Gene Page:APOF
Summary?
| GeneID | 319 |
| Symbol | APOF |
| Synonyms | Apo-F|LTIP |
| Description | apolipoprotein F |
| Reference | MIM:107760|HGNC:HGNC:615|Ensembl:ENSG00000175336|HPRD:00137|Vega:OTTHUMG00000170715 |
| Gene type | protein-coding |
| Map location | 12q13.3 |
| Pascal p-value | 0.042 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MCOLN1 | 0.92 | 0.92 |
| GSK3A | 0.91 | 0.90 |
| C11orf68 | 0.90 | 0.87 |
| AP2A2 | 0.89 | 0.88 |
| SCYL1 | 0.88 | 0.87 |
| PPP5C | 0.88 | 0.86 |
| KATNB1 | 0.88 | 0.86 |
| AGAP3 | 0.88 | 0.86 |
| TCF25 | 0.88 | 0.85 |
| MON1A | 0.88 | 0.87 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.8 | -0.72 | -0.60 |
| MT-CO2 | -0.70 | -0.58 |
| AF347015.26 | -0.70 | -0.58 |
| AF347015.21 | -0.70 | -0.60 |
| AF347015.2 | -0.70 | -0.56 |
| AF347015.33 | -0.69 | -0.58 |
| AF347015.15 | -0.68 | -0.56 |
| MT-CYB | -0.68 | -0.56 |
| AF347015.27 | -0.68 | -0.59 |
| AF347015.31 | -0.68 | -0.56 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005102 | receptor binding | TAS | Neurotransmitter (GO term level: 4) | 8093033 |
| GO:0005319 | lipid transporter activity | TAS | 6816269 | |
| GO:0015485 | cholesterol binding | TAS | 6816269 | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0008202 | steroid metabolic process | IEA | - | |
| GO:0008203 | cholesterol metabolic process | TAS | 6816269 | |
| GO:0006629 | lipid metabolic process | TAS | 8093033 | |
| GO:0006869 | lipid transport | TAS | 6816269 | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005576 | extracellular region | NAS | 14718574 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KIM WT1 TARGETS 8HR DN | 129 | 84 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP | 612 | 367 | All SZGR 2.0 genes in this pathway |
| NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP | 157 | 105 | All SZGR 2.0 genes in this pathway |
| HSIAO LIVER SPECIFIC GENES | 244 | 154 | All SZGR 2.0 genes in this pathway |
| SU LIVER | 55 | 32 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER | 49 | 29 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER DN | 540 | 340 | All SZGR 2.0 genes in this pathway |
| CHIANG LIVER CANCER SUBCLASS INTERFERON UP | 26 | 10 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA DN | 267 | 160 | All SZGR 2.0 genes in this pathway |
| CAIRO LIVER DEVELOPMENT DN | 222 | 141 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP D | 280 | 158 | All SZGR 2.0 genes in this pathway |
| ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN | 308 | 187 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |