SZGR2 - Beplay体育中心

概括?

基因	3297
象征	HSF1
Synonyms	HSTF1
Description	heat shock transcription factor 1
Reference	MIM:140580\|HGNC:HGNC:5224\|ENSEMBL：ENSG00000185122\|HPRD:00778\|Vega：Otthumg00000174604
Gene type	protein-coding
Map location	8Q24.3
Pascal p-value	0.39
Sherlock p-value	0.32
Fetal beta	0.147

数据源中的基因

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学	High-throughput literature-search	与精神分裂症关键词共同存在：精神分裂症，精神分裂症	Click to show details

第一节遗传学和表观遗传学注释

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

第四节。蛋白质蛋白相互作用注释

Interactors	Aliases B	Official full name B	Experimental	资源	PubMed ID
CEBPB	C/EBP-beta \| CRP2 \| IL6DBP \| LAP \| MGC32080 \| NF-IL6 \| TCF5	CCAAT/增强子结合蛋白（C/EBP），β	-	HPRD,BioGRID	11801594
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	HSF1 interacts with CBP. This interaction was modeled on a demonstrated interaction between human HSF1 and CBP from an unspecified species.	BIND	14960326
DNAJB1	HSPF1 \| Hdj1 \| Hsp40 \| Sis1	DnaJ (Hsp40) homolog, subfamily B, member 1	-	HPRD,BioGRID	9499401
ENO2	NSE	enolase 2 (gamma, neuronal)	两个杂交	BioGRID	16169070
FKBP4	FKBP52 \|FKBP59 \|HBI \|HSP56 \|PPIASE \|p52	FK506 binding protein 4, 59kDa	Reconstituted Complex	BioGRID	9222609
FKBP5	FKBP51 \|FKBP54 \|MGC111006 \|p54 \|PPIASE \|PTG-10	FK506结合蛋白5	Reconstituted Complex	BioGRID	9222609
GTF2A2	HsT18745 \| TF2A2 \| TFIIA	general transcription factor IIA, 2, 12kDa	-	HPRD	11005381
GTF2B	TF2B \| TFIIB	general transcription factor IIB	Reconstituted Complex	BioGRID	11005381
HSBP1	DKFZp686D1664 \| DKFZp686O24200 \| NPC-A-13	热休克因子结合蛋白1	in vitro in vivo 两个杂交	BioGRID	9649501
HSF2	MGC117376 \| MGC156196 \| MGC75048	heat shock transcription factor 2	-	HPRD,BioGRID	12813038
HSP90AA1	FLJ31884 \|HSP86 \|HSP89A \|HSP90A \|HSP90N \|HSPC1 \|HSPCA \|HSPCAL1 \|HSPCAL4 \|HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	Affinity Capture-Western Reconstituted Complex	BioGRID	9222609\|12621024
HSPA1A	FLJ54303 \| FLJ54370 \| FLJ54392 \| FLJ54408 \| FLJ75127 \| HSP70-1 \| HSP70-1A \| HSP70I \| HSP72 \| HSPA1 \| HSPA1B	热休克70KDA蛋白1A	-	HPRD,BioGRID	9699716
HSPA4	APG-2 \| HS24/P52 \| MGC131852 \| RY \| hsp70 \| hsp70RY	heat shock 70kDa protein 4	Reconstituted Complex	BioGRID	1628823\|9222609
HSPA8	HSC54 \| HSC70 \| HSC71 \| HSP71 \| HSP73 \| HSPA10 \| LAP1 \| MGC131511 \| MGC29929 \| NIP71	heat shock 70kDa protein 8	-	HPRD,BioGRID	7639722
MAPK3	ERK1 \| HS44KDAP \| HUMKER1A\| MGC20180 \| P44ERK1 \| P44MAPK \| PRKM3	mitogen-activated protein kinase 3	ERK1与HSF-1相互作用并磷酸化。	BIND	9155018
MAPK9	JNK-55 \| JNK2 \| JNK2A \| JNK2ALPHA \| JNK2B \| JNK2BETA \| PRKM9 \| SAPK \| p54a \| p54aSAPK	mitogen-activated protein kinase 9	-	HPRD,BioGRID	11527157
NCOA6	AIB3 \| ANTP \| ASC2 \| HOX1.1 \| HOXA7 \| KIAA0181 \| NRC \| PRIP \| RAP250 \| TRBP	nuclear receptor coactivator 6	Affinity Capture-Western Co-localization	BioGRID	14960326
NCOA6	AIB3 \| ANTP \| ASC2 \| HOX1.1 \| HOXA7 \| KIAA0181 \| NRC \| PRIP \| RAP250 \| TRBP	nuclear receptor coactivator 6	ASC-2 interacts with HSF1.	BIND	14960326
PPID	CYP-40 \| CYPD \| MGC33096	peptidylprolyl isomerase D	Reconstituted Complex	BioGRID	9222609
PRKDC	DNA-PKcs \| DNAPK \| DNPK1 \| HYRC \| HYRC1 \| XRCC7 \| p350	蛋白激酶，DNA激活，催化多肽	in vitro	BioGRID	9325337
PTGES3	P23 \| TEBP \| cPGES	prostaglandin E synthase 3 (cytosolic)	Reconstituted Complex	BioGRID	9222609
RALBP1	RIP1 \| RLIP1 \| RLIP76	ralA binding protein 1	Affinity Capture-Western Reconstituted Complex 两个杂交	BioGRID	12621024
SMARCA4	BAF190 \|BRG1 \|FLJ39786 \|SNF2 \|snf2-beta \|snf2l4 \|SNF2LB \|swi2 \|HSNF2B	SWI/SNF相关，矩阵相关，染色质的肌动蛋白依赖性调节剂，亚家族A，成员4	Affinity Capture-Western in vitro	BioGRID	8856972\|11486022
SMARCA4	BAF190 \|BRG1 \|FLJ39786 \|SNF2 \|snf2-beta \|snf2l4 \|SNF2LB \|swi2 \|HSNF2B	SWI/SNF相关，矩阵相关，染色质的肌动蛋白依赖性调节剂，亚家族A，成员4	-	HPRD	8856972\|9222609 \|11486022
SMARCB1	BAF47 \| INI1 \| RDT \| SNF5 \| SNF5L1 \| Sfh1p \| Snr1 \| hSNFS	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	共同分级	BioGRID	11486022
STAT1	DKFZp686B04100 \| ISGF-3 \| STAT91	signal transducer and activator of transcription 1, 91kDa	-	HPRD,BioGRID	9880553
SUB1	MGC102747 \| P15 \| PC4 \| p14	Sub1同源物（S. cerevisiae）	-	HPRD	11005381
SYMPK	FLJ27092 \| SPK \| SYM	symplekin	-	HPRD,BioGRID	14707147
TAF1	BA2R \| CCG1 \| CCGS \| DYT3 \| KAT4 \| N-TAF1 \| NSCL2 \| OF \| P250 \| TAF2A \| TAFII250	TAF1RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	-	HPRD	11005381
TAF9	AD-004 \|AK6 \|CGI-137 \|电影院\|cip \|MGC1603 \|MGC3647 \|MGC5067 \|MGC：1603 \|MGC：3647 \| MGC:5067 \| TAF2G \| TAFII31 \| TAFII32 \| TAFIID32	TAF9RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa	-	HPRD	11005381
TAF9	AD-004 \|AK6 \|CGI-137 \|电影院\|cip \|MGC1603 \|MGC3647 \|MGC5067 \|MGC：1603 \|MGC：3647 \| MGC:5067 \| TAF2G \| TAFII31 \| TAFII32 \| TAFIID32	TAF9RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa	-	HPRD	10821850
TBP	gtf2d \|GTF2D1 \|MGC117320 \|MGC126054 \|MGC126055 \|SCA17 \|tfiid	塔塔盒结合蛋白	-	HPRD,BioGRID	11005381
XRCC5	FLJ39089 \| KARP-1 \| KARP1 \| KU80 \| KUB2 \| Ku86 \| NFIV	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	in vitro	BioGRID	9325337
XRCC6	CTC75 \| CTCBF \| G22P1 \| KU70 \| ML8 \| TLAA	X-ray repair complementing defective repair in Chinese hamster cells 6	-	HPRD,BioGRID	11162511

V.途径注释

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PID P73PATHWAY	79	59	该途径中的所有SZGR 2.0基因
GARY CD5 TARGETS UP	473	314	该途径中的所有SZGR 2.0基因
ZHOU INFLAMMATORY RESPONSE LIVE DN	384	220	该途径中的所有SZGR 2.0基因
TIMOFEEVA GROWTH STRESS VIA STAT1 DN	16	12	该途径中的所有SZGR 2.0基因
SENESE HDAC1 TARGETS UP	457	269	该途径中的所有SZGR 2.0基因
SENESE HDAC1 AND HDAC2 TARGETS UP	238	144	该途径中的所有SZGR 2.0基因
SENESE HDAC2 TARGETS UP	114	66	该途径中的所有SZGR 2.0基因
Senese HDAC3靶向	501	327	该途径中的所有SZGR 2.0基因
Elvidge缺氧DN	146	94	该途径中的所有SZGR 2.0基因
RIZ ERYTHROID DIFFERENTIATION	77	51	该途径中的所有SZGR 2.0基因
TURJANSKI MAPK8 AND MAPK9 TARGETS	8	7	该途径中的所有SZGR 2.0基因
GROSS HYPOXIA VIA HIF1A UP	77	49	该途径中的所有SZGR 2.0基因
BENPORATH ES CORE NINE CORRELATED	100	68	该途径中的所有SZGR 2.0基因
NIKOLSKY BREAST CANCER 8Q23 Q24 AMPLICON	157	87	该途径中的所有SZGR 2.0基因
MUNSHI MULTIPLE MYELOMA DN	11	6	该途径中的所有SZGR 2.0基因
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	该途径中的所有SZGR 2.0基因
WELCSH BRCA1 TARGETS DN	141	92	该途径中的所有SZGR 2.0基因
MATZUK MATERNAL EFFECT	9	8	该途径中的所有SZGR 2.0基因
MATZUK POST-IMPLANTATION AND POST-PARTUM	14	13	该途径中的所有SZGR 2.0基因
MATZUK SPERMATOCYTE	72	55	该途径中的所有SZGR 2.0基因
开罗肝母细胞瘤上课	605	377	该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE LATE	1137	655	该途径中的所有SZGR 2.0基因
FEVR CTNNB1 TARGETS DN	553	343	该途径中的所有SZGR 2.0基因

Gene Page:HSF1