brain_putamen_basal |
RS9277438 | 6 | 33052303 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 8600 | gtex_brain_putamen_basal |
RS9277439 | 6 | 3.3.052315 | HLA-DPB1 | ENSG00000223865.6 | 3..821E-7 | 0.01 | 8612 | gtex_brain_putamen_basal |
RS9277440 | 6 | 3.3.052327 | HLA-DPB1 | ENSG00000223865.6 | 3..715E-7 | 0.01 | 8624 | gtex_brain_putamen_basal |
RS9277441 | 6 | 33052354 | HLA-DPB1 | ENSG00000223865.6 | 3..821E-7 | 0.01 | 8651 | gtex_brain_putamen_basal |
RS9277443 | 6 | 33052414 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 8711 | gtex_brain_putamen_basal |
RS9277444 | 6 | 3.3.052439 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 8736 | gtex_brain_putamen_basal |
RS9277445 | 6 | 3.3.052492 | HLA-DPB1 | ENSG00000223865.6 | 2.168E-7 | 0.01 | 8789 | gtex_brain_putamen_basal |
RS9277446 | 6 | 3.3.052498 | HLA-DPB1 | ENSG00000223865.6 | 1.594E-7 | 0.01 | 8795 | gtex_brain_putamen_basal |
RS1042187 | 6 | 33052768 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 9065 | gtex_brain_putamen_basal |
rs1042212 | 6 | 33052803 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 9100 | gtex_brain_putamen_basal |
rs1042331 | 6 | 33052950 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 9247 | gtex_brain_putamen_basal |
rs1042335 | 6 | 33052958 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 9255 | gtex_brain_putamen_basal |
RS1071597 | 6 | 33052986 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 9283 | gtex_brain_putamen_basal |
rs9277458 | 6 | 3.3.053167 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 9464 | gtex_brain_putamen_basal |
rs9277459 | 6 | 3.3.053248 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 9545 | gtex_brain_putamen_basal |
rs9277460 | 6 | 3.3.053252 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 9549 | gtex_brain_putamen_basal |
rs9277461 | 6 | 3.3.053270 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 9567 | gtex_brain_putamen_basal |
rs9277462 | 6 | 3.3.053271 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 9568 | gtex_brain_putamen_basal |
rs9277463 | 6 | 3.3.053307 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 9604 | gtex_brain_putamen_basal |
rs9277466 | 6 | 3.3.053399 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 9696 | gtex_brain_putamen_basal |
rs9277467 | 6 | 33053444 | HLA-DPB1 | ENSG00000223865.6 | 9.748E-7 | 0.01 | 9741 | gtex_brain_putamen_basal |
rs9277468 | 6 | 33053455 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 9752 | gtex_brain_putamen_basal |
rs9277469 | 6 | 3.3.053468 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 9765 | gtex_brain_putamen_basal |
RS9277470 | 6 | 33053477 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 9774 | gtex_brain_putamen_basal |
RS9277471 | 6 | 33053682 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 9979 | gtex_brain_putamen_basal |
RS9277481 | 6 | 33053820 | HLA-DPB1 | ENSG00000223865.6 | 3.394E-7 | 0.01 | 10117 | gtex_brain_putamen_basal |
rs9277490 | 6 | 33053968 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 10265 | gtex_brain_putamen_basal |
rs9277491 | 6 | 33053971 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 10268 | gtex_brain_putamen_basal |
rs9277492 | 6 | 33053982 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 10279 | gtex_brain_putamen_basal |
rs9277493 | 6 | 3.3.054046 | HLA-DPB1 | ENSG00000223865.6 | 3.659E-7 | 0.01 | 10343 | gtex_brain_putamen_basal |
rs9277494 | 6 | 33054057 | HLA-DPB1 | ENSG00000223865.6 | 3.428e-7 | 0.01 | 10354 | gtex_brain_putamen_basal |
rs9277497 | 6 | 33054091 | HLA-DPB1 | ENSG00000223865.6 | 1.631E-7 | 0.01 | 10388 | gtex_brain_putamen_basal |
RS9277511 | 6 | 3.3.054215 | HLA-DPB1 | ENSG00000223865.6 | 3..912E-7 | 0.01 | 10512 | gtex_brain_putamen_basal |
RS9277513 | 6 | 3.3.054231 | HLA-DPB1 | ENSG00000223865.6 | 7.576E-7 | 0.01 | 10528 | gtex_brain_putamen_basal |
RS9277514 | 6 | 3.3.054235 | HLA-DPB1 | ENSG00000223865.6 | 7.648E-7 | 0.01 | 10532 | gtex_brain_putamen_basal |
RS9277515 | 6 | 3.3.054268 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 10565 | gtex_brain_putamen_basal |
RS9277518 | 6 | 33054302 | HLA-DPB1 | ENSG00000223865.6 | 1.63E-7 | 0.01 | 10599 | gtex_brain_putamen_basal |
rs1126719 | 6 | 33054325 | HLA-DPB1 | ENSG00000223865.6 | 2.189E-7 | 0.01 | 10622 | gtex_brain_putamen_basal |
rs1126723 | 6 | 3.3.054331 | HLA-DPB1 | ENSG00000223865.6 | 2.189E-7 | 0.01 | 10628 | gtex_brain_putamen_basal |
rs1042544 | 6 | 3.3.054457 | HLA-DPB1 | ENSG00000223865.6 | 1.631E-7 | 0.01 | 10754 | gtex_brain_putamen_basal |
RS931 | 6 | 3.3.054550 | HLA-DPB1 | ENSG00000223865.6 | 4.117E-7 | 0.01 | 10847 | gtex_brain_putamen_basal |
RS928 | 6 | 3.3.054552 | HLA-DPB1 | ENSG00000223865.6 | 4.117E-7 | 0.01 | 10849 | gtex_brain_putamen_basal |
RS929 | 6 | 3.3.054619 | HLA-DPB1 | ENSG00000223865.6 | 4.123E-7 | 0.01 | 10916 | gtex_brain_putamen_basal |
RS9277532 | 6 | 33054711 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 11008 | gtex_brain_putamen_basal |
RS9277533 | 6 | 33054721 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 11018 | gtex_brain_putamen_basal |
RS9277534 | 6 | 33054807 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 11104 | gtex_brain_putamen_basal |
RS9277536 | 6 | 33054890 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 11187 | gtex_brain_putamen_basal |
RS9277537 | 6 | 3.3.055009 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 11306 | gtex_brain_putamen_basal |
RS9277538 | 6 | 33055047 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 11344 | gtex_brain_putamen_basal |
RS9277540 | 6 | 3.3.055123 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 11420 | gtex_brain_putamen_basal |
RS9277541 | 6 | 33055158 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 11455 | gtex_brain_putamen_basal |
RS9280312 | 6 | 33055196 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 11493. | gtex_brain_putamen_basal |
RS9277542 | 6 | 3.3.055247 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 11544 | gtex_brain_putamen_basal |
RS9277544 | 6 | 3.3.055308 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 11605 | gtex_brain_putamen_basal |
RS9277546 | 6 | 3.3.055346 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 11643 | gtex_brain_putamen_basal |
RS9277547 | 6 | 3.3.055367 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 11664 | gtex_brain_putamen_basal |
RS9277548 | 6 | 33055390 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 11687 | gtex_brain_putamen_basal |
RS9277549 | 6 | 33055419 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 11716 | gtex_brain_putamen_basal |
RS9277550 | 6 | 3.3.055487 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 11784 | gtex_brain_putamen_basal |
RS9277551 | 6 | 3.3.055494 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 11791 | gtex_brain_putamen_basal |
RS9277553 | 6 | 33055516 | HLA-DPB1 | ENSG00000223865.6 | 4.123E-7 | 0.01 | 11813 | gtex_brain_putamen_basal |
RS9277554 | 6 | 33055538 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 11835 | gtex_brain_putamen_basal |
rs3128963 | 6 | 3.3.055780 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 12077 | gtex_brain_putamen_basal |
rs3128964 | 6 | 33055818 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 12115 | gtex_brain_putamen_basal |
RS5875436 | 6 | 3.3.055843 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 12140 | gtex_brain_putamen_basal |
RS9282413 | 6 | 33056396 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 12693 | gtex_brain_putamen_basal |
RS3117228 | 6 | 3.3.056435 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 12732 | gtex_brain_putamen_basal |
RS9277566 | 6 | 3.3.056916 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 13213 | gtex_brain_putamen_basal |
RS9277568 | 6 | 33057055 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 13352 | gtex_brain_putamen_basal |
rs3130188 | 6 | 33057176 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 13473 | gtex_brain_putamen_basal |
RS3091282 | 6 | 33057198 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 13495 | gtex_brain_putamen_basal |
RS534504368 | 6 | 3.3.057511 | HLA-DPB1 | ENSG00000223865.6 | 5.184E-7 | 0.01 | 13808 | gtex_brain_putamen_basal |
RS3117225 | 6 | 33057711 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 14008 | gtex_brain_putamen_basal |
RS3097652 | 6 | 3.3.057835 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 14132 | gtex_brain_putamen_basal |
rs2295118 | 6 | 33060892 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 17189 | gtex_brain_putamen_basal |
RS3117216 | 6 | 33063403 | HLA-DPB1 | ENSG00000223865.6 | 4.127E-7 | 0.01 | 19700 | gtex_brain_putamen_basal |
rs3128930 | 6 | 3.3.075666 | HLA-DPB1 | ENSG00000223865.6 | 5.179E-7 | 0.01 | 3.1963 | gtex_brain_putamen_basal |
第二节。转录组注释
一般基因表达(GTEX)
![Not available](http://www.tjghsg.com/bioinfo/SZGR/GeneImg/HLA-DPB1_DE_GTEx.png)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达(brainspan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1:胎儿(13-26个概念后周),ST2:婴儿早期至童年(4个月至11年)和ST3:青春期至成年期(13-23年)
所示的栏表示表达分布的较低25%和上层25%。
大脑区域的顶级共表达基因
前10个积极共表达的基因 | ||
Gene | Pearson's Correlation | 斯皮尔曼的相关性 |
GPER | 0.86 | 0.89 |
SLC6A12 | 0.85 | 0.88 |
MVP | 0.85 | 0.90 |
PRELP | 0.84 | 0.89 |
apol3 | 0.84 | 0.86 |
EPAS1 | 0.83 | 0.88 |
GPR37L1 | 0.83 | 0.88 |
TGM2 | 0.83 | 0.84 |
PBXIP1 | 0.83 | 0.84 |
BCAM | 0.82 | 0.85 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | 斯皮尔曼的相关性 |
SUPV3L1 | -0.71 | -0.76 |
Med19 | -0.71 | -0.76 |
FRG1 | -0.71 | -0.78 |
DUSP12 | -0.71 | -0.74 |
ZNF821 | -0.70 | -0.70 |
ZBED5 | -0.70 | -0.77 |
STMN1 | -0.70 | -0.74 |
gnl3 | -0.70 | -0.73 |
PAK1IP1 | -0.69 | -0.73 |
CYP2R1 | -0.69 | -0.77 |
第三节。基因本体论注释
分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
---|---|---|---|---|
GO:0032395 | MHC class II receptor activity | TAS | 8105536 | |
生物过程 | 去学期 | 证据 | 神经关键字 | PubMed ID |
GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | IEA | - | |
去:0009405 | 发病 | TAS | 8105536 | |
去:0006955 | 免疫反应 | IEA | - | |
Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
去:0016020 | membrane | IEA | - | |
GO:0016021 | 膜不可或缺 | IEA | - | |
去:0005886 | plasma membrane | 经验 | 11048639|11827988|15489916 |17652306 |
|
GO:0042613 | MHC II类蛋白质复合物 | IEA | - |