Gene Page:HES1

Summary?
GeneID 3280
Symbol HES1
Synonyms HES-1|HHL|HRY|bHLHb39
Description hes family bHLH transcription factor 1
Reference MIM:139605|HGNC:HGNC:5192|Ensembl:ENSG00000114315|HPRD:00770|Vega:OTTHUMG00000155984
Gene type protein-coding
Map location 3q28-q29
Pascal p-value 0.151
Sherlock p-value 0.298
Fetal beta 1.462
DMG 2 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Montano_2016 Genome-wide DNA methylation analysis This dataset includes 172 replicated associations between CpGs with schizophrenia. 2
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance与Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 3

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg23542902 3 193807749 HES1 1.73E-5 -0.005 0.059 DMG:Montano_2016
cg04539944 3 193852359 HES1 1.16E-9 -0.023 1.25E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10521889 chrX 149836861 HES1 3280 0.13 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
BIN1 0.81 0.81
PNPLA6 0.81 0.79
DGKQ 0.78 0.83
MAPK8IP3 0.77 0.75
ABCF3 0.77 0.77
SIRT3 0.77 0.78
RANGAP1 0.77 0.75
RILPL1 0.76 0.76
MINK1 0.76 0.78
COG1 0.76 0.76
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GNG11 -0.51 -0.43
CLEC2B -0.47 -0.29
C1orf54 -0.45 -0.28
AF347015.21 -0.45 -0.23
IL32 -0.44 -0.38
AL050337.1 -0.44 -0.27
C1orf61 -0.44 -0.30
FAM159B -0.42 -0.50
SYCP3 -0.42 -0.29
NOSTRIN -0.40 -0.24

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003677 DNA binding TAS 7906273
GO:0016564 transcription repressor activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
: 0042668 auditory receptor cell fate determination IEA neuron (GO term level: 13) -
: 0045665 negative regulation of neuron differentiation IEA neuron (GO term level: 10) -
GO:0007399 nervous system development TAS neurite (GO term level: 5) 8020957
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA -
GO:0001889 liver development IEA -
GO:0006355 regulation of transcription, DNA-dependent IEA -
GO:0007155 cell adhesion IEA -
GO:0008284 positive regulation of cell proliferation IEA -
: 0048469 cell maturation IEA -
GO:0021983 pituitary gland development IEA -
GO:0030324 lung development IEA -
: 0045165 cell fate commitment IEA -
: 0045608 negative regulation of auditory receptor cell differentiation IEA -
: 0048505 regulation of timing of cell differentiation IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -
GO:0005737 cytoplasm IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG NOTCH SIGNALING PATHWAY 47 35 All SZGR 2.0 genes in this pathway
KEGG MATURITY ONSET DIABETES OF THE YOUNG 25 19 All SZGR 2.0 genes in this pathway
PID FANCONI PATHWAY 47 28 All SZGR 2.0 genes in this pathway
PID ATF2 PATHWAY 59 43 All SZGR 2.0 genes in this pathway
PID CMYB PATHWAY 84 61 All SZGR 2.0 genes in this pathway
PID DELTA NP63 PATHWAY 47 34 All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY 48 39 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 46 28 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH1 70 46 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF BETA CELL DEVELOPMENT 30 23 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH 103 64 All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255 177 All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS DN 384 230 All SZGR 2.0 genes in this pathway
SLEBOS HEAD AND NECK CANCER WITH HPV UP 84 43 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329 219 All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING UP 176 123 All SZGR 2.0 genes in this pathway
NAGASHIMA EGF SIGNALING UP 58 40 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459 276 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 All SZGR 2.0 genes in this pathway
LIU CDX2 TARGETS DN 8 5 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS UP 169 127 All SZGR 2.0 genes in this pathway
LUI THYROID CANCER CLUSTER 1 51 33 All SZGR 2.0 genes in this pathway
LUND SILENCED BY METHYLATION 16 12 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM1 229 137 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP 209 139 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS UP 127 79 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411 249 All SZGR 2.0 genes in this pathway
AMIT DELAYED EARLY GENES 18 15 All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230 156 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 40 HELA 42 29 All SZGR 2.0 genes in this pathway
AMIT EGF反应60海拉 46 32 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 60 MCF10A 39 24 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT UP 197 110 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398 262 All SZGR 2.0 genes in this pathway
SHIPP DLBCL VS FOLLICULAR LYMPHOMA DN 45 28 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207 145 All SZGR 2.0 genes in this pathway
NAKAJIMA EOSINOPHIL 30 20 All SZGR 2.0 genes in this pathway
ZHANG TARGETS OF EWSR1 FLI1 FUSION 88 68 All SZGR 2.0 genes in this pathway
HALMOS CEBPA TARGETS DN 46 26 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240 152 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM 302 191 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156 101 All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC UP 202 115 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C5 46 36 All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION MUSCLE DN 51 28 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317 208 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461 298 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430 288 All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP 174 96 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439 257 All SZGR 2.0 genes in this pathway
BUCKANOVICH T LYMPHOCYTE HOMING ON TUMOR DN 24 16 All SZGR 2.0 genes in this pathway
BOHN原发性免疫缺陷症侯群DN 40 31 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163 102 All SZGR 2.0 genes in this pathway
HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE UP 70 49 All SZGR 2.0 genes in this pathway
HOFFMANN IMMATURE TO MATURE B LYMPHOCYTE DN 50 36 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
CROONQUIST NRAS VS STROMAL STIMULATION DN 99 65 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G6 DN 19 13 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 DN 45 30 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 9 76 45 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841 431 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
FUKUSHIMA TNFSF11 TARGETS 16 14 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 1HR UP 34 26 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337 236 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517 302 All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222 159 All SZGR 2.0 genes in this pathway
ZWANG EGF INTERVAL DN 214 124 All SZGR 2.0 genes in this pathway