SZGR2 - Beplay体育中心

Summary？

基因	3320
Symbol	HSP90AA1
同义词	EL52\|HEL-S-65p\|HSP86\|HSP89A\|HSP90A\|HSP90N\|HSPC1\|HSPCA\|HSPCAL1\|HSPCAL4\|HSPN\|Hsp89\|Hsp90\|LAP-2\|LAP2
描述	heat shock protein 90kDa alpha family class A member 1
参考	MIM：140571\|HGNC：HGNC：5253\|Ensembl：ENSG00000080824\|HPRD：00777\|Vega:OTTHUMG00000171752
基因type	蛋白质编码
Map location	14Q32.33
Pascal P值	0.299
TADA P值	0.002
胎儿β	-0.198
DMG	2（＃研究）
Support	RNA AND PROTEIN SYNTHESIS COMPOSITESET

基因in Data Sources

基因set name	基因组方法	描述	信息
简历：PGCNP	Genome-wide Association Study	GWAS
DMG：Nishioka_2013	全基因组DNA甲基化分析	作者研究了来自18例第一期精神分裂症（FESZ）和15个正常对照的18例外周血细胞中DNA的甲基化谱。	4
DMG：Wockner_2014	全基因组DNA甲基化分析	该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。	4
DNM:Fromer_2014	整个外显子组测序分析	这项研究报道了WES对623个精神分裂症三重奏的研究，该研究使用基因组DNA报告了DNM。
PMID：cooccur	高通量文献搜索	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学	高通量文献搜索	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	点击显示详细信息
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	PPI网络中最短路径的贡献：0.4681

Section I. Genetics and epigenetics annotation

DNMtable

基因	Chromosome	Position	参考	alt	Transcript	AA更改	突变类型	筛	CG46	Trait	学习
HSP90AA1	chr14	102550757	C	CCT	NM_001017963 NM_005348	。。	边框边框			Schizophrenia	DNM:Fromer_2014

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	p（dis）	Beta (dis)	fdr（dis）	学习
CG13797425	14	102554977	HSP90AA1	1.5e-7	0.741	0.004	DMG：Wockner_2014
cg14893857	14	102554969	HSP90AA1	3.67E-5	0.47	0.02	DMG：Wockner_2014
cg23289024	14	102554846	HSP90AA1	5.143E-4	0.471	0.047	DMG：Wockner_2014
cg04281268	14	102606293	HSP90AA1		-0.02	0.96	DMG：Nishioka_2013

第二节。转录组注释

一般基因表达（GTEX）

基因expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

基因expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
基因	皮尔逊的相关性	Spearman's Correlation
MON1B	0.90	0.93
UPF1	0.90	0.91
CLEC16A	0.90	0.91
ZFYVE20	0.90	0.90
BICD2	0.89	0.91
POM121	0.89	0.89
DGCR2	0.89	0.90
PCNXL3	0.89	0.88
CLPB	0.89	0.89
TULP4	0.89	0.90

前10个负共表达基因
基因	皮尔逊的相关性	Spearman's Correlation
AF347015.21	-0.67	-0.75
C1orf54	-0.64	-0.74
AF347015.31	-0.64	-0.66
GNG11	-0.63	-0.68
MT-CO2	-0.61	-0.65
SYCP3	-0.60	-0.69
HIGD1B	-0.60	-0.63
VAMP5	-0.59	-0.61
AF347015.27	-0.59	-0.63
IFI27	-0.58	-0.58

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去:0000166	nucleotide binding	TAS		11470816
GO:0003674	Molecular_Function	nd		-
GO:0030235	nitric-oxide synthase regulator activity	ISS		-
去：0005524	ATP binding	TAS		11470816
GO：0051082	unfolded protein binding	IEA		-
GO:0042803	蛋白质同构化活性	TAS		11470816
去：0030911	TPR结构域结合	IDA		9660753
去：0030911	TPR结构域结合	TAS		12526792
生物过程	去学期	证据	神经关键字	PubMed ID
去：0006839	mitochondrial transport	TAS	谷氨酸（GO期限：6）	12526792
去：0006457	protein folding	IEA		-
GO:0006986	response to unfolded protein	NAS		2527334
去：0007165	信号转导	NAS		11470816
GO:0008150	生物_Process	nd		-
去：0042026	protein refolding	TAS		9660753
GO:0045429	positive regulation of nitric oxide biosynthetic process	ISS		-
细胞分量	去学期	证据	神经关键字	PubMed ID
去：0005829	cytosol	EXP		9580552\|10781589
去：0005829	cytosol	NAS		12526792
去：0005575	cellular_component	nd		-
去：0005737	细胞质	IEA		-
GO:0042470	melanosome	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	实验	资源	PubMed ID
AHR	-	芳基碳氢化合物受体	-	HPRD,BioGRID	7961671\|9083006
AHSA1	AHA1 \| C14orf3 \| p38	AHA1，热冲击激活剂90KDA蛋白ATPase同源1（酵母）	体外体内 Two-hybrid	Biogrid	12504007
AHSA1	AHA1 \| C14orf3 \| p38	AHA1，热冲击激活剂90KDA蛋白ATPase同源1（酵母）	-	HPRD	12604615
AHSA2	DKFZP564C236 \|FLJ34679 \|FLJ41715 \|HCH1	AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)	-	HPRD,BioGRID	12504007\|14739935
AIP	arA9 \| FKBP16 \| FKBP37 \| SMTPHN \| XAP2	芳基烃受体相互作用蛋白	-	HPRD	9111057\|9837941
AIP	arA9 \| FKBP16 \| FKBP37 \| SMTPHN \| XAP2	芳基烃受体相互作用蛋白	亲和力捕获 - 韦斯特恩	Biogrid	11013261
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	V-Akt鼠胸腺瘤病毒癌基因同源1	-	HPRD,BioGRID	10995457
Akt2	PKBB \| PKBBETA \| PRKBB \| RAC-BETA	V-Akt鼠胸腺瘤病毒癌基因同源2	-	HPRD	11988487
ALK	CD246 \| Ki-1 \| TFG/ALK	anaplastic lymphoma receptor tyrosine kinase	-	HPRD	11888936
APAF1	CED4 \| DKFZp781B1145	apoptotic peptidase activating factor 1	亲和力捕获 - 韦斯特恩	Biogrid	10934467
APOB	FLDB	apolipoprotein B (including Ag(x) antigen)	-	HPRD	11333259
ar	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	雄激素受体	-	HPRD,BioGRID	1525041
arnt	HIF-1beta \| HIF1B \| HIF1BETA \| TANGO \| bHLHe2	芳基碳氢化合物受体nuclear translocator	亲和力捕获 - 韦斯特恩	Biogrid	11013261
arntl	BMAL1 \|bmal1c \|JAP3 \|MGC47515 \|mop3 \|pasd3 \|抽动\|Bhlhe5	芳基碳氢化合物受体核转运剂样	-	HPRD,BioGRID	9079689
ASGR1	ASGPR \| CLEC4H1 \| Hs.12056	Asialogoprotein受体1	-	HPRD	12167617
BAG4	Bag-4 \|SODD	BCL2-associated athanogene 4	亲和力捕获 - 韦斯特恩	Biogrid	14559896
Birc5	API4 \|EPR-1	细菌病毒IAP重复含量5	Survivin interacts with Hsp90.	BIND	15894266
CALM1	CALML2 \| CAMI \| DD132 \| PHKD	calmodulin 1 (phosphorylase kinase, delta)	-	HPRD	8486648
CDC37	P50CDC37	cell division cycle 37 homolog (S. cerevisiae)	共晶结构体外	Biogrid	9685350\|14718169
CDC37	P50CDC37	cell division cycle 37 homolog (S. cerevisiae)	-	HPRD	9685350\|14718169
CHTF18	C16orf41 \| C321D2.2 \| C321D2.3 \| C321D2.4 \| CHL12 \| Ctf18 \| RUVBL	CTF18，染色体传播保真度因子18同源物（S. cerevisiae）	Affinity Capture-MS	Biogrid	12930902
CHUK	IKBKA \| IKK-alpha \| IKK1 \| IKKA \| NFKBIKA \| TCF16	保守的螺旋环螺旋无处不在激酶	-	HPRD	11864612
CSNK2A1	CK2A1 \| CKII	酪蛋白激酶2，α1多肽	-	HPRD,BioGRID	7794926
CSNK2A2	CK2A2 \| CSNK2A1 \| FLJ43934	casein kinase 2, alpha prime polypeptide	-	HPRD,BioGRID	7794926
CUL4A	-	cullin 4A	Affinity Capture-MS	Biogrid	12481031
DAP3	DAP-3 \|DKFZP686G12159 \|MGC126058 \|MGC126059 \|MRP-S29 \|MRPS29 \|BMRP-10	死亡相关蛋白3	-	HPRD,BioGRID	10903152
egfr	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	表皮生长因子受体（红细胞性白血病病毒（V-ERB-B）癌基因同源物，鸟类）	EGFR与HSP90相互作用。这种相互作用是基于未指定物种与人类HSP90的EGFR之间的相互作用进行建模的。	BIND	12471035
EIF2AK2	EIF2AK1 \| MGC126524 \| PKR \| PRKR	eukaryotic translation initiation factor 2-alpha kinase 2	-	HPRD,BioGRID	11447118
EIF2AK3	DKFZP781H1925 \|hri \|佩克\|PERK \|WRS	eukaryotic translation initiation factor 2-alpha kinase 3	-	HPRD,BioGRID	12446770
EPRS	DKFZp313B047 \| EARS \| GLUPRORS \| PARS \| PIG32 \| QARS \| QPRS	谷氨酰基 - 丙酰基-TRNA合成酶	-	HPRD,BioGRID	10913161
ERBB2	CD340 \|her-2 \|her-2/neu \|her2 \|neu \|ngl \|TKR1	V-ERB-B2红细胞白血病病毒性癌基因同源2，神经/胶质母细胞瘤衍生的癌基因同源物（Avian）	ERBB2interacts with HSP90. This interaction was modelled on a demonstrated interaction between human ERBB2 and monkey HSP90.	BIND	15643424
ERBB2	CD340 \|her-2 \|her-2/neu \|her2 \|neu \|ngl \|TKR1	V-ERB-B2红细胞白血病病毒性癌基因同源2，神经/胶质母细胞瘤衍生的癌基因同源物（Avian）	-	HPRD,BioGRID	11071886
ERN1	FLJ30999 \|IRE1 \|IRE1P \|MGC163277 \|MGC163279	内质网向原子核信号传导1	-	HPRD,BioGRID	12446770
ESR1	DKFZP686N23123 \|er \|ESR \|Esra \|时代\|NR3A1	雌激素受体1	-	HPRD,BioGRID	11911945
FANCA	FA \| FA-H \| FA1 \| FAA \| FACA \| FAH \| FANCH \| MGC75158	Fanconi anemia, complementation group A	Two-hybrid	Biogrid	14499622
FANCC	FA3 \| FAC \| FACC \| FLJ14675	Fanconi anemia, complementation group C	Two-hybrid	Biogrid	14499622
费斯	FPS	猫石棺ma oncogene	重构的复合物	Biogrid	9222609
FKBP5	FKBP51 \|FKBP54 \|MGC111006 \|p54 \|PPIASE \|PTG-10	FK506结合蛋白5	-	HPRD,BioGRID	9001212\|12538866
FNIP1	DKFZP686E18167 \|DKFZP781P0215 \|KIAA1961 \|MGC667	folliculin interacting protein 1	Affinity Capture-MS	Biogrid	17028174
GNA12	MGC104623 \| MGC99644 \| NNX3 \| RMP \| gep	鸟嘌呤核苷酸结合蛋白（G蛋白）α12	体外体内 Two-hybrid	Biogrid	11598136\|12117999
GNA12	MGC104623 \| MGC99644 \| NNX3 \| RMP \| gep	鸟嘌呤核苷酸结合蛋白（G蛋白）α12	-	HPRD	11598136 \| 12117999
gucy1b3	GC-S-BETA-1 \|GC-SB3 \|Guc1b3 \|Gucb3 \|GUCSB3 \|gucy1b1	鸟苷酸环化酶1，可溶性，β3	-	HPRD,BioGRID	12676772
HCFC1	CFF \|HCF-1 \|HCF1 \|HFC1 \|MGC70925 \|VCAF	宿主细胞因子C1（VP16-辅助蛋白）	Affinity Capture-MS	Biogrid	12670868
HIF1A	HIF-1alpha \| HIF1 \| HIF1-ALPHA \| MOP1 \| PASD8	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	-	HPRD,BioGRID	9079689
HSF1	HSTF1	heat shock transcription factor 1	亲和力捕获 - 韦斯特恩重构的复合物	Biogrid	9222609\|12621024
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	热休克蛋白90KDAα（胞质），A类成员1	Two-hybrid	Biogrid	16169070
HSPA1A	FLJ54303 \|FLJ54370 \|FLJ54392 \|FLJ54408 \|FLJ75127 \|HSP70-1 \|HSP70-1A \|HSP70I \|HSP72 \|HSPA1 \| HSPA1B	heat shock 70kDa protein 1A	重构的复合物	Biogrid	12093808
HSPA8	HSC54 \| HSC70 \| HSC71 \| HSP71 \| HSP73 \| HSPA10 \| LAP1 \| MGC131511 \| MGC29929 \| NIP71	heat shock 70kDa protein 8	-	HPRD,BioGRID	9269769
ikbkb	FLJ40509 \|ikk-beta \|ikk2 \|ikkb \|MGC131801 \|nfkbikb	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	-	HPRD	11864612
ikbkg	AMCBX1 \|FIP-3 \|fip3 \|fip3p \|ikk-gamma \|IP \|IP1 \|IP2 \|IPD2 \|Nemo	B细胞，激酶γ中Kappa光多肽基因增强子的抑制剂	-	HPRD	11864612
IRS4	IRS-4 \| PY160	胰岛素受体底物4	Affinity Capture-MS	Biogrid	11912194
LSM1	CASM \| YJL124C	LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)	-	HPRD,BioGRID	15231747
MAP3K7	TAK1 \| TGF1a	有丝分裂原激活的蛋白激酶激酶激酶7	-	HPRD	14743216
MAP3K7IP2	FLJ21885 \| KIAA0733 \| TAB2	有丝分裂原激活的蛋白激酶激酶激酶7相互作用蛋白2	-	HPRD	14743216
MAPK1	ERK \| ERK2 \| ERT1 \| MAPK2 \| P42MAPK \| PRKM1 \| PRKM2 \| p38 \| p40 \| p41 \| p41mapk	有丝分裂原激活的蛋白激酶1	-	HPRD	11748628
MYC	Bhlhe39 \|c-myc	v-myc myelocytomatosis viral oncogene homolog (avian)	-	HPRD,BioGRID	12644583
MYOD1	MYF3 \| MYOD \| PUM \| bHLHc1	myogenic differentiation 1	-	HPRD,BioGRID	1406681
NOS3	ecnos \|eNOS	一氧化氮合酶3（内皮细胞）	-	HPRD,BioGRID	11744239\|12124224
NPAS2	FLJ23138 \| MGC71151 \| MOP4 \| PASD4 \| bHLHe9	神经元PAS结构蛋白2	重构的复合物	Biogrid	9079689
NR3C1	GCCR \|GCR \|gr \|grl	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	-	HPRD,BioGRID	8621522\|8645634 \|8898375\|9334248 \|10066374
NR3C2	MCR \| MGC133092 \| MLR \| MR	nuclear receptor subfamily 3, group C, member 2	-	HPRD	9392437
PDPK1	MGC20087 \|MGC35290 \|PDK1 \|Pro0461	3-phosphoinositide dependent protein kinase-1	-	HPRD	11779851
PIM1	PIM	pim-1 oncogene	-	HPRD,BioGRID	11237709
PPARA	MGC2237 \|MGC2452 \|NR1C1 \|PPAR \|hppar	peroxisome proliferator-activated receptor alpha	-	HPRD,BioGRID	12482853
PPID	CYP-40 \|CYPD \|MGC33096	peptidylprolyl isomerase D	-	HPRD	12145316
PPP5C	FLJ36922 \|pp5 \|PPP5	protein phosphatase 5, catalytic subunit	-	HPRD	10400612
PPP5C	FLJ36922 \|pp5 \|PPP5	protein phosphatase 5, catalytic subunit	HSP90与PP5相互作用。这种相互作用是基于未指定物种的人类HSP90和PP5之间的相互作用进行建模的。	BIND	15664193
ptges3	P23 \| TEBP \| cPGES	前列腺素E合酶3（胞质）	-	HPRD,BioGRID	11812147\|12077419
RAF1	克拉夫\|NS5 \|RAF-1 \|C-Raf	V-RAF-1鼠白血病病毒癌基因同源1	RAF-1与HSP90相互作用。这种相互作用是建立在人RAF-1和猴子HSP90之间的相互作用上的模型。	BIND	15618521
RAF1	克拉夫\|NS5 \|RAF-1 \|C-Raf	V-RAF-1鼠白血病病毒癌基因同源1	-	HPRD,BioGRID	8408024
ralbp1	RIP1 \| RLIP1 \| RLIP76	rala结合蛋白1	亲和力捕获 - 韦斯特恩	Biogrid	12621024
RIPK1	FLJ39204 \| RIP \| RIP1	受体（TNFRSF） - 互动丝氨酸 - 硫代激酶1	-	HPRD	10744744
RPS3A	FTE1 \| MFTL \| MGC23240	核糖体蛋白S3A	Two-hybrid	Biogrid	16169070
RUNX1T1	AML1T1 \| CBFA2T1 \| CDR \| ETO \| MGC2796 \| MTG8 \| MTG8b \| ZMYND2	与RUNT相关的转录因子1；易位为1（Cyclin D相关）	-	HPRD	10076566
sgta	SGT \| alphaSGT \| hSGT	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	-	HPRD,BioGRID	12482202
SIM1	BHLHE14	single-minded homolog 1 (Drosophila)	重构的复合物	Biogrid	9020169
smyd3	FLJ21080 \|MGC104324 \|zmynd1 \|Znfn3A1 \|BA74P14.1	设置和mynd域包含3	smyd3interacts with HSP90A.	BIND	15235609
smyd3	FLJ21080 \|MGC104324 \|zmynd1 \|Znfn3A1 \|BA74P14.1	设置和mynd域包含3	-	HPRD,BioGRID	15235609
src	ASV \|src1 \|C-SRC \|P60-SRC	V-SRC肉瘤（Schmidt-Ruppin A-2）病毒癌基因同源物（Avian）	-	HPRD,BioGRID	1310678
STARD13	DLC2 \|FLJ37385 \|GT650	StAR-related lipid transfer (START) domain containing 13	Two-hybrid	Biogrid	14697242
Stat3	APRF \|FLJ20882 \|hies \|MGC16063	转录3的信号换能器和激活因子（急性相反应因子）	-	HPRD,BioGRID	12559950
STIP1	HOP \| IEF-SSP-3521 \| P60 \| STI1 \| STI1L	stress-induced-phosphoprotein 1	-	HPRD,BioGRID	10786835
STK11	lkb1 \|PJS	serine/threonine kinase 11	亲和力捕获 - 韦斯特恩重构的复合物	Biogrid	12489981
Stub1	芯片\|hspabp2 \|NY-CO-7 \|sdccag7 \|Ubox1	STIP1 homology and U-box containing protein 1	-	HPRD	1155 \| 111466327750
TERT	EST2 \|TCS1 \|TP2 \|trt \|hest2	telomerase reverse transcriptase	-	HPRD,BioGRID	12586360
tnfrsf1a	CD120a \| FPF \| MGC19588 \| TBP1 \| TNF-R \| TNF-R-I \| TNF-R55 \| TNFAR \| TNFR1 \| TNFR55 \| TNFR60 \| p55 \| p55-R \| p60	肿瘤坏死因子受体超家族，成员1a	-	HPRD	7876093
Tomm34	htom34p \|tom34 \|URCC3	translocase of outer mitochondrial membrane 34	-	HPRD	9660753
Tomm70a	FLJ90470	translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)	-	HPRD	12526792
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD,BioGRID	11507088\|12427754
TRADD	Hs.89862 \| MGC11078	通过死亡域与TNFRSF1A相关	-	HPRD	14743216
tuba1a	B-ALPHA-1 \| FLJ25113 \| LIS3 \| TUBA3	tubulin, alpha 1a	亲和力捕获 - 韦斯特恩	Biogrid	12621024
WASL	DKFZP779G0847 \|MGC48327 \|n-wasp \|nwasp	Wiskott-Aldrich syndrome-like	WASL (N-WASP) interacts with HSPCA (HSP90-alpha).	BIND	15791211

Section V. Pathway annotation

Pathway name	路径大小	＃szgr 2.0基因	信息
KEGG抗原处理和演示	89	65	All SZGR 2.0 genes in this pathway
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY	62	47	All SZGR 2.0 genes in this pathway
KEGG孕酮介导的卵母细胞成熟	86	59	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG前列腺癌	89	75	All SZGR 2.0 genes in this pathway
Biocarta No1途径	33	24	All SZGR 2.0 genes in this pathway
BIOCARTA AKT PATHWAY	22	16	All SZGR 2.0 genes in this pathway
Biocarta GCR途径	22	17	All SZGR 2.0 genes in this pathway
Biocarta P53Hypoxia途径	23	21	All SZGR 2.0 genes in this pathway
BIOCARTA HIF PATHWAY	15	12	All SZGR 2.0 genes in this pathway
Biocarta PPARA途径	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA TEL PATHWAY	18	15	All SZGR 2.0 genes in this pathway
PID HDAC CLASSII PATHWAY	34	27	All SZGR 2.0 genes in this pathway
PID MYC ACTIV PATHWAY	79	62	All SZGR 2.0 genes in this pathway
PID ILK PATHWAY	45	32	All SZGR 2.0 genes in this pathway
PID LKB1途径	47	37	All SZGR 2.0 genes in this pathway
PID端粒酶途径	68	48	All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY	82	60	All SZGR 2.0 genes in this pathway
PID PI3KCI PATHWAY	49	40	All SZGR 2.0 genes in this pathway
PID IL2 PI3K PATHWAY	34	27	All SZGR 2.0 genes in this pathway
PID AR TF PATHWAY	53	38	All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY	75	53	All SZGR 2.0 genes in this pathway
PID HIF1A途径	19	12	All SZGR 2.0 genes in this pathway
PID ERBB网络途径	15	13	All SZGR 2.0 genes in this pathway
PID VEGFR1途径	26	23	All SZGR 2.0 genes in this pathway
PID VEGFR1 2途径	69	57	All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY	35	30	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	13	9	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
组成性活性EGFR的反应组信号传导	18	13	All SZGR 2.0 genes in this pathway
EGFR在癌症中的反应组信号传导	109	80	All SZGR 2.0 genes in this pathway
REACTOME ENOS ACTIVATION AND REGULATION	20	14	All SZGR 2.0 genes in this pathway
Reactome细胞周期有丝分裂	325	185	All SZGR 2.0 genes in this pathway
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	66	43	All SZGR 2.0 genes in this pathway
来自有丝分裂中心体NLP的反应组损失	59	38	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	15	14	All SZGR 2.0 genes in this pathway
REACTOME SEMAPHORIN INTERACTIONS	68	53	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES	81	50	All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA LIFE CYCLE	203	72	All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	169	47	All SZGR 2.0 genes in this pathway
中村肿瘤区周围与中央	285	181	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP	408	247	All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS TOP50 UP	38	27	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN	310	188	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP	404	246	All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION UP	119	66	All SZGR 2.0 genes in this pathway
Mullighan NPM1突变签名1向上	276	165	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 2 UP	139	83	All SZGR 2.0 genes in this pathway
Mullighan NPM1签名3	341	197	All SZGR 2.0 genes in this pathway
Dittmer PTHLH靶向DN	73	51	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
Kim WT1靶向8小时	164	122	All SZGR 2.0 genes in this pathway
Bidus转移	214	134	All SZGR 2.0 genes in this pathway
Wamunyokoli卵巢癌LMP	265	158	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP	128	95	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR DN	75	50	All SZGR 2.0 genes in this pathway
berenjeno由Rhoa Up Troment	536	340	All SZGR 2.0 genes in this pathway
MARKS ACETYLATED NON HISTONE PROTEINS	15	9	All SZGR 2.0 genes in this pathway
MET的Seiden肿瘤发生	88	53	All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS	58	45	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC网络	779	480	All SZGR 2.0 genes in this pathway
buytaert光动力疗法压力	811	508	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
COLLIS PRKDC SUBSTRATES	20	15	All SZGR 2.0 genes in this pathway
Menssen MYC目标	53	35	All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN	187	122	All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CHICK	169	111	All SZGR 2.0 genes in this pathway
POMEROY MEDULLOBLASTOMA DESMOPLASIC VS CLASSIC UP	62	38	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
SHIPP DLBCL VS FOLLICULAR LYMPHOMA UP	45	30	All SZGR 2.0 genes in this pathway
彭雷帕霉素反应dn	245	154	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
松本自然杀手差分	475	313	All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP	151	103	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
CUI TCF21目标2 DN	830	547	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691年	1088	All SZGR 2.0 genes in this pathway
APRELIKOVA BRCA1 TARGETS	49	33	All SZGR 2.0 genes in this pathway
Yamazaki TCEB3靶向DN	215	132	All SZGR 2.0 genes in this pathway
张增殖与静止	51	41	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN	165	106	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C1	72	45	All SZGR 2.0 genes in this pathway
WENG POR TARGETS GLOBAL DN	23	14	All SZGR 2.0 genes in this pathway
tseng irs1靶向	113	71	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
CHENG RESPONSE TO NICKEL ACETATE	45	29	All SZGR 2.0 genes in this pathway
Weng Por靶向肝脏DN	20	11	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
Krige对Tosedostat 24小时DN的反应	1011	592	All SZGR 2.0 genes in this pathway
Creighton内分泌疗法抗性2	473	224	All SZGR 2.0 genes in this pathway
Bhati G2M被2methoxyestradiol逮捕	125	68	All SZGR 2.0 genes in this pathway
Mirlet7a3 DN的Brueckner目标	78	49	All SZGR 2.0 genes in this pathway
对Salirasib dn的Blum响应	342	220	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP	323	240	All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL UP	51	32	All SZGR 2.0 genes in this pathway
骨髓瘤与成熟B淋巴细胞中的Shaffer IRF4靶标	101	76	All SZGR 2.0 genes in this pathway
Hsiao家政基因	389	245	All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP	83	63	All SZGR 2.0 genes in this pathway
Kim所有疾病Calb1 Corr Up	548	370	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN	374	217	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
GUO TARGETS OF IRS1 AND IRS2	98	67	All SZGR 2.0 genes in this pathway
FU INTERACT WITH ALKBH8	13	8	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	目标位置			mirna id	mirna seq
miRNA family	UTR开始	UTR结束	匹配方法	mirna id	mirna seq
miR-361	46	53	1A,m8	HSA-MIR-361^脑	uuaucagaaucuccagggguac
mir-495	82	88	1A	hsa-miR-495^脑	AAACAAACAUGGUGCACUUCUUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click这里to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click这里查看与大脑相关的miRNA列表。

基因Page:HSP90AA1