Gene Page:ACACB

Summary?
GeneID 32
Symbol ACACB
Synonyms ACC2|ACCB|HACC275
Description acetyl-CoA carboxylase beta
Reference MIM:601557|HGNC:HGNC:85|Ensembl:ENSG00000076555|HPRD: 07044|Vega:OTTHUMG00000169250
Gene type protein-coding
Map location 12q24.11
Pascal p-value 0.057
Fetal beta -1.343
DMG 1 (# studies)
eGene Cortex
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg23435821 12 109592934 ACACB 2.38E-5 -0.859 0.017 DMG:Wockner_2014
cg19598685 12 109592525 ACACB 6.92E-5 -0.219 0.024 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17393398 chr2 176733893 ACACB 32 0.16 trans
rs3114010 chr4 179466033 ACACB 32 0.17 trans
rs10994209 chr10 61877705 ACACB 32 0.02 trans
rs17650385 chr13 87104244 ACACB 32 0.13 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SNTA1 0.87 0.80
NDRG2 0.85 0.81
TSC22D4 0.84 0.81
TREX1 0.82 0.79
TLCD1 0.81 0.76
TST 0.81 0.80
IL17RC 0.81 0.80
TNFSF13 0.81 0.77
ROM1 0.81 0.80
PLCD1 0.80 0.80
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GOPC -0.63 -0.65
PDS5B -0.62 -0.65
PHF14 -0.62 -0.71
STRBP -0.62 -0.67
AGTPBP1 -0.62 -0.67
MDGA2 -0.62 -0.71
CLASP2 -0.62 -0.65
KIAA1841 -0.61 -0.66
YTHDC2 -0.60 -0.62
UBP1 -0.60 -0.63

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG PYRUVATE METABOLISM 40 26 All SZGR 2.0 genes in this pathway
KEGG PROPANOATE METABOLISM 33 22 All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137 103 All SZGR 2.0 genes in this pathway
KEGG ADIPOCYTOKINE SIGNALING PATHWAY 67 57 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE 19 16 All SZGR 2.0 genes in this pathway
能源METABOLI REACTOME集成SM 120 84 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 168 115 All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN 175 82 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST NORMAL DUCTAL VS LOBULAR UP 68 40 All SZGR 2.0 genes in this pathway
HOOI ST7 TARGETS UP 94 57 All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS UP 269 146 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456 228 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA DN 284 156 All SZGR 2.0 genes in this pathway
BIDUS METASTASIS DN 161 93 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS UP 149 84 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
TERAMOTO OPN TARGETS CLUSTER 6 27 17 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP 236 139 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344 180 All SZGR 2.0 genes in this pathway
ASTIER INTEGRIN SIGNALING 59 44 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
LEIN CHOROID PLEXUS MARKERS 103 61 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388 234 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430 288 All SZGR 2.0 genes in this pathway
AMBROSINI FLAVOPIRIDOL TREATMENT TP53 109 63 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476 285 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267 160 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 DN 74 47 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA2 DN 80 51 All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS LATE UP 104 67 All SZGR 2.0 genes in this pathway
WANG METASTASIS OF BREAST CANCER ESR1 DN 30 18 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway