Gene Page:HSPB1

Summary?
GeneID 3315
Symbol HSPB1
Synonyms CMT2F|HEL-S-102|HMN2B|HS.76067|HSP27|HSP28|Hsp25|SRP27
Description heat shock protein family B (small) member 1
Reference MIM:602195|HGNC:HGNC:5246|Ensembl:ENSG00000106211|HPRD:09076|Vega:OTTHUMG00000023228
Gene type protein-coding
Map location 7q11.23
Pascal p-value 0.17
Sherlock p-value 0.763
Fetal beta -0.113
eGene Myers' cis & trans
Support G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统的搜索在酒吧Med for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0143

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs7607798 chr2 102043108 HSPB1 3315 0.07 trans
rs11722940 chr4 120233215 HSPB1 3315 0.19 trans
rs17595790 chr4 120276219 HSPB1 3315 0.15 trans
rs2700772 chr8 5837584 HSPB1 3315 0.08 trans
rs2700770 chr8 5837808 HSPB1 3315 0.08 trans
rs2247957 chr8 5845867 HSPB1 3315 0.18 trans
rs10842557 0 HSPB1 3315 0.03 trans
rs7215675 chr17 10905819 HSPB1 3315 0.08 trans
rs16944595 chr17 11242834 HSPB1 3315 0.13 trans
rs2073206 chr20 948279 HSPB1 3315 0.01 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0042802 identical protein binding 新闻学会 11003656
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006446 regulation of translational initiation TAS 10859165
GO:0006986 response to unfolded protein TAS 10859165
GO:0006928 cell motion TAS 16130169
GO:0006916 anti-apoptosis TAS 16130169
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005856 cytoskeleton TAS 16130169
GO:0005634 nucleus IEA -
GO:0005737 cytoplasm TAS 16130169
GO:0009986 cell surface IDA 12493773

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AKT1 AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 Affinity Capture-Western BioGRID 11042204
C1orf103 FLJ11269 | RIF1 | RP11-96K19.1 chromosome 1 open reading frame 103 Two-hybrid BioGRID 16169070
C7orf64 DKFZP564O0523 | DKFZp686D1651 | HSPC304 chromosome 7 open reading frame 64 Two-hybrid BioGRID 16169070
CRYAA CRYA1 | HSPB4 crystallin, alpha A - HPRD,BioGRID 11700327
CRYAB CRYA2 | CTPP2 | HSPB5 crystallin, alpha B - HPRD,BioGRID 1560006|11700327
CRYBB2 CCA2 | CRYB2 | CRYB2A | D22S665 crystallin, beta B2 - HPRD,BioGRID 11700327
CRYGC CCL | CRYG3 crystallin, gamma C - HPRD 11700327
CYCS CYC | HCS cytochrome c, somatic Affinity Capture-Western BioGRID 11784858
EIF4G1 DKFZp686A1451 | EIF4F | EIF4G | p220 eukaryotic translation initiation factor 4 gamma, 1 - HPRD 10859165
HSPB8 CMT2L | DHMN2 | E2IG1 | H11 | HMN2 | HMN2A | HSP22 heat shock 22kDa protein 8 - HPRD,BioGRID 11342557|14594798
|15122253
HSPB8 CMT2L | DHMN2 | E2IG1 | H11 | HMN2 | HMN2A | HSP22 heat shock 22kDa protein 8 HSP22 interacts with HSP27. BIND 14594798
IGSF21 FLJ41177 | MGC15730 immunoglobin superfamily, member 21 Two-hybrid BioGRID 16169070
ILK DKFZp686F1765 | P59 integrin-linked kinase Affinity Capture-MS BioGRID 17353931
MAGED1 DLXIN-1 | NRAGE melanoma antigen family D, 1 Affinity Capture-MS BioGRID 17353931
MAPKAPK2 MK2 mitogen-activated protein kinase-activated protein kinase 2 - HPRD,BioGRID 11042204
MAPKAPK2 MK2 mitogen-activated protein kinase-activated protein kinase 2 MK2 phosphorylates Hsp27. This interaction was modelled on a demonstrated interaction between human MK2 and Hsp27 from an unspecified species. BIND 15692053
MAPKAPK5 PRAK mitogen-activated protein kinase-activated protein kinase 5 - HPRD,BioGRID 9628874
MED31 3110004H13Rik | CGI-125 | FLJ27436 | FLJ36714 | Soh1 mediator complex subunit 31 Two-hybrid BioGRID 16169070
POP7 0610037N12Rik | RPP2 | RPP20 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) Rpp20 interacts with Hsp27 BIND 11158571
PPA1 IOPPP | MGC111556 | PP | PP1 | SID6-8061 pyrophosphatase (inorganic) 1 Two-hybrid BioGRID 16169070
TGFB1I1 ARA55 | HIC-5 | HIC5 | TSC-5 transforming growth factor beta 1 induced transcript 1 Two-hybrid BioGRID 11546764
TP53 FLJ92943 | LFS1 | TRP53 | p53 tumor protein p53 Two-hybrid BioGRID 16169070


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY 76 53 All SZGR 2.0 genes in this pathway
BIOCARTA MTA3 PATHWAY 19 10 All SZGR 2.0 genes in this pathway
BIOCARTA P38MAPK PATHWAY 40 31 All SZGR 2.0 genes in this pathway
BIOCARTA HSP27 PATHWAY 15 11 All SZGR 2.0 genes in this pathway
ST P38 MAPK PATHWAY 37 28 All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY 65 54 All SZGR 2.0 genes in this pathway
PID P38 MK2 PATHWAY 21 19 All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA DOWNSTREAM PATHWAY 38 29 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284 128 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330 155 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 50 All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 53 31 All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
TIMOFEEVA GROWTH STRESS VIA STAT1 DN 16 12 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430 232 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION UP 119 66 All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL DN 86 59 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362 238 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN 126 86 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN 162 116 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINED IN GRANULOCYTE UP 15 9 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP 185 126 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION GRANULOCYTE UP 55 34 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP 204 140 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP 157 104 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINED IN MONOCYTE UP 21 15 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINDED IN ERYTHROCYTE UP 44 30 All SZGR 2.0 genes in this pathway
PAPASPYRIDONOS UNSTABLE ATEROSCLEROTIC PLAQUE DN 43 29 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP 316 190 All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN 136 94 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 128 95 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 117 84 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
STREICHER LSM1 TARGETS UP 44 34 All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355 243 All SZGR 2.0 genes in this pathway
LI LUNG CANCER 41 30 All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178 108 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL 330 215 All SZGR 2.0 genes in this pathway
AIYAR COBRA1 TARGETS DN 29 18 All SZGR 2.0 genes in this pathway
STANHILL HRAS TRANSFROMATION UP 8 5 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN 2FC UP 14 7 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398 262 All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP 205 126 All SZGR 2.0 genes in this pathway
SWEET KRAS TARGETS UP 84 51 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
HADDAD T LYMPHOCYTE AND NK PROGENITOR UP 78 56 All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318 215 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246 180 All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT 51 41 All SZGR 2.0 genes in this pathway
DELLA RESPONSE TO TSA AND BUTYRATE 21 17 All SZGR 2.0 genes in this pathway
GEORGANTAS HSC MARKERS 71 47 All SZGR 2.0 genes in this pathway
ZHOU TNF SIGNALING 30MIN 54 36 All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP 77 57 All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN 88 58 All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN 96 71 All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE UP 45 33 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS 90 71 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
AMBROSINI FLAVOPIRIDOL TREATMENT TP53 109 63 All SZGR 2.0 genes in this pathway
HANN RESISTANCE TO BCL2 INHIBITOR DN 48 31 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP 147 98 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342 220 All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198 128 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA D UP 89 62 All SZGR 2.0 genes in this pathway
了吉西他滨阻力DN 122 84 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338 225 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418 282 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245 150 All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE 101 76 All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN PLASMA CELL VS MATURE B LYMPHOCYTE 67 51 All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389 245 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 15 31 19 All SZGR 2.0 genes in this pathway
VALK AML WITH CEBPA 37 27 All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422 277 All SZGR 2.0 genes in this pathway
KESHELAVA MULTIPLE DRUG RESISTANCE 88 56 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA UP 207 143 All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253 192 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841 431 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567 365 All SZGR 2.0 genes in this pathway
MIKHAYLOVA OXIDATIVE STRESS RESPONSE VIA VHL DN 6 5 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 DN 180 116 All SZGR 2.0 genes in this pathway
CHEMELLO SOLEUS VS EDL MYOFIBERS UP 35 16 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-539 91 97 1A hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU