Gene Page:HSPA1A

Summary?
GeneID 3303
Symbol HSPA1A
Synonyms HEL-S-103|HSP70-1|HSP70-1A|HSP70.1|HSP70I|HSP72|HSPA1
Description heat shock protein family A (Hsp70) member 1A
Reference MIM:140550|HGNC:HGNC:5232|Ensembl:ENSG00000204389|HPRD:00774|Vega:OTTHUMG00000031201
Gene type protein-coding
Map location 6p21.3
Pascal p-value 1E-12
Sherlock p-value 0.748
Fetal beta -0.325
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.033
Literature High-throughput literature-search Co-occurance与精神分裂症ophrenia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.183

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg11485463 6 31783240 HSPA1A;HSPA1L 2.689E-4 -0.368 0.038 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1879328 chr3 46568156 HSPA1A 3303 0.04 trans
rs7706288 chr5 141864248 HSPA1A 3303 0.15 trans
rs10842557 0 HSPA1A 3303 0.17 trans
rs35452 chr12 115539199 HSPA1A 3303 0.02 trans
rs16965683 chr15 38115683 HSPA1A 3303 0.09 trans
rs7215675 chr17 10905819 HSPA1A 3303 0.07 trans
rs2073206 chr20 948279 HSPA1A 3303 0.08 trans
rs8120542 chr20 24395092 HSPA1A 3303 0.19 trans
rs8114637 chr20 24395207 HSPA1A 3303 0.19 trans
rs9974024 chr20 24397274 HSPA1A 3303 0.19 trans
rs6515493 chr20 24401635 HSPA1A 3303 0.19 trans
rs6049703 chr20 24432425 HSPA1A 3303 0 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0005515 protein binding 新闻学会 15735003
GO:0005524 ATP binding IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006950 response to stress IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AIFM1 AIF | MGC111425 | PDCD8 apoptosis-inducing factor, mitochondrion-associated, 1 - HPRD,BioGRID 11533664
APAF1 CED4 | DKFZp781B1145 apoptotic peptidase activating factor 1 - HPRD 10934467
APEX1 APE | APE-1 | APE1 | APEN | APEX | APX | HAP1 | REF-1 | REF1 APEX nuclease (multifunctional DNA repair enzyme) 1 - HPRD 11133992
APOB FLDB apolipoprotein B (including Ag(x) antigen) - HPRD 9252351
AR AIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM androgen receptor Affinity Capture-Western BioGRID 1540595
BAG1 RAP46 BCL2-associated athanogene Reconstituted Complex BioGRID 14517289
BAG2 BAG-2 | KIAA0576 | MGC149462 | dJ417I1.2 BCL2-associated athanogene 2 - HPRD 9873016
BAG3 BAG-3 | BIS | CAIR-1 | MGC104307 BCL2-associated athanogene 3 - HPRD,BioGRID 9873016|10980614
BAG4 BAG-4 | SODD BCL2-associated athanogene 4 - HPRD,BioGRID 11527400
BAT3 BAG-6 | BAG6 | D6S52E | G3 HLA-B associated transcript 3 in vivo BioGRID 11230127
BCL2 Bcl-2 B-cell CLL/lymphoma 2 - HPRD,BioGRID 10354271
CDK9 C-2k | CDC2L4 | CTK1 | PITALRE | TAK cyclin-dependent kinase 9 - HPRD,BioGRID 10617616
CUL4A - cullin 4A Affinity Capture-MS BioGRID 12481031
DNAJB1 HSPF1 | Hdj1 | Hsp40 | Sis1 DnaJ (Hsp40) homolog, subfamily B, member 1 - HPRD 10593983
DNAJB11 ABBP-2 | ABBP2 | DJ9 | EDJ | ERdj3 | ERj3 | HEDJ | PRO1080 | UNQ537 | hDj9 DnaJ (Hsp40) homolog, subfamily B, member 11 - HPRD 11584023
EIF2AK1 HCR | HRI | KIAA1369 eukaryotic translation initiation factor 2-alpha kinase 1 in vivo BioGRID 12149123
EIF2AK2 EIF2AK1 | MGC126524 | PKR | PRKR eukaryotic translation initiation factor 2-alpha kinase 2 - HPRD 12397061
FANCC FA3 | FAC | FACC | FLJ14675 Fanconi anemia, complementation group C Affinity Capture-Western
Two-hybrid		 BioGRID 12397061|14499622
FANCC FA3 | FAC | FACC | FLJ14675 Fanconi anemia, complementation group C - HPRD 11500375|12397061
GRIN1 NMDA1 | NMDAR1 | NR1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 - HPRD 10862698
HSF1 HSTF1 heat shock transcription factor 1 - HPRD,BioGRID 9699716
HSF2 MGC117376 | MGC156196 | MGC75048 heat shock transcription factor 2 HSF2 interacts with hsp70i promoter. BIND 15662014
HSP90AA1 FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2 heat shock protein 90kDa alpha (cytosolic), class A member 1 Reconstituted Complex BioGRID 12093808
HSPBP1 - hsp70-interacting protein - HPRD 9830037
IKBKG AMCBX1 | FIP-3 | FIP3 | Fip3p | IKK-gamma | IP | IP1 | IP2 | IPD2 | NEMO inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma Reconstituted Complex BioGRID 11877453
KRT7 CK7 | K2C7 | K7 | MGC129731 | MGC3625 | SCL keratin 7 - HPRD 11888936
MAP3K5 ASK1 | MAPKKK5 | MEKK5 mitogen-activated protein kinase kinase kinase 5 - HPRD,BioGRID 12391142
MAP3K7IP2 FLJ21885 | KIAA0733 | TAB2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2 - HPRD 14743216
MSR1 CD204 | SCARA1 | SR-A | phSR1 | phSR2 macrophage scavenger receptor 1 - HPRD,BioGRID 11785981
NQO1 DHQU | DIA4 | DTD | NMOR1 | NMORI | QR1 NAD(P)H dehydrogenase, quinone 1 - HPRD 11821413
NR3C1 GCCR | GCR | GR | GRL nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) - HPRD,BioGRID 12093808
PEX5 FLJ50634 | FLJ50721 | FLJ51948 | PTS1-BP | PTS1R | PXR1 peroxisomal biogenesis factor 5 - HPRD 11415446
PPP1R15A GADD34 protein phosphatase 1, regulatory (inhibitor) subunit 15A - HPRD 12724406
PTMA MGC104802 | TMSA prothymosin, alpha - HPRD 11310559
RBX1 BA554C12.1 | MGC13357 | MGC1481 | RNF75 | ROC1 ring-box 1 Affinity Capture-MS BioGRID 12481031
RHOA ARH12 | ARHA | RHO12 | RHOH12 ras homolog gene family, member A Affinity Capture-Western BioGRID 12490434
SLC5A1 D22S675 | NAGT | SGLT1 solute carrier family 5 (sodium/glucose cotransporter), member 1 - HPRD,BioGRID 12082088
SOX9 CMD1 | CMPD1 | SRA1 SRY (sex determining region Y)-box 9 - HPRD,BioGRID 11356186
ST13 AAG2 | FAM10A1 | FAM10A4 | FLJ27260 | HIP | HOP | HSPABP | HSPABP1 | MGC129952 | P48 | PRO0786 | SNC6 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) in vivo BioGRID 8887650
STIP1 HOP | IEF-SSP-3521 | P60 | STI1 | STI1L stress-induced-phosphoprotein 1 - HPRD 12161444
STUB1 CHIP | HSPABP2 | NY-CO-7 | SDCCAG7 | UBOX1 STIP1 homology and U-box containing protein 1 - HPRD,BioGRID 10330192
TCERG1 CA150 | MGC133200 | TAF2S transcription elongation regulator 1 - HPRD 15456888
TOMM70A FLJ90470 translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) - HPRD 12526792
TP53 FLJ92943 | LFS1 | TRP53 | p53 tumor protein p53 - HPRD 7811761
TRIM24 PTC6 | RNF82 | TF1A | TIF1 | TIF1A | TIF1ALPHA | hTIF1 tripartite motif-containing 24 - HPRD 12677068
TTC1 FLJ46404 | TPR1 tetratricopeptide repeat domain 1 - HPRD 14503850


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG SPLICEOSOME 128 72 All SZGR 2.0 genes in this pathway
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS 183 132 All SZGR 2.0 genes in this pathway
KEGG ANTIGEN PROCESSING AND PRESENTATION 89 65 All SZGR 2.0 genes in this pathway
KEGG PRION DISEASES 35 28 All SZGR 2.0 genes in this pathway
BIOCARTA TID PATHWAY 19 15 All SZGR 2.0 genes in this pathway
BIOCARTA P53HYPOXIA PATHWAY 23 21 All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY 58 43 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 All SZGR 2.0 genes in this pathway
SAMOLS TARGETS OF KHSV MIRNAS DN 62 35 All SZGR 2.0 genes in this pathway
NOJIMA SFRP2 TARGETS UP 31 23 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP 136 80 All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL DN 86 59 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459 276 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR UP 164 122 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR UP 162 116 All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF UP 115 78 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
BARRIER CANCER RELAPSE NORMAL SAMPLE DN 31 19 All SZGR 2.0 genes in this pathway
VETTER TARGETS OF PRKCA AND ETS1 DN 16 10 All SZGR 2.0 genes in this pathway
MAHADEVAN RESPONSE TO MP470 DN 19 11 All SZGR 2.0 genes in this pathway
多尔STAT3 DN的目标 50 34 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309 199 All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS UP 110 71 All SZGR 2.0 genes in this pathway
STANHILL HRAS TRANSFROMATION UP 8 5 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
FUJIWARA PARK2 HEPATOCYTE PROLIFERATION UP 10 8 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR UP 116 79 All SZGR 2.0 genes in this pathway
SCHAEFFER前列腺癌发展48小时DN 428 306 All SZGR 2.0 genes in this pathway
DEN INTERACT WITH LCA5 26 21 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
赛尔维拉SDHB目标1的DN 38 22 All SZGR 2.0 genes in this pathway
UEDA CENTRAL CLOCK 88 62 All SZGR 2.0 genes in this pathway
LAMB CCND1 TARGETS 19 14 All SZGR 2.0 genes in this pathway
MENSSEN MYC TARGETS 53 35 All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6 144 98 All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318 215 All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS 126 90 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532 309 All SZGR 2.0 genes in this pathway
GENTILE UV LOW DOSE UP 27 19 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371 218 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244 165 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS DN 31 23 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP 105 73 All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP 120 89 All SZGR 2.0 genes in this pathway
DELLA RESPONSE TO TSA AND BUTYRATE 21 17 All SZGR 2.0 genes in this pathway
SATO SILENCED EPIGENETICALLY IN PANCREATIC CANCER 49 30 All SZGR 2.0 genes in this pathway
MOREIRA RESPONSE TO TSA UP 28 23 All SZGR 2.0 genes in this pathway
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN UP 30 21 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C0 107 72 All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR UP 93 65 All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C1 24 14 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282 183 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN 105 67 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461 298 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
COATES MACROPHAGE M1 VS M2 DN 78 44 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
HANN RESISTANCE TO BCL2 INHIBITOR DN 48 31 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
MISHRA CARCINOMA ASSOCIATED FIBROBLAST DN 24 13 All SZGR 2.0 genes in this pathway
LIN NPAS4 TARGETS UP 163 100 All SZGR 2.0 genes in this pathway
CADWELL ATG16L1 TARGETS DN 70 43 All SZGR 2.0 genes in this pathway
KRISHNAN FURIN TARGETS UP 12 6 All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE UP 149 85 All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429 260 All SZGR 2.0 genes in this pathway
VANASSE BCL2 TARGETS UP 40 25 All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422 277 All SZGR 2.0 genes in this pathway
KUROKAWA LIVER CANCER EARLY RECURRENCE UP 12 9 All SZGR 2.0 genes in this pathway
TIAN TNF SIGNALING NOT VIA NFKB 22 16 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221 135 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 5 30 22 All SZGR 2.0 genes in this pathway
DASU IL6 SIGNALING UP 59 44 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374 217 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN 336 211 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 All SZGR 2.0 genes in this pathway
DALESSIO TSA RESPONSE 29 16 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337 236 All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 2HR DN 55 35 All SZGR 2.0 genes in this pathway