Gene Page:APEH

Summary?
GeneID 327
Symbol APEH
Synonyms AARE|ACPH|APH|D3F15S2|D3S48E|DNF15S2|OPH
Description acylaminoacyl-peptide hydrolase
Reference MIM:102645|HGNC:HGNC:586|Ensembl:ENSG00000164062|HPRD:00034|织女:OTTHUMG00000156882
Gene type protein-coding
Map location 3p21.31
Pascal p-value 0.041
Sherlock p-value 0.988
Fetal beta -0.594
DMG 1 (# studies)
eGene Cortex

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg00904548 3 49720819 APEH 2.488E-4 0.469 0.037 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AK5 0.74 0.82
HPCAL4 0.73 0.73
RNF128 0.72 0.78
ARL1 0.71 0.75
ATP6V1C1 0.71 0.74
DGKG 0.71 0.70
IDH3A 0.71 0.74
MAP2K1 0.71 0.74
FAM69A 0.71 0.73
CAPS2 0.70 0.70
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SH2B2 -0.45 -0.52
SH3BP2 -0.43 -0.49
CARHSP1 -0.43 -0.50
SH2D2A -0.43 -0.49
EIF4EBP1 -0.43 -0.50
TRAF4 -0.43 -0.51
RPL28 -0.43 -0.54
IGFBP2 -0.43 -0.42
BCL7C -0.42 -0.54
KIAA1949 -0.42 -0.40

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004252 serine-type endopeptidase activity TAS glutamate (GO term level: 7) 2006156
GO:0016787 hydrolase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006508 proteolysis IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
GAZDA DIAMOND BLACKFAN ANEMIA PROGENITOR DN 66 42 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473 314 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS UP 135 82 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459 276 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293 179 All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544 307 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841 431 All SZGR 2.0 genes in this pathway
LI DCP2 BOUND MRNA 89 57 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway