Gene Page:HSPG2

Summary?
GeneID 3339
Symbol HSPG2
Synonyms HSPG|PLC|PRCAN|SJA|SJS|SJS1
Description heparan sulfate proteoglycan 2
Reference MIM:142461|HGNC:HGNC:5273|Ensembl:ENSG00000142798|HPRD:00804|Vega:OTTHUMG00000002674
Gene type protein-coding
Map location 1p36.1-p34
Pascal p-value 0.447
Fetal beta 0.203

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:Ambalavanan_2016 Whole Exome Sequencing This dataset includes 20 de novo mutations detected in 17 COS probands.
PMID:cooccur High-throughput literature-search 系统搜索PubMed的基因s co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
HSPG2 chr1 22192291 G A NM_005529 p.(=) synonymous SNV Childhood-onset schizophrenia DNM:Ambalavanan_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
KCNIP2 0.65 0.55
HPCA 0.60 0.53
TNFAIP8L3 0.59 0.39
SYTL5 0.58 0.55
RIN1 0.56 0.46
C1QTNF3 0.56 0.51
TOMM34 0.56 0.50
F12 0.56 0.62
PNCK 0.55 0.59
C20orf103 0.55 0.38
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.23 -0.29
AF347015.18 -0.23 -0.30
AF347015.2 -0.23 -0.27
MT-ATP8 -0.22 -0.28
ANKRD18B -0.21 -0.21
MT-CO2 -0.19 -0.28
AF347015.8 -0.19 -0.26
测试工程师 -0.18 -0.09
NOSTRIN -0.18 -0.25
AF347015.15 -0.18 -0.25

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
应用程序 AAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2 amyloid beta (A4) precursor protein - HPRD 9136074
COL13A1 COLXIIIA1 | FLJ42485 collagen, type XIII, alpha 1 - HPRD,BioGRID 11956183
FBLN1 FBLN fibulin 1 - HPRD,BioGRID 7500359
FBLN2 - fibulin 2 - HPRD 9431988
FBLN2 - fibulin 2 Reconstituted Complex BioGRID 11493006
FGF2 BFGF | FGFB | HBGF-2 fibroblast growth factor 2 (basic) - HPRD 11847221
FGF7 HBGF-7 | KGF fibroblast growth factor 7 (keratinocyte growth factor) - HPRD,BioGRID 10702276
FGFBP1 FGFBP | HBP17 fibroblast growth factor binding protein 1 - HPRD,BioGRID 11148217
FN1 CIG | DKFZp686F10164 | DKFZp686H0342 | DKFZp686I1370 | DKFZp686O13149 | ED-B | FINC | FN | FNZ | GFND | GFND2 | LETS | MSF fibronectin 1 Reconstituted Complex BioGRID 11493006
ITGB1 CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLAB integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) - HPRD 9431988
LAMA1 LAMA laminin, alpha 1 - HPRD,BioGRID 9688542
NID1 NID nidogen 1 - HPRD 11493006
NID2 - nidogen 2 (osteonidogen) - HPRD 9733643
NID2 - nidogen 2 (osteonidogen) Reconstituted Complex BioGRID 11493006
PDGFA PDGF-A | PDGF1 platelet-derived growth factor alpha polypeptide in vitro BioGRID 9692901
PDGFB FLJ12858 | PDGF2 | SIS | SSV | c-sis platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) - HPRD,BioGRID 9692901
PRELP MGC45323 | MST161 | MSTP161 | SLRR2A proline/arginine-rich end leucine-rich repeat protein - HPRD,BioGRID 11847210
SPARC ON secreted protein, acidic, cysteine-rich (osteonectin) - HPRD 2745554
TTR HsT2651 | PALB | TBPA transthyretin - HPRD,BioGRID 9307034


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG ECM受体相互作用 84 53 All SZGR 2.0 genes in this pathway
REACTOME HS GAG DEGRADATION 20 15 All SZGR 2.0 genes in this pathway
REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 49 33 All SZGR 2.0 genes in this pathway
REACTOME HS GAG BIOSYNTHESIS 31 17 All SZGR 2.0 genes in this pathway
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM 52 33 All SZGR 2.0 genes in this pathway
REACTOME GLYCOSAMINOGLYCAN METABOLISM 111 69 All SZGR 2.0 genes in this pathway
REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 25 17 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES 247 154 All SZGR 2.0 genes in this pathway
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT 46 37 All SZGR 2.0 genes in this pathway
REACTOME LIPOPROTEIN METABOLISM 28 24 All SZGR 2.0 genes in this pathway
REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT 16 15 All SZGR 2.0 genes in this pathway
REACTOME AMYLOIDS 83 63 All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP 205 140 All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN 169 118 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 TARGETS DN 158 102 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN 162 116 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK DN 196 131 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS UP 169 127 All SZGR 2.0 genes in this pathway
OXFORD RALA AND RALB TARGETS DN 9 5 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
SUNG METASTASIS STROMA UP 110 70 All SZGR 2.0 genes in this pathway
LAMB CCND1 TARGETS 19 14 All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION UP 71 51 All SZGR 2.0 genes in this pathway
SWEET KRAS TARGETS UP 84 51 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246 180 All SZGR 2.0 genes in this pathway
JOSEPH RESPONSE TO SODIUM BUTYRATE DN 64 45 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249 170 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244 165 All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP 175 116 All SZGR 2.0 genes in this pathway
MARIADASON监管BY HISTONE ACETYLATION UP 83 49 All SZGR 2.0 genes in this pathway
LINDVALL IMMORTALIZED BY TERT DN 80 56 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C1 19 15 All SZGR 2.0 genes in this pathway
VERRECCHIA EARLY RESPONSE TO TGFB1 58 43 All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE UP 95 64 All SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1 91 75 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293 203 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 13 30 20 All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351 238 All SZGR 2.0 genes in this pathway
AZARE NEOPLASTIC TRANSFORMATION BY STAT3 DN 17 10 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489 314 All SZGR 2.0 genes in this pathway
NABA PROTEOGLYCANS 35 23 All SZGR 2.0 genes in this pathway
NABA CORE MATRISOME 275 148 All SZGR 2.0 genes in this pathway
NABA BASEMENT MEMBRANES 40 22 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway