Gene Page:DNAJA1

Summary?
GeneID 3301
Symbol DNAJA1
Synonyms DJ-2|DjA1|HDJ2|HSDJ|HSJ-2|HSJ2|HSPF4|NEDD7|hDJ-2
Description DnaJ heat shock protein family (Hsp40) member A1
Reference MIM:602837|HGNC:HGNC:5229|HPRD:04159|
Gene type protein-coding
Map location 9p13.3
Pascal p-value 0.019
Sherlock p-value 0.268
eGene Myers' cis & trans
Support RNA AND PROTEIN SYNTHESIS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
Expression Meta-analysis of gene expression Pvalue: 2.107

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs13350793 0 DNAJA1 3301 0.12 trans
rs10848708 chr12 2931451 DNAJA1 3301 0.03 trans
rs2286601 chr12 2932176 DNAJA1 3301 0.09 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene 皮尔森的相关性 Spearman's Correlation
NFYA 0.95 0.90
FAM117B 0.95 0.97
VANGL2 0.95 0.88
VASH2 0.95 0.91
MLLT4 0.95 0.95
KDM5B 0.95 0.96
USP6NL 0.94 0.96
AUTS2 0.94 0.93
SLCO5A1 0.94 0.91
EPHB1 0.94 0.84
Top 10 negatively co-expressed genes
Gene 皮尔森的相关性 Spearman's Correlation
C5orf53 -0.64 -0.82
SERPINB6 -0.63 -0.78
HLA-F -0.63 -0.84
LHPP -0.63 -0.65
TNFSF12 -0.63 -0.69
FBXO2 -0.62 -0.67
AIFM3 -0.62 -0.82
ALDOC -0.62 -0.76
HEPN1 -0.62 -0.82
PTH1R -0.61 -0.75

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0008270 zinc ion binding IEA -
GO:0031072 heat shock protein binding IEA -
GO:0051082 unfolded protein binding IEA -
GO:0046872 metal ion binding IEA -
GO:0050750 low-density lipoprotein receptor binding IDA 15082773
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006457 protein folding IEA -
GO:0006457 protein folding TAS 8334160
GO:0007283 spermatogenesis IEA -
GO:0006986 response to unfolded protein TAS 8334160
GO:0030317 sperm motility IEA -
GO:0030521 androgen receptor signaling pathway IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005856 cytoskeleton IDA 18029348
GO:0005737 cytoplasm IDA 18029348
GO:0016020 membrane IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ARL4D ARF4L | ARL6 ADP-ribosylation factor-like 4D Two-hybrid BioGRID 16169070
CD58 LFA-3 | LFA3 CD58 molecule Two-hybrid BioGRID 16169070
CFTR ABC35 | ABCC7 | CF | CFTR/MRP | MRP7 | TNR-CFTR | dJ760C5.1 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) - HPRD,BioGRID 10075921
HSPA8 HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71 heat shock 70kDa protein 8 - HPRD,BioGRID 10075921
MAP3K7 TAK1 | TGF1a mitogen-activated protein kinase kinase kinase 7 - HPRD 14743216
MAP3K7IP2 FLJ21885 | KIAA0733 | TAB2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2 - HPRD 14743216
OSGEP FLJ20411 | GCPL1 | KAE1 | OSGEP1 | PRSMG1 O-sialoglycoprotein endopeptidase Affinity Capture-MS BioGRID 17353931
PTTG1 EAP1 | HPTTG | MGC126883 | MGC138276 | PTTG | TUTR1 pituitary tumor-transforming 1 - HPRD,BioGRID 9915854
TH1L HSPC130 | NELF-C | NELF-D | TH1 TH1-like (Drosophila) Two-hybrid BioGRID 16169070
TM4SF1 H-L6 | L6 | M3S1 | TAAL6 transmembrane 4 L six family member 1 Two-hybrid BioGRID 16169070
TRADD Hs.89862 | MGC11078 TNFRSF1A-associated via death domain - HPRD 14743216
UQCRC1 D3S3191 | QCR1 | UQCR1 ubiquinol-cytochrome c reductase core protein I Affinity Capture-MS BioGRID 17353931


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID AR TF PATHWAY 53 38 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431 263 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305 185 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS MAGENTA UP 28 18 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP 136 80 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557 331 All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA DN 146 94 All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A TARGETS UP 67 40 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
绿草ESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
LUI THYROID CANCER PAX8 PPARG DN 45 29 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
LUI TARGETS OF PAX8 PPARG FUSION 34 23 All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217 143 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
LIANG HEMATOPOIESIS STEM CELL NUMBER SMALL VS HUGE DN 33 22 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC DN 31 23 All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 8HR 5 DN 11 8 All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN 81 51 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN 169 102 All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN 187 122 All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK 169 111 All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP 83 56 All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN 169 112 All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN 245 154 All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337 230 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318 215 All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP 151 103 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240 152 All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA UP 71 49 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
HU GENOTOXIC DAMAGE 24HR 35 22 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP 105 73 All SZGR 2.0 genes in this pathway
APRELIKOVA BRCA1 TARGETS 49 33 All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP 120 89 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C0 107 72 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN 165 106 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR UP 47 39 All SZGR 2.0 genes in this pathway
KYNG RESPONSE TO H2O2 71 42 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA AND UV RADIATION 88 65 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195 135 All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354 216 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425 253 All SZGR 2.0 genes in this pathway
MATZUK MALE REPRODUCTION SERTOLI 28 23 All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL UP 51 32 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN 193 112 All SZGR 2.0 genes in this pathway
WINNEPENNINCKX MELANOMA METASTASIS UP 162 86 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 M 216 124 All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS DN 207 139 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374 217 All SZGR 2.0 genes in this pathway
GUO TARGETS OF IRS1 AND IRS2 98 67 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family 目标位置 miRNA ID miRNA seq
UTR start UTR end Match method
miR-217 38 44 1A hsa-miR-217 UACUGCAUCAGGAACUGAUUGGAU