Gene Page:APCS
Summary?
| GeneID | 325 |
| Symbol | APCS |
| Synonyms | HEL-S-92n|PTX2|SAP |
| Description | amyloid P component, serum |
| Reference | MIM:104770|HGNC:HGNC:584|Ensembl:ENSG00000132703|HPRD:00101|Vega:OTTHUMG00000022741 |
| Gene type | protein-coding |
| Map location | 1q21-q23 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | 系统搜索PubMed co-o基因ccurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.0235 | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.00814 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ILF2 | 0.97 | 0.96 |
| EIF3F | 0.97 | 0.95 |
| QARS | 0.96 | 0.95 |
| EIF3L | 0.96 | 0.95 |
| EIF3D | 0.96 | 0.93 |
| SNRNP40 | 0.96 | 0.93 |
| NUP88 | 0.96 | 0.94 |
| PCBP2 | 0.96 | 0.94 |
| RBMX | 0.95 | 0.94 |
| SSR2 | 0.95 | 0.94 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.27 | -0.70 | -0.88 |
| AF347015.33 | -0.69 | -0.89 |
| HLA-F | -0.69 | -0.78 |
| AF347015.31 | -0.69 | -0.85 |
| MT-CO2 | -0.69 | -0.86 |
| MT-CYB | -0.69 | -0.88 |
| AIFM3 | -0.68 | -0.77 |
| AF347015.8 | -0.67 | -0.88 |
| C5orf53 | -0.67 | -0.73 |
| AF347015.15 | -0.66 | -0.88 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005529 | sugar binding | IEA | - | |
| GO:0005509 | calcium ion binding | IEA | - | |
| GO:0051082 | unfolded protein binding | TAS | 10812074 | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0006457 | protein folding | TAS | 10812074 | |
| GO:0006953 | acute-phase response | TAS | 2987268 | |
| GO:0051131 | chaperone-mediated protein complex assembly | TAS | 10972085 | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005576 | extracellular region | NAS | 14718574 | |
| GO:0005615 | extracellular space | TAS | 10972085 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME AMYLOIDS | 83 | 63 | All SZGR 2.0 genes in this pathway |
| FUJIWARA PARK2 HEPATOCYTE PROLIFERATION UP | 10 | 8 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER ACOX1 UP | 64 | 40 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER CIPROFIBRATE UP | 60 | 42 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER DENA UP | 60 | 40 | All SZGR 2.0 genes in this pathway |
| HSIAO LIVER SPECIFIC GENES | 244 | 154 | All SZGR 2.0 genes in this pathway |
| SU LIVER | 55 | 32 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER WITH H3K27ME3 DN | 228 | 114 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER SURVIVAL UP | 185 | 112 | All SZGR 2.0 genes in this pathway |
| CHEN LIVER METABOLISM QTL CIS | 93 | 40 | All SZGR 2.0 genes in this pathway |
| YAMASHITA LIVER CANCER STEM CELL DN | 76 | 51 | All SZGR 2.0 genes in this pathway |
| HOSHIDA LIVER CANCER SUBCLASS S3 | 266 | 180 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA CLASSES DN | 210 | 141 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA POOR SURVIVAL | 16 | 9 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |
| SERVITJA LIVER HNF1A TARGETS DN | 157 | 105 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |