Gene Page:APC

概括?
GeneID 324
Symbol APC
Synonyms BTPS2|DP2|DP2.5|DP3|GS|PPP1R46
Description 腺瘤息肉大肠杆菌
参考 MIM:611731|HGNC:HGNC:583|Ensembl:ENSG00000134982|HPRD:01439|Vega:OTTHUMG00000128806
Gene type protein-coding
Map location 5q21-q22
Pascal p-value 0.072
Sherlock P值 0.045
Fetal beta 1.038
DMG 2 (# studies)
eGene Meta
Support COMPOSITESET
Darnell FMRP targets

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 2
PMID:cooccur High-throughput literature-search 系统的搜索页ubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学 High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details
Network 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 Contribution to shortest path in PPI network: 0.0228

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg16970232 5 112073433 APC -0.027 0.25 DMG:Nishioka_2013
cg16481008 5 112043117 APC 2.29E-9 -0.012 1.74E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
UQCRC1 0.88 0.85
NIT1 0.87 0.83
ARFIP2 0.87 0.83
ATP5B 0.87 0.82
TBRG4 0.86 0.84
MRPL37 0.86 0.82
NDUFA10 0.86 0.81
SLC41A3 0.85 0.81
PREB 0.85 0.83
RABGGTA 0.85 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.18 -0.62 -0.57
AF347015.21 -0.61 -0.50
AF347015.8 -0.61 -0.49
AL139819.3 -0.60 -0.59
AF347015.2 -0.59 -0.46
AF347015.26 -0.59 -0.49
MT-CO2 -0.58 -0.46
MT-ATP8 -0.57 -0.52
AF347015.33 -0.56 -0.48
MT-CYB -0.56 -0.47

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0008605 protein kinase CK2 regulator activity IDA 11972058
GO:0008017 microtubule binding IDA 11166179|16188939
GO:0008013 beta-catenin binding 新闻学会 11533658
GO:0008013 beta-catenin binding NAS 8259518
GO:0019901 protein kinase binding IDA 11283619
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007155 细胞粘附 NAS 8259518
GO:0006461 蛋白质复合物组件 IDA 16188939
GO:0007026 negative regulation of microtubule depolymerization IDA 11166179
GO:0009953 dorsal/ventral pattern formation IEA -
GO:0009952 前/后模式形成 IEA -
GO:0007050 细胞周期停滞 IDA 8521819
GO:0008285 negative regulation of cell proliferation IDA 8521819
GO:0009798 axis specification IEA -
GO:0006974 response to DNA damage stimulus IDA 14728717
GO:0045736 negative regulation of cyclin-dependent protein kinase activity IDA 8521819
GO:0051988 调节纺锤微管的附着 NAS 11283619
GO:0060070 Wnt受体信号通路通过β-catenin IC 9601641
GO:0060070 Wnt受体信号通路通过β-catenin NAS 11035805
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0000776 动力学 IDA 11283619
去：0005813 centrosome IDA 11283619
去：0005829 cytosol EXP 11955436|12000790|12820959
|15327769|16753179
GO:0005634 核 IDA 11035805|12955080
GO:0005737 细胞质 IDA 11035805|12955080
GO:0016328 lateral plasma membrane IDA 12072559
GO:0030877 beta-catenin destruction complex IDA 9601641|16188939

第四节。蛋白质蛋白相互作用注释

Interactors Aliases B Official full name B Experimental 资源 PubMed ID
APC BTPS2 | DP2 | DP2.5 | DP3 | GS 腺瘤息肉大肠杆菌 Affinity Capture-Western
Reconstituted Complex		 BioGRID 8389242|12070164
ARHGEF4 ASEF | ASEF1 | GEF4 | STM6 Rho guanine nucleotide exchange factor (GEF) 4 APC interacts with Asef. This interaction was modeled on a demonstrated interaction between human APC and Asef from an unspecified species. BIND 15572129
ARHGEF4 ASEF | ASEF1 | GEF4 | STM6 Rho guanine nucleotide exchange factor (GEF) 4 - HPRD,BioGRID 10947987
axin1 AXIN | MGC52315 axin 1 Reconstituted Complex
两个杂交		 BioGRID 9734785
axin1 AXIN | MGC52315 axin 1 - HPRD 11297546
axin2 轴|DKFZP781B0869 |MGC10366 |MGC126582 axin 2 - HPRD,BioGRID 10966653
bub1 bub1A | BUB1L | hBUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) - HPRD,BioGRID 11283619
bub1B bub1beta | BUBR1 | Bub1A | MAD3L | SSK1 | hBUBR1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) Biochemical Activity BioGRID 11283619
bub3 bub3L | hBUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) Affinity Capture-Western BioGRID 11283619
CDC20 CDC20A | MGC102824 | bA276H19.3 | p55CDC cell division cycle 20 homolog (S. cerevisiae) - HPRD 9637688|9811605
CSNK2A1 CK2A1 |CKII casein kinase 2, alpha 1 polypeptide Affinity Capture-Western
Reconstituted Complex		 BioGRID 11972058
CSNK2B CK2B |CK2N |CSK2B |g5a |MGC138222 |MGC138224 casein kinase 2, beta polypeptide Affinity Capture-Western BioGRID 11972058
CTBP1 BARS | MGC104684 C-terminal binding protein 1 CtBP interacts with APC. BIND 15525529
CTNNA1 CAP102 | FLJ36832 catenin (cadherin-associated protein), alpha 1, 102kDa Affinity Capture-Western BioGRID 7651399|8259519
CTNNB1 CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923 catenin (cadherin-associated protein), beta 1, 88kDa APC interacts with Beta-catenin. BIND 15525529
CTNNB1 CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923 catenin (cadherin-associated protein), beta 1, 88kDa - HPRD 12000790
CTNNB1 CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923 catenin (cadherin-associated protein), beta 1, 88kDa β-catenin与APC相互作用。这种相互作用是建立在人β-catenin和小鼠APC之间的相互作用上的建模的。 BIND 15294866
CTNNB1 CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923 catenin (cadherin-associated protein), beta 1, 88kDa Affinity Capture-Western
Co-crystal Structure
Far Western
Reconstituted Complex		 BioGRID 8259519|9286858
|11251183|11533658
|11707392|11712088
|11972058|12628243
DLG3 KIAA1232 | MRX | MRX90 | NE-Dlg | NEDLG | SAP102 discs, large homolog 3 (neuroendocrine-dlg, Drosophila) Affinity Capture-Western
Reconstituted Complex
两个杂交		 BioGRID 9188857
DLGAP1 DAP-1 | DAP-1-ALPHA | DAP-1-BETA | GKAP | MGC88156 | SAPAP1 | hGKAP discs, large (Drosophila) homolog-associated protein 1 - HPRD,BioGRID 9286858
GSK3B - glycogen synthase kinase 3 beta Affinity Capture-Western BioGRID 11251183
IQGAP1 HUMORFA01 | KIAA0051 | SAR1 | p195 IQ motif containing GTPase activating protein 1 APC interacts with IQGAP1. BIND 15572129
JUP ARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGB junction plakoglobin Affinity Capture-Western
Reconstituted Complex		 BioGRID 7651399|8074697
KIFAP3 FLJ22818 | KAP3 | SMAP | Smg-GDS | dJ190I16.1 kinesin-associated protein 3 - HPRD,BioGRID 11912492
MAD2L1 HSMAD2 | MAD2 MAD2 mitotic arrest deficient-like 1 (yeast) - HPRD,BioGRID 9637688
MAPRE1 EB1 | MGC117374 | MGC129946 microtubule-associated protein, RP/EB family, member 1 - HPRD,BioGRID 11470413|12388762
MAPRE2 EB1 | EB2 | RP1 microtubule-associated protein, RP/EB family, member 2 Affinity Capture-Western
Reconstituted Complex
两个杂交		 BioGRID 7606712|11470413
MUC1 CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUM mucin 1, cell surface associated Affinity Capture-Western BioGRID 15020226
PPP2R5A B56A | MGC131915 | PR61A 蛋白质磷酸酶2，调节亚基B'，α同工型 Co-localization BioGRID 11585828
PTK2 FADK | FAK | FAK1 | pp125FAK PTK2蛋白酪氨酸激酶2 - HPRD 7744883
PTPN13 DKFZp686J1497 | FAP-1 | PNP1 | PTP-BAS | PTP-BL | PTP1E | PTPL1 | PTPLE protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) Affinity Capture-Western
两个杂交		 BioGRID 10951583
RP1 DCDC4A | ORP1 retinitis pigmentosa 1 (autosomal dominant) - HPRD 10188731
SFN 是的 stratifin 亲和力捕获ms BioGRID 15778465
SIAH1 FLJ08065 | HUMSIAH | Siah-1 | Siah-1a | hSIAH1 缺席同源物1（果蝇）中有七个 - HPRD,BioGRID 11389840
TFAP2A AP-2 | AP-2alpha | AP2TF | BOFS | TFAP2 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) Affinity Capture-Western
Reconstituted Complex		 BioGRID 15331612
TUBA4A FLJ30169 | H2-ALPHA | TUBA1 微管蛋白，α4A Co-localization
Reconstituted Complex		 BioGRID 11166179
XPO1 CRM1 | DKFZp686B1823 exportin 1 (CRM1 homolog, yeast) Affinity Capture-Western
Reconstituted Complex		 BioGRID 12070164


V.途径注释

Pathway name Pathway size ＃szgr 2.0基因 Info
KEGG WNT SIGNALING PATHWAY 151 112 该途径中的所有SZGR 2.0基因
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 该途径中的所有SZGR 2.0基因
KEGG PATHWAYS IN CANCER 328 259 该途径中的所有SZGR 2.0基因
KEGG COLORECTAL CANCER 62 47 该途径中的所有SZGR 2.0基因
KEGG子宫内膜癌 52 45 该途径中的所有SZGR 2.0基因
KEGG基底细胞癌 55 44 该途径中的所有SZGR 2.0基因
BIOCARTA ALK PATHWAY 37 29 该途径中的所有SZGR 2.0基因
BIOCARTA GSK3 PATHWAY 27 26 该途径中的所有SZGR 2.0基因
BIOCARTA PITX2 PATHWAY 15 15 该途径中的所有SZGR 2.0基因
Biocarta PS1途径 14 14 该途径中的所有SZGR 2.0基因
BIOCARTA TGFB PATHWAY 19 14 该途径中的所有SZGR 2.0基因
BIOCARTA WNT PATHWAY 26 24 该途径中的所有SZGR 2.0基因
WNT SIGNALING 89 71 该途径中的所有SZGR 2.0基因
ST GRANULE CELL SURVIVAL PATHWAY 27 23 该途径中的所有SZGR 2.0基因
ST ADRENERGIC 36 29 该途径中的所有SZGR 2.0基因
ST WNT BETA CATENIN PATHWAY 34 28 该途径中的所有SZGR 2.0基因
ST MYOCYTE AD PATHWAY 27 25 该途径中的所有SZGR 2.0基因
PID BETA CATENIN DEG PATHWAY 18 17 该途径中的所有SZGR 2.0基因
PID MET PATHWAY 80 60 该途径中的所有SZGR 2.0基因
PID PS1 PATHWAY 46 39 该途径中的所有SZGR 2.0基因
PID CDC42 PATHWAY 70 51 该途径中的所有SZGR 2.0基因
PID CDC42 REG途径 30 22 该途径中的所有SZGR 2.0基因
PID WNT CANONICAL PATHWAY 20 18 该途径中的所有SZGR 2.0基因
PID P53下游途径 137 94 该途径中的所有SZGR 2.0基因
PID Beta Catenin nuc途径 80 60 该途径中的所有SZGR 2.0基因
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 40 26 该途径中的所有SZGR 2.0基因
Wnt的Reactome信号传导 65 41 该途径中的所有SZGR 2.0基因
REACTOME CTNNB1 PHOSPHORYLATION CASCADE 16 11 该途径中的所有SZGR 2.0基因
反应组凋亡 148 94 该途径中的所有SZGR 2.0基因
REACTOME APOPTOTIC EXECUTION PHASE 54 37 该途径中的所有SZGR 2.0基因
NAGASHIMA NRG1 SIGNALING DN 58 35 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 该途径中的所有SZGR 2.0基因
ENK UV RESPONSE EPIDERMIS DN 508 354 该途径中的所有SZGR 2.0基因
GAUSSMANN MLL AF4 FUSION TARGETS A UP 191 128 该途径中的所有SZGR 2.0基因
HAMAI APOPTOSIS VIA TRAIL UP 584 356 该途径中的所有SZGR 2.0基因
悍马皮肤癌进展 88 58 该途径中的所有SZGR 2.0基因
RASHI RESPONSE TO IONIZING RADIATION 3 48 31 该途径中的所有SZGR 2.0基因
MYLLYKANGAS AMPLIFICATION HOT SPOT 27 15 8 该途径中的所有SZGR 2.0基因
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 该途径中的所有SZGR 2.0基因
LIANG HEMATOPOIESIS STEM CELL NUMBER SMALL VS HUGE DN 33 22 该途径中的所有SZGR 2.0基因
PUJANA ATM PCC NETWORK 1442 892 该途径中的所有SZGR 2.0基因
BENPORATH MYC TARGETS WITH EBOX 230 156 该途径中的所有SZGR 2.0基因
GEORGES TARGETS OF MIR192 AND MIR215 893 528 该途径中的所有SZGR 2.0基因
SHEN SMARCA2 TARGETS UP 424 268 该途径中的所有SZGR 2.0基因
SHIN B CELL LYMPHOMA CLUSTER 7 27 22 该途径中的所有SZGR 2.0基因
DING LUNG CANCER MUTATED SIGNIFICANTLY 26 22 该途径中的所有SZGR 2.0基因
丁肺癌经常突变 12 10 该途径中的所有SZGR 2.0基因
ASTON MAJOR DEPRESSIVE DISORDER UP 49 36 该途径中的所有SZGR 2.0基因
FERNANDEZ BOUND BY MYC 182 116 该途径中的所有SZGR 2.0基因
Zhan多发性骨髓瘤 64 46 该途径中的所有SZGR 2.0基因
HOEGERKORP CD44 TARGETS DIRECT DN 14 7 该途径中的所有SZGR 2.0基因
WEIGEL OXIDATIVE STRESS BY HNE AND H2O2 39 29 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE DN 1237 837 该途径中的所有SZGR 2.0基因
Verrecchia对TGFB1的早期反应 58 43 该途径中的所有SZGR 2.0基因
伊万诺娃造血干细胞短期 32 15 该途径中的所有SZGR 2.0基因
LEE AGING CEREBELLUM UP 84 58 该途径中的所有SZGR 2.0基因
CHANG IMMORTALIZED BY HPV31 UP 84 55 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN 165 106 该途径中的所有SZGR 2.0基因
VERRECCHIA RESPONSE TO TGFB1 C3 14 10 该途径中的所有SZGR 2.0基因
LOPES METHYLATED IN COLON CANCER DN 28 26 该途径中的所有SZGR 2.0基因
RIZKI TUMOR INVASIVENESS 3D UP 210 124 该途径中的所有SZGR 2.0基因
DE YY1 TARGETS DN 92 64 该途径中的所有SZGR 2.0基因
HOQUE METHYLATED IN CANCER 56 45 该途径中的所有SZGR 2.0基因
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 该途径中的所有SZGR 2.0基因
BLUM RESPONSE TO SALIRASIB DN 342 220 该途径中的所有SZGR 2.0基因
GRESHOCK CANCER COPY NUMBER UP 323 240 该途径中的所有SZGR 2.0基因
BOYLAN MULTIPLE MYELOMA C CLUSTER UP 38 26 该途径中的所有SZGR 2.0基因
Yoshimura mapk8靶向 1305 895 该途径中的所有SZGR 2.0基因
ZHANG TLX TARGETS 36HR DN 185 116 该途径中的所有SZGR 2.0基因
MILI PSEUDOPODIA 43 27 该途径中的所有SZGR 2.0基因
MILI PSEUDOPODIA CHEMOTAXIS UP 74 45 该途径中的所有SZGR 2.0基因
米利伪足HAPTOTAXIS UP 518 299 该途径中的所有SZGR 2.0基因
LI PROSTATE CANCER EPIGENETIC 30 22 该途径中的所有SZGR 2.0基因
BOYLAN MULTIPLE MYELOMA PCA3 DN 69 38 该途径中的所有SZGR 2.0基因
DANG BOUND BY MYC 1103 714 该途径中的所有SZGR 2.0基因
GABRIELY MIR21 TARGETS 289 187 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position mirna id miRNA seq
UTR start UTR end Match method
mir-125/351 382 388 1A HSA-MIR-125B脑 UCCCUGAGACCCUAACUUGUGA
HSA-MIR-125A脑 UCCCUGAGACCCUUUAACCUGUG
miR-129-5p 404 411 1A,m8 hsa-miR-129脑 CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-142-3p 310 317 1A,m8 hsa-miR-142-3p uguaguuuccuacuuuaugga
mir-153 961 967 m8 hsa-miR-153 Uugcauagucacaaaaguga
hsa-miR-153 Uugcauagucacaaaaguga
mir-155 965 971 1A hsa-miR-155 UUAAUGCUAAUCGUGAUAGGGG
miR-203.1 822 829 1A,m8 HSA-MIR-203 UGAAAUGUUUAGGACCACUAG
miR-26 1248 1255 1A,m8 hsa-miR-26a脑 UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ uucaaguaauucaggauagguu
miR-27 462 468 1A hsa-miR-27a脑 UUCACAGUGGCUAAGUUCCGC
hsa-miR-27b脑 UUCACAGUGGCUAAGUUCUGC
miR-30-3p 859 865 m8 hsa-miR-30a-3p CUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3p CUUUCAGUCGGAUGUUUACAGC
miR-330 511 517 m8 HSA-MIR-330脑 GCAAAGCACGGCCUGCAGAGA
mir-374 359 365 1A hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
mir-381 741 747 1A hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-448 401 407 1A HSA-MIR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-450 404 410 1A HSA-MIR-450 UUUUUGCGAUGUGUUCCUAAUA
mir-496 847 853 1A hsa-miR-496 AUUACAUGGCCAAUCUC