Gene Page:HSPA2

Summary?
GeneID 3306
Symbol HSPA2
Synonyms HSP70-2|HSP70-3
Description heat shock protein family A (Hsp70) member 2
Reference MIM:140560|HGNC:HGNC:5235|Ensembl:ENSG00000126803|HPRD:07174|
Gene type protein-coding
Map location 14q24.1
Pascal p-value 4.169E-4
Sherlock p-value 0.46
Fetal beta -3.954
eGene Myers' cis & trans
Support CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统的search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6829546 chr4 12587664 HSPA2 3306 0.1 trans
rs6448932 chr4 12595798 HSPA2 3306 0.06 trans
rs1465923 chr4 77136210 HSPA2 3306 0.13 trans
rs6632306 chrX 35590460 HSPA2 3306 0.15 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PSMD1 0.90 0.87
HSPA8 0.89 0.88
GARS 0.87 0.82
PPME1 0.87 0.84
PSMD7 0.87 0.83
ALAS1 0.87 0.81
IMMT 0.86 0.80
STRAP 0.86 0.83
FKBP4 0.85 0.82
HNRNPH2 0.85 0.82
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.76 -0.66
MT-CO2 -0.74 -0.66
AF347015.8 -0.74 -0.64
AF347015.33 -0.74 -0.67
AF347015.2 -0.72 -0.65
AF347015.31 -0.71 -0.64
AP002478.3 -0.70 -0.68
AF347015.26 -0.69 -0.62
FXYD1 -0.69 -0.64
AF347015.18 -0.69 -0.67

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG SPLICEOSOME 128 72 All SZGR 2.0 genes in this pathway
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS 183 132 All SZGR 2.0 genes in this pathway
KEGG ANTIGEN PROCESSING AND PRESENTATION 89 65 All SZGR 2.0 genes in this pathway
REACTOME MEIOSIS 116 81 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
REACTOME CHROMOSOME MAINTENANCE 122 80 All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC SYNAPSIS 73 57 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
KIM RESPONSE TO TSA AND DECITABINE UP 129 73 All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA UP 183 119 All SZGR 2.0 genes in this pathway
LIU VMYB TARGETS UP 127 78 All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS DN 73 51 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394 258 All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM DN 25 18 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309 199 All SZGR 2.0 genes in this pathway
WEINMANN ADAPTATION TO HYPOXIA UP 29 24 All SZGR 2.0 genes in this pathway
WEINMANN ADAPTATION TO HYPOXIA DN 41 33 All SZGR 2.0 genes in this pathway
CEBALLOS TARGETS OF TP53 AND MYC UP 21 16 All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC DN 31 23 All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 8HR 5 DN 11 8 All SZGR 2.0 genes in this pathway
FRIDMAN SENESCENCE UP 77 60 All SZGR 2.0 genes in this pathway
FRIDMAN IMMORTALIZATION DN 34 24 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE UP 86 57 All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160 110 All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP 205 126 All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS DN 87 69 All SZGR 2.0 genes in this pathway
MA MYELOID DIFFERENTIATION DN 44 30 All SZGR 2.0 genes in this pathway
CROMER METASTASIS DN 81 58 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240 152 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP 225 139 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR UP 180 125 All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262 186 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244 151 All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND TBH 60 42 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419 273 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482 296 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317 208 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461 298 All SZGR 2.0 genes in this pathway
由喀斯特IWANAGA致癌PTEN 181 112 All SZGR 2.0 genes in this pathway
YAMASHITA METHYLATED IN PROSTATE CANCER 57 29 All SZGR 2.0 genes in this pathway
ENGELMANN CANCER PROGENITORS DN 70 44 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE DN 108 68 All SZGR 2.0 genes in this pathway
MATZUK SPERMATOCYTE 72 55 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342 220 All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299 189 All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346 192 All SZGR 2.0 genes in this pathway
WU ALZHEIMER DISEASE DN 19 12 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442 275 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA UP 207 143 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 1 68 50 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 182 102 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS UP 44 30 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS UP 217 131 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS GROUP1 136 76 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP 199 143 All SZGR 2.0 genes in this pathway