Gene Page:PRMT2

概括?
基因 3275
Symbol PRMT2
Synonyms HRMT1L1
Description protein arginine methyltransferase 2
Reference MIM:601961|HGNC:HGNC:5186|Ensembl:ENSG00000160310|HPRD:09060|Vega：Otthumg0000000048806
Gene type protein-coding
Map location 21q22.3
Pascal p-value 0.102
Sherlock p-value 0.948
Fetal beta 1.009
DMG 2 (# studies)
eGene 元

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg13271076 21 48055715 PRMT2 -0.019 0.92 DMG:Nishioka_2013
cg04493422 21 48055366 PRMT2 8.18E-9 -0.011 3.87E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception凌晨ks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SCP2 0.80 0.74
HSP90B1 0.80 0.76
NBR1 0.79 0.75
HSPA9 0.79 0.72
KDSR 0.78 0.74
加尔克 0.78 0.75
COPB2 0.78 0.71
MUT 0.77 0.71
C20orf43 0.77 0.69
CANX 0.77 0.72
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.57 -0.36
IL32 -0.51 -0.36
IFI27 -0.49 -0.37
AL022328.1 -0.46 -0.33
MT-CO2 -0.46 -0.37
C1orf61 -0.45 -0.29
C1orf54 -0.45 -0.24
AF347015.31 -0.45 -0.37
clec2b -0.44 -0.21
CXCL14 -0.44 -0.34

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
BAT2 D6S51 | D6S51E | DKFZp686D09175 | G2 HLA-B associated transcript 2 - HPRD,BioGRID 14667819
DMRTB1 - DMRT-like family B with proline-rich C-terminal, 1 两个杂交 BioGRID 16189514
ESR1 DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 雌激素受体1 Affinity Capture-Western
Reconstituted Complex		 BioGRID 12039952
ESR1 DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 雌激素受体1 PRMT2 interacts with ER-alpha. BIND 12039952
ESR2 ER-BETA | ESR-BETA | ESRB | ESTRB | Erb | NR3A2 estrogen receptor 2 (ER beta) PRMT2 interacts with ER-beta. BIND 12039952
FLJ12529 FLJ39024 | MGC9315 pre-mRNA cleavage factor I, 59 kDa subunit 两个杂交 BioGRID 16189514
HNRNPUL1 E1B-AP5 | E1BAP5 | FLJ12944 | HNRPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 - HPRD,BioGRID 11513728
NCOA1 F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42 nuclear receptor coactivator 1 PRMT2 interacts with SRC-1. BIND 12039952
NCOA6 AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBP nuclear receptor coactivator 6 PRMT2 interacts with PRIP. BIND 12039952
PGR NR3C3 | PR progesterone receptor PRMT2 interacts with PR. BIND 12039952
PPARG NR1C3 | PPARG1 | PPARG2 | PPARgamma peroxisome proliferator-activated receptor gamma PRMT2 interacts with PPAR-gamma. BIND 12039952
PRMT2 HRMT1L1 | MGC111373 protein arginine methyltransferase 2 PRMT2 interacts with itself. BIND 12039952
RARA NR1B1 | RAR retinoic acid receptor, alpha PRMT2 interacts with RAR. BIND 12039952
RXRA FLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1 retinoid X receptor, alpha PRMT2 interacts with RXR-alpha. BIND 12039952
THRB Erba-Beta |erba2 |Grth |MGC126109 |MGC126110 |NR1A2 |prth |thr1 |thrb1 |thrb2 thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) PRMT2 interacts with TR-beta. BIND 12039952


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
DAVICIONI MOLECULAR ARMS VS ERMS UP 332 228 该途径中的所有SZGR 2.0基因
THUM SYSTOLIC HEART FAILURE UP 423 283 该途径中的所有SZGR 2.0基因
OSMAN BLADDER CANCER DN 406 230 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 该途径中的所有SZGR 2.0基因
HAHTOLA MYCOSIS FUNGOIDES CD4 DN 116 71 该途径中的所有SZGR 2.0基因
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 该途径中的所有SZGR 2.0基因
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 该途径中的所有SZGR 2.0基因
PUJANA ATM PCC NETWORK 1442 892 该途径中的所有SZGR 2.0基因
NUYTTEN NIPP1 TARGETS DN 848 527 该途径中的所有SZGR 2.0基因
ONDER CDH1 TARGETS 2 UP 256 159 该途径中的所有SZGR 2.0基因
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225 163 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE UP 1691年 1088 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 48HR DN 504 323 该途径中的所有SZGR 2.0基因
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 该途径中的所有SZGR 2.0基因
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 该途径中的所有SZGR 2.0基因
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 该途径中的所有SZGR 2.0基因
Creighton内分泌疗法抗性1 528 324 该途径中的所有SZGR 2.0基因
Acevedo肝癌，H3K27me3 UP 295 149 该途径中的所有SZGR 2.0基因
Lee Liver Cancer生存DN 175 103 该途径中的所有SZGR 2.0基因
AGUIRRE PANCREATIC CANCER COPY NUMBER DN 238 145 该途径中的所有SZGR 2.0基因
LEE EARLY T LYMPHOCYTE DN 57 36 该途径中的所有SZGR 2.0基因
ZHANG TLX TARGETS 36HR UP 221 150 该途径中的所有SZGR 2.0基因
ZHANG TLX TARGETS 60HR UP 293 203 该途径中的所有SZGR 2.0基因
ZHANG TLX TARGETS UP 108 78 该途径中的所有SZGR 2.0基因
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317 177 该途径中的所有SZGR 2.0基因
CHEN METABOLIC SYNDROM NETWORK 1210 725 该途径中的所有SZGR 2.0基因
LI INDUCED T TO NATURAL KILLER UP 307 182 该途径中的所有SZGR 2.0基因
CERIBELLI GENES INACTIVE AND BOUND BY NFY 45 27 该途径中的所有SZGR 2.0基因