Gene Page:HMOX1

Summary?
GeneID 3162
Symbol HMOX1
Synonyms HMOX1D|HO-1|HSP32|bK286B10
Description heme oxygenase 1
Reference MIM:141250|HGNC:HGNC:5013|Ensembl:ENSG00000100292|HPRD:00782|Vega:OTTHUMG00000150960
Gene type protein-coding
Map location 22q13.1
Pascal p-value 0.636
Sherlock p-value 0.398
Fetal beta -0.483
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
简历:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统的search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17013080 chr1 208862652 HMOX1 3162 0.08 trans
rs16999761 chr4 107454800 HMOX1 3162 0.14 trans
rs2059867 chr5 31765789 HMOX1 3162 0.06 trans
rs1638755 chr7 157552811 HMOX1 3162 0 trans
rs17111364 chr10 97901813 HMOX1 3162 4.664E-5 trans
rs17076272 chr13 22726361 HMOX1 3162 0.06 trans
rs17076274 chr13 22726381 HMOX1 3162 0.06 trans
rs17622359 chr21 25283190 HMOX1 3162 0.1 trans
rs16979494 chrX 14301660 HMOX1 3162 0.02 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SFPQ 0.96 0.97
FUS 0.96 0.96
HNRNPR 0.96 0.96
PPM1G 0.95 0.97
SETDB1 0.95 0.94
KHDRBS1 0.95 0.96
HNRNPH1 0.95 0.96
SSRP1 0.95 0.95
GART 0.95 0.93
TUBB2B 0.95 0.78
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
HLA-F -0.77 -0.84
C5orf53 -0.74 -0.77
AIFM3 -0.74 -0.79
ALDOC -0.73 -0.75
TSC22D4 -0.73 -0.83
AF347015.27 -0.73 -0.90
AF347015.31 -0.72 -0.90
S100B -0.72 -0.84
PTH1R -0.72 -0.77
FBXO2 -0.72 -0.66

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG PORPHYRIN AND CHLOROPHYLL METABOLISM 41 23 All SZGR 2.0 genes in this pathway
BIOCARTA IL10 PATHWAY 17 14 All SZGR 2.0 genes in this pathway
PID FRA PATHWAY 37 28 All SZGR 2.0 genes in this pathway
PID HIF1 TFPATHWAY 66 52 All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
REACTOME IRON UPTAKE AND TRANSPORT 36 18 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PORPHYRINS 14 7 All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP 351 230 All SZGR 2.0 genes in this pathway
WILCOX RESPONSE TO PROGESTERONE UP 152 90 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP 306 188 All SZGR 2.0 genes in this pathway
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP 158 103 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS YELLOW UP 32 25 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR DN 41 29 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP 185 126 All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS DN 240 171 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329 196 All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF DN 118 78 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN 234 147 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
JOHANSSON GLIOMAGENESIS BY PDGFB UP 58 44 All SZGR 2.0 genes in this pathway
KAN RESPONSE TO ARSENIC TRIOXIDE 123 80 All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP 88 58 All SZGR 2.0 genes in this pathway
LUND SILENCED BY METHYLATION 16 12 All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM UP 81 57 All SZGR 2.0 genes in this pathway
XU HGF SIGNALING NOT VIA AKT1 48HR UP 35 20 All SZGR 2.0 genes in this pathway
DACOSTA ERCC3 ALLELE XPCS VS TTD DN 36 27 All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE LATE UP 57 41 All SZGR 2.0 genes in this pathway
WEINMANN ADAPTATION TO HYPOXIA UP 29 24 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514 319 All SZGR 2.0 genes in this pathway
LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL UP 83 51 All SZGR 2.0 genes in this pathway
STANHILL HRAS TRANSFROMATION UP 8 5 All SZGR 2.0 genes in this pathway
FURUKAWA DUSP6 TARGETS PCI35 UP 74 32 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769 437 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP 256 159 All SZGR 2.0 genes in this pathway
HOUSTIS ROS 36 29 All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN 121 79 All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC 182 116 All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318 215 All SZGR 2.0 genes in this pathway
HALMOS CEBPA TARGETS UP 52 34 All SZGR 2.0 genes in this pathway
ABRAHAM ALPC VS MULTIPLE MYELOMA UP 26 22 All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS 126 90 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183 111 All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD DN 162 102 All SZGR 2.0 genes in this pathway
TAVOR CEBPA TARGETS UP 48 36 All SZGR 2.0 genes in this pathway
XU CREBBP TARGETS UP 26 16 All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP 69 41 All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 6M 74 47 All SZGR 2.0 genes in this pathway
HARRIS HYPOXIA 81 64 All SZGR 2.0 genes in this pathway
CHUANG OXIDATIVE STRESS RESPONSE UP 28 18 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156 101 All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 3M 59 36 All SZGR 2.0 genes in this pathway
ZHENG RESPONSE TO ARSENITE UP 18 14 All SZGR 2.0 genes in this pathway
EHRLICH ICF SYNDROM DN 15 13 All SZGR 2.0 genes in this pathway
SARTIPY NORMAL AT INSULIN RESISTANCE UP 34 27 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C0 107 72 All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM UP 84 58 All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311 205 All SZGR 2.0 genes in this pathway
WENG POR DOSAGE 21 9 All SZGR 2.0 genes in this pathway
SEMENZA HIF1 TARGETS 36 32 All SZGR 2.0 genes in this pathway
SATO SILENCED BY DEACETYLATION IN PANCREATIC CANCER 50 30 All SZGR 2.0 genes in this pathway
WENG POR TARGETS LIVER UP 41 29 All SZGR 2.0 genes in this pathway
DASU IL6 SIGNALING SCAR DN 16 8 All SZGR 2.0 genes in this pathway
KYNG RESPONSE TO H2O2 71 42 All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN 264 168 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 473 224 All SZGR 2.0 genes in this pathway
SINGH NFE2L2 TARGETS 15 12 All SZGR 2.0 genes in this pathway
JEPSEN SMRT TARGETS 33 23 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN 105 67 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
由喀斯特IWANAGA致癌PTEN 181 112 All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE UP 126 92 All SZGR 2.0 genes in this pathway
奥巴马回应DARAPLADIB 29 20 All SZGR 2.0 genes in this pathway
CHO NR4A1 TARGETS 33 22 All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP 147 98 All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE 242 168 All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165 118 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
MELLMAN TUT1 TARGETS DN 47 29 All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP 181 106 All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR UP 101 65 All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222 141 All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253 192 All SZGR 2.0 genes in this pathway
DANG MYC TARGETS DN 31 25 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
ONGUSAHA BRCA1 TARGETS UP 13 11 All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456 287 All SZGR 2.0 genes in this pathway
QI HYPOXIA 140 96 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430 288 All SZGR 2.0 genes in this pathway
KUWANO RNA STABILIZED BY NO 7 7 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA VIA KDM3A 53 34 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279 155 All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467 251 All SZGR 2.0 genes in this pathway
VANOEVELEN MYOGENESIS SIN3A TARGETS 220 133 All SZGR 2.0 genes in this pathway